NORZEST 4mg Injection 2ml

Introduction About NORZEST 4MG INJECTION

NORZEST 4MG INJECTION contains Noradrenaline which belongs to the group of
medicines called Adrenergic and Dopaminergic agents. It is used in emergency
conditions to increase blood pressure to normal levels in adults. During NORZEST
4MG INJECTION management, your doctor will monitor your blood pressure, blood
volume, heart rate and the infusion site.

NORZEST 4MG INJECTION is not recommended for use in patients with low blood
pressure caused by low blood volume. NORZEST 4MG INJECTION should be used with
caution in patients with liver, heart or kidney disease, blood clots, diabetes
or over active thyroid gland.

NORZEST 4MG INJECTION will be given in pregnancy only if clearly necessary as it
may cause harm to unborn baby. It is not known whether NORZEST 4MG INJECTION
pass through the breast milk so it should be used with caution.

The safety and efficacy of NORZEST 4MG INJECTION in children and adolescents
under 18 years of age is not established so, contact your child’s doctor for
advice. The most common side effects of NORZEST 4MG INJECTION are low blood
pressure, slow heartbeat, anxiety, headache, etc. Call your doctor if any of the
symptoms worsen.

Uses Of NORZEST 4MG INJECTION

• Used in emergency conditions to increase blood pressure to normal levels

How NORZEST 4MG INJECTION Works

NORZEST 4MG INJECTION works by constricting the blood vessels, leading to
increase in blood pressure.

How to use NORZEST 4MG INJECTION

NORZEST 4MG INJECTION will be given to you only by a doctor or a nurse into a
vein as an intravenous infusion. Dose and duration will be decided by your
physician depending upon your age, body weight and disease condition.

Side Effects Of NORZEST 4MG INJECTION

Common

• high blood pressure, slow heartbeat
• lack of blood flow causing injury
• anxiety, headache
• breathing difficulty, excess fluid in the lungs
• blistering and tissue damage at injection site

Rare

Stop receiving NORZEST 4MG INJECTION and contact your doctor immediately if you
experience any of the following side effects:

• itchy rash (hives), swelling of the hands, feet, ankles, face, lips, mouth or throat causing difficulty in swallowing or breathing
• pain or swelling at injection site
• abnormal heart rhythm
• cold extremities or pain in the extremities

How To Manage Side Effects

Itchy skin:

Avoid hot showers because hot water can irritate the skin. Do not scratch the
affected area. Use sunscreen and protective clothing when outdoors. Use
moisturizers to soothe and hydrate the affected skin area. If symptom persists,
contact your doctor.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the head if required. Do not consume too much of alcohol.
If symptom persists, contact your doctor.

Warning & Precautions

!### Pregnancy

NORZEST 4MG INJECTION will be given in pregnancy only if clearly necessary as it
may cause harm to unborn baby. Consult your doctor for advice.

!### Breastfeeding

NORZEST 4MG INJECTION should be used with caution in breastfeeding women as it
is not known whether it passes through the breast milk. Consult your doctor for
advice.

!### Driving and Using Machines

Do not drive or operate any machines after receiving NORZEST 4MG INJECTION.

!### Kidney

NORZEST 4MG INJECTION should be used with caution in patients with severe kidney
disease. Contact your doctor for advice.

!### Liver

NORZEST 4MG INJECTION should be used with caution in patients with liver
failure. Contact your doctor for advice.

!### Allergy

Do not receive NORZEST 4MG INJECTION if you are allergic to Noradrenaline or any
of the other ingredients of this medicine.

!### Heart Disease

NORZEST 4MG INJECTION is not recommended for use in patients with low blood
pressure caused by low blood volume. NORZEST 4MG INJECTION should be used with
caution in patients with high blood pressure or blood clots or obstructions in
the blood vessels supplying the heart, low blood pressure following a heart
attack, Prinzmetal’s angina (a type of chest pain), left ventricular
dysfunction, heart attack or irregular heartbeat. Contact your doctor for
advice.

Others

Before receiving NORZEST 4MG INJECTION, inform your doctor if you have:

• diabetes
• over-active thyroid
• low oxygen levels in the blood
• raised carbon dioxide levels in the blood
• increased pressure inside the brain
• clots or obstructions in the blood vessels supplying the intestines or other parts of the body

Use in Paediatrics:

NORZEST 4MG INJECTION is not recommended for use in children and adolescents
under 18 years of age. Consult your child’s doctor for advice.

Use in Geriatrics:

Use NORZEST 4MG INJECTION with caution in elderly patients aged 65 years or
above. Consult your doctor for advice.

Interactions

A. Drug-Drug interactions:

Before receiving NORZEST 4MG INJECTION, inform your doctor if you are taking any
of the following medicines:

• medicines used for depression (Ex. fluoxetine, sertraline, selegiline, moclobemide, iproniazid, phenelzine, amitriptyline, nortriptyline, imipramine, desipramine, trimipramine)
• linezolid (used for bacterial infections)
• medicines used during surgery to numb the pain (Ex. halothane, cyclopropane, chloroform, enflurane, propofol)
• orciprenaline (medicine used in the management of asthma)
• dobutamine (medicine used for heart diseases)
• medicines used for high blood pressure (Ex. guanethidine, guanadrel, reserpine, methyldopa, prazosin, metoprolol, rauwolfia alkaloids)
• medicines used for irregular heartbeats (Ex. amiodarone, quinidine)
• cardiac glycosides like digoxin (used for heart failure)
• levodopa (medicine used for parkinson’s disease)
• medicines used for thyroid diseases (Ex. levothyroxine)
• oxytocin (medicine used to improve uterine contractions)
• medicines used for allergies (Ex. chlorpheniramine, cetirizine)
• amphetamine (used to increase wakefulness)
• doxapram (used for breathing disorders)
• mazindol (used to manage obesity)
• medicines used to manage migraine (Ex. ergotamine, dihydroergotamine)
• lithium (used to manage mental illness)

Overdosage:

NORZEST 4MG INJECTION will be administered to you only by a doctor or a nurse in
a hospital and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms like severely high blood
pressure, slow heartrate, severe headache, sensitivity to light, chest pain,
pale skin, high fever, intense sweating, vomiting or breathlessness.

Synopsis

Drug	:	Noradrenaline
Pharmacological Category	:	Adrenergic and Dopaminergic agent
Therapeutic Indication	:	Low blood pressure
Dosage Forms	:	Injection

More Information

• Keep NORZEST 4MG INJECTION out of reach of children
• Store NORZEST 4MG INJECTION below 25°C

FAQs About NORZEST 4MG INJECTION

What if I miss a dose of NORZEST 4MG INJECTION?

It is unlikely that you will miss a dose of NORZEST 4MG INJECTION, as it will be
given to you in hospital. However, please stick to the prescribed schedule as
agreed with your doctor for o
management. Tell your doctor whenever you miss to receive any dose.

Does anaesthesia affect NORZEST 4MG INJECTION use?

Using NORZEST 4MG INJECTION with propofol (an anaesthetic) may lead to propofol
infusion syndrome (PRIS), which is a serious condition that affects patients who
are being sedated with propofol during surgeries. Your doctor would observe
disorders in your body’s metabolism from blood tests.

Can NORZEST 4MG INJECTION be used in pregnancy?

NORZEST 4MG INJECTION may harm the unborn baby so, if you are pregnant, think
you may be pregnant or are planning for a baby, consult your doctor before
receiving it. Inform your doctor immediately if you become pregnant during
management with NORZEST 4MG INJECTION.

Can NORZEST 4MG INJECTION be given to children?

No. NORZEST 4MG INJECTION is used for adults and not recommended for children
and adolescents below 18 years of age. Consult your child’s doctor for advice.
The doctor will decide a proper dose or select a suitable alternative management
for your child.

Can I take other medicines with NORZEST 4MG INJECTION?

Before receiving NORZEST 4MG INJECTION, inform your doctor if you are taking,
have taken or might take any other medicine, including prescri
counter or any herbal medicine, as these might lead to significant side effects
by interacting with each other.

Useful Diagnostic Tests

• Echocardiogram