GLIMERIN M 500mg Tablet 15's

Introduction About GLIMERIN M 500MG TABLET

GLIMERIN M 500MG TABLET is used to manage type 2 diabetes mellitus when diet,
exercise and the single agent does not result in adequate glycemic control. It
is a combination of Glimepiride and Metformin which belongs to a group of
medicines called Antidiabetic agents. Glimepiride lowers blood sugar by causing
the pancreas to produce more insulin and helps the body to use insulin
efficiently. Metformin reduces the total amount of sugar released into the blood
by the liver.

Along management with GLIMERIN M 500MG TABLET follow regular exercise and diet
plan as advised by your doctor to achieve better results. Before taking GLIMERIN
M 500MG TABLET inform your doctor if you have type 1 diabetes mellitus, diabetic
ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your
doctor if you are pregnant or breastfeeding. It is not suitable for use in
children and adolescents under 18 years of age.

Avoid consum
it may increase or decrease the blood sugar lowering action of GLIMERIN M 500MG
TABLET and increases the risk of lactic acidosis. The most common side effects
of taking GLIMERIN M 500MG TABLET are taste disturbance, diarrhea or stomach
ache. Contact your doctor if any of the symptoms worsen.

Uses Of GLIMERIN M 500MG TABLET

• Used to manage type 2 diabetes mellitus (when diet, exercise and the single agent does not result in adequate glycemic control)

How GLIMERIN M 500MG TABLET Works

GLIMERIN M 500MG TABLET controls blood glucose levels, where Glimepiride works
by increasing the amount of insulin released by the pancreas in order to lower
the blood glucose. Metformin works by lowering glucose production in the liver,
delaying glucose absor
sensitivity to insulin.

How to use GLIMERIN M 500MG TABLET

• Take GLIMERIN M 500MG TABLET as advised by your physician
• Swallow GLIMERIN M 500MG TABLET with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition
• Do not stop taking GLIMERIN M 500MG TABLET without informing your doctor.

Side Effects Of GLIMERIN M 500MG TABLET

Common side effects of GLIMERIN M 500MG TABLET:

• taste disturbance
• diarrhea
• stomach pain
• loss of appetite

Stop taking GLIMERIN M 500MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• lactic acidosis
• inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
• severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
• severe low blood sugar levels

Warning & Precautions

!### Pregnancy

ContraindicatedGLIMERIN M 500MG TABLET should not be taken during pregnancy. Consult your
doctor before taking GLIMERIN M 500MG TABLET if you are planning to become
pregnant.

!### Breastfeeding

ContraindicatedGLIMERIN M 500MG TABLET should not be taken during breastfeeding as it may pass
through breast milk.

!### Driving and Using Machines

Use with CautionDo not drive or handle any machines if you experience low or high blood sugar
levels (symptoms include dizziness, tiredness, shaking or trembling) or if you
develop visual problems due to altered blood sugar levels.

!### Alcohol

Consult your doctorAvoid consum
it may increase or decrease the blood sugar lowering action of GLIMERIN M 500MG
TABLET and increases the risk of lactic acidosis.

!### Kidney

Consult your doctorGLIMERIN M 500MG TABLET is not recommended for use in patients with severe
kidney disease and it should be used with caution in patients with kidney
disease and your dose will beadjusted ifneeded depending upon kidney function.

!### Liver

Consult your doctorGLIMERIN M 500MG TABLET is not recommended if you have severe liver disease and
it should be used with caution in patients with liver disease and your dose will
be adjusted if needed depending upon liver function.

!### Allergy

ContraindicatedDo not take GLIMERIN M 500MG TABLET if you are allergic (hypersensitive) to
Glimepiride or Metformin or other sulfonylureas (such as glipizide,
glibenclamide) or sulfonamides (such as sulfamethoxazole).

!### Heart Disease

ContraindicatedGLIMERIN M 500MG TABLET is not recommended for use in patients with acute heart
problems or recently had a heart attack or have severe circulatory problems or
breathing difficulties (signs of heart failure).

!### Use In Pediatrics

ContraindicatedGLIMERIN M 500MG TABLET is not recommended for use in children and adolescents
(under 18 years of age).

!### Use In Geriatrics

Consult your doctorGLIMERIN M 500MG TABLET is not recommended for use in elderly patients (aged 75
years or above) and it should be used with caution in elderly patients (aged 65
years or above), especially in patients with impaired kidney function. Your
doctor may assess your kidney function more frequently during management with
GLIMERIN M 500MG TABLET.

Others

GLIMERIN M 500MG TABLET is not recommended for use, if you have:

• type 1 diabetes mellitus
• diabetic ketoacidosis
• uncontrolled diabetes or ketoacidosis
• dehydration
• severe infection

Before taking GLIMERIN M 500MG TABLET inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Interactions

A. Drug-Drug interactions:

Before taking GLIMERIN M 500MG TABLET inform to your doctor,  if you are taking
any of these medicines:

• Sulphonylureas (Ex. glibenclamide, insulin)
• Anabolics
• Anticoagulants (Ex. Warfarin)
• Anticonvulsants (Ex. Fenfluramine, Phenytoin)
• NSAIDs (Ex. Phenylbutazone, azopropazone, oxyphenbutazone)
• Class 1a anti-arrhythmic agent (Ex. Disopyramide)
• Fibrates (Ex. fenofibrate, nicotinic acid, colesevelam)
• Angiotensin-converting enzyme (Ex. captopril, lisinopril)
• Diuretics (Ex. furosemide, chlorthalidone, hydrochlorothiazide or diazoxide)
• Monoamine oxidase inhibitors (Ex. isocarboxazid, selegiline and chlorpromazine)
• Antigout agents (Ex. Allopurinol, probenecid, sulfinpyrazone)
• Alkylating agents (Ex. Cyclophosphamide, ifosfamide, trofosfamide)
• Tetracyclines (Ex. minocycline, doxycycline, chloramphenicol, fluconazole, miconazole
• Quinolones (Ex. moxifloxacin, ciprofloxacin, clarithromycin, rifampicin
• Tritoqualine, glucocorticoids (Ex. beclomethasone, hydrocortisone)
• Hemorrheologic agents (Ex. Pentoxifylline)
• Sulfonamides (Ex. sulfamethoxazole)
• Androstane class (Ex. testosterone)
• Natural or synthetic (Ex. oestrogens, progestogens)
• Sympatholytics (Ex. clonidine, methyldopa)
• Hormones (Ex. Levothyroxine)
• Adrenaline and sympathomimetics (Ex. phenylephrine, norepinephrine)
• Laxatives (Ex. bisacodyl)
• Antidiabetics (Ex. Glucagon)
• Barbiturates (Ex. pentobarbital, amobarbital)
• Carbonic anhydrase inhibitors (Ex. Acetazolamide)

Overdosage:

If you or anyone else takes too much of GLIMERIN M 500MG TABLET, contact your
doctor immediately or go to a nearest hospital straight away. Overdosage
symptoms of GLIMERIN M 500MG TABLET includes risk of low blood sugar levels.
Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps,
general feeling of not being well with severe tiredness, reduced body
temperature, low heartbeat, and difficulty in breathing.

Synopsis

Drug	:	Glimepiride, Metformin
Pharmacological Category	:	Sulfonylureas, Bigu
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

FAQs About GLIMERIN M 500MG TABLET

Q: What is GLIMERIN M 500MG TABLET used for?

A: GLIMERIN M 500MG TABLET is used to manage type 2 diabetes mellitus in adults.
This combination helps regulate blood sugar levels effectively in individuals
whose blood sugar is not adequately controlled by diet, exercise, or a single
diabetes medication. It helps reduce the risk of diabetes-related complications
such as heart disease, nerve damage, or kidney issues.

Q: How GLIMERIN M 500MG TABLET works?

A: GLIMERIN M 500MG TABLET contains a combination of two medicines namely,
glimepiride and metformin. Glimepiride stimulates the pancreas to release more
insulin, a hormone that lowers blood sugar levels. It also improves the body’s
response to insulin. Metformin decreases the amount of sugar produced by the
liver and reduces sugar absor
body’s ability to use insulin more effectively, making it a comprehensive
treatment for blood sugar control.

