ISOTROY 100 Liquid For Inhalation 100ml

Introduction About ISOTROY 100 LIQUID FOR INHALATION

ISOTROY 100 LIQUID FOR INHALATION contains Isoflurane which belongs to a group
of medicines known as General Anaesthetics. ISOTROY 100 LIQUID FOR INHALATION is
used for induction and maintenance of general anaesthesia during surgeries.

General Anaesthesia can be defined as a state of controlled unconsciousness.
There is temporary reduction in activity of central nervous system in brain
which in result causes complete loss of sensation in body and loss of
consciousness, which is required during surgery.

ISOTROY 100 LIQUID FOR INHALATION is not recommended for use in patients with or
family history of rapid rise in body temperature during anaesthesia (a condition
known as malignant hyperthermia). ISOTROY 100 LIQUID FOR INHALATION should be
used with caution in patients having liver, heart, kidney or lung problems,
increased intracr
diabetes.

ISOTROY 100 LIQUID FOR INHALATION is not recommended for use in pregnant women
unless it is clearly necessary. ISOTROY 100 LIQUID FOR INHALATION should be used
with caution in breastfeeding women as it is not known whether it passes through
the breast milk. ISOTROY 100 LIQUID FOR INHALATION should be used with caution
in children so, consult your child’s doctor for advice.

ISOTROY 100 LIQUID FOR INHALATION should be used with caution in elderly
patients aged above 65 years. The most common side effects of using ISOTROY 100
LIQUID FOR INHALATION areagitation, breath holding, chills or shivering, cough,
change in mental abilities, spasm of vocal cords, nausea and vomiting. Consult
your physician in case any of the symptoms worsen.

Uses Of ISOTROY 100 LIQUID FOR INHALATION

• Induction and maintenance of general anaesthesia during surgeries

How ISOTROY 100 LIQUID FOR INHALATION Works

ISOTROY 100 LIQUID FOR INHALATION is a general anaesthetic that works by
temporarily reducing the activity of the body’s central nervous system. This
leads to complete loss of sensation in the body, including loss of consciousness
and allowing surgery to be carried out without any pain or distress.

How to use ISOTROY 100 LIQUID FOR INHALATION

ISOTROY 100 LIQUID FOR INHALATION is administered by your doctor through a
vaporizer. Your doctor will decide the exact dose and duration of management for
you depending upon your age, body weight and disease condition and the type of
operation you are having and when ISOTROY 100 LIQUID FOR INHALATION is to be
given.

Side Effects Of ISOTROY 100 LIQUID FOR INHALATION

Common

• agitation
• breath holding
• chills/shivering
• cough, spasm of voice box
• change in mental abilities
• nausea, vomiting

Uncommon

• mood changes, nightmare
• fits
• retching
• high blood pressure causing headache, altered vision, nausea, vomiting
• low blood pressure (light-headedness, especially when getting up from a lying or sitting position)

Rare

If you or your child suffer from any of the following side effects after an
operation, tell your doctor or anaesthetist immediately:

• feel shivery, nausea, vomiting
• allergic reaction like skin rash or swelling of the face
• malignant hyperthermia (high fever, muscle rigidity, tachycardia, tachypnoea, cyanosis, arrhythmias, unstable blood pressure)
• fall in blood pressure
• increase in blood potassium levels (abnormality of heart rhythm in children during the postoperative period)
• difficulty breathing (bronchospasm)
• increased heart rate and irregular heartbeats
• increase in white blood cells, blood glucose, blood levels of certain enzymes and other blood cells
• agitation, delirium, mood problems, mental impairment, fits
• liver disease (yellowing of the skin and white of the eyes, abdominal pain)
• excessive blood loss after surgeries involving the womb
• small changes in moods (symptoms may persist up to 6 days after administration)
• increase in blood fluoride levels (due to your body breaking down isoflurane) with carbon monoxide levels

How To Manage Side Effects

Nausea, vomiting:

Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to
simple meals. Avoid eating oily or spicy foods. If symptom persists, contact
your doctor.

Headache:

Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving
balm on the head however, contact your doctor if your headache did not improve.

Skin rash:

Try to avoid hot water showers as it may irritate the skin. Do not rub or
scratch the affected skin area. Use sunscreen and protective clothing when
outdoors and regularly use moisturizers to soothe and hydrate the affected area.
Contact your physician in case rashes worsen.

Warning & Precautions

!### Pregnancy

ISOTROY 100 LIQUID FOR INHALATION is not recommended for use in pregnant women
unless it is clearly necessary. Consult your doctor for advice.

!### Breastfeeding

ISOTROY 100 LIQUID FOR INHALATION should be used with caution in breastfeeding
women as it is not known whether it may pass through the breast milk. Consult
your doctor for advice.

!### Driving and Using Machines

ISOTROY 100 LIQUID FOR INHALATION affects your mental alertness for 2-4 days. Do
not drive or operate machines after administration of ISOTROY 100 LIQUID FOR
INHALATION.

!### Kidney

ISOTROY 100 LIQUID FOR INHALATION should be used with caution in patients with
kidney disease. Consult your doctor for advice.

!### Liver

ISOTROY 100 LIQUID FOR INHALATION is not recommended for use in patients with a
history of hepatitis due to a halogenated inhalational anaesthetic or a history
of unexplained moderate to severe hepatic dysfunction (Ex. jaundice associated
with fever and/or eosinophilia) after anaesthesia with ISOTROY 100 LIQUID FOR
INHALATION or other halogenated inhalational anaesthetics. Consult your doctor
for advice.

!### Allergy

Do not use ISOTROY 100 LIQUID FOR INHALATION if you are allergic to isoflurane,
other halogenated agents or any of the other ingredients of medicine.

!### Lungs

ISOTROY 100 LIQUID FOR INHALATION should be used with caution in patients having
respiratory problems such as bronchoconstriction (tightening of air sacs in
lungs causing coughing, wheezing, shortness of breath). Consult your doctor for
advice.

!### Heart Disease

ISOTROY 100 LIQUID FOR INHALATION should be used with caution in patients
suffering from heart problems such as coronary heart disease, arrythmias
(irregular heartbeat), QT prolongation, Torsade’s De pointes (a specific type of
raised heart rate), low blood pressure or low blood volume. Consult your doctor
for advice.

Others

ISOTROY 100 LIQUID FOR INHALATION is not recommended for use if you:

• or anyone in your family, are susce
• are contraindicated to general anaesthesia

Before receiving ISOTROY 100 LIQUID FOR INHALATION inform your doctor if you
have:

• mitochondrial disease
• increased intracr
• Duchenne muscular dystrophy (inherited muscular weakness)
• myasthenia gravis (muscle weakness)
• a disease or illness which is not related to condition for which you are undergoing surgery (Ex. severe headache, nausea, vomiting, neuromuscular disease)
• cancer
• diabetes
• weakness
• previously been given an inhaled anaesthetic, especially in the last 3 months
• reacted badly after previous administration of ISOTROY 100 LIQUID FOR INHALATION or other similar anaesthetics (Ex. development of jaundice, fever, liver or blood problems)

Use in Paediatrics:

ISOTROY 100 LIQUID FOR INHALATION should be used with caution in children as it
may cause increase in saliva flow and respiratory secretions and cause
laryngospasm (spasm of vocal cord). Consult your child’s doctor for advice.

Use in Geriatrics:

ISOTROY 100 LIQUID FOR INHALATION should be used with caution in elderly
patients aged above 65 years of age as it may require dose adjustments. Consult
your doctor for advice.

Interactions

A. Drug-Drug interactions:

Before administration of ISOTROY 100 LIQUID FOR INHALATION, inform your doctor
if you are taking any of the following medicines:

• medicines used for management of high blood pressure and heart diseases (Ex. labetalol, acebutolol, atenolol, nifedipine, verapamil, amlodipine)
• opioids such as codeine, fentanyl, tramadol (used for management of severe pain)
• zolpidem, zopiclone (medicines used for management of insomnia)
• epinephrine, isoprenaline, ephedrine, norepinephrine (medicines for management of hypersensitivity, heart diseases, respiratory problems, etc.)
• amphetamine, dextroamphetamine (medicines used for attention deficit hyperactivity disorder)
• ephedrine (used for decongestion)
• isoniazid (used for management of tuberculosis)
• phenelzine, selegiline, isocarboxazid, St. John’s Wort (medicines used for management of depression)
• succinylcholine, atracurium, pancuronium, rocuronium, vecuronium (muscle relaxants used in anaesthesia)
• inhalational anaesthetics, such as N2O (used in anaesthesia)
• disulfiram (used to manage alcohol addiction)

Overdosage:

ISOTROY 100 LIQUID FOR INHALATION will be administered to you only by a doctor
or a nurse in a hospital and so it is unlikely to receive an overdose. However,
consult your doctor or nurse if you experience any unusual symptoms after
ISOTROY 100 LIQUID FOR INHALATION administration such as hypotension (low blood
pressure) and respiratory depression or cessation of breathing.

Synopsis

Drug	:	Isoflurane
Pharmacological Category	:	General Anaesthetic
Therapeutic Indication	:	General Anaesthesia during Surgeries
Dosage Forms	:	Liquid for Inhalation

More Information

• Keep ISOTROY 100 LIQUID FOR INHALATION out of reach of children
• Store ISOTROY 100 LIQUID FOR INHALATION below 30°C

FAQs About ISOTROY 100 LIQUID FOR INHALATION

What is General Anaesthesia?

General Anaesthesia can be defined as state of controlled unconsciousness. There
is temporary reduction in activity of central nervous system in brain which in
result causes complete loss of sensation in body, loss of consciousness which
helps to carry out surgery.

How ISOTROY 100 LIQUID FOR INHALATION works?

ISOTROY 100 LIQUID FOR INHALATION is a general anaesthetic that works by
temporarily reducing the activity of the body’s central nervous system. This
leads to complete loss of sensation in the body, including loss of consciousness
and allowing surgery to be carried out without any pain or distress.

Is ISOTROY 100 LIQUID FOR INHALATION safe for use in pregnant women?

ISOTROY 100 LIQUID FOR INHALATION is not recommended for use in pregnant women
unless it is clearly necessary. If you are pregnant, think you may be pregnant
or are planning for a child, consult your doctor before taking it.

How fast does ISOTROY 100 LIQUID FOR INHALATION work?

Inhalation of ISOTROY 100 LIQUID FOR INHALATION can induce general anaesthesia
in 7 to 10 minutes, with analgesia (loss of pain), muscle relaxation and loss of
consciousness. ISOTROY 100 LIQUID FOR INHALATION is mildly pungent and may cause
coughing, laryngospasm and breath holding in an unconscious individual.

How is ISOTROY 100 LIQUID FOR INHALATION given?

ISOTROY 100 LIQUID FOR INHALATION is administered by your doctor through a
vaporizer. Your doctor will decide the exact dose and duration of management for
you depending upon your age, body weight and the type of operation you are
having and when ISOTROY 100 LIQUID FOR INHALATION is to be given.

Useful Diagnostic Tests

• Liver function tests
• Kidney function test
• Complete blood count
• Electrocardiogram (ECG)
• Blood glucose
• Respiratory function