DAGLUPA 10 Tablet 10's

Introduction About DAGLUPA 10 TABLET

DAGLUPA 10 TABLET is used to manage type II diabetes mellitus when diet and
exercise does not result in adequate control on blood glucose levels. It is also
used in the management of heart failure and chronic kidney disease (reduced
kidney function). It contains Dapagliflozin which belongs to the group of
medicines called Antidiabetic agents.

During therapy with DAGLUPA 10 TABLET, your doctor might regularly monitor blood
sugar levels and kidney functions to avoid the risk of unwanted side effects.
Before taking the medicine, inform your doctor if you have any liver or kidney
problems. You must also inform your doctor if you have type I diabetes, severe
low blood pressure, severe dehydration or conditions which can cause dehydration
(such as nausea, vomiting, fever, serious illness or any surgery).

The most common side effects are back pain, passing more urine, constipation,
dizziness and rash. Consult your physician if any of these side effect worsens.

Uses Of DAGLUPA 10 TABLET

It is used to manage:

• Type II diabetes mellitus
• Heart failure
• Chronic kidney disease

How DAGLUPA 10 TABLET Works

DAGLUPA 10 TABLET contains Dapagliflozin which works by blocking the action of a
protein called SGLT-2 in the kidneys. This action manages the reabsor
glucose and sodium ions in the kidneys. As a result, it excretes excess glucose
and from the body in the form urine leading to decrease in blood sugar levels.
It also protects kidney function and manages it from further damage.
Additionally, it reduces the strain on the heart and helps it to pump blood more
efficiently with less pressure.

How to use DAGLUPA 10 TABLET

• Take DAGLUPA 10 TABLET as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine. It can be taken with or without meals
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
• Do not stop taking DAGLUPA 10 TABLET unless your doctor advice you to stop

Side Effects Of DAGLUPA 10 TABLET

Common side effects of DAGLUPA 10 TABLET:

• fungal infections of genital (thrush) causing itching, irritation, unusual discharge, odor
• back pain
• passing more urine, increased urine frequency
• dizziness
• skin rash
• dehydration, thirst
• constipation
• dry mouth

Stop taking DAGLUPA 10 TABLET and contact your doctor immediately if you
experience any of the following side effects such as:

• signs of allergic reaction (skin rash, itching, swelling of the face, tongue or throat, causing difficulty in breathing and swallowing)
• signs of diabetic ketoacidosis (nausea or vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to breath, a sweet or metallic taste in the mouth or a different odor to urine or sweat, and rapid weight loss)
• pain, swelling, redness or tenderness of the genitals or the areas between the genitals and the anus accomp
• signs of urinary tract infection (such as fever and/or chills, burning sensation while passing urine, pain in the back or side)
• bloody urine
• signs of low blood sugar levels (shaking, sweating, anxiety, hunger, fast heartbeat, headache, change in vision, mood swings, confusion)

Warning & Precautions

!### Pregnancy

Consult your doctorThere are limited for the use of DAGLUPA 10 TABLET in pregnant women Therefore,
the use of this medicine is not recommended during the second and third
trimesters of pregnancy.

!### Breastfeeding

Consult your doctorIt is unknown whether DAGLUPA 10 TABLET and/or its metabolites are excreted in
human milk. Consult your doctor before taking the medicine.

!### Driving and Using Machines

Use with CautionDAGLUPA 10 TABLET does not affect your ability to drive or operate any heavy
tools or machines. However, if it is combined with other antidiabetic medicines,
it may cause dizziness, shakiness, or vision changes. Therefore, do not drive or
handle any heavy tools if your ability is affected by the medicine.

!### Alcohol

Consult your doctorAvoid consum
the risk of unwanted side effects.

!### Kidney

Use with CautionDAGLUPA 10 TABLET should be used with caution in patients with kidney problems.

!### Liver

Use with CautionDAGLUPA 10 TABLET should be used with caution in patients with liver problems.

!### Allergy

ContraindicatedDo not take DAGLUPA 10 TABLET if you are allergic to Dapagliflozin or any other
ingredients of this medicine.

!### Use In Pediatrics

Consult your doctorThere is no data available in children below 10 years of age. Consult your
doctor for advice.

!### Use In Geriatrics

Use with CautionDAGLUPA 10 TABLET should be used with caution in elderly patients (aged 65 years
or above).

Others

Before taking DAGLUPA 10 TABLET, inform your doctor if you:

• have type I diabetes (insulin-dependent diabetes)
• have diabetes related kidney problem
• have low blood pressure
• have uncontrollably high levels of blood glucose levels
• have fever, nausea, vomiting or if you are unable to eat or drink anything
• often get infections of the urinary tract
• are on fasting
• are dehydrated (due to recent vomiting, diarrhea or other reasons)
• have any serious illness or had a major surgery recently

Interactions

A. Drug-Drug interactions:

Before taking the medicine, inform your doctor if you are taking any of the
following medicines such as:

• diuretics (Ex. furosemide, hydrochlorothiazide)
• Antidiabetics (Ex. insulin or glimepiride, gliclazide)

Overdosage:

If you or anyone else accidentally take too much of DAGLUPA 10 TABLET, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Dapagliflozin
Pharmacological Category	:	SGLT-2 Inhibitors
Therapeutic Indication	:	Type II Diabetes Mellitus, Heart Failure, Chronic Kidney Disease
Dosage Forms	:	Tablet

FAQs About DAGLUPA 10 TABLET

Q: What is DAGLUPA 10 TABLET used for?

A: DAGLUPA 10 TABLET is used to manage type II diabetes mellitus in adults and
in children (aged 10 years or older) when diet and exercise does not result in
adequate control on blood glucose levels. It can also be used to manage heart
failure and chronic kidney disease (reduced kidney function) in adults.

Q: Is DAGLUPA 10 TABLET safe to use in children?

A: There are limited for the use of DAGLUPA 10 TABLET in pregnant women
Therefore, the use of this medicine is not recommended during the second and
third trimesters of pregnancy.

Q: Can the use of DAGLUPA 10 TABLET cause weight loss?

A: DAGLUPA 10 TABLET may cause weight loss in some individuals. It is because of
excessive loss of fluid from the body in the form of urine. However, consult
your doctor if this side effect troubles you.

Q: Can DAGLUPA 10 TABLET affects pregnancy?

A: There are limited for the use of DAGLUPA 10 TABLET in pregnant women
Therefore, the use of this medicine is not recommended during the second and
third trimesters of pregnancy.

Q: Can DAGLUPA 10 TABLET cause urinary tract infection?

A: Yes, taking DAGLUPA 10 TABLET may cause urinary tract infections in few
peoples. Not every individual gets the side effect, so it is always better to
practice good hygiene. Contact your doctor for advice.

Q: How does DAGLUPA 10 TABLET work?

A: DAGLUPA 10 TABLET is a SGLT-2 inhibitor. It works by blocking the action of a
protein called SGLT-2 in the kidneys. This action manages the reabsor
glucose and sodium ions in the kidneys. As a result, it excretes excess glucose
and from the body in the form urine leading to decrease in blood sugar levels.
It also protects kidney function and manages it from further damage.
Additionally, it reduces the strain on the heart and helps it to pump blood more
efficiently with less pressure.

Q: How and when to take DAGLUPA 10 TABLET?

A: Take DAGLUPA 10 TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. It can be taken with
or without meals.

Q: How long should I take DAGLUPA 10 TABLET?

A: You need to take DAGLUPA 10 TABLET as long as your doctor prescribes you the
medicine. Your doctor will decide the correct dose and duration of therapy for
you depending upon your age, body weight and disease condition.

Q: What to do if I forgot to take a dose of DAGLUPA 10 TABLET?

A: If you forgot to take a dose of DAGLUPA 10 TABLET, take it as soon as you
remember. However, if it is time for the next dose of DAGLUPA 10 TABLET, skip
the missed dose and take the next one regularly.

Q: What are the most common side effects of taking DAGLUPA 10 TABLET?

A: The most common side effects of taking DAGLUPA 10 TABLET are genital
infections, back pain, passing more urine, constipation, dizziness and rash.
Contact your physician if any of these side effect worsens.

Q: Will taking a higher dose of DAGLUPA 10 TABLET be more effective?

A: No, taking a higher dose of DAGLUPA 10 TABLET will not be effective rather it
can lead to toxicity. Always take the dose prescribed by your doctor. If the
prescribed dose is not effective for you, consult your doctor for advice. Your
doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking DAGLUPA 10 TABLET?

A: Before taking DAGLUPA 10 TABLET inform your doctor if you have any liver or
kidney problems. You must also inform your doctor if you have severe low blood
pressure or are severely dehydrated due to excessive vomiting or diarrhea. Along
with the therapy, follow the diet and lifestyle changes advised by your doctor
to achieve better results.

Q: Can I take DAGLUPA 10 TABLET with metformin?

A: Studies have shown that the combination of DAGLUPA 10 TABLET with metformin
may effectively control blood sugar levels. However, the combination should be
used only under careful medical supervision.

Q: Can DAGLUPA 10 TABLET be taken with insulin?

A: Co-administration of DAGLUPA 10 TABLET with insulin is considered risky as
they increase the chance of hypoglycemia (decreased blood sugar levels).
Therefore, consult your doctor before taking it.

Q: Can DAGLUPA 10 TABLET cause constipation?

A: Yes. Constipation is a common side effect of taking DAGLUPA 10 TABLET. Eat
plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as
drink plenty of water and exercise more regularly while taking this medicine.
Contact your doctor if this side effect bothers you.

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin