Velpacruz S Tablet 28'S

Introduction About VELPACRUZ S TABLET

VELPACRUZ S TABLET is a combination of Sofosbuvir and Velpatasvir which belongs
to the group of medicines called Antiviral agents. It is used to manage chronic
(long-term) Hepatitis C infection.

Hepatitis C infection is a viral infection caused due to hepatitis C virus.
It predominantly affects the liver and causes severe liver damage. It spreads
mostly through contact with blood from an infected person (such as through
sharing needles).

VELPACRUZ S TABLET is suitable for use both in adults and in children (aged 3
years or above). Before taking VELPACRUZ S TABLET inform your doctor if you have
diabetes, kidney problems or any other liver problems apart from hepatitis C
infection (such as liver transplant or hepatitis B infection). Do not take
VELPACRUZ S TABLET without consulting your doctor if you are pregnant or
breastfeeding.

During management with VELPACRUZ S TABLET, your doctor will regularly monitor
your blood sugar levels and blood count to access improvement in your health
condition and to avoid the risk of unwanted side effects.

The most common side effects of taking VELPACRUZ S TABLET are headache,
tiredness and skin rashes. Consult your doctor if they trouble you.

Uses Of VELPACRUZ S TABLET

• Manage chronic Hepatitis C infection

How VELPACRUZ S TABLET Works

VELPACRUZ S TABLET is an antiviral agent. It acts by blocking the actions of
certain viral enzymes (HIV-reverse transcriptase) that is required for the viral
cell to grow and multiply. As a result, it controls the multiplication of
harmful viral cells within the body which reduces the severity of the infection.

How to use VELPACRUZ S TABLET

Take VELPACRUZ S TABLET as directed by your physician. Swallow the medicine with
a glass of water. Do not crush or chew the medicine. VELPACRUZ S TABLET can be
taken with or without meals.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and severity of the infection. Do not stop
taking VELPACRUZ S TABLET without consulting your doctor as it may reduce its
effectiveness.

Side Effects Of VELPACRUZ S TABLET

Common

• headache
• tiredness
• skin rash

Rare

Stop taking VELPACRUZ S TABLET and contact your doctor immediately if you
experience any of the following side effects:

• signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, nose, throat which causes difficulty in breathing or swallowing)
• severe skin reactions causing widespread skin rashes with severe itching, blistering and peeling of skin, accomp

How To Manage Side Effects

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

Warning & Precautions

!### Pregnancy

There is no proper information regrading the use of VELPACRUZ S TABLET during
pregnancy. Therefore, if you are pregnant or think you may be pregnant, consult
your doctor before taking this medicine. Pregnancy should be avoided if this
medicine is combined with another antiviral agent known as ribavirin.

!### Breastfeeding

VELPACRUZ S TABLET may pass through the breast milk. Therefore, it is not
recommended for use in breastfeeding women. Consult your doctor for advice
before taking it.

!### Driving and Using Machines

Do not drive or handle any machines if your ability is affected by VELPACRUZ S
TABLET.

!### Kidney

VELPACRUZ S TABLET should be used with caution in patients with kidney problems
(such as dialysis). Therefore, consult your doctor before taking it.

!### Liver

VELPACRUZ S TABLET should be used with caution in patients with other liver
problems apart from hepatitis C infection such as awaiting a liver transplant or
hepatitis B infection. Therefore, consult your doctor before taking it.

!### Allergy

Do not take VELPACRUZ S TABLET if you are allergic to Velpatasvir or Sofosbuvir.

!### Heart Disease

VELPACRUZ S TABLET should be used with caution if you have heart problems.
Consult your doctor for advice.

Others

Before taking VELPACRUZ S TABLET, inform your doctor if you:

• are taking medicines for any on-going viral infections
• have diabetes

Use in Paediatrics:

VELPACRUZ S TABLET is not recommended for use in children aged below 3 years.
Therefore, consult your doctor before taking it.

Use in Geriatrics:

VELPACRUZ S TABLET should be used with caution in elderly people. Therefore,
consult your doctor before taking it.

Interactions

A. Drug - Drug interactions:

Before taking VELPACRUZ S TABLET inform your doctor if you are taking any of the
following medicines such as:

• rifampicin, rifabutin, rifapentine (used to manage tuberculosis)
• St. John’s wort (a medicine used to manage depression)
• medicines used to manage epilepsy (such as carbamazepine, phenobarbital, phenytoin, oxcarbazepine)
• rosuvastatin (a medicine used to manage high blood cholesterol levels)
• amiodarone, digoxin (used to manage irregular heart rate)
• warfarin, dabigatran, vitamin k antagonists (used for blood thinning)
• medicines used to suppress your immune system (such as tacrolimus, cyclosporine)
• tenofovir disoproxil fumarate, tipranavir (used to manage HIV infection)
• medicines used to manage stomach ulcers or heartburn (such as aluminium hydroxide, omeprazole, lansoprazole, rabeprazole, pantoprazole, esomeprazole, famotidine, cimetidine, nizatidine or r

Overdosage:

If you or anyone else accidentally took more VELPACRUZ S TABLET, consult your
doctor immediately.

Synopsis

Drug	:	Velpatasvir, Sofosbuvir
Pharmacological Category	:	HCV NS5A inhibitors, nucleotide polymerase inhibitors
Therapeutic Indication	:	Hepatitis C infection
Dosage Forms	:	Tablet

More Information

• Keep VELPACRUZ S TABLET out of reach of children
• Store VELPACRUZ S TABLET at room temperature

FAQs About VELPACRUZ S TABLET

What is VELPACRUZ S TABLET?

VELPACRUZ S TABLET is an antiviral medicine used to manage Hepatitis C
infection.

Is VELPACRUZ S TABLET safe?

VELPACRUZ S TABLET is safe at doses prescribed by the physician.

How does VELPACRUZ S TABLET work in our body?

VELPACRUZ S TABLET acts by blocking the actions of certain viral enzymes
(HIV-reverse transcriptase) that is required for the viral cell to grow and
multiply. This reduces multiplication of viral cells and manages the spread of
infection.

Can I stop taking VELPACRUZ S TABLET if I feel unwell?

No. Do not stop taking VELPACRUZ S TABLET without consulting your doctor. Take
VELPACRUZ S TABLET regularly, because if you miss a dose of VELPACRUZ S TABLET
or take it at irregular intervals, you may experience some unpleasant reactions.
If you wish to discontinue VELPACRUZ S TABLET due to unpleasant symptoms,
consult your doctor for advice.

What to do if I forget to take a dose of VELPACRUZ S TABLET?

If you miss a dose of VELPACRUZ S TABLET take it as soon as you remember.
However, if it is time to take the next dose, skip the missed dose and take the
next one at regular time. Do not take a double dose of VELPACRUZ S TABLET to
compensate the missed dose.

Can VELPACRUZ S TABLET manage Hepatitis C completely?

Yes. VELPACRUZ S TABLET acts by reducing the number of viral cells within the
body. Eventually, it can eliminate the virus from the body and can manage
hepatitis C completely.

What are the precautions to be followed while taking VELPACRUZ S TABLET?

Before taking VELPACRUZ S TABLET inform your doctor if you have diabetes, kidney
problems or any other liver problems apart from hepatitis C infection (such as
liver transplant or hepatitis B infection). Do not take VELPACRUZ S TABLET
without consulting your doctor if you are pregnant or breastfeeding. Regularly
visit your doctor and take all the blood tests recommended for you. Do not stop
taking VELPACRUZ S TABLET without consulting your doctor.

Can VELPACRUZ S TABLET be used in children?

VELPACRUZ S TABLET is not recommended for use in children aged below 3 years.
Children aged above 3 years must consult their doctor before taking this
medicine. Therefore, consult your doctor for advice.

How to take VELPACRUZ S TABLET?

Take VELPACRUZ S TABLET as directed by your physician. Swallow the medicine with
a glass of water. Do not crush or chew the medicine. VELPACRUZ S TABLET can be
taken with or without meals. Continue to take VELPACRUZ S TABLET regularly as
advised by your physician for maximum benefits.

Useful Diagnostic Tests

• Complete Blood Count
• Bilirubin Total
• Hepatitis B s (Surface) Antigen
• Hepatitis C Virus Total Antibody
• Liver Function Test