ONEOVA 2.5 Tablet 5's

Introduction About ONEOVA 2.5 TABLET

ONEOVA 2.5 TABLET contains Letrozole which belongs to the group of medicines
called Hormonal Chemotherapeutic agents. It is used for breast cancer in
postmenopausal women. It can be given either as an initial therapy or following
therapy with other medicines such as tamoxifen. It is also used for patients
with advanced breast cancer with breast tumour spreading to other parts of the
body. Breast cancer can be defined as the uncontrollable growth and division of
cells present in the breast. It is predominantly caused due to hormonal
imbalance (increased estrogen production) or due to lifestyle factors. Symptoms
include breast pain or tenderness, purple or red colored breasts, nipple
discharge and lump growths.

Before taking ONEOVA 2.5 TABLET inform your doctor if you have any problems in
your kidneys or liver. You must also inform your doctor before taking ONEOVA 2.5
TABLET if you have a history of any bone problems such as osteoporosis or joint
pain.

ONEOVA 2.5 TABLET is only intended for use in women who have reached their
menopause. It is strictly not recommended for use in pregnant women as it may
cause serious harm to the growing baby. The most common side effects of taking
ONEOVA 2.5 TABLET are hot flushes, fatigue, increased sweating, joint pain, hair
loss, vaginal bleeding, and high blood cholesterol levels. Talk to your doctor
if any of these above side effect bothers you.

Uses Of ONEOVA 2.5 TABLET

It is used:

• for breast cancer in postmenopausal women
• as an initial therapy or following therapy with other medicines (such as tamoxifen)

How ONEOVA 2.5 TABLET Works

ONEOVA 2.5 TABLET contains Letrozole which is an aromatase inhibitor acts by
blocking the actions of an enzyme called aromatase in the body which is involved
in the production of estrogen. This suppresses the release of excessive estrogen
in the body that triggers breast cancer. As a result, it slows down from growing
and spreading to other parts of the body.

How to use ONEOVA 2.5 TABLET

Take ONEOVA 2.5 TABLET as advised by your physician. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration of therapy for you depending upon your age, body
weight and disease condition.

Side Effects Of ONEOVA 2.5 TABLET

Serious

Stop taking ONEOVA 2.5 TABLET and contact your doctor immediately if you
experience any of the following side effects:

• Signs of blood clot (such as difficulty in breathing, fainting, rapid heart rate, chest pain, bluish skin discoloration, leg, or foot pain)
• Tendon rupture causing bone pain, inflammation of the tendons
• Severe persistent blurred vision
• Severe fever, chills, or mouth ulcers due to infections
• Swelling and redness along a vein which is tender painful when touched
• Sudden onset of oppressive chest pain
• Signs of a brain disorder or a stroke (weakness, paralysis, or numbness in any part of the body, loss of coordination, nausea, or difficulty in speaking or breathing)
• Signs of allergic reactions (such as swelling of the face and throat)
• Hepatitis (symptoms include loss of appetite, dark-colored urine, yellow skin and eyes, nausea)
• Signs of serious skin reactions (such as skin rash, red skin, blistering and peeling of the skin, accomp

Common

• Hot flushes
• Feeling weak or tired
• Increased sweating
• Joint pain, muscle pain
• Skin rash
• Headache, dizziness
• Nausea, vomiting
• Indigestion
• Constipation
• Diarrhoea
• loss of appetite
• Swelling of arms, hands, feet, ankles
• weight gain
• Depression
• Hair loss, dry skin
• Vaginal bleeding
• Palpitations (rapid heartbeat)

Uncommon

• Feeling anxious, nervous or irritated
• Drowsiness
• Memory problems, insomnia (lack of sleep)
• Pain or burning sensation in the hands or wrist (carpal tunnel syndrome)
• Impaired sensation of touch, tingling or numbness
• Vaginal discharge or dryness
• Breast pain
• Thirst, taste disorder, dry mouth
• Weight loss
• Urinary tract infection, increased frequency of urination
• Cough
• Inflammation of the mouth and lips (stomatitis)

How To Manage Side Effects

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Consult your doctor if your
dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Consult your doctor if your headache worsens.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Warning & Precautions

!### Pregnancy

ContraindicatedONEOVA 2.5 TABLET is not recommended for use during pregnancy. Consult your
doctor before taking ONEOVA 2.5 TABLET.

!### Breastfeeding

ContraindicatedONEOVA 2.5 TABLET is not recommended for use in breast-feeding women. Therefore,
consult your doctor before taking it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizzy, tired, drowsy or
generally unwell after taking ONEOVA 2.5 TABLET.

!### Alcohol

Consult your doctorAvoid consum
reactions.

