Sepmax Tablet 10'S

Introduction About SEPMAX

SEPMAX is a combination of Sulphamethoxazole and Trimethoprim which belongs to
the group of medicines called Antibiotics. It is used to manage lung infections
(pneumonia or Pneumocystis jiroveci pneumonia) caused by a bacteria called
Pneumocystis jirovecii and toxoplasmosis (infection with the Toxoplasma gondii
parasite).

It can also be used to manage urinary tract infections, respiratory tract
infections (such as bronchitis), ear infections (such as otitis media) and an
infection called nocardiosis which can affect the lungs, skin and brain. SEPMAX
is suitable for use both in adults and in adolescents (aged 12 years or above).

Take SEPMAX for the stipulated duration as instructed by your doctor even if you
feel better during the midway of the therapy to achieve better results. Failing
to complete the full course of the therapy or skipping doses in between the
therapy may not result in adequate infection control.

Before taking SEPMAX inform your doctor if you have any liver or kidney
problems. You must also inform your doctor if you have asthma, any allergic
conditions, genetic disorders, blood-related disorders, folic acid deficiency,
high blood potassium levels or if you are malnourished as a precaution.

Consult your doctor before taking this medicine if you are pregnant or
breastfeeding. The most common side effects of taking SEPMAX are headache,
nausea, diarrhea, high blood potassium levels, fungal infections of the mouth or
vagina and skin rashes. Consult your doctor if any of these side effects
troubles you.

Uses Of SEPMAX

It is used in adults and in adolescents (aged 12 years or above) to manage the
following bacterial infections:

• Lung infections (Ex. Pneumonia or Pneumocystis jiroveci pneumonia) caused by a bacteria called Pneumocystis jirovecii
• Toxoplasmosis (an infection with the Toxoplasma gondii parasite)
• Urinary tract infections
• Respiratory tract infections (Ex. bronchitis)
• Ear infections (Ex. otitis media)
• Nocardiosis (a bacterial infection that affects the lungs, skin and brain)

How SEPMAX Works

SEPMAX is a powerful antibiotic. It kills the susce
the production of certain essential vitamins (folate) that are necessary for the
bacteria to grow, multiply and survive. Therefore, it destroys the susce
bacteria and manages their further growth and multiplication within the body
which helps in reducing the severity of the infection.

How to use SEPMAX

Take SEPMAX as advised by your physician. Swallow SEPMAX with a glass of water.
Do not crush or chew the medicine. SEPMAX can be taken with or without food.

Your doctor will decide the correct dose and duration of therapy for you
depending on your age, body weight and severity of the infection.

Do not stop taking SEPMAX once your symptom subsides. It is important to take
SEPMAX for the stipulated duration as recommended by your doctor to achieve
better results.

Side Effects Of SEPMAX

Common

• high potassium levels in blood causing abnormal heartbeats
• fungal infection (thrush or candidiasis) of mouth or vagina
• headache, nausea, diarrhoea
• skin rashes

Uncommon

• vomiting

Rare

Stop taking SEPMAX and contact your doctor immediately if you experience any of
the following side effects:

• severe allergic reactions (such as skin rashes, itching, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing, chest pain and fainting)
• severe skin reactions (such as generalised skin redness with pustules accomp
• signs of abnormal WBC count (such as fever, swollen glands, weakness, light-headedness, shortness of breath, bruising with or without skin rash)
• unexpected worsening of cough and shortness of breath

How To Manage Side Effects

!### Diarrhea

Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated.
Consuming ORS can also be beneficial. Do not consume any medicine on your own
without consulting your doctor. If your diarrhea worsens, contact your doctor
immediately.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

!### Nausea And Vomiting

Take SEPMAX with, or just after meals. Stick to simple meals. Avoid eating
oil-rich or spicy foods. Please consult your doctor immediately if you
experience severe nausea and vomiting.

Warning & Precautions

!### Pregnancy

Use with CautionSEPMAX should be used with caution in pregnant women. Therefore, consult your
doctor for advice before taking it.

!### Breastfeeding

Use with CautionSEPMAX should be used with caution in breastfeeding women. Therefore, consult
your doctor for advice before taking it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected
by SEPMAX.

!### Alcohol

Consult your doctorAvoid consum

!### Kidney

Consult your doctorSEPMAX is not recommended for use in patients with severe kidney problems. It
should be used with caution in patients with other kidney problems. Therefore,
consult your doctor before taking it.

!### Liver

ContraindicatedSEPMAX is not recommended for use in patients with severe liver problems.
Therefore, consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take SEPMAX if you are allergic to Sulphamethoxazole, trimethoprim,
sulphonamide medicines (such as gliclazide, glibenclamide) or to thiazide
diuretics (such as Bendroflumethiazide).

!### Lungs

Use with CautionSEPMAX should be used with caution in patients with asthma. Therefore, consult
your doctor before taking it.

!### Use In Pediatrics

ContraindicatedSEPMAX is not recommended for use in children and adolescents (aged below 12
years). However, consult your doctor for advice before taking it.

!### Use In Geriatrics

Use with CautionSEPMAX should be used with caution in elderly patients. Therefore, consult your
doctor for advice before taking it.

Others

SEPMAX is not recommended for use if you:

• ever had bleeding problems (such as thrombocytopenia)
• have porphyria (a rare blood disorder)

Before taking SEPMAX, consult your doctor if you:

• have any allergic conditions (such as watery eyes, itchy nose, repeated sneezing)
• have anemia or vitamin B9 (folic acid) deficiency
• have G6PD deficiency (a genetic disorder that affect metabolism)
• have phenylketonuria (build-up of an amino acid called phenylal
• are underweight or malnourished
• have high blood potassium levels
• have very low RBC, WBC and platelet counts in blood

Interactions

A. Drug-Drug Interactions:

Before taking SEPMAX, inform your doctor if you are taking any of the following
medicines such as:

• diuretics (medicines used to remove excess water from the body) such as furosemide, hydrochlorothiazide
• pyrimethamine (a medicine used to manage malaria)
• medicines used for blood thinning (such as warfarin)
• phenytoin (a medicine used to manage epilepsy)
• medicines used to manage diabetes (such as glibenclamide, glipizide, tolbutamide or repaglinide)
• rifampicin (an antibiotic used to manage tuberculosis)
• medicines used to manage heart problems (such as digoxin or procainamide)
• amantadine (a medicine used to manage Parkinson’s disease)
• medicines used to manage HIV infections (such as zidovudine or lamivudine)
• medicines that can increase the amount of potassium in blood, such as potassium-sparging diuretics (Ex. spironolactone, acetazolamide), certain steroids (like prednisolone) or ACE inhibitors (Ex. captopril, enalapril, lisinopril)
• medicines used to suppress immune function and to manage graft rejection (such as ciclosporin, azathioprine)
• methotrexate (a medicine used to manage certain cancers or joint pain)
• folinic acid (a type of vitamin B9 supplement)
• contrace

B. Drug-Food Interaction:

SEPMAX is preferably taken with meals to avoid unwanted stomach problems.
However, it can also be taken on an empty stomach. Avoid consuming foods rich in
potassium while taking this medicine.

Overdosage:

If you or anyone else accidentally took more SEPMAX, consult your doctor
immediately or visit the nearby hospital. Symptoms of overdosage might include
nausea, vomiting, dizziness and confusion.

Synopsis

Drug	:	Sulphamethoxazole, Trimethoprim
Pharmacological Category	:	Sulphonamides, Diaminopyrimidine
Therapeutic Indication	:	Bacterial Infections
Dosage Forms	:	Tablet, Syrup, Suspension, Injection, Infusion, Eye drops

More Information

• Keep SEPMAX out of reach of children
• Store SEPMAX at room temperature

FAQs About SEPMAX

Q: What is the use of SEPMAX?

A: SEPMAX is used to manage severe bacterial infections including lung
infections, toxoplasmosis (infection with the Toxoplasma gondii parasite),
urinary tract infections, respiratory tract infections (such as bronchitis), ear
infections (such as otitis media) and an infection called nocardiosis which can
affect the lungs, skin and brain.

Q: How SEPMAX works in my body?

A: SEPMAX is a powerful antibiotic. It kills the susce
blocking the production of certain essential vitamins (folate) that is necessary
for the bacteria to grow, multiply and survive. Therefore, it destroys the
susce
the body which helps in reducing the severity of the infection.

Q: How should I take SEPMAX?

A: Take SEPMAX as advised by your physician. It can be taken with or without
food. Swallow the medicine with a glass of water. Do not crush or chew the
medicine.

Q: For how long should I take SEPMAX?

A: TakeSEPMAX for the stipulated duration as prescribed by your doctor. Do not
skip the medicine or stop taking it on your own as it can cause the infection to
reappear.

Q: Can SEPMAX be given to pregnant women?

A: SEPMAX should be used with caution in pregnant women. Therefore, consult your
doctor for advice before taking it.

Q: What precautions should I follow while taking SEPMAX?

A: Before taking SEPMAX inform your doctor if you have any liver or kidney
problems. You must also inform your doctor if you have asthma, any allergic
conditions, genetic disorders, blood-related disorders or if you are
malnourished as a precaution. Consult your doctor before taking this medicine if
you are pregnant or breastfeeding. Regularly visit your doctor for check-up and
perform all medical tests recommended by your doctor without fail. Take SEPMAX
for the stipulated duration recommended by your doctor to achieve better
results. Failing to do so may cause the symptom to re-occur.

Q: What are the common side effects of taking SEPMAX?

A: The most common side effects of taking SEPMAX are headache, nausea, diarrhea,
high blood potassium levels, fungal infections of mouth or vagina and skin
rashes. Consult your doctor if any of these side effects troubles you.

Q: Can I stop taking SEPMAX once my symptoms subside?

A: Do not stop taking this medicine once your symptom subsides. It is important
to take the full course of SEPMAX to achieve better results. Failing to complete
the full course of the therapy or skipping doses in between the therapy may not
result in adequate infection control. It may also cause your symptoms to
reappear.

Q: Can the use of SEPMAX cause diarrhea?

A: SEPMAX may cause diarrhea in some individuals. If you experience diarrhea,
drink plenty of fluids, such as water or fruit juice to keep yourself hydrated.
Consuming ORS can also be beneficial. Do not consume any medicine on your own
without consulting your doctor. If your diarrhea worsens contact your doctor
immediately.

Q: What should I do if I forgot to take a dose of SEPMAX?

A: If you forgot to take a dose of SEPMAX, take it as soon as you remember.
However, if it is time to take the next dose, skip the missed dose and take the
next one at regular times. Do not take a double dose to compensate the forgotten
dose.

Useful Diagnostic Tests

• Complete blood count