Mefbull DS Suspension 60ml

Introduction About MEFBULL DS SUSPENSION

MEFBULL DS SUSPENSION is a combination of Mefenamic acid and Paracetamol, which
belongs to a group of medicines called Non-steroidal Anti-inflammatory Drugs
(NSAIDs) and Analgesics and Antipyretics. It is indicated for the management of
fever in children. It is also used for the management of mild to moderate pain
such as headache, toothache, joint or muscle pain, and period pain.

MEFBULL DS SUSPENSION is not recommended for use in patients with asthma or
aspirin-sensitive asthma, severe liver, kidney, or heart disease. Contact your
doctor before taking.

MEFBULL DS SUSPENSION is generally not recommended for use in pregnant women.
Contact your doctor before taking.

MEFBULL DS SUSPENSION is generally not recommended for use in breastfeeding
women as it may pass through the breast milk. Contact your doctor before taking
it.

MEFBULL DS SUSPENSION is not recommended for use in children under 6 months of
age. Contact your doctor before taking.

MEFBULL DS SUSPENSION should be used with caution in elderly patients (aged 65
years or above). Contact your doctor before taking.

The most common side effects of this medicine are skin rash, nausea, vomiting,
diarrhea, abdominal pain, constipation, indigestion, flatulence, anorexia, dry
mouth, heartburn, pe
stomatitis. Contact your doctor if any of the side effects worsen.

Uses Of MEFBULL DS SUSPENSION

It is used to manage:

• fever
• mild to moderate pain (headache, toothache, joint or muscle pains, and period pains)

How MEFBULL DS SUSPENSION Works

MEFBULL DS SUSPENSION helps to relieve fever and pain, where paracetamol acts on
the hypothalamus (heat regulating center) of the brain, resulting in peripheral
vasodilation, sweating, and loss of body heat, and it also increases the pain
threshold by inhibiting COX-1 and COX-2 enzymes, and mefenamic acid works by
inhibiting COX-1 and COX-2 enzymes, which are involved in prostaglandin
synthesis (responsible for pain and inflammation).

How to use MEFBULL DS SUSPENSION

Take this medicine as advised by your doctor. Shake well before use. Your doctor
will decide the correct dose and duration of therapy for you depending upon your
age, body weight, and disease condition.

Side Effects Of MEFBULL DS SUSPENSION

Common

• skin rash
• nausea, vomiting
• abdominal pain
• diarrhea
• constipation
• indigestion
• flatulence
• anorexia
• dry mouth
• heartburn
• pe
• perforation or GI bleeding
• ulcerative stomatitis

Uncommon

• gastritis

Rare

Stop taking MEFBULL DS SUSPENSION and contact your doctor immediately if you
experience any of the following side effects:

• allergic reactions such as skin rashes, redness, hives, boils, severe itching, flaking skin, and swelling of the face, lips, tongue, or throat causing sudden wheezing, fluttering, tightness of the chest or collapse, or difficulty breathing or swallowing
• patchy rashes and peeling of skin with blistering of the mouth, eyes, and genitals
• thrombocytopenic purpura
• yellowing of your skin or eyes, pale faeces, and dark urine
• severe pain in the abdomen and back with fever, loss of appetite, nausea, and vomiting
• passing blood in stools or black tarry stools
• vomiting blood or dark particles like coffee ground
• fever, sore throat, and mouth ulcers due to infections
• unusual bruising or bleeding, for example nosebleeds, pinpoint red spots on the skin, and rashes on the skin and mouth
• tiredness, shortness of breath, and paleness of skin caused by anemia
• seizures
• headache, nausea, vomiting, tiredness, muscle cramps (low sodium levels)
• sudden headache, fever, stiff neck, sensitivity to bright light, drowsiness, and muscle pain, with or without a rash
• fever, rash, nausea, aches and pains, passing more or less urine than usual, passing red urine or passing urine at night due to changes in kidneys
• sudden loss of vision or colour vision, blurring of vision, eye pain
• low body temperature, feeling cold with pale-looking skin (in children)

How To Manage Side Effects

!### Constipation

Eat plenty of fiber-rich foods such as fresh fruits, vegetables, and cereals.
Drink plenty of water and exercise more regularly. Consult your doctor if
constipation persists.

!### Diarrhea

Drink lots of fluids, such as water or fruit juices, to keep you hydrated. Do
not take any medicine on your own to manage diarrhea. Contact your doctor if the
diarrhea does not improve.

!### Indigestion

Eat smaller meals but take them frequently. Eat and exercise regularly. Contact
your doctor if the digestion does not improve.

!### Nausea And Vomiting

Take this medicine with or just after meals. Stick to simple meals. Avoid eating
oily or spicy foods. Consult your doctor if the nausea and vomiting do not
improve.

!### Stomach Pain

Try to rest and relax. Eat small meals but take them frequently. Keep a heating
pad on your stomach. Contact your doctor if the stomach pain does not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedMEFBULL DS SUSPENSION is not recommended for use in pregnant women. Contact your
doctor before taking.

!### Breastfeeding

ContraindicatedMEFBULL DS SUSPENSION is generally not recommended for use in breastfeeding
women as it may pass through the breast milk. Consult your doctor before taking
it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizziness, drowsiness, fatigue,
and visual disturbances after taking MEFBULL DS SUSPENSION.

!### Alcohol

ContraindicatedAvoid consum
the risk of liver injury and stomach bleeding.

!### Kidney

ContraindicatedMEFBULL DS SUSPENSION is not recommended for use in patients with severe kidney
disease. Contact your doctor before taking.

!### Liver

ContraindicatedMEFBULL DS SUSPENSION is not recommended for use in patients with severe liver
disease. Contact your doctor before taking.

!### Allergy

ContraindicatedDo not take MEFBULL DS SUSPENSION if you are allergic to mefenamic acid,
paracetamol, sucrose, or other NSAIDs such as aspirin, ibuprofen, celecoxib, or
any other ingredients of this medicine.

!### Lungs

ContraindicatedMEFBULL DS SUSPENSION is not recommended for use in patients with lung diseases
such as asthma, sinusitis with or without nasal polyps (aspirin triad), or
aspirin-sensitive asthma. Contact your doctor before taking.

!### Heart Disease

ContraindicatedMEFBULL DS SUSPENSION is not recommended for use in patients with severe heart
disease or hypertension. Contact your doctor before taking.

!### Use In Pediatrics

Consult your doctorMEFBULL DS SUSPENSION is not recommended for use in children under 6 months of
age. Your doctor will prescribe the right dose depending on your child’s age,
body weight, and disease condition. Contact your doctor before taking.

!### Use In Geriatrics

Use with CautionMEFBULL DS SUSPENSION should be used with caution in elderly patients (aged 65
years or above). Contact your doctor before taking.

Others

MEFBULL DS SUSPENSION is not recommended for use if you:

• have pe
• have inflammatory bowel disease (Ex. ulcerative colitis, Crohn's disease)
• have obstructive uropathy
• had coronary artery bypass graft (CABG) surgery

Before taking MEFBULL DS SUSPENSION, inform your doctor if you have:

• hyperthyroidism
• closed-angle glaucoma
• fluid retention or edema
• poor general health
• previous anaphylactic reactions to NSAIDs
• anemia
• intolerance to fructose or other sugars
• bleeding disorder
• major operation
• connective tissue disorder (Ex. Systemic Lupus Erythematous)
• epilepsy
• dehydration
• diabetes
• high cholesterol levels
• smoking history

Interactions

A. Drug-Drug interactions:

Inform your physician if you are taking any of the following medicine:

• cholestyramine (medicines used to decrease high cholesterol levels)
• metoclopramide and domperidone (medicine used to manage nausea and vomiting)
• medicines used to thin the blood (Ex. warfarin, aspirin, clopidogrel)
• medicine used to manage seizures (Ex. phenytoin, phenobarbitone)
• isoniazid (medicines used for tuberculosis)
• medicine used for high blood pressure or heart diseases (captopril, atenolol, ramipril, valsartan, chlorothiazide, chlorthalidone, sotalol, diltiazem)
• ibuprofen, ketoprofen, diclofenac, celecoxib (medicine used to manage pain)
• lithium (medicine used to manage depression and m
• medicines used for heartburn or indigestion (Ex. magnesium hydroxide)
• medicine used to manage bacterial infections (Ex. chloramphenicol, aminoglycosides like amikacin, tobramycin, gentamicin, and quinolone antibiotics like ciprofloxacin)
• digoxin (medicine used for heart failure)
• medicines suppress the immune system (Ex. cyclosporine, tacrolimus, methotrexate)
• medicines used to manage diabetes mellitus (Ex. glimepiride, metformin, glipizide, glibenclamide)
• antiplatelet like low-dose aspirin (medicine used to manage platelet aggregation)
• corticosteroids (medicines used to manage arthritis and inflammation)
• mifepristone (medicines used to terminate pregnancy)
• zidovudine (medicine used for HIV infection, AIDS)
• oral contrace
• medicines used to manage depression (Ex. paroxetine)
• medicines used for anxiety and depression (Ex. amitriptyline)
• barbiturates (used for insomnia)
• probenecid (medicines used to manage gout)
• propantheline (medicines used to manage ulcers)
• narcotic analgesics (medicines sued to manage severe pain)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your
doctor immediately. Symptoms of overdose are severe stomach pain, coffee
ground-like vomit, dark stool, ringing in the ears, change in amount of urine,
unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing,
confusion, and severe headache.

Synopsis

Drug	:	Mefenamic acid, Paracetamol
Pharmacological Category	:	Non-Steroidal Anti-Inflammatory Drugs, Analgesics, and Antipyretics
Therapeutic Indication	:	Fever and Pain
Dosage Forms	:	Tablet, Syrup, Suspension, Oral suspension

More Information

Storage

• Keep out of reach of children
• Store MEFBULL DS SUSPENSION below 30°C

FAQs About MEFBULL DS SUSPENSION

Q: Does MEFBULL DS SUSPENSION cause gastritis?

A: Yes. MEFBULL DS SUSPENSION may cause gastritis, bleeding in the stomach or
intestine. Contact your doctor before taking.

Q: Does MEFBULL DS SUSPENSION cause jaundice?

A: Yes. MEFBULL DS SUSPENSION may cause jaundice. Contact your doctor if you
experience unusual symptoms such as yellowish discolouration of skin and whites
of the eye, dark urine, and pale stools.

Q: Can I use MEFBULL DS SUSPENSION in children?

A: Yes. MEFBULL DS SUSPENSION is used in children above 6 months of age. Contact
your doctor before taking the medicine.

Q: Does MEFBULL DS SUSPENSION cause breathlessness?

A: Yes. MEFBULL DS SUSPENSION may cause breathlessness. Stop taking MEFBULL DS
SUSPENSION and consult your doctor immediately if you experience unusual
symptoms such as difficulty breathing and chest pain.

Q: Can I drink alcohol while using MEFBULL DS SUSPENSION?

A: No. Avoid consum
increases the risk of liver injury and stomach bleeding.

Q: What is MEFBULL DS SUSPENSION used for?

A: MEFBULL DS SUSPENSION is indicated for the management of fever in children.
It is also used for the management of mild to moderate pain such as headache,
toothache, joint or muscle pain, and period pain.

Q: How does MEFBULL DS SUSPENSION work?

A: MEFBULL DS SUSPENSION helps to relieve fever and pain, where paracetamol acts
on the hypothalamus (heat-regulating center) of the brain, resulting in
peripheral vasodilation, sweating, and loss of body heat, and it also increases
the pain threshold by inhibiting COX-1 and COX-2 enzymes, and mefenamic acid
works by inhibiting COX-1 and COX-2 enzymes, which are involved in prostaglandin
synthesis (responsible for pain and inflammation).

Q: Who should avoid taking MEFBULL DS SUSPENSION?

A: MEFBULL DS SUSPENSION is not recommended for use in patients with severe
kidney disease, severe liver disease, allergies to Mefenamic acid, Paracetamol,
or sucrose, or to other NSAIDs such as aspirin, ibuprofen, celecoxib, lung
diseases such as asthma, sinusitis with or without nasal polyps (aspirin triad)
or aspirin-sensitive asthma, severe heart disease or hypertension, pe
bleeding in the stomach or severe gastritis, active ulceration/bleeding, or
chronic inflammation of the upper or lower gastrointestinal (GI) tract,
inflammatory bowel disease (Ex. ulcerative colitis, Crohn's disease),
obstructive uropathy, or had coronary artery bypass graft (CABG) surgery.
Contact your doctor before taking.

Q: What precautions must be taken while using MEFBULL DS SUSPENSION?

A: Before taking MEFBULL DS SUSPENSION, inform your doctor if you have
hyperthyroidism, closed-angle glaucoma, fluid retention or edema, poor general
health, previous anaphylactoid reactions to NSAIDs, anemia, intolerance to
fructose or other sugars, bleeding disorder, major operation, connective tissue
disorder (Ex. Systemic Lupus Erythematous, epilepsy, dehydration, diabetes, high
cholesterol levels, smoking history)

Q: Is MEFBULL DS SUSPENSION safe for pregnant women?

A: MEFBULL DS SUSPENSION is not recommended for use in pregnant women. Contact
your doctor before taking.

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Kidney Function Test (KFT)
• Liver Function Test (LFT)
• Serum Electrolytes/ Electrolytes Profile
• Healthy Midlife Checkup
• Men Health Checkup - Advanced
• Complete Women Checkup
• Full Body Checkup - Gold
• Full Body Checkup – Silver