NOR EPINEPH 2mg Injection 2ml

Introduction About NOR EPINEPH 2MG INJECTION

NOR EPINEPH 2MG INJECTION contains Noradrenaline which belongs to the group of
medicines called Adrenergic and Dopaminergic agents. It is used in emergency
conditions to increase blood pressure to normal levels in adults. During NOR
EPINEPH 2MG INJECTION management, your doctor will monitor your blood pressure,
blood volume, heart rate and the infusion site.

NOR EPINEPH 2MG INJECTION is not recommended for use in patients with low blood
pressure caused by low blood volume. NOR EPINEPH 2MG INJECTION should be used
with caution in patients with liver, heart or kidney disease, blood clots,
diabetes or over active thyroid gland.

NOR EPINEPH 2MG INJECTION will be given in pregnancy only if clearly necessary
as it may cause harm to unborn baby. It is not known whether NOR EPINEPH 2MG
INJECTION pass through the breast milk so it should be used with caution.

The safety and efficacy of NOR EPINEPH 2MG INJECTION in children and adolescents
under 18 years of age is not established so, contact your child’s doctor for
advice. The most common side effects of NOR EPINEPH 2MG INJECTION are low blood
pressure, slow heartbeat, anxiety, headache, etc. Call your doctor if any of the
symptoms worsen.

Uses Of NOR EPINEPH 2MG INJECTION

• Used in emergency conditions to increase blood pressure to normal levels

How NOR EPINEPH 2MG INJECTION Works

NOR EPINEPH 2MG INJECTION works by constricting the blood vessels, leading to
increase in blood pressure.

How to use NOR EPINEPH 2MG INJECTION

NOR EPINEPH 2MG INJECTION will be given to you only by a doctor or a nurse into
a vein as an intravenous infusion. Dose and duration will be decided by your
physician depending upon your age, body weight and disease condition.

Side Effects Of NOR EPINEPH 2MG INJECTION

Common

• high blood pressure, slow heartbeat
• lack of blood flow causing injury
• anxiety, headache
• breathing difficulty, excess fluid in the lungs
• blistering and tissue damage at injection site

Rare

Stop receiving NOR EPINEPH 2MG INJECTION and contact your doctor immediately if
you experience any of the following side effects:

• itchy rash (hives), swelling of the hands, feet, ankles, face, lips, mouth or throat causing difficulty in swallowing or breathing
• pain or swelling at injection site
• abnormal heart rhythm
• cold extremities or pain in the extremities

How To Manage Side Effects

Itchy skin:

Avoid hot showers because hot water can irritate the skin. Do not scratch the
affected area. Use sunscreen and protective clothing when outdoors. Use
moisturizers to soothe and hydrate the affected skin area. If symptom persists,
contact your doctor.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the head if required. Do not consume too much of alcohol.
If symptom persists, contact your doctor.

Warning & Precautions

!### Pregnancy

NOR EPINEPH 2MG INJECTION will be given in pregnancy only if clearly necessary
as it may cause harm to unborn baby. Consult your doctor for advice.

!### Breastfeeding

NOR EPINEPH 2MG INJECTION should be used with caution in breastfeeding women as
it is not known whether it passes through the breast milk. Consult your doctor
for advice.

!### Driving and Using Machines

Do not drive or operate any machines after receiving NOR EPINEPH 2MG INJECTION.

!### Kidney

NOR EPINEPH 2MG INJECTION should be used with caution in patients with severe
kidney disease. Contact your doctor for advice.

!### Liver

NOR EPINEPH 2MG INJECTION should be used with caution in patients with liver
failure. Contact your doctor for advice.

!### Allergy

Do not receive NOR EPINEPH 2MG INJECTION if you are allergic to Noradrenaline or
any of the other ingredients of this medicine.

!### Heart Disease

NOR EPINEPH 2MG INJECTION is not recommended for use in patients with low blood
pressure caused by low blood volume. NOR EPINEPH 2MG INJECTION should be used
with caution in patients with high blood pressure or blood clots or obstructions
in the blood vessels supplying the heart, low blood pressure following a heart
attack, Prinzmetal’s angina (a type of chest pain), left ventricular
dysfunction, heart attack or irregular heartbeat. Contact your doctor for
advice.

Others

Before receiving NOR EPINEPH 2MG INJECTION, inform your doctor if you have:

• diabetes
• over-active thyroid
• low oxygen levels in the blood
• raised carbon dioxide levels in the blood
• increased pressure inside the brain
• clots or obstructions in the blood vessels supplying the intestines or other parts of the body

Use in Paediatrics:

NOR EPINEPH 2MG INJECTION is not recommended for use in children and adolescents
under 18 years of age. Consult your child’s doctor for advice.

Use in Geriatrics:

Use NOR EPINEPH 2MG INJECTION with caution in elderly patients aged 65 years or
above. Consult your doctor for advice.

Interactions

A. Drug-Drug interactions:

Before receiving NOR EPINEPH 2MG INJECTION, inform your doctor if you are taking
any of the following medicines:

• medicines used for depression (Ex. fluoxetine, sertraline, selegiline, moclobemide, iproniazid, phenelzine, amitriptyline, nortriptyline, imipramine, desipramine, trimipramine)
• linezolid (used for bacterial infections)
• medicines used during surgery to numb the pain (Ex. halothane, cyclopropane, chloroform, enflurane, propofol)
• orciprenaline (medicine used in the management of asthma)
• dobutamine (medicine used for heart diseases)
• medicines used for high blood pressure (Ex. guanethidine, guanadrel, reserpine, methyldopa, prazosin, metoprolol, rauwolfia alkaloids)
• medicines used for irregular heartbeats (Ex. amiodarone, quinidine)
• cardiac glycosides like digoxin (used for heart failure)
• levodopa (medicine used for parkinson’s disease)
• medicines used for thyroid diseases (Ex. levothyroxine)
• oxytocin (medicine used to improve uterine contractions)
• medicines used for allergies (Ex. chlorpheniramine, cetirizine)
• amphetamine (used to increase wakefulness)
• doxapram (used for breathing disorders)
• mazindol (used to manage obesity)
• medicines used to manage migraine (Ex. ergotamine, dihydroergotamine)
• lithium (used to manage mental illness)

Overdosage:

NOR EPINEPH 2MG INJECTION will be administered to you only by a doctor or a
nurse in a hospital and so it is unlikely to receive an overdose. However,
consult your doctor or nurse if you experience any unusual symptoms like
severely high blood pressure, slow heartrate, severe headache, sensitivity to
light, chest pain, pale skin, high fever, intense sweating, vomiting or
breathlessness.

Synopsis

Drug	:	Noradrenaline
Pharmacological Category	:	Adrenergic and Dopaminergic agent
Therapeutic Indication	:	Low blood pressure
Dosage Forms	:	Injection

More Information

• Keep NOR EPINEPH 2MG INJECTION out of reach of children
• Store NOR EPINEPH 2MG INJECTION below 25°C

FAQs About NOR EPINEPH 2MG INJECTION

What if I miss a dose of NOR EPINEPH 2MG INJECTION?

It is unlikely that you will miss a dose of NOR EPINEPH 2MG INJECTION, as it
will be given to you in hospital. However, please stick to the prescribed
schedule as agreed with your doctor for o
INJECTION management. Tell your doctor whenever you miss to receive any dose.

Does anaesthesia affect NOR EPINEPH 2MG INJECTION use?

Using NOR EPINEPH 2MG INJECTION with propofol (an anaesthetic) may lead to
propofol infusion syndrome (PRIS), which is a serious condition that affects
patients who are being sedated with propofol during surgeries. Your doctor would
observe disorders in your body’s metabolism from blood tests.

Can NOR EPINEPH 2MG INJECTION be used in pregnancy?

NOR EPINEPH 2MG INJECTION may harm the unborn baby so, if you are pregnant,
think you may be pregnant or are planning for a baby, consult your doctor before
receiving it. Inform your doctor immediately if you become pregnant during
management with NOR EPINEPH 2MG INJECTION.

Can NOR EPINEPH 2MG INJECTION be given to children?

No. NOR EPINEPH 2MG INJECTION is used for adults and not recommended for
children and adolescents below 18 years of age. Consult your child’s doctor for
advice. The doctor will decide a proper dose or select a suitable alternative
management for your child.

Can I take other medicines with NOR EPINEPH 2MG INJECTION?

Before receiving NOR EPINEPH 2MG INJECTION, inform your doctor if you are
taking, have taken or might take any other medicine, including prescri
over the counter or any herbal medicine, as these might lead to significant side
effects by interacting with each other.

Useful Diagnostic Tests

• Echocardiogram