LAMIHOPE Z Tablet 60's

Introduction About LAMIHOPE Z TABLET

LAMIHOPE Z TABLET is a combination of Lamivudine and Zidovudine which belongs to
the group of medicines called Anti-viral agents. It is used to manage HIV
infection. HIV (human immunodeficiency virus) infection is a viral infection
that damages our immune system and weakens our body’s ability to fight against
various infections.

Before taking LAMIHOPE Z TABLET inform your doctor if you have any liver
problems, kidney problems or hepatitis B or C infection. Do not take LAMIHOPE Z
TABLET if you are allergic to lamivudine or zidovudine.

Although LAMIHOPE Z TABLET can manage HIV infection, it is important for you to
follow certain measures to manage the spread of infections to the other people
(such as avoid having unprotected sexual intercourse or sharing needles or
personal items like toothbrush, razors etc with other people). LAMIHOPE Z TABLET
is not recommended for use in pregnant and in breastfeeding women.

The most common side effects of taking LAMIHOPE Z TABLET are headache,
dizziness, nausea, vomiting, fever, general sensation of being unwell, lack of
sleep, muscle pains or cramps, joint pain, runny nose and low RBC or WBC count
in blood. Consult your doctor if any of these side effects trouble you.

Uses Of LAMIHOPE Z TABLET

• Manage HIV infection

How LAMIHOPE Z TABLET Works

LAMIHOPE Z TABLET is an anti-viral medicine. It controls the multiplication of
viral cell within the body, by blocking the actions of certain viral enzymes
(HIV-reverse transcriptase) that is required for their growth and survival. It
can also increase the number of certain types of white blood cells (CD4) in the
body which improves immunity among the affected patients.

How to use LAMIHOPE Z TABLET

Take LAMIHOPE Z TABLET as directed by your physician. Swallow the medicine with
a glass of water. Do not crush or chew the medicine. LAMIHOPE Z TABLET can be
taken with or without meals.

Your doctor will decide the correct dose and for how long LAMIHOPE Z TABLET must
be taken depending upon your age, body weight and severity of the infection. Do
not stop taking LAMIHOPE Z TABLET without consulting your doctor as it may
reduce its effectiveness.

Side Effects Of LAMIHOPE Z TABLET

Common

• Headache, dizziness
• Nausea, vomiting
• Diarrhea, stomach pain, loss of appetite
• Tiredness, lack of energy
• Fever, general sensation of being unwell, cough
• Lack of sleep (insomnia)
• Muscle pains or cramps
• Joint pain
• Nasal irritation, runny nose
• Skin rash, hair loss
• Low RBC or WBC count in blood
• Liver problems (causing yellowing of skin)

Uncommon

• Shortness of breath
• Bloating
• Low platelet count in blood

Rare

• Changes in taste
• Passing more urine than usual
• Enlarged breasts in men
• Changes in colour of the skin or nails
• Tingling or numbness of body parts

Stop taking LAMIHOPE Z TABLET and contact your doctor immediately if you
experience any of the following side effects:

• Loss of fat from face, arms and legs (signs of lipoatrophy)
• Signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and throat causing difficulty in breathing or swallowing)
• Liver inflammation, jaundice, enlarged liver, fatty liver
• Lactic acidosis (causing drowsiness, nausea, vomiting, stomach pain, deep or rapid breathing, numbness of weakness in the limbs)
• Inflammation of pancreas
• Chest pain
• Fits, depression, anxiety
• Opportunistic infections or flaring up of old infections
• pure red cell aplasia (failure of bone marrow to produce new red blood cells)
• signs of infections (such as fever, headache, stomach-ache, breathing difficulty)
• signs of auto-immune disorders (such as muscle weakness, rapid or irregular heartbeat, tremor, hyperactivity, general weakness)
• signs of osteonecrosis (death of bone cells causing joint stiffness, pain in the hip, knee or shoulder and difficulty in moving)
• signs of liver problems (such as yellowing of the skin and whites of the eye, dark urine, light-coloured stools, loss of appetite, nausea, pain, tenderness on the right side of stomach)

How To Manage Side Effects

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

Nausea and vomiting:

Take LAMIHOPE Z TABLET with or just after a meal or a snack. Stick to simple
meals. Avoid eating rich or spicy food. Consult your doctor if your nausea
worsens.

Warning & Precautions

!### Pregnancy

LAMIHOPE Z TABLET is not recommended for use in pregnant women unless considered
necessary by the physician. Therefore, consult your doctor before taking it.

!### Breastfeeding

Breastfeeding should be discontinued in mothers infected with HIV infection.
However, consult your doctor before taking LAMIHOPE Z TABLET if you wish to
breastfeed.

!### Driving and Using Machines

Do not drive or operate any machines if your ability is affected by LAMIHOPE Z
TABLET.

!### Alcohol

Avoid consum

!### Kidney

LAMIHOPE Z TABLET should be used with caution in patients with kidney problems.
Therefore, consult your doctor before taking it.

!### Liver

LAMIHOPE Z TABLET should be used with caution in patients with liver diseases or
a previous history of liver infections (such as Hepatitis B or C infection).
Therefore, consult your doctor before taking it.

!### Allergy

Do not take LAMIHOPE Z TABLET if you are allergic to lamivudine or to
zidovudine.

Others

LAMIHOPE Z TABLET is not recommended for use if you:

• have a very low RBC or WBC count in blood

Before taking LAMIHOPE Z TABLET inform your doctor if you:

• are overweight
• have a weak immune system
• take corticosteroids to heal any auto-immune conditions
• are an alcoholic

Use in paediatrics:

LAMIHOPE Z TABLET should be used with caution in children and in adolescents
(aged below 18 years; minimum body weight 14 kg). Therefore, consult your doctor
before taking it.

Use in geriatrics:

LAMIHOPE Z TABLET should be used with caution in elderly people. Therefore,
consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking LAMIHOPE Z TABLET inform your doctor if you are taking any of the
following medicines such as:

• other medicines used to manage HIV infection (such as emtricitabine, lamivudine combinations (such as tenofovir/lamivudine, lamivudine/stavudine)
• ribavirin, ganciclovir (used to manage viral infections)
• co-trimoxazole (trimethoprim/sulfamethoxazole) used to manage bacterial infections
• cladribine (an anti-cancer medicine used to manage hairy cell leukaemia)
• phenytoin and sodium valproate (medicines used to manage epilepsy)
• interferons (used to improve immunity) such as pegylated interferon alpha2B
• pyrimethamine (a medicine used to manage malaria or parasitic infection)
• dapsone (a medicine used to manage leprosy)
• medicines used to manage fungal infections (such as amphotericin B, fluconazole or flucytosine)
• pentamidine or atovaquone (used to manage parasitic infections)
• probenecid (a medicine used to manage gout)
• methadone (a medicine used for pain relief)
• medicines used to manage cancer (such as vincristine, vinblastine or doxorubicin)
• clarithromycin (a medicine used to manage bacterial infections)
• medicines containing sorbitol and other sugar alcohols such as xylitol, mannitol, lactitol or maltitol

Overdosage:

If you or anyone else accidentally took more LAMIHOPE Z TABLET, consult your
doctor immediately.

Synopsis

Drug	:	Lamivudine, Zidovudine
Pharmacological Category	:	Nucleoside Reverse Transcriptase Inhibitors
Therapeutic Indication	:	HIV infection
Dosage Forms	:	Tablet

More Information

• Keep LAMIHOPE Z TABLET out of reach of children
• Store LAMIHOPE Z TABLET at room temperature

FAQs About LAMIHOPE Z TABLET

Q: What is LAMIHOPE Z TABLET?

A: LAMIHOPE Z TABLET is an antiviral medicine used to manage HIV infection. It
acts by reducing the multiplication of viral cells within the body. It also
improves immunity by increasing the numbers of certain white blood cells (CD4)
in the body which is required to fight against various infections.

Q: Is LAMIHOPE Z TABLET safe?

A: LAMIHOPE Z TABLET should be used only under medical supervision. It may cause
few side effects like headache, dizziness, nausea, vomiting, fever, general
sensation of being unwell, lack of sleep, muscle pains or cramps, joint pain,
runny nose and low RBC or WBC count in blood. Consult your doctor if any of
these side effects trouble you.

Q:How doesLAMIHOPE Z TABLET work in our body?

A: LAMIHOPE Z TABLET acts by blocking the actions of certain viral enzymes
(HIV-reverse transcriptase) that is required for the viral cell to grow and
multiply. This reduces the multiplication of viral cells within the body. It can
also improve immunity in the affected patients by increasing the number of
certain types of white blood cells (CD4) in the body which is required to fight
against various infection.

Q: Can I stop taking LAMIHOPE Z TABLET if I feel unwell?

A: No. Do not stop taking LAMIHOPE Z TABLET without consulting your doctor. Take
LAMIHOPE Z TABLET regularly, because if you miss a dose of LAMIHOPE Z TABLET or
take it at irregular intervals, you may not achieve better results.

Q: What to do if I forget to take a dose of LAMIHOPE Z TABLET?

A: If you miss a dose of LAMIHOPE Z TABLET take it as soon as you remember.
However, if it is time to take the next dose, skip the missed dose and take the
next one at regular time. Do not take a double dose of LAMIHOPE Z TABLET to
compensate the missed dose.

Q: Can LAMIHOPE Z TABLET manage HIV completely?

A: No. LAMIHOPE Z TABLET cannot not manage HIV infection completely. It can
reduce only the number of viral cells present in the body and maintains them at
a lower level.

Q: What are the precautions to be followed while taking LAMIHOPE Z TABLET?

A: Before taking LAMIHOPE Z TABLET inform your doctor if you have kidney or
liver problems (such as hepatitis C or B infection). Regularly visit your doctor
and take all the blood tests recommended for you. Consult your doctor before
taking LAMIHOPE Z TABLET if you are pregnant or breastfeeding. Do not stop
taking LAMIHOPE Z TABLET without consulting your doctor. Take LAMIHOPE Z TABLET
regularly without fail. Inform your doctor immediately if you experience any
signs of allergic reactions after taking LAMIHOPE Z TABLET.

Q: Can LAMIHOPE Z TABLET be used in children?

A: LAMIHOPE Z TABLET should be used with caution in children and in adolescents
(aged below 18 years; minimum body weight 14 kg). Therefore, consult your doctor
before taking it.

Q: How to take LAMIHOPE Z TABLET?

A: Take LAMIHOPE Z TABLET as directed by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. LAMIHOPE Z TABLET can
be taken with or without meals. Continue to take LAMIHOPE Z TABLET regularly as
advised by your physician for maximum benefits.

Useful Diagnostic Tests

• Complete Blood Count