ZYMASE DP Tablet 10's

Introduction About ZYMASE DP TABLET

ZYMASE DP TABLET is a combination of Diclofenac, Paracetamol and
Serratiope
Anti-inflammatory Drugs (NSAID),  Analgesics and Anti-pyrectics. It is used to
relieve symptoms such as fever, pain and inflammation associated with
musculoskeletal and joint disorders.

ZYMASE DP TABLET is not recommended for use in patients with asthma (aspirin
sensitive asthma), urticaria or acute rhinitis precipitated by aspirin or other
NSAIDs, severe liver disease or kidney disease, severe congestive heart failure,
ischemic heart disease (heart attack), blockages of blood vessels to the heart
and in patients with history or active pe
vomiting blood) or perforation or active gastrointestinal bleeding.

ZYMASE DP TABLET should be used with caution in patients with pre-existing
asthma, seasonal allergic rhinitis, nasal polyps, chronic obstructive pulmonary
disease or chronic infections of the respiratory tract, mild to moderate
congestive heart failure and high blood pressure.

ZYMASE DP TABLET is not recommended for use in children.It should be used with
caution in elderly patients (aged 65 years or above). Consult your doctor before
taking ZYMASE DP TABLET.

The most common side effects of taking ZYMASE DP TABLET are nausea, vomiting,
stomach pain, diarrhoea, indigestion, flatulence and gastritis. Consult your
physician if any of the side effects worsen during or after management with
ZYMASE DP TABLET.

Uses Of ZYMASE DP TABLET

• Relieves symptoms such as fever, pain and inflammation associated with musculoskeletal and joint disorders

How ZYMASE DP TABLET Works

ZYMASE DP TABLET helps to manage pain, where Diclofenac inhibits COX-1 and COX-2
and blocks the production of prostaglandins (which are responsible for pain),
while paracetamol works by decreasing fever by acting on the hypothalamus
(heat-regulation centre in the brain) produces peripheral vasodilation,
resulting in increased blood flow through the skin, sweating and heat loss. It
also increases the pain threshold by inhibiting COX-1 and COX-2 enzymes and
serratiope
swelling in the affected area. It also breaks abnormal proteins at the site of
inflammation and promotes healing. Together, relieves fever and pain
effectively.

How to use ZYMASE DP TABLET

Take ZYMASE DP TABLET as advised by your physician. Swallow ZYMASE DP TABLET
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration of ZYMASE DP TABLET for you depending upon
your age, body weight and disease condition.

Side Effects Of ZYMASE DP TABLET

Common

• nausea, vomiting, stomach pain, diarrhoea, indigestion
• rash, itching
• flatulence, constipation, burping, gastritis (indigestion, stomachache, vomiting)
• ulcers in the stomach or intestines, bleeding/perforation, heartburn
• headache, dizziness, feeling sleepy
• difficulty in sleeping
• inflammation of the intestines causing nausea, diarrhoea and abdominal pain
• abnormal formation of foetus

Uncommon

• swelling of the mouth
• urticaria
• drowsiness, tiredness, shakiness
• oedema (fluid retention in the body causing swelling of legs and feet)
• bleeding from the vagina, menstrual disturbances like heavy or light bleeding and delayed periods
• purpura (purple spots on the skin)
• infection of the vagina (itching, burning, soreness, pain during intercourse and or urination)
• blurred vision
• depression and anxiety
• high blood pressure
• fever, chills, loss of appetite
• ulcers in mouth, dryness of mouth
• vertigo or tinnitus (ringing in ears)
• pricking or tingling sensation (pins and needles)

Rare

• inflammation of the lungs causing coughing and increased sputum
• breast pain
• vomiting blood
• worsening of ulcerative colitis
• damage to the gullet
• swelling of the tongue
• low blood pressure
• hair loss
• increased sensitivity to light
• nightmares

Stop taking ZYMASE DP TABLET and contact your physician immediately if you
experience any of the following side effects:

• symptoms of liver damage or elevated liver enzymes such as fever, chills, headache, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine or jaundice (yellowish discolouration of skin and whites of eye)
• symptoms of pancreatitis (inflammation of the pancreas, causing severe abdominal pain radiating to back)
• severe allergic reactions such as skin rash, reddening, blisters, swelling of the hands, feet, ankles, face, lips or throat, which may cause difficulty in swallowing or breathing or wheezing or anaphylactic shock (collapse)
• swelling of the hands, feet, ankles, face, lips or throat, which may cause difficulty in swallowing or breathing
• symptoms of stroke such as weakness or inability to move one side of body (paralysis) and slurred speech
• chest pain or heart failure or change in heart rate
• decrease in white blood cells and can lead to infections with symptoms such as fever, chills, sore throat or flu-like symptoms
• passing black or bloodstained stools or vomiting blood and severe stomach pain due to bleeding or hole formation in the stomach or intestines
• symptoms of stevens-johnson syndrome, exfoliative dermatitis and toxic epidermal necrolysis such as rash, blistering or peeling of the skin
• symptoms of meningitis such as neck stiffness, headache, nausea, vomiting, fever or loss of consciousness
• difficulty in breathing

How To Manage Side Effects

Nausea or vomiting:

Take ZYMASE DP TABLET with or just after meals. Stick to simple meals. Avoid
eating oily, spicy or fried foods. Consult your doctor if nausea and vomiting
does not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a
pain-relieving balm on the forehead if necessary. Do not consume alcohol.
Consult your doctor if headache worsens.

Diarrhoea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Do
not take any medicine on your own for managing diarrhoea. Consult your doctor if
diarrhoea does not improve.

Constipation:

Eat fibre rich foods such as fresh fruits, vegetables and cereals. Drink more
water and exercise regularly. Consult your doctor if constipation did not
improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals.
Keep a heat pad on your stomach. Do not self-manage on your own and consult your
doctor if the symptom does not improve.

Warning & Precautions

!### Pregnancy

ZYMASE DP TABLET is generally not recommended for use during pregnancy and in
women planning for pregnancy. Consult your doctor before taking ZYMASE DP
TABLET.

!### Breastfeeding

ZYMASE DP TABLET is not recommended for use in breastfeeding women as it may
pass through the breast milk. Consult your doctor before taking ZYMASE DP
TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you experience dizziness or drowsiness
after taking ZYMASE DP TABLET.

!### Alcohol

Avoid consum
unwanted effects.

!### Kidney

ZYMASE DP TABLET is not recommended for use in patients with severe kidney
disease. It should be used with caution in patients with impaired kidney
function. Consult your doctor before taking ZYMASE DP TABLET.

!### Liver

ZYMASE DP TABLET is not recommended for use in patients with severe liver
disease. It should be used with caution in patients with impaired liver
function. Consult your doctor before taking ZYMASE DP TABLET.

!### Allergy

Do not take ZYMASE DP TABLET if you are either allergic to diclofenac,
paracetamol, serratiope
NSAIDs such as ibuprofen, naproxen.

!### Lungs

ZYMASE DP TABLET is not recommended for use in patients with asthma (aspirin
sensitive asthma), acute rhinitis precipitated by aspirin or other NSAIDs and
should be used with caution in patients with pre-existing asthma, seasonal
allergic rhinitis, nasal polyps, chronic obstructive pulmonary diseases or
chronic infections of the respiratory tract. Consult your doctor before taking
ZYMASE DP TABLET.

Heart Disease

ZYMASE DP TABLET is not recommended for use in patients with severe congestive
heart failure, ischemic heart disease (heart attack), blockages of blood vessels
to the heart and in the setting of coronary artery bypass graft surgery (CABG).
It should be used with caution in patients with impaired cardiac function, mild
to moderate congestive heart failure and high blood pressure. Consult your
doctor before taking ZYMASE DP TABLET.

Others

ZYMASE DP TABLET is not recommended for use if you have:

• active pe
• urticaria due to acetylsalicylic acid or other NSAIDs
• peripheral arterial disease (problems with blood circulation)
• inflammation of the intestines such as ulcerative colitis or Crohn’s disease
• cerebrovascular disease (stroke) such as stroke, mini-stroke (TIA) or blockages of blood vessels to the brain
• dehydration problems

Before taking ZYMASE DP TABLET, inform your doctor if you have:

• low body weight
• systemic lupus erythematosus (SLE)
• mixed connective tissue disorders
• have ase
• blood clotting disorders or haematological abnormalities
• allergic to other substances such as skin reactions, pruritus or urticaria
• hyperlipidaemia
• diabetes mellitus
• smoking habit

Use in paediatrics:

ZYMASE DP TABLET is not recommended for use in children. Consult your child’s
doctor for advice.

Use in geriatrics:

ZYMASE DP TABLET should be used with caution in elderly patients (aged 65 years
or above). Consult your doctor before taking ZYMASE DP TABLET.

Interactions

A. Drug-Drug interactions:

Before taking ZYMASE DP TABLET, inform your doctor if you are taking any of the
following medicines:

• aspirin or ibuprofen (medicines used to manage pain)
• corticosteroids such as (used to manage inflammation)
• methotrexate, imatinib (used to manage cancer)
• cyclosporine, tacrolimus (medicines used to manage rejection of transplanted organ)
• lithium (medicines used to manage m
• enalapril, furosemide, propranolol (medicines used for high blood pressure and heart diseases)
• mifepristone (medicines used for abortion)
• ciprofloxacin, trimethoprim, chloramphenicol (medicines used for bacterial infections)
• metoclopramide and domperidone (medicines used for nausea and vomiting)
• colestipol and cholestyramine (medicines used to decrease high cholesterol levels)
• zidovudine (medicines used for HIV infection)
• anti-platelet agents Ex. aspirin (medicines used to manage platelet aggregation)
• selective serotonin reuptake inhibitors (SSRIs) Ex.  fluoxetine, sertraline (medicines used to manage depression)
• antidiabetics such as (medicines used to manage diabetes mellitus)
• ketoconazole, fluconazole, miconazole and voriconazole (medicines used to manage fungal infections)
• digoxin (medicines used for heart failure)
• phenytoin (medicines used to manage fits)
• potassium-sparing drugs Ex. spironolactone (medicines used to manage high blood pressure)
• magnesium-containing antacids (medicines used to manage heartburn)
• sulfinpyrazone (used to manage gout)
• amiodarone (medicines used to manage heart rhythm disorders)
• warfarin (medicines used to manage or to manage blood clots)

Overdosage:

If you or anyone else accidentally take too much of ZYMASE DP TABLET, consult
your doctor immediately or visit the nearby hospital. Overdosage symptoms of
ZYMASE DP TABLET includes headache, nausea, vomiting, diarrhoea, epigastric
pain, gastrointestinal bleeding, dizziness, disorientation, excitation, coma,
drowsiness, tinnitus, fainting, occasionally convulsions, acute kidney failure
and liver damage.

Synopsis

Drug	:	Diclofenac, Paracetamol and Serratiope
Pharmacological Category	:	Nonsteroidal Anti-inflammatory Drugs, Analgesics and Anti-pyrectics
Therapeutic Indication	:	Relieves fever, pain and inflammation
Dosage Forms	:	Tablet

More Information

• Keep ZYMASE DP TABLET out of reach of children
• Store ZYMASE DP TABLET at room temperature

FAQs About ZYMASE DP TABLET

What is ZYMASE DP TABLET and why is it prescribed?

ZYMASE DP TABLET is a combination of Diclofenac, Paracetamol and
Serratiope
Anti-inflammatory Drugs (NSAID),  Analgesics and Anti-pyrectics. It is used to
relieve symptoms such as fever, pain and inflammation associated with
musculoskeletal and joint disorders.

What are the common side effects of taking ZYMASE DP TABLET?

The most common side effects of taking ZYMASE DP TABLET are nausea, vomiting,
stomach pain, diarrhoea, indigestion, ulcers in the stomach or intestines,
bleeding/perforation, heartburn, etc. Consult your physician if any of the side
effects worsen.

Does ZYMASE DP TABLET cause bleeding?

Yes, ZYMASE DP TABLET may increase the risk of bleeding, ulceration and
perforation in stomach and intestine and it is not recommended for use in
patients with history or active gastric or intestinal ulcer, bleeding (blood in
stools, vomiting blood) or perforation. Consult your doctor before taking ZYMASE
DP TABLET.

Can ZYMASE DP TABLET be used in patients with liver problems?

ZYMASE DP TABLET is not recommended for use in patients with severe liver
disease. It should be used with caution in patients with impaired liver
function. Consult your doctor before taking ZYMASE DP TABLET.

IsZYMASE DP TABLET safe to use in pregnant women?

No, ZYMASE DP TABLET is generally not recommended for use during pregnancy and
in women planning for pregnancy. Consult your doctor for advice before taking
this medicine if you are pregnant or planning to get pregnant.

Useful Diagnostic Tests

• Liver function test
• Kidney function test