Mext 7.5mg Tablet 10'S

Introduction About MEXT 7.5MG TABLET

MEXT 7.5MG TABLET contains Methotrexate, which belongs to the group of medicines
called Antimetabolites. MEXT 7.5MG TABLET is used to manage active rheumatoid
arthritis in adults, which is a form of severe arthritis occurring due to
unknown reasons (idiopathic) and old age and is non-responsive to conventional
painkillers (such as Non-Steroidal Anti Inflammatory Drugs Ex. Aceclofenac).

MEXT 7.5MG TABLET is also used to manage its polyarthritic forms (characterized
by the involvement of five or more joints), which are severe, active, and
idiopathic in nature and affect young people (Juvenile Idiopathic Arthritis,
JIA).

MEXT 7.5MG TABLET is also used to manage psoriasis and relapsed (reoccurred) and
refractory (unaffected by other conventional managements) Non-Hodgkin’s
lymphoma, which is a type of cancer of the lymphatic system.

Psoriasis is a skin condition characterized by itchy scales that is not
responsive to conventional managements such as phototherapy and retinoids.

Before taking MEXT 7.5MG TABLET, it is recommended to inform the doctor about
your medical and family history, including the list of medicines (prescri
non-prescri

Also, MEXT 7.5MG TABLET is not recommended to be taken by pregnant and nursing
women, women planning pregnancy, those who drink huge amounts of alcohol, or
patients suffering from liver and kidney impairment.

MEXT 7.5MG TABLET is not recommended in children for the management of psoriasis
and rheumatoid arthritis. However, MEXT 7.5MG TABLET can be used with caution in
children to manage polyarticular juvenile idiopathic arthritis, which is
characterized by the involvement of five or more joints that are of severe,
active, juvenile, and idiopathic character. Consult the doctor before taking
MEXT 7.5MG TABLET.

In addition, caution must be exercised by patients suffering from lung
disorders, blood disorders, and gastric disorders before taking MEXT 7.5MG
TABLET.

Care must be taken to avoid taking products containing caffeine, such as black
tea, coffee, and cold drinks, while taking MEXT 7.5MG TABLET.

The common side effects seen after taking MEXT 7.5MG TABLET are headache,
nausea, vomiting, dizziness, and altered levels of blood cells. Consult a doctor
if any of the above side effects worsen after taking MEXT 7.5MG TABLET.

Uses Of MEXT 7.5MG TABLET

It is used to manage:

• active rheumatoid arthritis
• psoriasis
• arthritis in patients suffering from psoriasis (psoriatic arthritis)
• relapsed and refractory (unaffected by other conventional managements) Non-Hodgkin’s Lymphoma
• polyarticular juvenile idiopathic arthritis

How MEXT 7.5MG TABLET Works

MEXT 7.5MG TABLET contains methotrexate that works by interfering with the
growth of those cells in the body that reproduce quickly. As a result, the
growth of those cells gets retarded, thus serving as an anti-tumour agent. Also,
it decreases the undesired reactions of the body’s own immune-defense mech
thereby working as an effective immunosuppressant. Additionally, it also
exhibits anti-inflammatory effects, thereby reducing pain, swelling, and
redness. As a result, it manages the symptoms associated with diseases such as
rheumatoid arthritis and psoriasis.

How to use MEXT 7.5MG TABLET

Take MEXT 7.5MG TABLET as advised by your physician. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending on your age, body weight, and
disease condition.

Side Effects Of MEXT 7.5MG TABLET

Common

• sore throat due to inflammation
• soreness in the mouth and lips
• loss of appetite
• nausea, vomiting
• stomach pain
• increase in the level of liver enzymes
• infections
• diarrhea
• feeling tired and exhausted
• headache
• dizziness
• development of a rash and reddening of the skin
• loss of hair
• formation of ulcers in the mouth

Uncommon

• fever and general deterioration of the body, along with an increased level of local infections
• decrease in the number of red blood cells (anaemia)
• decrease in the number of platelets (reduced blood clotting)
• altered blood count
• swelling of the lymph nodes
• development of inflammation and ulcers of the vagina
• decreased serum albumin (type of protein) level
• increased pigmentation of the skin
• viral infections of the skin, such as herpes
• joint or muscle pain
• inflammation and ulcers of the bladder
• fatty liver
• chills
• fits
• sensitivity to light
• brown skin
• loss of hair
• increase in rheumatic nodules
• pain in the lesions associated with psoriasis

Rare

• cramps, swelling in the legs, redness, breathlessness, and chest pain
• feeling depressed
• feeling weak on one side of the body (hemiparesis)
• diabetes
• decreased blood pressure
• inflammation of the gums
• acne
• whitening of the skin
• painful skin rash, such as shingles
• severe disturbances of vision
• mood fluctuations
• inflammatory conditions of the heart
• thromboembolic complications
• pericardial tamponade (filling of fluid such as blood around the heart)

Stop taking MEXT 7.5MG TABLET and consult your doctor immediately if you
experience any of the following:

• formation of scar tissue in the lungs (pulmonary fibrosis), development of pneumonia indicated by shortness of breath along with thick mucus
• severe allergic reactions characterized by tightness in the chest, swelling of the face, throat, and hands, along with difficulty breathing
• severe toxic reactions of the skin resulting in the formation of vesicles, as seen in Stevens-Johnson Syndrome, toxic epidermal necrolysis (Lyell’s syndrome)
• decreased white blood cells, characterized by fever and general deterioration of the body, along with an increased level of local infections
• painful urination
• kidney damage
• inflammation and/or damage to the liver is characterized by yellowing of the skin and eyes along with fever, itchy skin, and a swollen or tender stomach
• ulcer and/or bleeding in the stomach, characterized by black tar-like stools, vomiting blood, and stomach pain
• formation of blood clots characterized by cramps, swelling in the legs, redness, breathlessness, and chest pain
• decreased formation of urine
• fever, chills, shivering along with a rapid heartbeat, breathing
• presence of blood in the urine
• fits (convulsions)
• spitting or coughing blood
• disorders of the brain, such as encephalopathy
• easy tendency to bleed and bruise, persistent bleeding
• loss of coordination
• loss of the ability to speak and/or understand speech
• weakness and inability to move one side of the body or the whole body
• miscarriage and/or damage to the fetus (in women)

How To Manage Side Effects

!### Diarrhea

Stick to simple meals. Avoid eating heavily rich or spicy food. Drink an oral
rehydration solution to compensate for the loss of water and minerals. stay
hydrated. Consult your doctor if it persists for a long time or worsens with
time.

!### Dizziness Or Drowsiness

Take an adequate amount of rest and sleep. Stay hydrated and replenish yourself
with electrolytes. Also, do not indulge in driving or using heavy machinery, as
it may prove to be dangerous.

Headache

Stay hydrated and take as much rest as possible. Stay away from bright lights
and loud sounds. Apply a pain-relieving balm to the forehead. If the headache
persists or worsens, consult your doctor.

!### Nausea And Vomiting

Stick to simple meals. Avoid eating heavily rich or spicy food. Stay hydrated.
Consult your doctor if it persists for a long time or worsens with time.

Warning & Precautions

!### Pregnancy

ContraindicatedMEXT 7.5MG TABLET is not recommended for use if you are pregnant and/or are
planning to become pregnant since it can be harmful to the foetus (growing baby)
and lead to various malformations. Consult your doctor before taking MEXT 7.5MG
TABLET.

!### Breastfeeding

ContraindicatedMEXT 7.5MG TABLET is not recommended if you are a nursing mother. Consult your
doctor before taking MEXT 7.5MG TABLET.

!### Driving and Using Machines

ContraindicatedMEXT 7.5MG TABLET is not recommended if you feel tired or dizzy after taking the
medicine. Consult your doctor before taking MEXT 7.5MG TABLET.

!### Alcohol

Consult your doctorIt is recommended to avoid the consum
TABLET, as it may increase the risk of liver damage. Consult your doctor before
taking MEXT 7.5MG TABLET.

!### Kidney

ContraindicatedMEXT 7.5MG TABLET is not recommended if you have or have had a kidney disorder
and/or are receiving any dialysis> management. Consult your doctor before taking
MEXT 7.5MG TABLET.

!### Liver

ContraindicatedMEXT 7.5MG TABLET is not recommended if you have a liver disorder. Consult your
doctor before taking MEXT 7.5MG TABLET.

!### Allergy

ContraindicatedMEXT 7.5MG TABLET is not recommended if you are allergic to methotrexate and/or
any other constituent of MEXT 7.5MG TABLET. Consult your doctor before taking
MEXT 7.5MG TABLET.

!### Lungs

Use with CautionMEXT 7.5MG TABLET is recommended to be taken with caution if you have issues
with lung function and are diagnosed with pleural effusion. Consult your doctor
before taking MEXT 7.5MG TABLET.

!### Use In Pediatrics

Consult your doctorMEXT 7.5MG TABLET is not recommended in children for the management of psoriasis
and rheumatoid arthritis. However, MEXT 7.5MG TABLET can be used with caution in
children to manage polyarticular juvenile idiopathic arthritis. Your doctor will
prescribe the right dose depending on your child’s age, body weight, and health
condition. Consult your doctor for advice before taking MEXT 7.5MG TABLET.

!### Use In Geriatrics

Use with CautionMEXT 7.5MG TABLET is recommended to be administered with caution and in a lower
dosage to elders due to diminished function of the liver and kidneys and reduced
folate levels in the blood in old age. Also, it is recommended to closely
monitor the elderly, taking MEXT 7.5MG TABLET for the identification of possible
side effects. Consult the doctor before taking MEXT 7.5MG TABLET.

Others

MEXT 7.5MG TABLET is not recommended for use if you:

• have bone marrow disorders
• have blood disorders
• have an impaired immune system
• have a severe and/or existing infection (Ex. tuberculosis, HIV)
• have ulcers in the gastro-intestinal tract
• have inflammation and ulcers of the mouth
• are receiving vaccinations containing live vaccines

Before taking MEXT 7.5MG TABLET, inform your doctor if you:

• have diabetes
• are overweight
• suffer from diarrhea
• ulcers in the colon (ulcerative colitis)
• are receiving radiotherapy for various conditions, such as X-rays and UV-rays
• have folate deficiency
• have lactose and/or galactose intolerance
• have mental illness

Interactions

A. Drug-Drug Interactions:

Before taking MEXT 7.5MG TABLET, inform your doctor if you are taking any of the
following medicines:

• medicines used to manage bacterial infections (Ex. amoxicillin, ciprofloxacin)
• medicines used to increase urine excretion (Ex. frusemide)
• medicines used to manage increased sugar levels (Ex. metformin)
• medicines used to manage fits (Ex. phenytoin)
• medicines used to manage increased cholesterol levels (Ex. cholestyramine)
• medicines used to manage gout (Ex. probenecid)
• medicines to manage reduced folic acid levels (Ex. folic acid preparations)
• medicines used to manage severe heartburn or ulcers (Ex. omeprazole)
• other medicines used to manage rheumatoid arthritis (Ex. leflunomide)
• medicines that can be harmful to the liver (Ex. sulfasalazine)
• medicines used in the management of cancer (Ex. doxorubicin, cisplatin, and mercaptopurine)
• medicines used to manage pain (Ex. ibuprofen, naproxen, diclofenac)
• other medicines used to manage rheumatoid arthritis and psoriasis (Ex. leflunomide, phenylbutazone, or amidopyrine)
• medicines used to manage asthma (Ex. theophylline)
• medicines used in organ transplantation (Ex. cyclosporin, azathioprine)
• medicines used to induce sleep (Ex. phenobarbitone)
• medicines used to induce calmness and relieve anxiety (Ex. diazepam)
• medicines used for oral contrace
• medicines used to manage skin conditions (Ex. retinoids)
• medicines used to manage malaria (Ex. pyrimethamine)
• medicines that contain live vaccines (Ex. MMR vaccine)
• medicines used for general anesthesia and pain relief (Ex. nitrous oxide)
• medicines used to manage heart problems (Ex. amiodarone)
• medicines used to manage heart failure (Ex. digoxin)
• medicines used for the management of various inflammatory conditions like skin diseases and allergic reactions (Ex. hydrocortisone)

B. Drug-Food interactions:

It is recommended to avoid the consum
as black tea, coffee, and soft drinks, along with MEXT 7.5MG TABLET, to manage
dehydration.

Overdosage:

If you or someone else accidentally takes too much MEXT 7.5MG TABLET, it is
recommended to consult your doctor immediately. Symptoms of overdosage with MEXT
7.5MG TABLET are an easy tendency to bruise or bleed, nausea, vomiting, and
unusual weakness, along with the development of mouth sores and ulcers.

Synopsis

Drug	:	Methotrexate
Pharmacological Category	:	Anti-metabolites
Therapeutic Indication	:	Rheumatoid Arthritis, Psoriasis, Cancer
Dosage Forms	:	Injection, Gel, Capsule, Tablet

More Information

• Keep MEXT 7.5MG TABLET out of the reach and sight of children
• Store MEXT 7.5MG TABLET at a temperature below 25°C

FAQs About MEXT 7.5MG TABLET

Q: What is MEXT 7.5MG TABLET used for?

A: MEXT 7.5MG TABLET is used to manage active rheumatoid arthritis in adults,
which is a form of severe arthritis occurring due to unknown reasons
(idiopathic) and old age and is non-responsive to conventional painkillers (such
as non-steroidal anti-inflammatory drugs, Ex. Aceclofenac). MEXT 7.5MG TABLET is
also used to manage the polyarthritic forms (characterized by the involvement of
five or more joints), which are severe, active, and idiopathic in nature and
affect young people (Juvenile Idiopathic Arthritis, JIA).

Q: Can I take MEXT 7.5MG TABLET in pregnancy?

A:MEXT 7.5MG TABLET is not recommended for use in pregnant women and/or in women
who are planning pregnancy because it can be harmful for the fetus (a growing
baby in the womb). Consult your doctor before taking MEXT 7.5MG TABLET.

Q: Can I take MEXT 7.5MG TABLET if I’m breastfeeding a baby?

A: MEXT 7.5MG TABLET is not recommended for nursing mothers due to a lack of
safety data. Consult your doctor before taking MEXT 7.5MG TABLET.

Q: Can MEXT 7.5MG TABLET be taken by children?

A: MEXT 7.5MG TABLET is not recommended in children for the management of
psoriasis and rheumatoid arthritis. However, MEXT 7.5MG TABLET can be used with
caution in children to manage polyarticular juvenile idiopathic arthritis. Your
doctor will prescribe the right dose depending on your child’s age, body weight,
and health condition. Consult your doctor for advice before taking MEXT 7.5MG
TABLET.

Q: Can MEXT 7.5MG TABLET be used by the elderly?

A: MEXT 7.5MG TABLET is recommended to be administered with caution and in a
lower dosage to elders due to diminished function of the liver and kidneys and
reduced folate levels in the blood in old age. Also, it is recommended to
closely monitor the elderly, taking MEXT 7.5MG TABLET for the identification of
possible side effects. Consult the doctor before taking MEXT 7.5MG TABLET.

Q: Is there any specific food to avoid while taking MEXT 7.5MG TABLET?

A:It is recommended to avoid the consum
as black tea, coffee, and soft drinks, along with MEXT 7.5MG TABLET, to manage
dehydration.

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Liver Function Test (LFT)
• Kidney Function Test (KFT)