Letoval 2.5mg Tablet 5'S

Introduction About LETOVAL 2.5MG TABLET

LETOVAL 2.5MG TABLET contains Letrozole which belongs to the group of medicines
called Hormonal Chemotherapeutic agents. It is used for breast cancer in
postmenopausal women. It can be given either as an initial therapy or following
therapy with other medicines such as tamoxifen. It is also used for patients
with advanced breast cancer with breast tumour spreading to other parts of the
body. Breast cancer can be defined as the uncontrollable growth and division of
cells present in the breast. It is predominantly caused due to hormonal
imbalance (increased estrogen production) or due to lifestyle factors. Symptoms
include breast pain or tenderness, purple or red colored breasts, nipple
discharge and lump growths.

Before taking LETOVAL 2.5MG TABLET inform your doctor if you have any problems
in your kidneys or liver. You must also inform your doctor before taking LETOVAL
2.5MG TABLET if you have a history of any bone problems such as osteoporosis or
joint pain.

LETOVAL 2.5MG TABLET is only intended for use in women who have reached their
menopause. It is strictly not recommended for use in pregnant women as it may
cause serious harm to the growing baby. The most common side effects of taking
LETOVAL 2.5MG TABLET are hot flushes, fatigue, increased sweating, joint pain,
hair loss, vaginal bleeding, and high blood cholesterol levels. Talk to your
doctor if any of these above side effect bothers you.

Uses Of LETOVAL 2.5MG TABLET

It is used:

• for breast cancer in postmenopausal women
• as an initial therapy or following therapy with other medicines (such as tamoxifen)

How LETOVAL 2.5MG TABLET Works

LETOVAL 2.5MG TABLET contains Letrozole which is an aromatase inhibitor acts by
blocking the actions of an enzyme called aromatase in the body which is involved
in the production of estrogen. This suppresses the release of excessive estrogen
in the body that triggers breast cancer. As a result, it slows down from growing
and spreading to other parts of the body.

How to use LETOVAL 2.5MG TABLET

Take LETOVAL 2.5MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration of therapy for you depending upon your age,
body weight and disease condition.

Side Effects Of LETOVAL 2.5MG TABLET

Serious

Stop taking LETOVAL 2.5MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• Signs of blood clot (such as difficulty in breathing, fainting, rapid heart rate, chest pain, bluish skin discoloration, leg, or foot pain)
• Tendon rupture causing bone pain, inflammation of the tendons
• Severe persistent blurred vision
• Severe fever, chills, or mouth ulcers due to infections
• Swelling and redness along a vein which is tender painful when touched
• Sudden onset of oppressive chest pain
• Signs of a brain disorder or a stroke (weakness, paralysis, or numbness in any part of the body, loss of coordination, nausea, or difficulty in speaking or breathing)
• Signs of allergic reactions (such as swelling of the face and throat)
• Hepatitis (symptoms include loss of appetite, dark-colored urine, yellow skin and eyes, nausea)
• Signs of serious skin reactions (such as skin rash, red skin, blistering and peeling of the skin, accomp

Common

• Hot flushes
• Feeling weak or tired
• Increased sweating
• Joint pain, muscle pain
• Skin rash
• Headache, dizziness
• Nausea, vomiting
• Indigestion
• Constipation
• Diarrhoea
• loss of appetite
• Swelling of arms, hands, feet, ankles
• weight gain
• Depression
• Hair loss, dry skin
• Vaginal bleeding
• Palpitations (rapid heartbeat)

Uncommon

• Feeling anxious, nervous or irritated
• Drowsiness
• Memory problems, insomnia (lack of sleep)
• Pain or burning sensation in the hands or wrist (carpal tunnel syndrome)
• Impaired sensation of touch, tingling or numbness
• Vaginal discharge or dryness
• Breast pain
• Thirst, taste disorder, dry mouth
• Weight loss
• Urinary tract infection, increased frequency of urination
• Cough
• Inflammation of the mouth and lips (stomatitis)

How To Manage Side Effects

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Consult your doctor if your
dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Consult your doctor if your headache worsens.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Warning & Precautions

!### Pregnancy

ContraindicatedLETOVAL 2.5MG TABLET is not recommended for use during pregnancy. Consult your
doctor before taking LETOVAL 2.5MG TABLET.

!### Breastfeeding

ContraindicatedLETOVAL 2.5MG TABLET is not recommended for use in breast-feeding women.
Therefore, consult your doctor before taking it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizzy, tired, drowsy or
generally unwell after taking LETOVAL 2.5MG TABLET.

!### Alcohol

Consult your doctorAvoid consum
reactions.

!### Kidney

Use with CautionLETOVAL 2.5MG TABLET should be used with caution in patients with severe kidney
diseases. Therefore, consult your doctor before taking it.

!### Liver

Use with CautionLETOVAL 2.5MG TABLET should be used with caution in patients with severe liver
diseases. Therefore, consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take LETOVAL 2.5MG TABLET if you are allergic to Letrozole.

!### Use In Pediatrics

ContraindicatedLETOVAL 2.5MG TABLET is not recommended for use in children and adolescents
(aged below 18 years). Therefore, consult your doctor before taking it.

!### Use In Geriatrics

Use with CautionLETOVAL 2.5MG TABLET should be used with caution in elderly patients (aged 65
years or older). Therefore, consult your doctor before taking it.

Others

LETOVAL 2.5MG TABLET is not recommended for use if you:

• have not gone through menopause

Before taking LETOVAL 2.5MG TABLET, inform your doctor if you have:

• a history of bone fractures or osteoporosis
• osteoporosis (weak bones) or joint inflammation

Interactions

A. Drug-Drug interactions:

Before taking LETOVAL 2.5MG TABLET inform your doctor if you are taking any of
the following medicines such as:

• Other medicines used for cancer (Ex. tamoxifen, anastrozole)
• Cimetidine (medicine used to manage stomach ulcer)
• Warfarin (medicine used for blood thinning)

Over dosage:

If you or anyone else accidentally took more of LETOVAL 2.5MG TABLET, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Letrozole
Pharmacological Category	:	Aromatase inhibitor
Therapeutic Indication	:	Breast cancer in postmenopausal women
Dosage Forms	:	Tablet, Capsule

More Information

• Keep LETOVAL 2.5MG TABLET out of reach of children
• Store LETOVAL 2.5MG TABLET at room temperature

FAQs About LETOVAL 2.5MG TABLET

Q: How does LETOVAL 2.5MG TABLET works?

A: LETOVAL 2.5MG TABLET contains Letrozole which is an aromatase inhibitor acts
by blocking the actions of an enzyme called aromatase in the body which is
involved in the production of estrogen. This suppresses the release of excessive
estrogen in the body that triggers breast cancer. As a result, it slows down
from growing and spreading to other parts of the body.

Q: Can I take LETOVAL 2.5MG TABLET during breastfeeding?

A: No. LETOVAL 2.5MG TABLET is not recommended for use in breast-feeding women.
Therefore, consult your doctor before taking.

Q: Can LETOVAL 2.5MG TABLET cause headache?

A: Yes. LETOVAL 2.5MG TABLET may cause headache in some individuals. If you
experience headache, rest and relax. Drink plenty of fluids such as water or
electrolytes. Apply a pain-relieving balm on the head if required. Consult your
doctor if your headache worsens.

Q: Can LETOVAL 2.5MG TABLET increase the risk of infections?

A: LETOVAL 2.5MG TABLET may cause a drop in the number of white blood cells in
the body and may weaken your immune system. As a result, you may be at greater
risk of getting infected while taking LETOVAL 2.5MG TABLET. To avoid this, your
doctor will regular monitor your blood counts as a precaution. However, inform
your doctor if you experience any signs of infection such as fever.

Q: Can the use of LETOVAL 2.5MG TABLET make me feel tired?

A: Yes. LETOVAL 2.5MG TABLET may make you feel tired easily. This is because, it
reduces the levels of red blood cells in your blood and may make you anaemic.
Consult your doctor if you experience tiredness after taking LETOVAL 2.5MG
TABLET. Tiredness can also occur if you have any pre-existing disease conditions
such as liver or kidney impairment while taking this medicine.

Q: Can I drive a car after taking LETOVAL 2.5MG TABLET?

A: LETOVAL 2.5MG TABLET may make you feel tired, dizzy, or drowsy. Therefore, do
not drive or operate any heavy tools or machines if your ability is affected by
LETOVAL 2.5MG TABLET.

Q: How to take LETOVAL 2.5MG TABLET?

A: Take LETOVAL 2.5MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine.

Q: What should I do if I forget to take a dose of LETOVAL 2.5MG TABLET?

A: If you forget to take a dose of LETOVAL 2.5MG TABLET, or vomited immediately
after taking the dose, take it as soon as you remember. Do not take the medicine
twice to make up for the forgotten dose.

Q: How to control nausea caused due to LETOVAL 2.5MG TABLET?

A: Generally, anticancer medicines are associated with uncontrollable nausea and
vomiting. To avoid this, your doctor would prescribe a suitable medicine to
control them along with LETOVAL 2.5MG TABLET. If not, consult your doctor for a
suitable anti-emetic medicine. Do not self-manage nausea.

Useful Diagnostic Tests

• Breast Cancer (CA 15.3/ ER/ PR)