Oriprim Suspension 60ml

Introduction About ORIPRIM SUSPENSION

ORIPRIM SUSPENSION is a combination of Sulphamethoxazole and Trimethoprim which
belongs to the group of medicines called Antibiotics. It is used in infants and
in children (aged between 6 weeks-12 years) to manage severe lung infections and
toxoplasmosis (an infection with the Toxoplasma gondii parasite).

It can also be used to manage urinary tract infections, respiratory tract
infections (such as bronchitis), ear infections (such as otitis media) and an
infection called nocardiosis which can affect the lungs, skin and brain.

ORIPRIM SUSPENSION must be taken for the stipulated duration as instructed by
your doctor to achieve better results. Failing to complete the full course of
the therapy or skipping doses in between the therapy may not result in adequate
infection control.

Talk to your doctor before administering this medicine to your child, if your
child has any problems in their liver or kidneys. You must also inform your
doctor if your child has asthma, any allergic conditions, genetic disorders,
blood-related disorders, folic acid deficiency or high blood potassium levels as
a precaution.

The most common side effects of taking ORIPRIM SUSPENSION are headache, nausea,
diarrhea, high blood potassium levels, fungal infections of mouth or vagina and
skin rashes. Consult your doctor if any of these side effect troubles your
child.

Uses Of ORIPRIM SUSPENSION

It is used in infants and in children (aged between 6 weeks-12 years) to manage
the following bacterial infections:

• Lung infections (Ex. Pneumonia or Pneumocystis jiroveci pneumonia) caused by a bacteria called Pneumocystis jirovecii
• Toxoplasmosis (an infection with the Toxoplasma gondii parasite)
• Urinary tract infections
• Respiratory tract infections (Ex. bronchitis)
• Ear infections (Ex. otitis media)
• Nocardiosis (a bacterial infection that affects lungs, skin and brain)

How ORIPRIM SUSPENSION Works

ORIPRIM SUSPENSION is a powerful antibiotic. It kills the susce
by blocking the production of certain essential vitamins (folate) that is
necessary for the bacteria to grow, multiply and survive. Therefore, it destroys
the susce
within the body which helps in reducing the severity of the infection.

How to use ORIPRIM SUSPENSION

Administer ORIPRIM SUSPENSION to your child as advised by your physician. Shake
well before use. Measure the required quantity of the medicine in a measuring
cup and administer it to your child.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Do not stop therapy with ORIPRIM SUSPENSION without consulting the doctor as it
may make the symptoms re-appear once again. It is important to take ORIPRIM
SUSPENSION for the stipulated duration as recommended by your doctor to achieve
better results.

Side Effects Of ORIPRIM SUSPENSION

Common

• high potassium levels in blood causing abnormal heart beats
• fungal infection (thrush or candidiasis) of mouth or vagina
• headache, nausea, diarrhoea
• skin rashes

Uncommon

• vomiting

Rare

Stop administering ORIPRIM SUSPENSION to your child and contact your doctor
immediately if your child experiences any of the following side effects:

• severe allergic reactions (such as skin rashes, itching, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing, chest pain and fainting)
• severe skin reactions (such as generalised skin redness with pustules accomp
• signs of abnormal WBC count (such as fever, swollen glands, weakness, light-headedness, shortness of breath, bruising with or without skin rash)
• unexpected worsening of cough and shortness of breath

How To Manage Side Effects

!### Diarrhea

Make sure that your child drinks plenty of fluids, such as water or fruit juice
to keep themself hydrated. Consuming ORS can also be beneficial. If diarrhea
worsens, contact your doctor immediately.

Headache

Make your child rest and relax. Keep them hydrated by making them drink plenty
of fluids such as water or electrolytes. Applying a pain-relieving balm on their
forehead can be beneficial. Consult your doctor if the headache worsens in your
child.

!### Nausea And Vomiting

Make sure that your child takes ORIPRIM SUSPENSION with, or just after meals.
Provide your child with simple meals. Avoid giving them oil rich or spicy foods.
Please consult your doctor immediately if your child experience severe nausea or
vomiting.

Warning & Precautions

!### Driving and Using Machines

Use with CautionDo not let your child drive or handle any heavy tools if their ability is
affected by ORIPRIM SUSPENSION.

!### Kidney

Consult your doctorORIPRIM SUSPENSION is not recommended for use in children with severe kidney
problems. It should be used with caution in children with other kidney problems.
Therefore, consult your doctor before administering it to your child.

!### Liver

ContraindicatedORIPRIM SUSPENSION is not recommended for use in children with severe liver
problems. Therefore, consult your doctor before administering it to your child.

!### Allergy

ContraindicatedDo not administer ORIPRIM SUSPENSION to your child if your child is allergic to
Sulphamethoxazole, trimethoprim, sulphonamide medicines (such as gliclazide,
glibenclamide) or to thiazide diuretics (such as Bendroflumethiazide).

!### Lungs

Use with CautionORIPRIM SUSPENSION should be used with caution in children with asthma.
Therefore, consult your doctor before administering it to your child.

!### Use In Pediatrics

Consult your doctorORIPRIM SUSPENSION is suitable for use in infants and in children (aged between
6 weeks to 12 years). It is not recommended for use in infants aged less than 6
weeks. Therefore, consult your doctor before administering it to your child.

Others

ORIPRIM SUSPENSION is not recommended for use if your child:

• has a history of bleeding problems (such as thrombocytopenia)
• has porphyria (a rare blood disorder)

Before administering ORIPRIM SUSPENSION, consult your doctor if your child:

• has any allergic conditions (such as watery eyes, itchy nose, repeated sneezing)
• has anemia or vitamin B9 (folic acid) deficiency
• has G6PD deficiency (a genetic disorder that affects metabolism)
• has phenylketonuria (build-up of an amino acid called phenylal
• is underweight or malnourished
• has high blood potassium levels
• has a very low RBC, WBC and platelet counts in blood

Interactions

A. Drug-Drug Interactions:

Before administering ORIPRIM SUSPENSION to your child, inform your doctor if
your child is taking any of the following medicines such as:

• pyrimethamine (a medicine used to manage malaria)
• medicines used for blood thinning (such as warfarin)
• phenytoin (a medicine used to manage epilepsy)
• medicines used to manage diabetes (such as glibenclamide, glipizide, tolbutamide or repaglinide)
• rifampicin (an antibiotic used to manage tuberculosis)
• medicines used to manage heart problems (such as digoxin or procainamide)
• amantadine (a medicine used to manage Parkinson’s disease)
• medicines used to manage HIV infections (such as zidovudine or lamivudine)
• medicines that can increase the amount of potassium in blood, such as potassium-sparging diuretics (Ex. spironolactone, acetazolamide), certain steroids (like prednisolone) or ACE inhibitors (Ex. captopril, enalapril, lisinopril)
• medicines used to suppress immune function and to manage graft rejection (such as ciclosporin, azathioprine)
• methotrexate (a medicine used to manage certain cancers or joint pain)
• folinic acid (a type of vitamin B9 supplement)

B. Drug-Food Interaction:

ORIPRIM SUSPENSION is preferably taken with meals to avoid unwanted stomach
problems. However, it can also be taken on an empty stomach. Avoid consuming
foods rich in potassium while taking this medicine.

Overdosage:

If your child accidentally swallowed more ORIPRIM SUSPENSION, consult your
doctor immediately or visit the nearby hospital. Symptoms of overdoage might
include nausea, vomiting, dizziness and confusion.

Synopsis

Drug	:	Sulphamethoxazole, Trimethoprim
Pharmacological Category	:	Sulphonamides, Diaminopyrimidine
Therapeutic Indication	:	Bacterial Infections
Dosage Forms	:	Tablet, Syrup, Suspension, Injection, Infusion, Eye drops

More Information

• Keep ORIPRIM SUSPENSION out of reach of children
• Store ORIPRIM SUSPENSION at room temperature

FAQs About ORIPRIM SUSPENSION

Q: What is the use of ORIPRIM SUSPENSION?

A: ORIPRIM SUSPENSION is used in infants and in children (aged between 6
weeks-12 years) to manage severe lung infections and toxoplasmosis (an infection
with the Toxoplasma gondii parasite). It can also be used to manage urinary
tract infections, respiratory tract infections (such as bronchitis), ear
infections (such as otitis media) and an infection called nocardiosis which can
affect the lungs, skin and brain.

Q: How ORIPRIM SUSPENSION works in my body?

A: ORIPRIM SUSPENSION is a powerful antibiotic. It kills the susce
bacteria by blocking the production of certain essential vitamins (folate) that
is necessary for the bacteria to grow, multiply and survive. Therefore, it
destroys the susce
multiplication within the body which helps in reducing the severity of the
infection.

Q: Is ORIPRIM SUSPENSION safe?

A: ORIPRIM SUSPENSION is considered safe at doses prescribed by the physician.

Q: How should I take ORIPRIM SUSPENSION?

A: Shake well before use. Measure the required quantity of the medicine in a
measuring cup and administer it to your child.

Q: For how long should I take ORIPRIM SUSPENSION?

A: TakeORIPRIM SUSPENSION for the stipulated duration as prescribed by your
doctor. Do not skip the medicine or stop taking it on your own as it can cause
the infection to reappear.

Q: What are the common side effects of taking ORIPRIM SUSPENSION?

A: The most common side effects of taking ORIPRIM SUSPENSION are headache,
nausea, diarrhea, high blood potassium levels, fungal infections of mouth or
vagina and skin rashes. Consult your doctor if any of these side effect troubles
your child.

Q: Can I stop taking ORIPRIM SUSPENSION once my symptoms subside?

A: Do not stop taking this medicine once the symptom subsides. It is important
to take the full course of ORIPRIM SUSPENSION to achieve better results. Failing
to complete the full course of the therapy or skipping doses in between the
therapy may not result in adequate infection control. It may also cause your
symptoms to reappear.

Q: Can the use of ORIPRIM SUSPENSION cause diarrhea?

A: ORIPRIM SUSPENSION may cause diarrhea in some children. If your child
experience diarrhea, make sure that they drink plenty of water or fruit juice to
manage dehydration. Consuming ORS can also be beneficial. If diarrhea worsens,
contact your doctor immediately.

Q: What should I do if I forgot to take a dose of ORIPRIM SUSPENSION?

A: If you forgot to take a dose of ORIPRIM SUSPENSION, take it as soon as you
remember. However, if it is time to take the next dose, skip the missed dose and
take the next one at regular times. Do not take a double dose to compensate the
forgotten dose.

Useful Diagnostic Tests

• Complete blood count