RIPADEP PLUS 2mg Tablet 10's

Introduction About RIPADEP PLUS 2MG TABLET

RIPADEP PLUS 2MG TABLET is a combination of Repaglinide and Metformin which
belongs to the group of medicines called Anti-diabetic agents. It is indicated
as an adjunct to diet and exercise to improve glycemic control in adults with
type 2 diabetes mellitus who are already managed with Meglitinide and Metformin
or who have inadequate glycemic control on a Meglitinide alone or Metformin.

During course of the management your doctor might regularly monitor your blood
glucose level and kidney function test at regular intervals to avoid any
untoward side effects. Avoid consum
2MG TABLET.

RIPADEP PLUS 2MG TABLET is not recommended for use in patients with cardiac,
kidney or respiratory failure, impaired liver or kidney function, diabetic
ketoacidosis, type-1 diabetes mellitus and if you are dehydrated. Before taking
RIPADEP PLUS 2MG TABLET, inform your doctor if you have any planned major
surgery.

RIPADEP PLUS 2MG TABLET should not be used in pregnant women and breastfeeding
women. This medicine is not recommended for use in children and adolescents
(aged below 18 years) and it should be used with caution in elderly patients
(aged 65 years and above).

The most common side effect of taking RIPADEP PLUS 2MG TABLET are diarrhea,
nausea, vomiting, stomach pain and taste disturbances. Consult your doctor if
any of the side effects worsen.

Uses Of RIPADEP PLUS 2MG TABLET

• Manage type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycemic control

How RIPADEP PLUS 2MG TABLET Works

RIPADEP PLUS 2MG TABLET is a combination of Repaglinide and Metformin where
Repaglinide is a meglitinide analogue which increases the amount of insulin
released by the pancreas. This manages blood glucose from rising very high after
the meals. Metformin is a bigu
absor

How to use RIPADEP PLUS 2MG TABLET

Take RIPADEP PLUS 2MG TABLET as advised by your physician. Swallow the medicine
with a glass of water immediately before or up to 30 minutes before the meal. Do
not crush or chew the medicine. Your doctor will decide the correct dose and
duration for you depending upon your age, body weight and disease condition.

Side Effects Of RIPADEP PLUS 2MG TABLET

Common

• taste disturbance
• nausea, vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• altered blood sugar levels

Rare

• cardiac disorders

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids such as water to keep yourself hydrated. Avoid eating
high-fat foods, dairy products and spicy foods. Do not consume any medicine on
your own without consulting your doctor to manage diarrhea.

!### Nausea And Vomiting

Stick to simple meals while taking this medicine. Avoid eating oily, fried or
spicy food. Do not perform any strenuous activities immediately after eating and
do not lie down or sleep immediately after eating. If the symptom does not
improve, consult your doctor.

!### Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller meals more
frequently. Keep a heat pad on your stomach. If the symptom does not improve,
consult your doctor.

Warning & Precautions

!### Pregnancy

Consult your doctorRIPADEP PLUS 2MG TABLET is not recommended for use in pregnant women, as it is
not known if it causes any potential harm to the unborn baby. Consult your
doctor before taking it.

!### Breastfeeding

ContraindicatedRIPADEP PLUS 2MG TABLET is not recommended for use in breast-feeding women.
Consult your doctor before taking it.

!### Driving and Using Machines

Use with CautionYour ability to drive or use a machine may be affected if your blood sugar is
low. Do not drive or operate any machines if you experience any unusual
reactions.

!### Alcohol

ContraindicatedConsum
2MG TABLET since it may increase the risk of lactic acidosis.

!### Kidney

ContraindicatedRIPADEP PLUS 2MG TABLET is not recommended for use in patients with renal
failure or renal dysfunction. Consult your doctor before taking it.

!### Liver

ContraindicatedRIPADEP PLUS 2MG TABLET is not recommended for use in patients with hepatic
insufficiency. Consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take RIPADEP PLUS 2MG TABLET if you are allergic to Repaglinide and
Metformin.

!### Lungs

ContraindicatedRIPADEP PLUS 2MG TABLET is not recommended for use in patients with respiratory
failure. Consult your doctor before taking it.

!### Heart Disease

ContraindicatedRIPADEP PLUS 2MG TABLET is not recommended for use in patients with acute or
chronic disease which may cause tissue hypoxia such as cardiac failure or
recently had myocardial infarction. Consult your doctor before taking it.

!### Use In Pediatrics

ContraindicatedRIPADEP PLUS 2MG TABLET is not recommended for use in children and adolescents
(aged below 18 years). Consult your child’s doctor for advice.

!### Use In Geriatrics

Use with CautionRIPADEP PLUS 2MG TABLET should be used with caution in elderly patients (aged 65
years and above). Consult your doctor before taking it.

Others

RIPADEP PLUS 2MG TABLET is not recommended for use if you:

• have diabetes mellitus type 1, c-pe
• have diabetic ketoacidosis
• have severe infection
• are dehydrated
• have severe infection or shock

Before taking RIPADEP PLUS 2MG TABLET, inform your doctor if you:

are about to have major surgery

Interactions

A. Drug-Drug interactions:

Before taking RIPADEP PLUS 2MG TABLET, inform your doctor if you are taking any
of the following medicines:

• gemfibrozil (used to lower increased fat levels in the blood)
• thiazide diuretics such as hydrochlorothiazide, angiotensin-converting enzyme (ACE) inhibitors (used to manage high blood pressure) Ex. captopril, enalapril
• corticosteroids such as cortisone, hydrocortisone and prednisone (used to manage inflammation)
• anabolic steroids such as nandrolone (used in the management of anemia of renal insufficiency)
• oral contrace
• danazol (used to manage breast cysts and endometriosis)
• thyroid hormones such as levothyroxine (used to manage underactive thyroid gland)
• clarithromycin, trimethoprim, rifampicin (used to manage bacterial infections)
• itraconazole, ketoconazole (used to manage fungal infections)
• ciclosporin (used to suppress the immune system)
• aspirin, clopidogrel (used to manage blood clots)
• phenytoin, carbamazepine, phenobarbital (used to manage epilepsy)
• St. john’s wort (herbal medicine) (used to manage depression)

Overdosage:

If you or anyone else accidentally take too much of RIPADEP PLUS 2MG TABLET,
consult your doctor immediately or visit the nearby hospital. Overdosage symptom
of RIPADEP PLUS 2MG TABLET includes lactic acidosis and low blood sugar levels
with symptoms such as dizziness, sweating, tremor, headache and in severe cases
it may cause seizures and loss of consciousness.

Synopsis

Drug	:	Repaglinide, Metformin
Pharmacological Category	:	Meglitinides, Bigu
Therapeutic Indication	:	Type 2 diabetes mellitus
Dosage Forms	:	Tablet

More Information

• Keep RIPADEP PLUS 2MG TABLET out of reach of children
• Store at room temperature

FAQs About RIPADEP PLUS 2MG TABLET

Q: IsRIPADEP PLUS 2MG TABLETsafe during pregnancy?

A: RIPADEP PLUS 2MG TABLET is not recommended for use during pregnancy as it is
not known if it causes any potential harm to the unborn baby. If you are
pregnant, think you may be pregnant or are planning to get pregnant, inform your
doctor before taking RIPADEP PLUS 2MG TABLET.

Q:Can RIPADEP PLUS 2MG TABLET be stopped on my own?

A: Continue taking RIPADEP PLUS 2MG TABLET until your doctor tells you to stop.
This is to help keep your blood sugar under normal levels. If you have any
further doubts regarding the use of RIPADEP PLUS 2MG TABLET, contact your
doctor.

Q:What precautions do I need to follow while taking RIPADEP PLUS 2MG
TABLET?

A: Patients taking RIPADEP PLUS 2MG TABLET must inform their doctor about their
pre-existing disease conditions like kidney, liver or heart problems. Contact
your doctor immediately if you have any unusual symptoms.

Q:Can RIPADEP PLUS 2MG TABLET be used in patients with heart problems?

A: RIPADEP PLUS 2MG TABLET is not recommended for use in patients with acute or
chronic disease which may cause tissue hypoxia such as cardiac failure or
recently had myocardial infarction. Consult your doctor before taking it.

Q:What are the common side effect of RIPADEP PLUS 2MG TABLET?

A: The most common side effect of taking RIPADEP PLUS 2MG TABLET are diarrhea,
nausea, vomiting, stomach pain, loss of appetite and taste disturbances. Consult
your doctor if any of the side effects worsen.

Useful Diagnostic Tests

• Glucose-Fasting Blood
• Glucose-Postprandial Blood
• Glycosylated Hemoglobin