!### Kidney

Use with CautionONEOVA 2.5 TABLET should be used with caution in patients with severe kidney
diseases. Therefore, consult your doctor before taking it.

!### Liver

Use with CautionONEOVA 2.5 TABLET should be used with caution in patients with severe liver
diseases. Therefore, consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take ONEOVA 2.5 TABLET if you are allergic to Letrozole.

!### Use In Pediatrics

ContraindicatedONEOVA 2.5 TABLET is not recommended for use in children and adolescents (aged
below 18 years). Therefore, consult your doctor before taking it.

!### Use In Geriatrics

Use with CautionONEOVA 2.5 TABLET should be used with caution in elderly patients (aged 65 years
or older). Therefore, consult your doctor before taking it.

Others

ONEOVA 2.5 TABLET is not recommended for use if you:

• have not gone through menopause

Before taking ONEOVA 2.5 TABLET, inform your doctor if you have:

• a history of bone fractures or osteoporosis
• osteoporosis (weak bones) or joint inflammation

Interactions

A. Drug-Drug interactions:

Before taking ONEOVA 2.5 TABLET inform your doctor if you are taking any of the
following medicines such as:

• Other medicines used for cancer (Ex. tamoxifen, anastrozole)
• Cimetidine (medicine used to manage stomach ulcer)
• Warfarin (medicine used for blood thinning)

Over dosage:

If you or anyone else accidentally took more of ONEOVA 2.5 TABLET, consult your
doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Letrozole
Pharmacological Category	:	Aromatase inhibitor
Therapeutic Indication	:	Breast cancer in postmenopausal women
Dosage Forms	:	Tablet, Capsule

More Information

• Keep ONEOVA 2.5 TABLET out of reach of children
• Store ONEOVA 2.5 TABLET at room temperature

FAQs About ONEOVA 2.5 TABLET

Q: How does ONEOVA 2.5 TABLET works?

A: ONEOVA 2.5 TABLET contains Letrozole which is an aromatase inhibitor acts by
blocking the actions of an enzyme called aromatase in the body which is involved
in the production of estrogen. This suppresses the release of excessive estrogen
in the body that triggers breast cancer. As a result, it slows down from growing
and spreading to other parts of the body.

Q: Can I take ONEOVA 2.5 TABLET during breastfeeding?

A: No. ONEOVA 2.5 TABLET is not recommended for use in breast-feeding women.
Therefore, consult your doctor before taking.

Q: Can ONEOVA 2.5 TABLET cause headache?

A: Yes. ONEOVA 2.5 TABLET may cause headache in some individuals. If you
experience headache, rest and relax. Drink plenty of fluids such as water or
electrolytes. Apply a pain-relieving balm on the head if required. Consult your
doctor if your headache worsens.

Q: Can ONEOVA 2.5 TABLET increase the risk of infections?

A: ONEOVA 2.5 TABLET may cause a drop in the number of white blood cells in the
body and may weaken your immune system. As a result, you may be at greater risk
of getting infected while taking ONEOVA 2.5 TABLET. To avoid this, your doctor
will regular monitor your blood counts as a precaution. However, inform your
doctor if you experience any signs of infection such as fever.

Q: Can the use of ONEOVA 2.5 TABLET make me feel tired?

A: Yes. ONEOVA 2.5 TABLET may make you feel tired easily. This is because, it
reduces the levels of red blood cells in your blood and may make you anaemic.
Consult your doctor if you experience tiredness after taking ONEOVA 2.5 TABLET.
Tiredness can also occur if you have any pre-existing disease conditions such as
liver or kidney impairment while taking this medicine.

Q: Can I drive a car after taking ONEOVA 2.5 TABLET?

A: ONEOVA 2.5 TABLET may make you feel tired, dizzy, or drowsy. Therefore, do
not drive or operate any heavy tools or machines if your ability is affected by
ONEOVA 2.5 TABLET.

Q: How to take ONEOVA 2.5 TABLET?

A: Take ONEOVA 2.5 TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine.

Q: What should I do if I forget to take a dose of ONEOVA 2.5 TABLET?

A: If you forget to take a dose of ONEOVA 2.5 TABLET, or vomited immediately
after taking the dose, take it as soon as you remember. Do not take the medicine
twice to make up for the forgotten dose.

Q: How to control nausea caused due to ONEOVA 2.5 TABLET?

A: Generally, anticancer medicines are associated with uncontrollable nausea and
vomiting. To avoid this, your doctor would prescribe a suitable medicine to
control them along with ONEOVA 2.5 TABLET. If not, consult your doctor for a
suitable anti-emetic medicine. Do not self-manage nausea.

Useful Diagnostic Tests

• Breast Cancer (CA 15.3/ ER/ PR)