Valodex 20mg Tablet 10'S

Introduction About VALODEX 20MG TABLET

VALODEX 20MG TABLET contains Tamoxifen which belongs to the group of medicines
called Anti-estrogen agents. It is used for breast cancer. This medicine is also
used for reproductive health in women caused by a failure to produce and release
eggs. Breast cancer is a disease in which cells in the breast grow out of
control. There are different kinds of breast cancer. The kind of breast cancer
depends on which cells in the breast turn into cancer.

Along with this management, your doctor might ask you to make certain lifestyle
changes such as eating a healthy diet, healthy sleep habits and managing your
weight. Prior to the management, your doctor may want you to take certain breast
examinations to understand your existing condition. VALODEX 20MG TABLET is not
recommended for use in patients with a history of blood clots (including
family).

VALODEX 20MG TABLET should be used with caution in patients with a history of
hereditary angioedema. VALODEX 20MG TABLET is not recommended for use in
pregnant women. Inform your doctor before taking VALODEX 20MG TABLET if you are
breastfeeding. VALODEX 20MG TABLET is not recommended for use in children. The
most common side effects of taking VALODEX 20MG TABLET are nausea, fluid
retention, skin rash, hot flushes, tiredness and anemia. Consult your doctor if
any of the above side effects worsen or persist for a long time.

Uses Of VALODEX 20MG TABLET

• Used for breast cancer

How VALODEX 20MG TABLET Works

VALODEX 20MG TABLET works by binding to estrogen receptors and blocking the
effects of estrogen (natural female hormone) in the breast tissue. This slows
down the growth and multiplication of breast cancer cells.

How to use VALODEX 20MG TABLET

Take VALODEX 20MG TABLET as advised by your physician. Swallow the medicine with
water. Do not crush or chew the medicine. Your doctor will decide the correct
dose and duration for you depending upon your age, body weight and disease
condition.

Side Effects Of VALODEX 20MG TABLET

Common

• Nausea
• Vomiting
• Fluid retention
• Skin rash
• Hot flushes (feeling of warmth)
• Tiredness
• Anemia
• Changes in vision due to cataracts or changes to the retina of eye
• Increased amounts of fats in blood
• Allergic reactions
• Leg cramps
• Changes in the womb (including changes to its lining and benign growths)
• Headache, light-headedness
• Itching of the genitals
• Thinning of the hair
• Diarrhea
• Constipation
• Changes in blood tests of liver function
• Formation of fatty liver cells
• Muscle pain
• Sensory changes
• Increased risk of blood clots

Uncommon

• Blood problems
• Changes in vision and difficulty seeing
• Swelling of the pancreas
• Changes in the amount of calcium in your blood
• Inflammation of the lungs

Rare

• Changes in the cornea of eye
• Problems with the nerve that connects retina to your brain
• Swelling of the o
• Damage to blood vessels causing reddish or purplish dots on the skin
• Severe skin disorder (redness, blistering and peeling)
• Non-cancerous mass in inner lining of vagina
• Worsening of the symptoms of breast cancer such as an increase in pain and/or an increase in the size of the affected tissue may occur

Stop taking VALODEX 20MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• Swelling of the calf or leg, chest pain, being short of breath or suddenly feeling weak
• Symptoms of a stroke (sudden onset of weakness or paralysis of the arms or legs, being unable to move the arms or legs, sudden difficulty with speaking, walking, in holding things or in thinking)
• Difficulty in breathing, swelling of the face, lips, tongue or throat which may make it difficult to swallow (angioedema)
• Nettle rash (hives or urticaria)
• Reddish non-elevated, target-like or circular patches on the trunk, often with central blisters, skin peeling, ulcers of mouth, throat, nose, genitals and eyes (Stevens-Johnson syndrome, toxic epidermal necrolysis)
• Unusual bleeding from vagina
• Irregular periods, especially if associated with heavier bleeding as this could be a warning sign for a certain type of cancer affecting the lining of womb (endometrial cancer)
• Vaginal discharge
• Feeling of discomfort in the lower tummy (pelvis)

How To Manage Side Effects

!### Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals and
drink plenty of water. Exercise more regularly.

!### Diarrhea

Drink lots of water or fruit juice to keep hydrated. Do not consume any medicine
on your own without consulting your doctor.

Headache

Avoid bright lights, taken enough rest and drink lots of water.

!### Nausea And Vomiting

Take this medicine with or just after meals. Stick to simple meals. Avoid eating
oily or spicy foods.

Warning & Precautions

!### Pregnancy

ContraindicatedVALODEX 20MG TABLET is not recommended for use in pregnant women. Consult your
doctor immediately if you think you may have become pregnant.

!### Breastfeeding

Consult your doctorInform your doctor if you are breastfeeding before taking VALODEX 20MG TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or handle any machines if you experience tiredness after taking
VALODEX 20MG TABLET.

!### Allergy

ContraindicatedDo not take VALODEX 20MG TABLET  if you are allergic to Tamoxifen or any other
ingredients of this medicine.

!### Use In Pediatrics

ContraindicatedVALODEX 20MG TABLET is not recommended for use in children. Consult your doctor
before taking.

Others

VALODEX 20MG TABLET is not recommended for use if you:

• Are taking management for reproductive health
• Have or had blood clots in the past
• Have family history of blood clots
• Have illness which runs in the family that increases the risk of blood clots

Before taking VALODEX 20MG TABLET, inform your doctor if you:

• Are to undergo planned surgery
• Have a history of hereditary angioedema
• Are intolerant to certain sugars (lactose)

Interactions

A. Drug-Drug interactions:

Before taking, VALODEX 20MG TABLET, inform your doctor if you are taking any of
the following medicine:

• Oral contrace
• Hormone replacement therapy (HRT)
• Antidepressants (Ex. paroxetine, fluoxetine)
• Bupropion (used as antidepressant or aid smoking cessation)
• Quinidine (used for cardiac arrhythmia)
• Cincalet/cinacalcet (used for disorders of the parathyroid gland)
• Blood thinning medicines such as warfarin
• Rifampicin (used for tuberculosis)
• Medicines used for breast cancer (Ex. anastrozole, letrozole and exemestane)

Overdosage:

If you or anyone else accidentally takes too much of VALODEX 20MG TABLET,
consult your doctor immediately or visit the nearby hospital. Symptoms of
overdose are uncontrollable shaking of a part of the body, unsteadiness and
dizziness.

Synopsis

Drug	:	Tamoxifen
Pharmacological Category	:	Anti-estrogens
Therapeutic Indication	:	Breast cancer
Dosage Forms	:	Tablet, Capsule

More Information

Storage

• Keep VALODEX 20MG TABLET out of reach of children
• Do not store above 25°C

FAQs About VALODEX 20MG TABLET

Q: What is VALODEX 20MG TABLET used for?

A: It is used for breast cancer. This medicine is also used for reproductive
health in women caused by a failure to produce and release eggs.

Q: What if I stop taking VALODEX 20MG TABLET?

A: Do not stop taking VALODEX 20MG TABLET, even if you start feeling well,
unless your doctor tells you. Stopping it early may increase the risk.

Q: Can VALODEX 20MG TABLET be used in pregnant women?

A: No. VALODEX 20MG TABLET is not recommended for use in pregnant women as it
can affect the unborn child.

Q: What are common side effects of taking VALODEX 20MG TABLET?

A: VALODEX 20MG TABLET may cause hot flushes, night sweats, sleep disturbance,
vaginal irritation, headache, loss of sex drive and mood changes, fluid
retention, nausea and vomiting.

Q: What if I forget to take VALODEX 20MG TABLET?

A: If you forget to take VALODEX 20MG TABLET, take it as soon as you remember.
If it is near to your next dose, skip it and follow your usual dosing schedule.
Do not take two doses at the same time.