Temcad 250mg Capsule 5'S

Introduction About TEMCAD 250MG CAPSULE

TEMCAD 250MG CAPSULE contains Temozolomide, which belongs to the group of
medicines called Antineoplastic agents. It is used for specific forms of brain
tumours in adults with newly diagnosed glioblastoma multiforme, which is used
first together with radiotherapy as a concomitant phase of therapy and then used
alone as a monotherapy. It is also used in children (above 3 years) and adults
to manage malignant gliomas, such as glioblastoma multiforme or anaplastic
astrocytoma, if they return or get worse after standard management.

Glioblastoma multiforme is an aggressive type of cancer that affects the brain
or spinal cord and is generally characterized by symptoms such as headache,
nausea, drowsiness, blurred vision, personality changes, and seizures.

Along with this management, your doctor might advise you to take liver function
tests to assess the hepatotoxicity and function of your liver. Before taking
TEMCAD 250MG CAPSULE, inform your doctor if you have or ever had a hepatitis B
infection (serious liver infection).

TEMCAD 250MG CAPSULE is not recommended for use if you have certain kinds of
blood cells that are severely reduced, such as white blood cells and platelet
count. TEMCAD 250MG CAPSULE should be used with caution during pregnancy only if
it is clearly necessary and not recommended for use in breastfeeding women. It
is not recommended for use in children below 3 years of age and should be used
with caution in children and adolescents (from 3 to 18 years of age). Consult
your doctor before taking TEMCAD 250MG CAPSULE. The most common side effects of
taking TEMCAD 250MG CAPSULE are loss of appetite, difficulty while speaking,
headache, vomiting, nausea, diarrhea, and constipation. Consult and inform your
doctor if any of these symptoms get worse.

Uses Of TEMCAD 250MG CAPSULE

It is used for:

• Specific forms of brain tumours in newly diagnosed glioblastoma multiforme (in adults)
• Malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma (in adults and children)

How TEMCAD 250MG CAPSULE Works

TEMCAD 250MG CAPSULE works by damaging the genetic material (DNA and RNA) of the
cancer cells inside the brain cells and works against the cell growth and
multiplication.

How to use TEMCAD 250MG CAPSULE

Take TEMCAD 250MG CAPSULE as advised by your physician. Swallow TEMCAD 250MG
CAPSULE with a glass of water and do not chew or crush the medicine. Your doctor
will decide the correct dose and duration for you depending upon your age, body
weight, and disease condition.

Side Effects Of TEMCAD 250MG CAPSULE

Common

• Loss of appetite
• Difficulty while speaking
• Headache
• Vomiting, nausea
• Diarrhea
• Constipation
• Rash
• Hair loss
• Tiredness
• Infections
• Feeling sick, extreme tiredness, loss of appetite (signs of neutropenia)
• Fever, cough, runny nose (signs of lymphopenia)
• Prolonged cuts, bleeding from gums, blood in urine (signs of thrombocytopenia)
• Allergic reactions
• Memory impairment
• Depression, anxiety, confusion, sleeplessness
• Difficulty concentrating
• Dizziness
• Visual disturbances
• Deafness, ringing in the ears, earache
• Blood clot in the lung or legs
• High blood pressure
• Shortness of breath
• Bronchitis
• Cough and cold
• Inflammation of sinuses
• Stomach or abdominal pain
• Dry skin, itching
• Muscle damage, muscle aches and pain, muscle weakness
• Joint and back pain
• Frequent urination
• Fever
• Flu-like symptoms such as chills, cough, fever, and muscle aches
• Pain
• Fluid retention
• Weight gain or loss
• Radiation injury such as weakness, hair loss, and bloody vomit

Uncommon

• New or reactivated cytomegalovirus infections such as chickenpox, herpes simplex
• Signs of reactivated hepatitis B virus infections such as abdominal pain, dark urine, fever, and joint pain
• Secondary cancers, including leukemia (blood cancer)
• Reduced blood cell counts, such as pancytopenia
• Red spots under the skin
• Signs of diabetes insipidus
• Piles
• Dry mouth
• Blisters on body or in mouth
• Skin peeling, skin eru
• Increased sensitivity to sunlight
• Urticaria (red, itchy skin)
• Increased sweating
• Change in skin colour
• Vaginal bleeding or irritation
• Absent or heavy menstrual periods
• Breast pain
• Sexual impotence
• Shivering

Stop taking TEMCAD 250MG CAPSULE and contact your doctor if you experience any
of the following side effects:

• Signs of a severe allergic (hypersensitive) reaction such as itchy red skin, wheezing, or other breathing difficulty
• Uncontrolled bleeding
• Seizures (fits)
• Fever and symptoms of infections such as cough, chills, sweat
• Chills
• Severe headache

How To Manage Side Effects

!### Constipation

Try to eat high-fiber foods such as vegetables, cereals, and fresh fruit, and
drink plenty of water. Consult and inform your doctor about receiving alternate
management for constipation.

!### Diarrhea

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on
your own to manage diarrhea; consult and inform your doctor if the symptom gets
worse.

!### Dizziness Or Drowsiness

Try to rest and get enough sleep. Try to avoid driving or operating any tools or
machines while you feel dizzy. Limit consum
dizziness. Consult and inform your doctor if the symptom does not improve.

Headache

If TEMCAD 250MG CAPSULE causes headache, then take rest and drink plenty of
fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a
painkiller. Headaches should usually go away after the first week of taking
TEMCAD 250MG CAPSULE. If headaches last more than a week or are severe, consult
and inform your doctor.

!### Nausea And Vomiting

Try to take TEMCAD 250MG CAPSULE with or just after a meal or a snack. Stick to
simple meals. Avoid eating rich or spicy food. Consult your doctor if the
symptom gets worse.

Warning & Precautions

!### Pregnancy

Monitoring requiredTEMCAD 250MG CAPSULE should be used in pregnant women only if it is clearly
necessary. Women with childbearing potential should use effective contrace
precautions, which should be continued for at least 6 months following the
completion of> management. Consult your doctor before taking TEMCAD 250MG
CAPSULE.

!### Breastfeeding

ContraindicatedTEMCAD 250MG CAPSULE is not recommended for use in breastfeeding women. Consult
your doctor before taking TEMCAD 250MG CAPSULE.

!### Driving and Using Machines

ContraindicatedTEMCAD 250MG CAPSULE may cause tiredness or sleepiness. If you experience any
such effects, avoid driving and using machines. Consult your doctor before
taking TEMCAD 250MG CAPSULE.

!### Kidney

Use with CautionTEMCAD 250MG CAPSULE should be used with caution in patients with kidney
problems such as severe renal impairment. Consult your doctor for advice before
taking TEMCAD 250MG CAPSULE.

!### Liver

Use with CautionTEMCAD 250MG CAPSULE should be used with caution in patients with mild,
moderate, and severe hepatic impairment. Consult your doctor for advice before
taking TEMCAD 250MG CAPSULE.

!### Allergy

ContraindicatedDo not take TEMCAD 250MG CAPSULE if you are allergic to Temozolomide or any of
the other ingredients of this medicine.

!### Lungs

Use with CautionTEMCAD 250MG CAPSULE should be used with caution in patients with lung disease
such as pneumocystis jirovecii pneumonia (serious fungal infection of lungs).
Consult your doctor before taking TEMCAD 250MG CAPSULE.

!### Use In Pediatrics

ContraindicatedTEMCAD 250MG CAPSULE is not recommended for use in children below 3 years of
age. There is limited information in patients over 3 years of age who have taken
TEMCAD 250MG CAPSULE. Consult your doctor before taking TEMCAD 250MG CAPSULE.

!### Use In Geriatrics

Use with CautionTEMCAD 250MG CAPSULE should be used with caution in elderly patients (aged 70
years or above). Consult your doctor before taking TEMCAD 250MG CAPSULE.

Others

TEMCAD 250MG CAPSULE is not recommended for use if you:

• Have certain kinds of blood cells that are severely reduced, such as white blood cells and platelet count

Before taking TEMCAD 250MG CAPSULE, inform your doctor if you:

• Have signs of anemia (low red blood cell count)
• Have signs of low platelet count
• Have a risk of other changes in blood cells, such as leukemia (blood cancer)

Interactions

A. Drug-Drug Interactions:

Before taking TEMCAD 250MG CAPSULE, inform your doctor if you are taking any of
the following medicines:

• Dacarbazine (used for cancer of the lymph system and malignant melanoma)

Overdosage:

If you or anyone else accidentally takes too much of TEMCAD 250MG CAPSULE,
consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Temozolomide
Pharmacological Category	:	Antineoplastic agents
Therapeutic Indication	:	Glioblastoma multiforme, Anaplastic astrocytoma
Dosage Forms	:	Capsule, Tablet, Injection

More Information

Storage

• Keep the medicine out of reach of children
• Store TEMCAD 250MG CAPSULE at room temperature

FAQs About TEMCAD 250MG CAPSULE

Q: What TEMCAD 250MG CAPSULE is used for?

A: TEMCAD 250MG CAPSULE is used for specific forms of brain tumours in adults
with newly diagnosed glioblastoma multiforme, which is used first together with
radiotherapy as a concomitant phase of therapy and then used alone as a
monotherapy. It is also used in children (above 3 years) and adults to manage
malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma, if
they return or get worse after standard management.

Q: How should TEMCAD 250MG CAPSULE be taken?

A: Take TEMCAD 250MG CAPSULE as advised by your physician. Swallow TEMCAD 250MG
CAPSULE with a glass of water and do not chew or crush the medicine. Your doctor
will decide the correct dose and duration for you depending upon your age, body
weight, and disease condition.

Q: What are the side effects of TEMCAD 250MG CAPSULE?

A: The most common symptoms of taking TEMCAD 250MG CAPSULE are loss of appetite,
difficulty while speaking, headache, vomiting, nausea, diarrhea, and
constipation. Consult and inform your doctor if any of these symptoms get worse.

Q: What happens if you forget to take TEMCAD 250MG CAPSULE?

A: If you forget to take TEMCAD 250MG CAPSULE at the usual time, take your dose
as soon as possible and then continue with your medication at the usual times.
Avoid taking a double dose to make up for forgotten individual doses. Consult
and inform your doctor before taking TEMCAD 250MG CAPSULE if you have queries on
the missed dose.

Q: Is TEMCAD 250MG CAPSULE safe to use in children?

A: TEMCAD 250MG CAPSULE is not recommended for use in children below 3 years of
age. There is limited information in patients over 3 years of age who have taken
TEMCAD 250MG CAPSULE. Consult your doctor before taking TEMCAD 250MG CAPSULE.

Q: How does TEMCAD 250MG CAPSULE work?

A: TEMCAD 250MG CAPSULE works by damaging the genetic material (DNA and RNA) of
the cancer cells inside the brain cells and works against cell growth and
multiplication.

Q: Is TEMCAD 250MG CAPSULE safe during pregnancy?

A: TEMCAD 250MG CAPSULE should be used in pregnant women only if it is clearly
necessary. Women with childbearing potential should use effective contrace
precautions, which should be continued for at least 6 months following the
completion of> management. Consult your doctor before taking TEMCAD 250MG
CAPSULE.

Q: Who should not take TEMCAD 250MG CAPSULE?

A: TEMCAD 250MG CAPSULE is not recommended for use if you have certain kinds of
blood cells that are severely reduced, such as white blood cells and platelet
count, or if you are allergic to temozolomide or any of the other ingredients of
this medicine.

Q: What precautions must be taken while using TEMCAD 250MG CAPSULE?

A: TEMCAD 250MG CAPSULE should be used with caution in patients with kidney
problems such as severe renal impairment, mild, moderate, and severe hepatic
impairment, lung disease such as pneumocystis jirovecii pneumonia (serious
fungal infection of lungs), signs of anemia (low red blood cell count), signs of
low platelet count, or have a risk of other changes in blood cells such as
leukemia (blood cancer). Consult your doctor for advice before taking TEMCAD
250MG CAPSULE.

Q: When should I stop taking TEMCAD 250MG CAPSULE?

A: Stop taking TEMCAD 250MG CAPSULE and contact your doctor if you experience
any of the following side effects, such as signs of a severe allergic reaction
such as itchy red skin, wheezing or other breathing difficulty, uncontrolled
bleeding, seizures (fits), fever, and symptoms of infections such as cough,
chills, sweat, chills, and severe headache.

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Liver Function Test (LFT)
• Cancer Screening Package For Male
• Cancer Screening Package For Female
• Jaanch Tumor Panel (Female)
• Jaanch Tumor Panel (Male)