ENZYL 40mg Capsule 28's

Introduction About ENZYL 40MG CAPSULE

ENZYL 40MG CAPSULE contains Enzalutamide, which belongs to the group of
medicines called Androgen receptor inhibitors. It is used to manage adult men
with prostate cancer who no longer respond to hormone therapy or surgical
management or if the cancer, despite responding to management, has spread to
other parts of the body.

Prostate cancer occurs in the prostate gland (a gland in males that produces the
seminal fluid to transport sperm). Symptoms include problems while urinating
(difficulty, decreased force, or blood in the urine), blood in the semen, bone
pain, erectile dysfunction, and weight loss.

Enzalutamide acts by blocking the activity of hormones called androgens (such as
testosterone). By blocking androgens, it stops the growth of prostate cancer
cells and can further induce cancer cell death and tumour regression.

Before taking ENZYL 40MG CAPSULE, inform your doctor if you have kidney
problems, liver problems, or heart conditions like arrhythmia (heart rhythm
problem). ENZYL 40MG CAPSULE is not recommended for use by pregnant and
breastfeeding women. ENZYL 40MG CAPSULE is not recommended for use in children
and adolescents. Consult your doctor before taking it.

The most common side effects of taking ENZYL 40MG CAPSULE are tiredness, broken
bones, hot flushes, high blood pressure, headaches, feeling anxious, dry skin,
itching, difficulty remembering, and breast enlargement in men. Consult your
doctor if any of the symptoms worsen.

Uses Of ENZYL 40MG CAPSULE

• To manage prostate cancer

How ENZYL 40MG CAPSULE Works

ENZYL 40MG CAPSULE works by blocking the activity of hormones called androgens
(such as testosterone). By blocking androgens, it stops the growth of prostate
cancer cells and can induce cancer cell death and tumour regression.

How to use ENZYL 40MG CAPSULE

Take ENZYL 40MG CAPSULE as advised by your physician. Swallow it with a glass of
water. Do not crush or chew the medicine. Your doctor will decide the correct
dose and duration for you depending on your age, body weight, and disease
condition.

Side Effects Of ENZYL 40MG CAPSULE

Common

• Tiredness and falling
• Broken bones
• Hot flushes, high blood pressure, blockage of the arteries in the heart (ischemic heart disease)
• Headaches
• Feeling anxious, symptoms of restlessness
• An uncontrollable urge to move a part of the body, usually the legs
• Dry skin and itching
• Difficulty remembering, reduced concentration, and forgetfulness
• Change in sense of taste
• Breast enlargement in men (gynecomastia)

Uncommon

• Hallucinations
• Difficulty thinking clearly
• Low white blood cell count

Rare

• Posterior reversible encephalopathy syndrome (a reversible condition involving the brain)

Stop taking it and contact your doctor immediately if you experience:

• Seizures

How To Manage Side Effects

Headache

Drink enough water and avoid bright lights. A cold compress will also have a
soothing effect.

Warning & Precautions

!### Pregnancy

ContraindicatedENZYL 40MG CAPSULE is not recommended for use by pregnant women. Consult your
doctor before taking it. Women who are or may become pregnant should not handle
broken or damaged medicine without wearing protection like gloves.

!### Breastfeeding

ContraindicatedENZYL 40MG CAPSULE is not recommended for breastfeeding women. Consult your
doctor before taking it.

!### Driving and Using Machines

Use with CautionENZYL 40MG CAPSULE may have a moderate influence on the ability to drive and use
machines, so avoid driving or handling machines while on ENZYL 40MG CAPSULE.

!### Kidney

Use with CautionENZYL 40MG CAPSULE should be taken with caution in patients with severe kidney
disease. Consult your doctor before taking it.

!### Liver

Use with CautionENZYL 40MG CAPSULE should be used with caution in patients with severe liver
disease. Consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take ENZYL 40MG CAPSULE if you are allergic to enzalutamide.

!### Heart Disease

Use with CautionENZYL 40MG CAPSULE should be taken with caution in patients with heart or blood
vessel conditions, including heart rhythm problems (arrhythmia). Consult your
doctor before taking it.

!### Use In Pediatrics

ContraindicatedENZYL 40MG CAPSULE is not recommended for use in children and adolescents.
Consult your doctor before taking it.

!### Use In Geriatrics

Consult your doctorYour doctor will give you the right dose depending on your age, body weight, and
disease condition. Consult your doctor before taking ENZYL 40MG CAPSULE.

Others

Before taking ENZYL 40MG CAPSULE, inform your doctor if you:

• Have seizures or fits

Interactions

A. Drug-drug interactions:

Before taking ENZYL 40MG CAPSULE, inform your doctor if you are taking any of
the following medicines:

• Anticoagulants (Ex. warfarin, acenocoumarol, and clopidogrel)
• Medicines used to manage asthma and other respiratory diseases (Ex. aminophylline, theophylline).
• Medicines used to manage certain psychiatric disorders such as depression and schizophrenia (Ex. clozapine, olanzapine, chlorpromazine, mesoridazine, thioridazine, amitriptyline, desipramine, doxepin, imipramine, maprotiline, risperidone, ziprasidone, bupropion, lithium, mirtazapine, diazepam, midazolam, and haloperidol)
• Medicines used to manage cholesterol (Ex. gemfibrozil, atorvastatin, simvastatin)
• Medicines used to manage pain (Ex. fentanyl, tramadol, pethidine, methadone)
• Medicines used to manage cancer (Ex. cabazitaxel, docetaxel)
• Medicines used to manage epilepsy (Ex. carbamazepine, clonazepam, phenytoin, primidone, and valproic acid)
• Medicines used to manage sleep disorders (Ex. zolpidem)
• Medicines used to manage heart conditions or lower blood pressure (Ex. bisoprolol, digoxin, diltiazem, felodipine, nicardipine, nifedipine, propranolol, and verapamil), to manage heart conditions or strokes (Ex. dabigatran etexilate), to manage heart rhythm problems (Ex. quinidine, procainamide, amiodarone, and sotalol)
• Medicines used to manage serious diseases related to inflammation (Ex. dexamethasone, prednisolone)
• Medicines used to manage HIV infection (Ex. indinavir, ritonavir)
• Medicines used to manage bacterial infections (Ex. clarithromycin, doxycycline)
• Medicines used to manage thyroid disorders (Ex. levothyroxine)
• Medicines used to manage gout (Ex. colchicine)
• Medicines used to manage stomach disorders (Ex. omeprazole)
• Medicines used to manage organ rejection (Ex. tacrolimus)
• Moxifloxacin (a medicine used to manage bacterial infections)

Overdosage:

If you or anyone else accidentally takes too much of ENZYL 40MG CAPSULE, consult
your doctor immediately or visit the nearby hospital. The symptoms of an
overdose are seizures.

Synopsis

Drug	:	Enzalutamide
Pharmacological Category	:	Androgen receptor inhibitors
Therapeutic Indication	:	Prostate cancer
Dosage Forms	:	Tablet

More Information

Storage

• Keep ENZYL 40MG CAPSULE out of reach of children
• Store below 30°C

FAQs About ENZYL 40MG CAPSULE

Q: Can ENZYL 40MG CAPSULE cause confusion?

A: Yes, ENZYL 40MG CAPSULE can develop a condition involving the brain called
posterior reversible encephalopathy syndrome. If you have seizures, an
increasing headache, confusion, blindness, or vision problems, please contact
your doctor as soon as possible.

Q: What if I forget to take ENZYL 40MG CAPSULE?

A: If you forget to take ENZYL 40MG CAPSULE at the usual time, take it as soon
as you remember. If you forget it for the whole day, take it the following day.
If you forget to take the medicine for more than one day, talk to your doctor
immediately. Do not take a double dose.

Q: Is ENZYL 40MG CAPSULE a chemotherapy drug?

A: No, ENZYL 40MG CAPSULE is not a chemotherapy drug, despite being used in the
management of cancer. It is a type of hormone therapy that works to inhibit
prostate cancer cells from growing and spreading by blocking the action of a
group of hormones called androgens.

Q: Can ENZYL 40MG CAPSULE be taken by a woman?

A: No. ENZYL 40MG CAPSULE is not recommended for women. It is used to manage
prostate cancer in men.

Q: What is ENZYL 40MG CAPSULE used for?

A: ENZYL 40MG CAPSULE is used to manage adult men with prostate cancer who no
longer respond to hormone therapy or surgical management or if the cancer,
despite responding to management, has spread to other parts of the body.

Q: How does ENZYL 40MG CAPSULE work?

A: ENZYL 40MG CAPSULE works by blocking the activity of hormones called
androgens (such as testosterone). By blocking androgens, it stops the growth of
prostate cancer cells and can induce cancer cell death and tumour regression.

Q: How should I take ENZYL 40MG CAPSULE?

A: Take ENZYL 40MG CAPSULE as advised by your physician. Swallow it with a glass
of water. Do not crush or chew the medicine. Your doctor will decide the correct
dose and duration for you depending on your age, body weight, and disease
condition.

Q: When to stop taking ENZYL 40MG CAPSULE?

A: Always take ENZYL 40MG CAPSULE as advised by your doctor. Stop taking it and
contact your doctor immediately if you experience seizures.

Q: What are the side effects of ENZYL 40MG CAPSULE?

A: The most common side effects of taking ENZYL 40MG CAPSULE are tiredness,
broken bones, hot flushes, high blood pressure, headaches, feeling anxious, dry
skin, itching, difficulty remembering, and breast enlargement in men. Consult
your doctor if any of the symptoms worsen.

Q: Is ENZYL 40MG CAPSULE safe for pregnant women?

A: ENZYL 40MG CAPSULE is not recommended for use by pregnant women. Consult your
doctor before taking it. Women who are or may become pregnant should not handle
broken or damaged medicine without wearing protection like gloves.

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Urine Routine & Microscopy
• Prostate Specific Antigen - Psa (Total)
• Prostate Specific Antigen - Psa (Free)
• Health
• Prostatic Acid Phosphatase (Pap)