TERLIFUL Injection 10ml

Introduction About TERLIFUL INJECTION

TERLIFUL INJECTION contains Terlipressin which belongs to the group of medicines
called Vasopressin Analogues. It is used for the management of bleeding
oesophageal varices (bleeding from dilated veins in the food pipe leading to
your stomach).

Bleeding oesophageal varices occur when swollen veins (varices) in your lower
food pipe rupture and bleed. During TERLIFUL INJECTION management, your doctor
may want you to take several blood tests to monitor side effects.

Before receiving TERLIFUL INJECTION, inform your doctor if you have any heart or
kidney problems, se
TERLIFUL INJECTION should be used in pregnant women only if your doctor finds it
necessary and should be used in breastfeeding women only after discussing the
potential risk to your baby.

TERLIFUL INJECTION is not recommended for use in children and adolescents due to
lack of experience. The most common side effects of receiving TERLIFUL INJECTION
are headache, temporary stomach pain or diarrhea, pale face or skin, stomach
cramps in women, etc. Contact your doctor if any of the symptoms get worse over
time.

Uses Of TERLIFUL INJECTION

• Manage bleeding oesophageal varices

How TERLIFUL INJECTION Works

TERLIFUL INJECTIONreduces bleeding by releasing substance called lysine
vasopressin that acts on the walls of the blood vessels and constricts them,
thus decreasing the blood flow to the affected veins.

How to use TERLIFUL INJECTION

TERLIFUL INJECTION will be given to you only by a doctor or a nurse into a vein
as an intravenous infusion. Your doctor will decide the correct dose and
duration of management depending upon your age, body weight and disease
condition.

Side Effects Of TERLIFUL INJECTION

Common

• very slow heart rate, high or low blood pressure
• signs in ECG showing insufficient blood supply in the heart vessels
• insufficient blood supply in arms, legs and skin
• paleness of face or skin
• headache
• temporary stomach cramps or diarrhoea
• abdominal cramps in women

Uncommon

• chest pain, rapid rise in blood pressure, heart attack, throbbing sensation
• skin or lips becoming bluish
• hot flushes, heart failure
• excess fluid on the lungs, breathlessness due to spasm in the bronchial muscles
• temporary nausea or vomiting
• inflammation of the lymph vessels
• reduced blood supply to the intestines
• uterine cramps, reduced blood flow to the uterus
• too little sodium in the blood if not monitored

Rare

• breathlessness

Stop receiving TERLIFUL INJECTION and contact your doctor immediately if you
experience any of the following side effects:

• severe breathlessness due to an asthma attack
• severe trouble with or stopping breathing
• severe pain in the chest, severe and persistent irregular heartbeats
• locally dead skin (necrosis)
• convulsions (fits)
• kidney failure

How To Manage Side Effects

Diarrhea:

Drink lots of fluids, such as water or fruit juice for hydration. Do not consume
any medicine on your own without asking your doctor. If symptom persists,
contact your doctor.

Stomach pain:

Try to rest and relax. Try to have smaller and frequent meals. Keep a heat pad
on your stomach. If symptom persists, contact your doctor.

Headache:

Try to take rest in a quiet dark room. Don’t involve yourself in exertive
activities. Apply a pain-relieving balm on your forehead. If symptom persists,
contact your doctor.

Warning & Precautions

!### Pregnancy

TERLIFUL INJECTION should be used in pregnant women only if considered clearly
necessary. Consult your doctor for advice.

!### Breastfeeding

TERLIFUL INJECTION should be used in breastfeeding women only after discussing
the potential risk to your baby. Consult your doctor for advice.

!### Driving and Using Machines

It is not studied whether TERLIFUL INJECTION affects the ability to drive and
use machines. Consult your doctor if you feel any side effect during management
with TERLIFUL INJECTION that may stop you from driving or using machines.

!### Kidney

TERLIFUL INJECTION should be taken with caution in patients with impaired kidney
function. Consult your doctor for advice.

!### Liver

No dose adjustment of TERLIFUL INJECTION is required in patients with liver
failure. Consult your doctor for advice.

!### Allergy

Do not receive TERLIFUL INJECTION if you are allergic to Terlipressin or any of
the other ingredients of this medicine.

!### Lungs

TERLIFUL INJECTION should be used with caution in patients having bronchial
asthma or other conditions that affect your breathing. Consult your doctor for
advice.

!### Heart Disease

TERLIFUL INJECTION should be used in caution in patients having uncontrolled
high blood pressure, insufficient blood circulation in the heart vessels (Ex.
angina), arteriosclerosis (hardening of the arteries), irregular heartbeats or
in those who previously had a heart attack. Consult your doctor for advice.

Others

Before receiving TERLIFUL INJECTION, inform your doctor if you have:

• a severe infection called se
• poor blood circulation to your brain (Ex. stroke) or to your legs (peripheral vascular disease)
• disturbances in electrolyte levels in your blood
• decreased amount of fluid in your circulation or have already lost a large amount of blood

Use in Paediatrics:

TERLIFUL INJECTION is not recommended for use in children and adolescents due to
lack of experience. Consult your child’s doctor for advice.

Use in Geriatrics:

TERLIFUL INJECTION should be used with caution in elderly patients (aged above
70 years). Consult your doctor for advice.

Interactions

A. Drug - Drug interactions:

Before receiving TERLIFUL INJECTION, inform your doctor if you are taking any of
the following medicines:

• medicines used to lower high blood pressure (Ex. atenolol, sotalol, furosemide, spironolactone)
• medicines used to induce anaesthesia (Ex. sufent
• medicines used to manage irregular beating of the heart (Ex. quinidine, procainamide, disopyramide, amiodarone, ibutilide, dofetilide)
• erythromycin (used to manage bacterial infections)
• medicines used to manage allergies (Ex. chlorphenamine, promethazine)
• certain medicines used to manage depression (Ex. nortriptyline, amitriptyline)

Overdosage:

TERLIFUL INJECTION will be administered to you only by a doctor or a nurse in a
hospital and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Terlipressin
Pharmacological Category	:	Vasopressin Analogue
Therapeutic Indication	:	Bleeding oesophageal varices
Dosage Forms	:	Injection

More Information

• Keep TERLIFUL INJECTION out of reach of children
• Store in a refrigerator at 2-8°C

FAQs About TERLIFUL INJECTION

Is TERLIFUL INJECTION safe for use during pregnancy?

TERLIFUL INJECTION should only be used during pregnancy if it is necessary to
manage your condition. If you are pregnant, think you may be pregnant or are
planning for a baby, contact your doctor before receiving it.

What if I miss a dose of TERLIFUL INJECTION?

Please stick to the prescribed schedule as agreed with your doctor for o
efficacy of TERLIFUL INJECTION management. Tell your doctor whenever you forget
to receive any dose.

Is TERLIFUL INJECTION suitable for children?

TERLIFUL INJECTION is not recommended for use in children and adolescents due to
lack of experience. Consult your child’s doctor for advice. The doctor will
advise a proper dose or select a suitable alternative management for your child.

Can TERLIFUL INJECTION be stopped?

Continue receiving TERLIFUL INJECTION until your doctor tells you to stop,
unless you experience any unwanted effects, worsening of your condition or any
new symptoms. Contact your doctor in such case.

Can I take other medicines with TERLIFUL INJECTION?

Before receiving TERLIFUL INJECTION, inform your doctor if you are taking, have
taken or are going to take any other medicine, including prescri
counter or any herbal product, as these might lead to serious side effects by
interacting with each other.

Useful Diagnostic Tests

• GI endoscopy