Q: What is the best time to take GLIMERIN M 500MG TABLET?

A: It is usually recommended to take GLIMERIN M 500MG TABLET with meals to
minimize the risk of gastrointestinal side effects such as nausea or upset
stomach. Following your doctor’s instructions regarding the timing is essential,
as they might tailor the dose to suit your lifestyle and blood sugar patterns.

Q: How many doses of GLIMERIN M 500MG TABLET can be taken in a day?

A: The dosage depends on the individual’s medical condition, blood sugar levels,
and response to treatment. Typically, it is taken once or twice daily with
meals, but the exact dose should be determined by a doctor. Taking more than the
prescribed dose can lead to hypoglycemia (low blood sugar), so it’s crucial to
stick to the recommended schedule.

Q: Can GLIMERIN M 500MG TABLET be used during pregnancy?

A: The combination of Glimepiride + Metformin is generally not recommended
during pregnancy due to the potential risk of harming the unborn baby. Instead,
insulin is preferred for controlling blood sugar levels in pregnant women with
diabetes. If you are pregnant or planning to conceive, consult your doctor for a
safe treatment plan.

Q: Can GLIMERIN M 500MG TABLET control blood sugar levels?

A: Yes, this medicine is highly effective in controlling blood sugar levels in
people with type 2 diabetes especially when diet, lifestyle changes and
treatment with single agents does not yield o
However, its effectiveness also depends on maintaining a healthy lifestyle,
including regular exercise and a balanced diet. Regular monitoring of blood
sugar is essential to ensure the medication works o

Q: Who should not use GLIMERIN M 500MG TABLET?

A: GLIMERIN M 500MG TABLET is not suitable for individuals with severe kidney or
liver disease, type 1 diabetes or diabetic ketoacidosis, known allergies to
glimepiride, metformin, or any other ingredients in the medicine, or a history
of lactic acidosis. Therefore, always inform your doctor about any pre-existing
conditions or medications you are taking to avoid adverse effects.

Q: What are the common side effects of GLIMERIN M 500MG TABLET?

A: The most common side effects of GLIMERIN M 500MG TABLET include nausea,
vomiting, diarrhea, stomach pain, dizziness, or low blood sugar (hypoglycemia.
Consult your doctor if any of these side effects worsens.

Q: Is GLIMERIN M 500MG TABLET safe?

A: Yes, GLIMERIN M 500MG TABLET is generally safe when taken as prescribed.
However, regular monitoring of kidney and liver function is necessary, as
prolonged use can affect these organs. Additionally, following the recommended
dose and schedule minimizes the risk of side effects.

Q: Can GLIMERIN M 500MG TABLET be taken on an empty stomach or before food?

A: No, it is best taken with food to reduce the risk of stomach upset and
hypoglycemia. Food helps slow down the absor
sudden drop in blood sugar levels, which can cause dizziness or weakness.

Q: Is GLIMERIN M 500MG TABLET safe for kidney patients?

A: GLIMERIN M 500MG TABLET is not suitable for individuals with severe kidney
disease, as it can increase the risk of lactic acidosis, a potentially
life-threatening condition. Mild to moderate kidney impairment requires dose
adjustment and close monitoring. Always consult your doctor before starting or
continuing this medication.

Q: How long will it take for GLIMERIN M 500MG TABLET to control blood sugar levels?

A: GLIMERIN M 500MG TABLET begins to lower blood sugar within a few hours of
taking a dose. However, achieving o
weeks, depending on individual response and adherence to the prescribed regimen,
diet, and exercise plan.

Q: Can I stop taking GLIMERIN M 500MG TABLET once my blood sugar is controlled?

A: No, stopping the medication without your doctor’s advice can cause your blood
sugar levels to rise again, leading to complications. Diabetes is a chronic
condition requiring ongoing management. Your doctor may adjust the dose or
switch medications based on your progress, but self-discontinuation is not
recommended.

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin