VIROPIL Tablet 90's

Introduction About VIROPIL TABLET

VIROPIL TABLET is a combination of Dolutegravir, Lamivudine, and Tenofovir which
belongs to the group of medicines called Antiretroviral drugs. It is used to
manage HIV (human immunodeficiency virus) infection.

HIV (human immunodeficiency virus) is a virus that attacks cells that help the
body fight infection, making a person more vulnerable to other infections and
diseases. As the virus destroys and impairs the function of immune cells,
infected individuals gradually become immunodeficient, and reach the most
advanced stage of HIV infection called Acquired Immunodeficiency Syndrome
(AIDS).

It may present with the symptoms of any other infection like fever, throat pain,
extreme tiredness, weight loss, muscle pain.

During the course of the management your doctor might take regular blood tests
to avoid any unwanted side effects.

Avoid consum
problems. Consult your doctor before taking.

Before taking VIROPIL TABLET, inform your doctor if you have any kidney, liver,
or bone problems. Consult your doctor before taking.

VIROPIL TABLET should be used with caution in pregnant and breastfeeding women
only if considered necessary by your doctor. Consult your doctor before taking.

Your doctor will prescribe the right dose depends on your child’s age, body
weight and disease condition. Consult your doctor before taking VIROPIL TABLET.

The most common side effects of taking VIROPIL TABLET are trouble sleeping,
diarrhea, pain, tiredness, headache, rash, depression, and fever and cough.
Contact your doctor if any of the above side effects worsen.

Uses Of VIROPIL TABLET

• Used to manage HIV infection

How VIROPIL TABLET Works

VIROPIL TABLET helps to control HIV infection where Dolutegravir inhibits an
enzyme (HIV integrase) by binding to the active site and interrupts the HIV
replication cycle, resulting in the inhibition of viral activity, and Tenofovir
and Lamivudine inhibit HIV replication through incorporation into viral DNA by
the enzyme HIV reverse transcriptase, resulting in obstruction of viral DNA
synthesis.

How to use VIROPIL TABLET

Take VIROPIL TABLET as advised by your physician. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of VIROPIL TABLET

Common

• trouble sleeping
• diarrhea
• pain
• tiredness
• headache
• rash
• depression
• fever, cough (in children)

Rare

Stop taking VIROPIL TABLET and consult your doctor immediately if you experience
any of the following side effects:

• risk of inflammation of the pancreas (pancreatitis)
• new or worsening of existing kidney problems (kidney failure)
• bone problems (bone pain, softening or thinning which may lead to fractures)
• changes in immune system
• lactic acidosis (extreme weakness or tiredness, unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, cold arms and legs, dizziness, light-headedness, fast or irregular heartbeat)
• worsening of hepatitis B infection
• allergic reaction (rash, fever, feeling generally unwell, tiredness, muscle or joint pain, blisters or sores in mouth, blisters or peeling of the skin, redness or swelling of the eyes, swelling of the mouth, face, lips, tongue, or trouble breathing)
• serious liver problems (yellow skin or the white part of eyes, dark urine, light-colored stools, loss of appetite for several days or longer, nausea, vomiting, pain, or softness on the right side of stomach area)

How To Manage Side Effects

Nausea or Vomiting:

Take VIROPIL TABLET with, or just after meals. Stick to simple meals. Avoid
eating oily or spicy foods. Get adequate rest. Drink lots of fluids, especially
water. Have small sips if you feel sick. Do not take any medicine for nausea or
vomiting without asking your doctor.

Headache:

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress
free. Ask your doctor before taking any medicine for headache.

Diarrhea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do
not consume any medicine on your own without consulting your doctor.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller meals more
frequently. Keep a heat pad on your stomach. If the symptom does not improve,
contact your doctor.

Warning & Precautions

!### Pregnancy

VIROPIL TABLET should be used in pregnant women only if considered necessary by
your doctor. Consult your doctor for advice.

!### Breastfeeding

VIROPIL TABLET should be used in breastfeeding women only if considered
necessary by your doctor. Consult your doctor for advice.

!### Driving and Using Machines

Do not drive or use any machines if you feel dizzy after taking VIROPIL TABLET.

!### Alcohol

Avoid consum
problems.

!### Kidney

VIROPIL TABLET should be used with caution in patients with kidney problems or
receive kidney dialysis> management. Consult your doctor before taking it.

!### Liver

VIROPIL TABLET should be used with caution in patients with liver problems
including hepatitis B infection. Consult your doctor before taking it.

!### Allergy

Do not take VIROPIL TABLET if you are allergic to Dolutegravir, Lamivudine,
Tenofovir or any of the other ingredients of this medicine.

Others

Before taking VIROPIL TABLET, inform your doctor if you:

• have bone problems like a history of bone fractures

Use in pediatrics:

Your doctor will prescribe the right dose depends on your child’s age, body
weight and disease condition. Consult your doctor before taking VIROPIL TABLET.

Interactions

A. Drug - Drug interactions:

Before taking VIROPIL TABLET, inform your doctor if you are taking any of the
following medicine:

• dofetilide (used to manage heart conditions)
• metformin (used to manage diabetes)
• medicines used to manage indigestion and heartburn (Ex. magnesium carbonate, calcium bicarbonate)
• calcium supplements, iron supplements and multivitamins
• medicines used to manage HIV infection (Ex. etravirine, efavirenz, fosamprenavir, ritonavir, diadanosine, nevirapine or tipranavir)
• medicines used to manage tuberculosis and other bacterial infections (Ex. rifampicin, gentamycin, pentamidine or vancomycin)
• medicines used to manage fits (Ex. phenytoin, phenobarbital, oxcarbazepine, carbamazepine)
• St John’s wort (used to manage depression)
• amphotericin B (used to manage fungal infection)
• medicines used to manage viral function (Ex. foscarnet, ganciclovir, cidofovir, adefovir)
• tacrolimus (used after an organ transplant)
• interleukin-2 (used to manage cancer)
• medicines used to relieve pain and inflammation (Ex, ibuprofen, indomethacin)

Overdosage:

If you or anyone else accidentally took too much of VIROPIL TABLET, contact your
doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Dolutegravir, Lamivudine, Tenofovir
Pharmacological Category	:	Integrase inhibitor, Nucleoside analogue reverse transcriptase inhibitor, Nucleotide reverse transcriptase inhibitor
Therapeutic Indication	:	HIV infection
Dosage Forms	:	Tablet

More Information

• Keep VIROPIL TABLET out of reach of children
• Store below 30°C

FAQs About VIROPIL TABLET

Q: DoesVIROPIL TABLETmanage HIV infection?

A: VIROPIL TABLET does not completely manage HIV infection. While taking this
medicine, you may still develop infections or other diseases associated with HIV
infection. Consult your doctor for advice.

Q: Is VIROPIL TABLET safe in pregnancy?

A: Before taking VIROPIL TABLET, inform your doctor if you are pregnant, think
you may be pregnant or are planning to get pregnant because it may harm your
unborn baby. Consult your doctor before taking VIROPIL TABLET.

Q: Can VIROPIL TABLET be used on children?

A: Your doctor will prescribe the right dose depends on your child’s age, body
weight and disease condition. Consult your doctor before taking VIROPIL TABLET.

Q: What if I miss a dose of VIROPIL TABLET?

A: If you miss a dose of VIROPIL TABLET, take it as soon as you remember.
However, omit the missed dose if it is almost time for the next dose. Do not
take VIROPIL TABLET twice to make up for a forgotten dose.

Q: Can I stop taking VIROPIL TABLET?

A: Do not stop taking VIROPIL TABLET without consulting your doctor. If you have
any more doubts regarding the use of VIROPIL TABLET, ask your doctor.

Useful Diagnostic Tests

• Complete blood count
• CD4 Count Test