Rabezox D Capsule 10'S

Introduction About RABEZOX D CAPSULE

RABEZOX D CAPSULE is used to manage Gastro-Esophageal Reflux Disease (GERD)
among patients who have not responded adequately to rabeprazole alone. It is a
combination of Domperidone and Rabeprazole which belongs to the group of
medicines called Dopamine Antagonists and Proton pump inhibitors respectively.
It can also be used to manage pe
NSAIDs use.

Along management with RABEZOX D CAPSULE, try to eat less spicy foods and drink
plenty of water. Avoid smoking or alcohol consum
existing condition. Patients receiving long-term management with the medicine
should be kept on regular surveillance to rule out the risk of hypomagnesaemia
(decreased magnesium levels in blood) and bone fracture, predominantly in the
elderly patients and in patients with other recognized risk factors.

Before taking RABEZOX D CAPSULE inform your doctor if you have any liver, kidney
or heart problems. Your doctor may reduce the dose or suggest an alternative
therapy. It is not recommended for use in pregnant or breastfeeding women and in
children (aged less than 18 years). It should be used with caution in elderly
patients (above 65 years of age). The most common side effects are nausea,
vomiting, stomach pain, diarrhea or constipation. Consult your doctor if any of
these above side effects worsen.

Uses Of RABEZOX D CAPSULE

It is used to manage:

• pe
• Gastro-Esophageal Reflux Disease (GERD)

How RABEZOX D CAPSULE Works

RABEZOX D CAPSULE reduces stomach ulcers and acid reflux, where Rabeprazole acts
by inhibiting the secretions of stomach acid and Domperidone acts by increasing
bowel movements and facilitating gastric emptying, thus leading to rapid symptom
relief and healing of stomach ulcers and esophageal lesions.

How to use RABEZOX D CAPSULE

• Take RABEZOX D CAPSULE as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition

Side Effects Of RABEZOX D CAPSULE

Common side effects of RABEZOX D CAPSULE:

• nausea, vomiting
• diarrhea, constipation, stomach pain, flatulence
• cough, sore throat, runny nose
• back pain
• headache, dizziness
• dry mouth
• benign polyps in the stomach
• indigestion, belching in the stomach (excess air accumulation in the stomach)
• urinary tract infection

Stop taking RABEZOX D CAPSULE and contact your doctor immediately if you
experience the following side effects:

• severe allergic reaction (sudden wheezing, swelling of lips, face or body, rash, fainting or difficulties swallowing)
• symptoms of liver problems (yellow skin, dark urine and tiredness)
• severe skin reactions such as erythema multiforme, stevens-johnson syndrome or toxic epidermal necrolysis (reddening of skin with blisters or peeling and may be associated with a high fever and joint pains, also severe blisters and bleeding in the lips, eyes, mouth, nose and genitals)
• seizures
• involuntary movements of the face or arms and legs, excessive trembling, excessive muscle stiffness or muscle spasm
• heart rhythm disorders (rapid or irregular heartbeat)

Warning & Precautions

!### Pregnancy

ContraindicatedRABEZOX D CAPSULE is not recommended for use in pregnant women.

!### Breastfeeding

ContraindicatedRABEZOX D CAPSULE is not recommended for use in breast-feeding women.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you experience sleepiness, confusion or
less control over your movements.

!### Alcohol

Consult your doctorAvoid consum
aggravate your existing condition.

!### Kidney

ContraindicatedRABEZOX D CAPSULE is not recommended for use in patients with kidney impairment.

!### Liver

Consult your doctorRABEZOX D CAPSULE is not recommended for use in patients with moderate or severe
liver impairment and it should be used with caution in patients with liver
problems.

!### Allergy

ContraindicatedDo not take RABEZOX D CAPSULE if you are allergic to Domperidone or Rabeprazole
or any other ingredients of this medicine.

!### Heart Disease

ContraindicatedRABEZOX D CAPSULE is not recommended for use in patients with heart problems
such as prolongation of QT interval or congestive heart failure.

!### Use In Pediatrics

ContraindicatedRABEZOX D CAPSULE is not recommended for use in children and adolescents (aged
less than 18 years) due to lack of safety and effectiveness.

!### Use In Geriatrics

Use with CautionRABEZOX D CAPSULE should be taken with caution in elderly patients (aged 65
years or above).

Others

RABEZOX D CAPSULE is not recommended for use if you:

• Have bloody stools or bleeding in the gut
• Have blockage or tear in the intestines
• Have severe fluid or electrolyte disturbances
• Have prolactinoma
• Have phenylketonuria
• Have problem that causes low levels of potassium or magnesium or high levels of potassium in the blood
• Have hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsor

Before taking RABEZOX D CAPSULE, inform your physician if you:

• Have osteoporosis
• Have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
• Are going to test Chromogr

Interactions

A. Drug-Drug interactions:

Before taking the medicine, inform to your doctor if you are taking any of these
medicines:

• Prokinetic agent (Ex. Cisapride, dolasetron, prucalopride, diphem
• Cardiac glycosides (Ex. Digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
• Ant-viral agents (Ex. Atazanavir, nelfinavir, saquinavir, Telaprevir)
• Antipsychotics (Ex. Haloperidol, pimozide, sertindole)
• Antidepressants (Ex. Escitalopram or citalopram)
• Antibiotics (Ex. Moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin)
• Antimalarials (Ex. Halofantrine, lumefantrine)
• Antihistamines (Ex. Mizolastine, mequitazine)
• Nonsteroidal antiestrogens (Ex. Toremifene, vandet
• Antimetabolites (Ex. Methotrexate)
• Antihypertensives (Ex. Bepridil)
• Opioid narcotics (Ex. Methadone)
• Iron salts
• Immunosuppressants (Ex. Tacrolimus or mycophenolate mofetil)
• Antifungals (Ex. Ketoconazole, itraconazole)
• Anti-infective (Ex. Pentamidine)
• Anticoagulants (Ex. Warfarin)

Overdosage:

If you or anyone else take too much of RABEZOX D CAPSULE, contact your doctor
immediately or go to a hospital straight away. Overdosage symptoms are altered
consciousness, agitation, convulsions, disorientation, sleepiness and
extrapyramidal reactions (such as rigidity, tremor, drooling).

Synopsis

Drug	:	Domperidone, Rabeprazole
Pharmacological Category	:	Dopamine antagonist, Proton pump inhibitor
Therapeutic Indication	:	Pe
Dosage Forms	:	Tablet, Capsule

More Information

FAQs About RABEZOX D CAPSULE

Q: Can RABEZOX D CAPSULE cause diarrhea?

A: Yes. RABEZOX D CAPSULE may cause diarrhea in some individuals. Keep yourself
hydrated by drinking plenty of fluids, oral electrolytes and juices. Do not
self-manage diarrhea if it persists for a longer period. Contact your doctor for
advice.

Q: Can RABEZOX D CAPSULE cause acid reflux?

A: No. RABEZOX D CAPSULE is used to manage Gastro-Esophageal Reflux Disease
(GERD) and does not cause acid reflux. If you experience any unusual symptoms
after taking the medicine, consult your doctor for advice.

Q: Can RABEZOX D CAPSULE cause kidney damage?

A: RABEZOX D CAPSULE may rarely cause damage to your kidneys (Ex. interstitial
nephritis). However, inform your doctor immediately if you experience any signs
of kidney damage such as dark urine, blood in urine, painful urination or lower
abdominal discomfort during management with this medicine.

Q: When and how should I take RABEZOX D CAPSULE?

A: Take RABEZOX D CAPSULE on an empty stomach or as advised by your physician.
Swallow the medicine as a whole and do not crush or chew the medicine.

Q: Can RABEZOX D CAPSULE be used in children?

A: No. RABEZOX D CAPSULE is not recommended for use in children and adolescents
(below 18 years) due to lack of safety and effectiveness. Consult your child’s
doctor if your child experiences any symptoms of gastro-esophageal reflux
disease or pe
stomach pain, heartburn, burping, etc).

Useful Diagnostic Tests

• Complete Blood Count (CBC)
• Stool Complete Analysis