ZORYL 1mg Tablet 10's

Introduction About ZORYL 1MG TABLET

ZORYL 1MG TABLET is used for the management of Type II diabetes mellitus when
diet and exercise alone does not result in adequate blood sugar control. It
contains Glimepiride which belongs to the group of medicines called
Anti-diabetic agents. It stimulates the pancreas to secrete more insulin (a
hormone involved in glucose metabolism). It also makes our body more sensitive
to insulin which helps in digesting the circulating sugars (glucose) in the
blood, thereby reducing blood sugar levels.

Along with the therapy, your doctor might ask you to make certain lifestyle
changes such as following a healthy diet, regular physical exercise and quitting
alcohol consum
any liver or kidney problems. You must also inform your doctor if you have any
hormonal problems, genetic disorders (such as G6PD deficiency) or if you are
malnourished, starved, on an irregular diet. ZORYL 1MG TABLET is not suitable
for use in patients with type I diabetes mellitus. Consult your doctor if you
are pregnant or planning to become pregnant or breastfeeding.

The most common side effect of taking ZORYL 1MG TABLET is hypoglycemia (low
blood sugar levels) which can be identified through symptoms such as increased
hunger, sweating, shakiness, weakness or an irregular heartbeat. To avoid this,
your doctor will periodically monitor your blood sugar levels and adjust the
dose of the medicine accordingly. You can also carry a sugary snack (such as
biscuits, glucose drinks or sweet candies) along with you as a precaution and
have them immediately if you experience any signs of hypoglycemia. However,
consult your doctor if there is no improvement in your condition.

Uses Of ZORYL 1MG TABLET

• Used to manage Type II diabetes mellitus

How ZORYL 1MG TABLET Works

ZORYL 1MG TABLET stimulates the pancreas to secrete more insulin (a hormone
involved in glucose metabolism). It also makes our body more sensitive to
insulin which helps in digesting the circulating sugars (glucose) in the blood,
thereby reducing blood sugar levels.

How to use ZORYL 1MG TABLET

• Take ZORYL 1MG TABLET preferably after meals or as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine.
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
• Do not stop taking ZORYL 1MG TABLET unless your doctor advice you to stop

Side Effects Of ZORYL 1MG TABLET

Common side effects of ZORYL 1MG TABLET:

• hypoglycemia (low blood sugar levels)

Stop taking ZORYL 1MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• severe allergic reaction (inflammation of blood vessels, skin rash, swelling of the face, eyelids, lips, tongue or throat which causes difficulty in breathing or swallowing, drop in blood pressure)
• signs of liver problems (such as fever, yellowing of skin and whites of the eyes, weakness, fatigue, weight loss and loss of appetite)
• increased skin sensitivity to sun
• signs of severe decrease in blood sugar level (such as confusion, headache, excessive sweating, clammy skin, trembling, weakness, double vision, excessive hunger, nausea, vomiting, problems in sleeping, feeling agitated, unable to concentrate, drowsiness, slowed reactions, depression, trouble seeing or speaking, paralysis, numbness, dizziness, hallucinations, difficulty in breathing, slowed or faster heartbeat with chest pain)

Warning & Precautions

!### Pregnancy

Monitoring requiredThere are no adequate and well-controlled studies in pregnant women. ZORYL 1MG
TABLET should be used during pregnancy only if the potential benefit justifies
the potential risk to the fetus.

!### Breastfeeding

Consult your doctorIt is not known whether ZORYL 1MG TABLET is excreted in human milk. Consult your
doctor for advice.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected
by the medicine.

!### Alcohol

Consult your doctorAvoid consum
the risk of unwanted side effects.

!### Kidney

Consult your doctorZORYL 1MG TABLET is not recommended for use in patients with severe kidney
problems. It should be used with caution in patients with other kidney problems.

!### Liver

Consult your doctorZORYL 1MG TABLET is not recommended for use in patients with severe liver
problems. It should be used with caution in patients with other liver problems.

!### Allergy

ContraindicatedDo not take ZORYL 1MG TABLET if you are allergic to Glimepiride or any other
ingredients of this medicine.

!### Use In Pediatrics

ContraindicatedZORYL 1MG TABLET is not recommended in pediatric patients because of its adverse
effects on body weight and hypoglycemia.

!### Use In Geriatrics

Use with CautionZORYL 1MG TABLET should be used with caution in elderly patients (aged above 65
years).

Others

ZORYL 1MG TABLET is not recommended for use if you:

• have type I diabetes mellitus
• have diabetic ketoacidosis

Before taking ZORYL 1MG TABLET, inform your doctor if you:

• are recovering from any injury, operation, infections or from any form of stress
• have G6PD deficiency
• have sugar intolerance
• are malnourished, starved, on an irregular diet, or feeling weak
• had made any sudden changes to diet
• are on fasting
• perform extreme physical exercises without proper carbohydrate intake
• have hormonal problems (Ex. disorders of pituitary gland, adrenal cortex or thyroid gland)

Interactions

A. Drug-Drug interactions:

Before taking ZORYL 1MG TABLET, inform your doctor if you are taking any of the
following medicines:

• Anti-diabetics agents (Ex. insulin or metformin)
• Non-steroidal anti-inflammatory agents (Ex. aspirin, ibuprofen, phenylbutazone, azopropazone, oxyphenbutazone)
• Antibiotics (Ex. amikacin, nitrofurantoin, sulfamethoxazole, tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin)
• Anti-fungal agents (Ex. fluconazole, miconazole)
• Anti-coagulants (Ex. warfarin)
• Class II AASs (Ex. nandrolone, oxymethalone)
• Hormone replacement (Ex. testosterone)
• Benzamides (Ex. moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine)
• Anti-lipidemic agents (Ex. fenofibrate, nicotinic acid, colesevelam)
• Angiotensin-converting enzyme (ACE) inhibitors (Ex. enalapril, lisinopril, ramipril)
• Antihypertensives (Ex. atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
• Class 1a anti-arrhythmic agent (Ex. disopyramide)
• Anti-gout agents (Ex. allopurinol, probenecid, sulfinpyrazone)
• Alkylating agents (Ex. cyclophosphamide, ifosfamide, trofosfamide)
• Anticonvulsants (Ex. fenfluramine)
• Hemorrheologic agents (Ex. pentoxifylline)
• Enzyme inhibitor (Ex. tritoqualine)
• Alpha blockers (Ex. prazosin, doxazosin)
• Hormonal replacement therapy (Ex. estradiol)
• Thiazide diuretics (Ex. hydrochlorothiazide)
• Hormones (Ex. Levothyroxine)
• Antipsychotics (Ex. chlorpromazine, prochlorperazine, lithium)
• corticosteroids (Ex. prednisolone, betamethasone)
• Bronchodilators (Ex. salbutamol, terbutaline)
• Alpha- and beta-adrenergic agonists (Ex. adrenaline)
• Laxatives (Ex. lactulose, liquid paraffin)
• Anti-convulsant (Ex. phenytoin)
• Barbiturates (Ex. phenobarbital)
• Carbonic anhydrase inhibitors (Ex. azetazolamide)
• Glycogenolytic agents (Ex. Glucagon, diazoxide)
• H2 blockers (Ex. Cimetidine)

Overdosage:

If you or anyone else accidentally took more of ZORYL 1MG TABLET, you may
experience the signs of hypoglycemia (such as increased hunger, sweating,
headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and
confusion). To manage this, consume any sugary food immediately. If the symptom
did not improve or worsens contact your doctor immediately.

Synopsis

Drug	:	Glimepiride
Pharmacological Category	:	Sulfonylureas
Therapeutic Indication	:	Type 2 diabetes mellitus
Dosage Forms	:	Tablet

More Information

FAQs About ZORYL 1MG TABLET

Q: What is ZORYL 1MG TABLET used for?

A: ZORYL 1MG TABLET is an antidiabetic medicine used to manage Type II diabetes
mellitus when diet, exercise and lifestyle changes alone does not result in
adequate response.

Q: How and when to take ZORYL 1MG TABLET?

A: Take ZORYL 1MG TABLET preferably after meals or as advised by your physician.
Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Q: How long should I take ZORYL 1MG TABLET?

A: You need to take ZORYL 1MG TABLET as long as your doctor or physician
prescribes you the medicine.

Q: What is the best time to take ZORYL 1MG TABLET?

A: ZORYL 1MG TABLET must be taken with meals to avoid gastrointestinal side
effects. Consult your doctor for advice.

Q: What to do if I forgot to take a dose of ZORYL 1MG TABLET?

A: If you forgot to take a dose of ZORYL 1MG TABLET, take it as soon as you
remember. However, if it is time for the next dose of ZORYL 1MG TABLET, skip the
missed dose and take the next one regularly. Do not take a double dose to
compensate the missed ones.

Q: What are the most common side effects of taking ZORYL 1MG TABLET?

A: The most common side effects of taking ZORYL 1MG TABLET is hypoglycemia. To
avoid this, your doctor will periodically monitor your blood sugar levels and
adjust the dose of ZORYL 1MG TABLET accordingly. You can also carry a sugary
snack (such as biscuits, glucose drinks or sweet candies) along with you as a
precaution and have them immediately if you experience any signs of
hypoglycemia.

Q: Can I stop taking ZORYL 1MG TABLET without consulting your doctor?

A: No. You should not stop taking ZORYL 1MG TABLET without consulting your
doctor because it may lead to reversal of symptoms. If you feel better after
using ZORYL 1MG TABLET, consult your doctor for advice.

Q: Will taking a higher dose of ZORYL 1MG TABLET be more effective?

A: No, taking a higher dose of ZORYL 1MG TABLET will not be effective rather it
can lead to unwanted side effects. Always take the dose prescribed by your
doctor. If the prescribed dose is not effective for you, consult your doctor for
advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking ZORYL 1MG TABLET?

A: Before taking ZORYL 1MG TABLET, inform your doctor if you have any liver or
kidney problems. You must also inform your doctor if you have hormonal problems,
genetic problems (surgery in the gut) or if you are malnourished. It is not
suitable for use in patients with type I diabetes mellitus.

Q: Can I take medication for high blood pressure along with ZORYL 1MG TABLET?

A: It is not advisable to take medicines to control blood pressure while taking
ZORYL 1MG TABLET without consulting your doctor. Therefore, consult your doctor
before taking any antihypertensive such as beta blockers (Ex. atenolol,
propranolol) along with the medicine as they have known interactions with the
medicine.

Q: What should I do if I experience low blood sugar after taking ZORYL 1MG TABLET?

A: Low blood sugar is a common side effect of taking ZORYL 1MG TABLET. Try to
have sugar rich food items such as fruit juice, glucose tablets or gel, soft
drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If you
have not gained o
the blood sugar levels once again. In case of persistent low blood sugar levels,
consult your doctor immediately.

Q: Can ZORYL 1MG TABLET be taken with insulin?

A: Co-administration of ZORYL 1MG TABLET with insulin is considered risky as
they are increased chances of hypoglycemia (decreased blood sugar levels).

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin