TRANCE 500 Injection 5ml

Introduction About TRANCE 500 INJECTION

TRANCE 500 INJECTION contains Tranexamic Acid which belongs to the group of
medicines called Antifibrinolytics. It is used in the management of bleeding in
conditions such as heavy menstrual bleeding in women, gastrointestinal bleeding
(bleeding in digestive tract, anywhere from the throat to rectum), bleeding due
to thrombolytic therapy (medicine that is used to breakdown blood clots) and
after having surgeries (such as ear, nose, throat, prostate gland, urinary
tract, gynecological, abdominal or heart surgery) in adults and children above
one year of age.

TRANCE 500 INJECTION is not recommended for use in patients with severe kidney
impairment, blood clotting disorder or consum
affecting the blood’s ability to clot and stop the bleeding) or history of
seizures (fits). Your doctor may recommend you to take relevant tests to
understand your existing condition.

Before receiving TRANCE 500 INJECTION, inform your doctor if you had or have
blood in the urine, are at risk of having a blood clot, excessive clotting or
bleeding throughout the body (disseminated intravascular coagulation).

TRANCE 500 INJECTION is not recommended for use in the first trimester of
pregnancy and in breast-feeding women. It should be used with caution in
pregnant women only if clearly advised by the doctor. TRANCE 500 INJECTION
should be used with caution in elderly patients, especially in patients with the
evidence of renal failure.

The most common side effects of receiving TRANCE 500 INJECTION are nausea or
vomiting and diarrhea. Inform your doctor immediately if any of the side effect
worsens.

Uses Of TRANCE 500 INJECTION

Prevent and manages bleeding in children (aged above one) and adults in
conditions such as:

• heavy menstrual bleeding in women
• gastrointestinal bleeding
• after having surgeries (such as ear, nose, throat, heart, abdominal, gynaecological and prostrate or urinary tract surgery)
• bleeding due to medicine that is used to breakdown blood clots (thrombolytic therapy)

How TRANCE 500 INJECTION Works

TRANCE 500 INJECTION manages bleeding by blocking the plasminogen from binding
with fibrin which results in bleeding. As a result, it manages and controls
bleeding associated with various factors.

How to use TRANCE 500 INJECTION

TRANCE 500 INJECTION will be given to you only by a doctor or a nurse into a
vein as an intravenous injection. Your doctor will decide the correct dose,
frequency and duration for you depending upon your age, body weight and disease
condition.

Side Effects Of TRANCE 500 INJECTION

Common

• diarrhea
• nausea, vomiting

Uncommon

• skin rashes

Rare

Inform your doctor immediately if you experience any of the following side
effects while receiving TRANCE 500 INJECTION:

• severe allergic reaction (signs include redness of the skin and lumpy skin rashes, difficulty in breathing, swelling of face, mouth, lips or eyelids, unexplained high temperature (fever) and fainting)
• swelling of the throat that causes breathing and swallowing difficulty
• symptoms of a blood clot (such as swelling or pain in the legs or chest, headache, weakness of the face and limbs on one side of the body)

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating
high-fat or spicy foods. Inform your doctor if the symptom gets worse.

!### Nausea And Vomiting

Stick to simple meals while receiving this medicine. Avoid eating oily rich,
fried or spicy foods. Do not lie down or sleep immediately after eating. Inform
your doctor if the symptom does not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedTRANCE 500 INJECTION is not recommended for use in the first trimester of
pregnancy. It should be used with caution in pregnant women only if considered
clearly necessary. Women of childbearing potential should use effective
contrace
receiving TRANCE 500 INJECTION.

!### Breastfeeding

ContraindicatedTRANCE 500 INJECTION is not recommended for use in breastfeeding women as it
passes through breast milk. Consult your doctor for advice.

!### Kidney

Consult your doctorTRANCE 500 INJECTION is not recommended for use in patients with severe kidney
impairment. It should be used with caution in patients with mild to moderate
kidney impairment. Your doctor may adjust the dose depending upon the kidney
function. Consult your doctor before receiving TRANCE 500 INJECTION.

!### Liver

Use with CautionTRANCE 500 INJECTION can be used with caution in patients with liver impairment.
Consult your doctor before receiving TRANCE 500 INJECTION.

!### Allergy

ContraindicatedDo not receive TRANCE 500 INJECTION if you are allergic to Tranexamic acid or
any other ingredients of this medicine.

!### Use In Pediatrics

Use with CautionTRANCE 500 INJECTION should be used with caution in children above 1 year of
age. Your child’s doctor will adjust the dose based on the bodyweight of the
child. Consult child’s doctor for advice before administration of TRANCE 500
INJECTION.

!### Use In Geriatrics

Use with CautionTRANCE 500 INJECTION should be used with caution in elderly patients, especially
in patients with the evidence of renal failure. Consult your doctor before
receiving TRANCE 500 INJECTION.

Others

TRANCE 500 INJECTION is not recommended for use if you:

• have blood clotting disorder or consum
• have history of seizures (fits)

Before receiving TRANCE 500 INJECTION, inform your physician if you:

• have blood in the urine (which may lead to urinary tract obstruction)
• are at risk of having a blood clot
• have excessive clotting or bleeding throughout the body (disseminated intravascular coagulation)

Interactions

A. Drug-Drug interactions:

Before receiving TRANCE 500 INJECTION, inform your doctor if you have received
or taking any of the following medicines:

• ethinyl estradiol, levonorgestrel (oral contrace
• thrombolytic agents such as streptokinase, reteplase, tenecteplase (medicines that manage blood clot)
• antifibrinolytics such as aminocaproic acid, aprotinin (medicines that help the blood to clot)

Overdosage:

TRANCE 500 INJECTION will be given to you only by a doctor or nurse in a
hospital, and so it is unlikely to receive an overdose. However, if you
experience any unusual symptoms contact your doctor immediately. Symptoms
include dizziness, headache, low blood pressure and convulsions (fits).

Synopsis

Drug	:	Tranexamic Acid
Pharmacological Category	:	Antifibrinolytics
Therapeutic Indication	:	Prevent and manages bleeding in certain conditions
Dosage Forms	:	Injection, Gel, Tablet

More Information

• Store at room temperature

FAQs About TRANCE 500 INJECTION

Q: CanTRANCE 500 INJECTION be used in elderly patients?

A: TRANCE 500 INJECTION should be used with caution in elderly patients,
especially in patients with the evidence of renal failure. Consult your doctor
for advice before receiving TRANCE 500 INJECTION.

Q: Is TRANCE 500 INJECTION safe to use during pregnancy?

A: TRANCE 500 INJECTION is not recommended for use in the first trimester of
pregnancy. It should be used with caution in pregnant women only if clearly
advised by the doctor. Women of childbearing potential should use effective
contrace
receiving TRANCE 500 INJECTION.

Q: CanTRANCE 500 INJECTION be used in patients with impaired kidney
function?

A: TRANCE 500 INJECTION is not recommended for use in patients with severe
kidney impairment. It should be used with caution in patients with mild to
moderate kidney impairment. Your doctor may adjust the dose depending upon the
kidney function. Consult your doctor before receiving TRANCE 500 INJECTION.

Q: Does TRANCE 500 INJECTION cause nausea?

A: Yes, TRANCE 500 INJECTION may cause nausea in some individuals. To manage
this effect, stick to simple meals while receiving this medicine. Avoid eating
oily rich, fried or spicy foods. Do not lie down or sleep immediately after
eating. Inform your doctor if the symptom does not improve.

Q: HowTRANCE 500 INJECTION is administered?

A: TRANCE 500 INJECTION will be given to you only by a doctor or a nurse into a
vein as an intravenous injection. It should not be injected into a muscle
(intramuscularly). Your doctor will decide the correct dose, frequency and
duration for you depending upon your age, body weight and disease condition.

Useful Diagnostic Tests

• Complete blood count
• Liver function test
• Kidney function test
• Bleeding Time/clotting time
• Eye test