ACTIFUL Tablet 15's

Introduction About ACTIFUL TABLET

ACTIFUL TABLET contains Midodrine which belongs to the group of medicines called
Alpha -1 Selective Adrenergic Receptor Agonist. It is used to manage low blood
pressure (hypotension) in adults. Symptoms of low blood pressure include blurred
or fading vision, dizziness or light-headedness, fainting, feeling sick,
difficult in concentrating.

Midodrine acts on the blood vessels via the sympathetic nervous system (part of
nervous system that cause increase in heart rate, blood pressure, breathing
rate, and dilatation of pupil) to correct imbalances of blood distribution, such
as preventing too much blood pooling in the legs when standing up which may
cause low blood pressure. Your doctor may regularly monitor the blood pressure
when you are lying down and when you are standing up as there may be a risk of
your blood pressure rising when you lie down (Ex. at night).

ACTIFUL TABLET is not recommended for use in patients having severe heart
disease.ACTIFUL TABLET should be used with caution in patient having severe
kidney disease, liver problems. Consult your doctor for advice before
takingACTIFUL TABLET, if you are pregnant or breast-feeding.ACTIFUL TABLET is
not recommended for use in children and adolescents below the age of 18 years.
The most common side effects of takingACTIFUL TABLET are increased blood
pressure when lying down, headache, nausea (feeling sick), vomiting, heartburn.
Consult your doctor if the symptom worsens.

Uses Of ACTIFUL TABLET

• Used to manage certain severe forms of low blood pressure in adults by increasing the blood pressure

How ACTIFUL TABLET Works

ACTIFUL TABLET acts on the blood vessels via the sympathetic nervous system
(part of nervous system that cause increase in heart rate, blood pressure,
breathing rate, and dilatation of pupil) to correct the imbalances of blood
distribution, such as preventing too much blood pooling in the legs when
standing up which may cause low blood pressure.

How to use ACTIFUL TABLET

TakeACTIFUL TABLET as advised by your physician. Swallow this medicine, do not
crush, or chew the medicine. Your doctor will decide the correct dose and
duration for you depending upon your age, body weight and disease condition.

Side Effects Of ACTIFUL TABLET

Common

• Pain when urinating
• Tingling and itching
• Increased blood pressure when lying down
• Headache
• Nausea (feeling sick), vomiting
• Heartburn
• Inflammation of the lining inside the mouth
• Flushing
• Rash
• Chills
• Difficulty in urinating

Uncommon

• Sleep disturbances including difficulty sleeping
• Restlessness
• Agitation (state of anxiety), irritability
• Slowed heart rate
• Urge to urinate

Rare

• Rapid, irregular or fast heartbeat
• Chest pain
• Signs of increased liver enzymes such stomach pain, dark urine, fatigue (feeling tired), itching, jaundice (yellowing of your skin or eyes)
• Dizziness or light headedness
• Stroke
• Visual disturbances

How To Manage Side Effects

!### Dizziness Or Drowsiness

When you feel dizzy, lie or sit down immediately. If you're experiencing a
severe episode of vertigo, lie in a dark and quite place with eyes closed.
Driving should be avoided, if you experience frequent dizziness without warning.
Talk to your doctor if the symptom worsens.

Headache

Apply hot or cold-water bag on your head. Try taking rest in a quiet and dark
room. Massage with mild pressure on scalp or head.

!### Nausea And Vomiting

Take this medicine with, or just after meals. Stick to simple meals. Avoid
eating oil rich or spicy foods, sugary snacks, and drinks. Avoid drinking too
much liquid along with your meals, drink slowly in between meals. Consult your
doctor if your symptom does not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedACTIFUL TABLET is not recommended for use in pregnant. Consult your doctor
before takingACTIFUL TABLET.

!### Breastfeeding

ContraindicatedACTIFUL TABLET is not recommended for use during breast-feeding. Discuss with
your doctor before takingACTIFUL TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizzy or lightheaded after
takingACTIFUL TABLET. Consult your doctor before takingACTIFUL TABLET.

!### Kidney

ContraindicatedACTIFUL TABLET is not recommended for use in patients with severe kidney
disease. Consult your doctor before takingACTIFUL TABLET.

!### Liver

Use with CautionACTIFUL TABLET should be used with caution in patients having liver impairment.
Consult your doctor before takingACTIFUL TABLET.

!### Allergy

ContraindicatedACTIFUL TABLET is not recommended for use if you are allergic to Midodrine.

!### Heart Disease

ContraindicatedACTIFUL TABLET is not recommended for use in patients with severe heart disease
including slow pulse, heart attack, heart failure, heart rhythm disorders,
widening of the aorta (aortic aneurysm) or other cardiovascular diseases and
also in patients with high blood pressure, or a form of low blood pressure known
as vasovagal hypotension. Consult your doctor before takingACTIFUL TABLET.

!### Use In Pediatrics

ContraindicatedACTIFUL TABLET is not recommended for use in children and adolescents (under 18
years of age). Consult your doctor before takingACTIFUL TABLET.

!### Use In Geriatrics

Use with CautionACTIFUL TABLET is used with caution in patients above 60 years of age. Usually
the management is initiated with the lowest dose and gradually increased
depending upon the clinical condition of the patient. Consult your doctor before
takingACTIFUL TABLET.

Others

ACTIFUL TABLET is not recommended for use if you have:

• Difficulty in urinating
• Have elevated pressure in the eye (glaucoma) or poor vision because of diabetes
• Hyperthyroidism (overactive thyroid gland)
• Hormonal disorders caused by a tumour in the adrenal medulla (pheochromocytoma)
• Enlarged prostate

Before takingACTIFUL TABLET, inform your doctor if you have:

• Serious disorder of the nervous system (autonomic nervous system disorders)
• Problems with blood circulation
• Disease of the prostate

Interactions

A. Drug-Drug interactions:

• Reserpine and guanethidine (medicines used to reduce high blood pressure)
• Antihistamines like cetirizine, chlorpheniramine (used to manage allergies)
• Hormones for the thyroid like thyroxine
• Tricyclic antidepressants like clomipramine, amoxapine, amitriptyline and MAO-inhibitors such as selegiline, isocarboxazid, phenelzine, (both used to manage depression)
• Vasoconstrictors like epinephrine, dopamine, phenyl epinephrine (medicines that narrow blood vessels)
• Sympathomimetic agents such as ephedrine, isoproterenol, metaproterenol, (medicines that have a stimulating effect on certain parts of the nervous system)
• Prazosin and phentolamine (medicines used to manage heart disease
• Digitalis preparations such as digitoxin, digoxin (medicines used to manage heart disease)
• Fludrocortisone acetate (medicine used to reduce inflammation)
• Perphenazine (medicine used to manage mental or mood disorders)
• Amiodarone (medicine used to manage irregular heartbeat)
• Metoclopramide (medicine used to prevent vomiting)

Overdosage:

If you or anyone else accidentally take too much ofACTIFUL TABLET, consult your
doctor immediately or visit the nearby hospital. The most common symptoms of
overdose are high blood pressure (hypertension), slow heart rate (bradycardia),
difficulty urinating and feeling of coldness.

Synopsis

Drug	:	Midodrine
Pharmacological Category	:	Alpha -1 Selective Adrenergic Receptor Agonist
Therapeutic Indication	:	Low blood pressure
Dosage Forms	:	Tablet

More Information

Storage

• KeepACTIFUL TABLET out of reach of children
• Store at room temperature

FAQs About ACTIFUL TABLET

Q: CanACTIFUL TABLET cause heart palpitations?

A: Yes,ACTIFUL TABLET may cause irregular and fast heartbeat as it is one of the
side effects of this medicine. This may result in the risk of falling down.
Other symptoms include blurred vision, weakness, or tiredness, feeling sick.
Consult your doctor immediately if you experience any abnormal heartbeat or
signs of abnormal heartbeat (such as chest pain, dizziness, fainting).

Q: How doesACTIFUL TABLET works?

A: ACTIFUL TABLET acts on the blood vessels via the sympathetic nervous system
(part of nervous system that cause increase in heart rate, blood pressure,
breathing rate, and dilatation of pupil) to correct the imbalances of blood
distribution, such as preventing too much blood pooling in the legs when
standing up which may cause low blood pressure.

Q: Is it safe to useACTIFUL TABLET in older patients?

A: Yes, but it should be used with caution in elderly with regular monitoring of
blood pressure levels and your doctor may monitor your vital organs as it may
cause damage to liver, kidney, and heart.

Q: What happens if I stop takingACTIFUL TABLET?

A: Do not stop takingACTIFUL TABLET without talking to your doctor first.
Stopping this medicine suddenly can cause your blood pressure to fall and may
increase the risk of blurred vision, dizziness, fainting or death.

Q: Who should not takeACTIFUL TABLET?

A: You should not useACTIFUL TABLET if you have severe heart disease, overactive
thyroid, an adrenal gland tumour, kidney disease, heart disease, liver disease,
painful urination, or if your blood pressure is high even while lying
down. Consult your doctor immediately if you experience any unusual effects.

Useful Diagnostic Tests

• Kidney function test