Glimza M2 Tablet 10's

Introduction About GLIMZA M2 TABLET

GLIMZA M2 TABLET is used to manage type 2 diabetes mellitus when diet, exercise
and the single agent does not result in adequate glycemic control. It is a
combination of Glimepiride and Metformin which belongs to a group of medicines
called Antidiabetic agents. Glimepiride lowers blood sugar by causing the
pancreas to produce more insulin and helps the body to use insulin efficiently.
Metformin reduces the total amount of sugar released into the blood by the
liver.

Along management with GLIMZA M2 TABLET follow regular exercise and diet plan as
advised by your doctor to achieve better results. Before taking GLIMZA M2 TABLET
inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis,
severe liver or kidney disease, acute heart problems. Inform your doctor if you
are pregnant or breastfeeding. It is not suitable for use in children and
adolescents under 18 years of age.

Avoid consum
increase or decrease the blood sugar lowering action of GLIMZA M2 TABLET and
increases the risk of lactic acidosis. The most common side effects of taking
GLIMZA M2 TABLET are taste disturbance, diarrhea or stomach ache. Contact your
doctor if any of the symptoms worsen.

Uses Of GLIMZA M2 TABLET

• Used to manage type 2 diabetes mellitus (when diet, exercise and the single agent does not result in adequate glycemic control)

How GLIMZA M2 TABLET Works

GLIMZA M2 TABLET controls blood glucose levels, where Glimepiride works by
increasing the amount of insulin released by the pancreas in order to lower the
blood glucose. Metformin works by lowering glucose production in the liver,
delaying glucose absor
sensitivity to insulin.

How to use GLIMZA M2 TABLET

• Take GLIMZA M2 TABLET as advised by your physician
• Swallow GLIMZA M2 TABLET with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition
• Do not stop taking GLIMZA M2 TABLET without informing your doctor.

Side Effects Of GLIMZA M2 TABLET

Common side effects of GLIMZA M2 TABLET:

• taste disturbance
• diarrhea
• stomach pain
• loss of appetite

Stop taking GLIMZA M2 TABLET and contact your doctor immediately if you
experience any of the following side effects:

• lactic acidosis
• inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
• severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
• severe low blood sugar levels

Warning & Precautions

!### Pregnancy

ContraindicatedGLIMZA M2 TABLET should not be taken during pregnancy. Consult your doctor
before taking GLIMZA M2 TABLET if you are planning to become pregnant.

!### Breastfeeding

ContraindicatedGLIMZA M2 TABLET should not be taken during breastfeeding as it may pass through
breast milk.

!### Driving and Using Machines

Use with CautionDo not drive or handle any machines if you experience low or high blood sugar
levels (symptoms include dizziness, tiredness, shaking or trembling) or if you
develop visual problems due to altered blood sugar levels.

!### Alcohol

Consult your doctorAvoid consum
increase or decrease the blood sugar lowering action of GLIMZA M2 TABLET and
increases the risk of lactic acidosis.

!### Kidney

Consult your doctorGLIMZA M2 TABLET is not recommended for use in patients with severe kidney
disease and it should be used with caution in patients with kidney disease and
your dose will beadjusted ifneeded depending upon kidney function.

!### Liver

Consult your doctorGLIMZA M2 TABLET is not recommended if you have severe liver disease and it
should be used with caution in patients with liver disease and your dose will be
adjusted if needed depending upon liver function.

!### Allergy

ContraindicatedDo not take GLIMZA M2 TABLET if you are allergic (hypersensitive) to Glimepiride
or Metformin or other sulfonylureas (such as glipizide, glibenclamide) or
sulfonamides (such as sulfamethoxazole).

!### Heart Disease

ContraindicatedGLIMZA M2 TABLET is not recommended for use in patients with acute heart
problems or recently had a heart attack or have severe circulatory problems or
breathing difficulties (signs of heart failure).

!### Use In Pediatrics

ContraindicatedGLIMZA M2 TABLET is not recommended for use in children and adolescents (under
18 years of age).

!### Use In Geriatrics

Consult your doctorGLIMZA M2 TABLET is not recommended for use in elderly patients (aged 75 years
or above) and it should be used with caution in elderly patients (aged 65 years
or above), especially in patients with impaired kidney function. Your doctor may
assess your kidney function more frequently during management with GLIMZA M2
TABLET.

Others

GLIMZA M2 TABLET is not recommended for use, if you have:

• type 1 diabetes mellitus
• diabetic ketoacidosis
• uncontrolled diabetes or ketoacidosis
• dehydration
• severe infection

Before taking GLIMZA M2 TABLET inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Interactions

A. Drug-Drug interactions:

Before taking GLIMZA M2 TABLET inform to your doctor,  if you are taking any of
these medicines:

• Sulphonylureas (Ex. glibenclamide, insulin)
• Anabolics
• Anticoagulants (Ex. Warfarin)
• Anticonvulsants (Ex. Fenfluramine, Phenytoin)
• NSAIDs (Ex. Phenylbutazone, azopropazone, oxyphenbutazone)
• Class 1a anti-arrhythmic agent (Ex. Disopyramide)
• Fibrates (Ex. fenofibrate, nicotinic acid, colesevelam)
• Angiotensin-converting enzyme (Ex. captopril, lisinopril)
• Diuretics (Ex. furosemide, chlorthalidone, hydrochlorothiazide or diazoxide)
• Monoamine oxidase inhibitors (Ex. isocarboxazid, selegiline and chlorpromazine)
• Antigout agents (Ex. Allopurinol, probenecid, sulfinpyrazone)
• Alkylating agents (Ex. Cyclophosphamide, ifosfamide, trofosfamide)
• Tetracyclines (Ex. minocycline, doxycycline, chloramphenicol, fluconazole, miconazole
• Quinolones (Ex. moxifloxacin, ciprofloxacin, clarithromycin, rifampicin
• Tritoqualine, glucocorticoids (Ex. beclomethasone, hydrocortisone)
• Hemorrheologic agents (Ex. Pentoxifylline)
• Sulfonamides (Ex. sulfamethoxazole)
• Androstane class (Ex. testosterone)
• Natural or synthetic (Ex. oestrogens, progestogens)
• Sympatholytics (Ex. clonidine, methyldopa)
• Hormones (Ex. Levothyroxine)
• Adrenaline and sympathomimetics (Ex. phenylephrine, norepinephrine)
• Laxatives (Ex. bisacodyl)
• Antidiabetics (Ex. Glucagon)
• Barbiturates (Ex. pentobarbital, amobarbital)
• Carbonic anhydrase inhibitors (Ex. Acetazolamide)

Overdosage:

If you or anyone else takes too much of GLIMZA M2 TABLET, contact your doctor
immediately or go to a nearest hospital straight away. Overdosage symptoms of
GLIMZA M2 TABLET includes risk of low blood sugar levels. Symptoms of lactic
acidosis include vomiting, bellyache with muscle cramps, general feeling of not
being well with severe tiredness, reduced body temperature, low heartbeat, and
difficulty in breathing.

Synopsis

Drug	:	Glimepiride, Metformin
Pharmacological Category	:	Sulfonylureas, Bigu
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

FAQs About GLIMZA M2 TABLET

Q: What is GLIMZA M2 TABLET used for?

A: GLIMZA M2 TABLET is used to manage type 2 diabetes mellitus in adults. This
combination helps regulate blood sugar levels effectively in individuals whose
blood sugar is not adequately controlled by diet, exercise, or a single diabetes
medication. It helps reduce the risk of diabetes-related complications such as
heart disease, nerve damage, or kidney issues.

Q: How GLIMZA M2 TABLET works?

A: GLIMZA M2 TABLET contains a combination of two medicines namely, glimepiride
and metformin. Glimepiride stimulates the pancreas to release more insulin, a
hormone that lowers blood sugar levels. It also improves the body’s response to
insulin. Metformin decreases the amount of sugar produced by the liver and
reduces sugar absor
to use insulin more effectively, making it a comprehensive treatment for blood
sugar control.

Q: What is the best time to take GLIMZA M2 TABLET?

A: It is usually recommended to take GLIMZA M2 TABLET with meals to minimize the
risk of gastrointestinal side effects such as nausea or upset stomach. Following
your doctor’s instructions regarding the timing is essential, as they might
tailor the dose to suit your lifestyle and blood sugar patterns.

Q: How many doses of GLIMZA M2 TABLET can be taken in a day?

A: The dosage depends on the individual’s medical condition, blood sugar levels,
and response to treatment. Typically, it is taken once or twice daily with
meals, but the exact dose should be determined by a doctor. Taking more than the
prescribed dose can lead to hypoglycemia (low blood sugar), so it’s crucial to
stick to the recommended schedule.

Q: Can GLIMZA M2 TABLET be used during pregnancy?

A: The combination of Glimepiride + Metformin is generally not recommended
during pregnancy due to the potential risk of harming the unborn baby. Instead,
insulin is preferred for controlling blood sugar levels in pregnant women with
diabetes. If you are pregnant or planning to conceive, consult your doctor for a
safe treatment plan.

Q: Can GLIMZA M2 TABLET control blood sugar levels?

A: Yes, this medicine is highly effective in controlling blood sugar levels in
people with type 2 diabetes especially when diet, lifestyle changes and
treatment with single agents does not yield o
However, its effectiveness also depends on maintaining a healthy lifestyle,
including regular exercise and a balanced diet. Regular monitoring of blood
sugar is essential to ensure the medication works o

Q: Who should not use GLIMZA M2 TABLET?

A: GLIMZA M2 TABLET is not suitable for individuals with severe kidney or liver
disease, type 1 diabetes or diabetic ketoacidosis, known allergies to
glimepiride, metformin, or any other ingredients in the medicine, or a history
of lactic acidosis. Therefore, always inform your doctor about any pre-existing
conditions or medications you are taking to avoid adverse effects.

Q: What are the common side effects of GLIMZA M2 TABLET?

A: The most common side effects of GLIMZA M2 TABLET include nausea, vomiting,
diarrhea, stomach pain, dizziness, or low blood sugar (hypoglycemia. Consult
your doctor if any of these side effects worsens.

Q: Is GLIMZA M2 TABLET safe?

A: Yes, GLIMZA M2 TABLET is generally safe when taken as prescribed. However,
regular monitoring of kidney and liver function is necessary, as prolonged use
can affect these organs. Additionally, following the recommended dose and
schedule minimizes the risk of side effects.

Q: Can GLIMZA M2 TABLET be taken on an empty stomach or before food?

A: No, it is best taken with food to reduce the risk of stomach upset and
hypoglycemia. Food helps slow down the absor
sudden drop in blood sugar levels, which can cause dizziness or weakness.

Q: Is GLIMZA M2 TABLET safe for kidney patients?

A: GLIMZA M2 TABLET is not suitable for individuals with severe kidney disease,
as it can increase the risk of lactic acidosis, a potentially life-threatening
condition. Mild to moderate kidney impairment requires dose adjustment and close
monitoring. Always consult your doctor before starting or continuing this
medication.

Q: How long will it take for GLIMZA M2 TABLET to control blood sugar levels?

A: GLIMZA M2 TABLET begins to lower blood sugar within a few hours of taking a
dose. However, achieving o
depending on individual response and adherence to the prescribed regimen, diet,
and exercise plan.

Q: Can I stop taking GLIMZA M2 TABLET once my blood sugar is controlled?

A: No, stopping the medication without your doctor’s advice can cause your blood
sugar levels to rise again, leading to complications. Diabetes is a chronic
condition requiring ongoing management. Your doctor may adjust the dose or
switch medications based on your progress, but self-discontinuation is not
recommended.

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin