Zidolam 150/300mg Tablet 10'S

Introduction About ZIDOLAM 150/300MG TABLET

ZIDOLAM 150/300MG TABLET is a combination of Lamivudine and Zidovudine which
belongs to the group of medicines called Anti-viral agents. It is used to manage
HIV infection. HIV (human immunodeficiency virus) infection is a viral infection
that damages our immune system and weakens our body’s ability to fight against
various infections.

Before taking ZIDOLAM 150/300MG TABLET inform your doctor if you have any liver
problems, kidney problems or hepatitis B or C infection. Do not take ZIDOLAM
150/300MG TABLET if you are allergic to lamivudine or zidovudine.

Although ZIDOLAM 150/300MG TABLET can manage HIV infection, it is important for
you to follow certain measures to manage the spread of infections to the other
people (such as avoid having unprotected sexual intercourse or sharing needles
or personal items like toothbrush, razors etc with other people). ZIDOLAM
150/300MG TABLET is not recommended for use in pregnant and in breastfeeding
women.

The most common side effects of taking ZIDOLAM 150/300MG TABLET are headache,
dizziness, nausea, vomiting, fever, general sensation of being unwell, lack of
sleep, muscle pains or cramps, joint pain, runny nose and low RBC or WBC count
in blood. Consult your doctor if any of these side effects trouble you.

Uses Of ZIDOLAM 150/300MG TABLET

• Manage HIV infection

How ZIDOLAM 150/300MG TABLET Works

ZIDOLAM 150/300MG TABLET is an anti-viral medicine. It controls the
multiplication of viral cell within the body, by blocking the actions of certain
viral enzymes (HIV-reverse transcriptase) that is required for their growth and
survival. It can also increase the number of certain types of white blood cells
(CD4) in the body which improves immunity among the affected patients.

How to use ZIDOLAM 150/300MG TABLET

Take ZIDOLAM 150/300MG TABLET as directed by your physician. Swallow the
medicine with a glass of water. Do not crush or chew the medicine. ZIDOLAM
150/300MG TABLET can be taken with or without meals.

Your doctor will decide the correct dose and for how long ZIDOLAM 150/300MG
TABLET must be taken depending upon your age, body weight and severity of the
infection. Do not stop taking ZIDOLAM 150/300MG TABLET without consulting your
doctor as it may reduce its effectiveness.

Side Effects Of ZIDOLAM 150/300MG TABLET

Common

• Headache, dizziness
• Nausea, vomiting
• Diarrhea, stomach pain, loss of appetite
• Tiredness, lack of energy
• Fever, general sensation of being unwell, cough
• Lack of sleep (insomnia)
• Muscle pains or cramps
• Joint pain
• Nasal irritation, runny nose
• Skin rash, hair loss
• Low RBC or WBC count in blood
• Liver problems (causing yellowing of skin)

Uncommon

• Shortness of breath
• Bloating
• Low platelet count in blood

Rare

• Changes in taste
• Passing more urine than usual
• Enlarged breasts in men
• Changes in colour of the skin or nails
• Tingling or numbness of body parts

Stop taking ZIDOLAM 150/300MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• Loss of fat from face, arms and legs (signs of lipoatrophy)
• Signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and throat causing difficulty in breathing or swallowing)
• Liver inflammation, jaundice, enlarged liver, fatty liver
• Lactic acidosis (causing drowsiness, nausea, vomiting, stomach pain, deep or rapid breathing, numbness of weakness in the limbs)
• Inflammation of pancreas
• Chest pain
• Fits, depression, anxiety
• Opportunistic infections or flaring up of old infections
• pure red cell aplasia (failure of bone marrow to produce new red blood cells)
• signs of infections (such as fever, headache, stomach-ache, breathing difficulty)
• signs of auto-immune disorders (such as muscle weakness, rapid or irregular heartbeat, tremor, hyperactivity, general weakness)
• signs of osteonecrosis (death of bone cells causing joint stiffness, pain in the hip, knee or shoulder and difficulty in moving)
• signs of liver problems (such as yellowing of the skin and whites of the eye, dark urine, light-coloured stools, loss of appetite, nausea, pain, tenderness on the right side of stomach)

How To Manage Side Effects

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

Nausea and vomiting:

Take ZIDOLAM 150/300MG TABLET with or just after a meal or a snack. Stick to
simple meals. Avoid eating rich or spicy food. Consult your doctor if your
nausea worsens.

Warning & Precautions

!### Pregnancy

ZIDOLAM 150/300MG TABLET is not recommended for use in pregnant women unless
considered necessary by the physician. Therefore, consult your doctor before
taking it.

!### Breastfeeding

Breastfeeding should be discontinued in mothers infected with HIV infection.
However, consult your doctor before taking ZIDOLAM 150/300MG TABLET if you wish
to breastfeed.

!### Driving and Using Machines

Do not drive or operate any machines if your ability is affected by ZIDOLAM
150/300MG TABLET.

!### Alcohol

Avoid consum

!### Kidney

ZIDOLAM 150/300MG TABLET should be used with caution in patients with kidney
problems. Therefore, consult your doctor before taking it.

!### Liver

ZIDOLAM 150/300MG TABLET should be used with caution in patients with liver
diseases or a previous history of liver infections (such as Hepatitis B or C
infection). Therefore, consult your doctor before taking it.

!### Allergy

Do not take ZIDOLAM 150/300MG TABLET if you are allergic to lamivudine or to
zidovudine.

Others

ZIDOLAM 150/300MG TABLET is not recommended for use if you:

• have a very low RBC or WBC count in blood

Before taking ZIDOLAM 150/300MG TABLET inform your doctor if you:

• are overweight
• have a weak immune system
• take corticosteroids to heal any auto-immune conditions
• are an alcoholic

Use in paediatrics:

ZIDOLAM 150/300MG TABLET should be used with caution in children and in
adolescents (aged below 18 years; minimum body weight 14 kg). Therefore, consult
your doctor before taking it.

Use in geriatrics:

ZIDOLAM 150/300MG TABLET should be used with caution in elderly people.
Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking ZIDOLAM 150/300MG TABLET inform your doctor if you are taking any
of the following medicines such as:

• other medicines used to manage HIV infection (such as emtricitabine, lamivudine combinations (such as tenofovir/lamivudine, lamivudine/stavudine)
• ribavirin, ganciclovir (used to manage viral infections)
• co-trimoxazole (trimethoprim/sulfamethoxazole) used to manage bacterial infections
• cladribine (an anti-cancer medicine used to manage hairy cell leukaemia)
• phenytoin and sodium valproate (medicines used to manage epilepsy)
• interferons (used to improve immunity) such as pegylated interferon alpha2B
• pyrimethamine (a medicine used to manage malaria or parasitic infection)
• dapsone (a medicine used to manage leprosy)
• medicines used to manage fungal infections (such as amphotericin B, fluconazole or flucytosine)
• pentamidine or atovaquone (used to manage parasitic infections)
• probenecid (a medicine used to manage gout)
• methadone (a medicine used for pain relief)
• medicines used to manage cancer (such as vincristine, vinblastine or doxorubicin)
• clarithromycin (a medicine used to manage bacterial infections)
• medicines containing sorbitol and other sugar alcohols such as xylitol, mannitol, lactitol or maltitol

Overdosage:

If you or anyone else accidentally took more ZIDOLAM 150/300MG TABLET, consult
your doctor immediately.

Synopsis

Drug	:	Lamivudine, Zidovudine
Pharmacological Category	:	Nucleoside Reverse Transcriptase Inhibitors
Therapeutic Indication	:	HIV infection
Dosage Forms	:	Tablet

More Information

• Keep ZIDOLAM 150/300MG TABLET out of reach of children
• Store ZIDOLAM 150/300MG TABLET at room temperature

FAQs About ZIDOLAM 150/300MG TABLET

Q: What is ZIDOLAM 150/300MG TABLET?

A: ZIDOLAM 150/300MG TABLET is an antiviral medicine used to manage HIV
infection. It acts by reducing the multiplication of viral cells within the
body. It also improves immunity by increasing the numbers of certain white blood
cells (CD4) in the body which is required to fight against various infections.

Q: Is ZIDOLAM 150/300MG TABLET safe?

A: ZIDOLAM 150/300MG TABLET should be used only under medical supervision. It
may cause few side effects like headache, dizziness, nausea, vomiting, fever,
general sensation of being unwell, lack of sleep, muscle pains or cramps, joint
pain, runny nose and low RBC or WBC count in blood. Consult your doctor if any
of these side effects trouble you.

Q:How doesZIDOLAM 150/300MG TABLET work in our body?

A: ZIDOLAM 150/300MG TABLET acts by blocking the actions of certain viral
enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow
and multiply. This reduces the multiplication of viral cells within the body. It
can also improve immunity in the affected patients by increasing the number of
certain types of white blood cells (CD4) in the body which is required to fight
against various infection.

Q: Can I stop taking ZIDOLAM 150/300MG TABLET if I feel unwell?

A: No. Do not stop taking ZIDOLAM 150/300MG TABLET without consulting your
doctor. Take ZIDOLAM 150/300MG TABLET regularly, because if you miss a dose of
ZIDOLAM 150/300MG TABLET or take it at irregular intervals, you may not achieve
better results.

Q: What to do if I forget to take a dose of ZIDOLAM 150/300MG TABLET?

A: If you miss a dose of ZIDOLAM 150/300MG TABLET take it as soon as you
remember. However, if it is time to take the next dose, skip the missed dose and
take the next one at regular time. Do not take a double dose of ZIDOLAM
150/300MG TABLET to compensate the missed dose.

Q: Can ZIDOLAM 150/300MG TABLET manage HIV completely?

A: No. ZIDOLAM 150/300MG TABLET cannot not manage HIV infection completely. It
can reduce only the number of viral cells present in the body and maintains them
at a lower level.

Q: What are the precautions to be followed while taking ZIDOLAM 150/300MG
TABLET?

A: Before taking ZIDOLAM 150/300MG TABLET inform your doctor if you have kidney
or liver problems (such as hepatitis C or B infection). Regularly visit your
doctor and take all the blood tests recommended for you. Consult your doctor
before taking ZIDOLAM 150/300MG TABLET if you are pregnant or breastfeeding. Do
not stop taking ZIDOLAM 150/300MG TABLET without consulting your doctor. Take
ZIDOLAM 150/300MG TABLET regularly without fail. Inform your doctor immediately
if you experience any signs of allergic reactions after taking ZIDOLAM 150/300MG
TABLET.

Q: Can ZIDOLAM 150/300MG TABLET be used in children?

A: ZIDOLAM 150/300MG TABLET should be used with caution in children and in
adolescents (aged below 18 years; minimum body weight 14 kg). Therefore, consult
your doctor before taking it.

Q: How to take ZIDOLAM 150/300MG TABLET?

A: Take ZIDOLAM 150/300MG TABLET as directed by your physician. Swallow the
medicine with a glass of water. Do not crush or chew the medicine. ZIDOLAM
150/300MG TABLET can be taken with or without meals. Continue to take ZIDOLAM
150/300MG TABLET regularly as advised by your physician for maximum benefits.

Useful Diagnostic Tests

• Complete Blood Count