Divaine 50mg Tablet 10'S

Introduction About DIVAINE 50MG TABLET

DIVAINE 50MG TABLET contains Minocycline, which belongs to the group of
medicines called Antibiotics. It is used to manage certain forms of bacterial
infections that affect the ears, eyes, throat, nose, and respiratory system
(chest infections), gonorrhoea or pelvic, skin infections (acne), urinary tract
infections and prostate infections. It also helps in the management of
meningitis carriers. It is also used in the management of infections before and
after an operation.

Before taking DIVAINE 50MG TABLET, inform your doctor if you have or ever had
liver or kidney problems. Avoid consum
while taking DIVAINE 50MG TABLET, as it may lead to unwanted side effects.

DIVAINE 50MG TABLET should be used with caution among women who are pregnant or
breastfeeding as it can affect the development of the unborn baby. DIVAINE 50MG
TABLET should be used with caution by adults and adolescents but not recommended
for use under the age of 12 years. The most common side effects of taking
DIVAINE 50MG TABLET are dizziness and fever. Consult your doctor if any of the
symptoms worsen.

Uses Of DIVAINE 50MG TABLET

• Manage varied types of infections, such as bacterial infections that affect ears, eyes, throat, nose and respiratory system (chest infections), gonorrhoea or pelvic, skin infections (acne), urinary tract infections and prostate infections
• Manage meningitis carriers
• Prevention of infection before and after an operation

How DIVAINE 50MG TABLET Works

DIVAINE 50MG TABLET has properties of immunomodulatory, anti-inflammatory and
neuroprotective effects. It can work by any of the following mech
inhibitory effect on activities of enzymes such as MMPs or iNOS; reduction in
protein tyrosine nitration because of scavenging properties; inhibition of
activation of caspase-1 and caspase 3; enhancement of Bcl-2-derived effects
which protects the cells against apoptosis; inhibition of the activity of
PARP-1; reduction in the amount of p38 MAPK phosphorylation. All these
activities of minocycline help in fighting against various bacterial infections.

How to use DIVAINE 50MG TABLET

Take DIVAINE 50MG TABLET as advised by your physician. Swallow the medicine with
a glass of water. Do not crush or chew. You can take DIVAINE 50MG TABLET while
sitting down or standing.

Your doctor will decide the correct dose and duration for you depending on your
age, body weight and disease condition.

Side Effects Of DIVAINE 50MG TABLET

Common

• dizziness

Uncommon

• fever

Rare

• vertigo (spinning sensation)
• tinnitus (ringing in ears) and other hearing problems
• loss of appetite
• headache
• diarrhoea
• feeling or being sick
• hair loss
• abnormal and unexplained bruising and bleeding for a longer period. This might indicate low platelet levels in the blood
• discolouration of teeth
• cough
• reduced sense of touch
• feeling of pins and needles in the hands or feet
• muscle and joint pain
• skin problems such as itching, skin rashes, nettle rashes, the appearance of the same skin reaction in the same area after taking medicine, and the occurrence of red round lumps under the skin below the knee
• redness, pain, or tenderness, swelling around a vein (vasculitis)
• increased levels of liver enzymes or urea observed in blood test
• increase in a specific type of WBCs seen in blood test

Stop taking DIVAINE 50MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• severe headaches
• eye problems such as blurred or double vision, loss of vision
• urine problems such as little or no urine production, discomfort, or pain during the passing of urine, and the production of dark or cloudy urine with lower back pain. These are indications of serious kidney problems
• skin problems such as the occurrence of purple painful lumps on the skin (erythema nodosum), patches of dark skin colour, burning, tingling or redness of the skin after exposure to direct or artificial sunlight
• inflammation is seen in various parts such as the liver, blood vessels, tongue, vagina or mouth, and intestines which causes severe nausea and vomiting, stomach cramps or diarrhoea and itching of the anus. These are indicative of the growth of tetracycline-resistance bacteria
• recurrent and frequent infections causing fever, chest infections, severe chills, or mouth ulcers. These are signs of low WBCs levels in the blood
• dark urine, pale stools, loss of appetite, yellowing of skin or whites of eyes, and stomach pain. These are indications of serious liver problems.
• fatigue, chest pain or pressure and shortness of breath during exercise are signs of inflamed heart muscles (myocarditis)
• sudden sharp chest pain which aggravates by deep breathing or coughing. These are signs of inflammation of the membrane surrounding the heart (pericarditis)
• muscle pain
• inflammation, pain, swelling or stiffness of joints with fever
• allergic reaction is seen as red itchy swollen skin, severe skin rashes, and swelling seen on the face, mouth, lips, tongue, or throat which results in breathing difficulties
• tiredness, weakness, or pale skin
• breathing problems such as wheezing, shortness of breath at rest, coughing with chest tightness or worsening of asthma
• stomach cramps, watery diarrhoea might be with blood, loss of appetite, and feeling sick (nausea or being sick). This may be a sign of pancreas inflammation
• severe skin reactions, blistering of skin, mouth, genitals, and eyes, peeling, or flaking of skin
• hair loss, weight loss, fever, rash (especially on the face), generalized feeling of being unwell and pain in joints. These are signs of Systemic Lupus Erythematous
• fits
• changes in the level of blood cells (drug reaction with eosinophilia and systemic symptoms – DRESS)

How To Manage Side Effects

Vomiting:

Take DIVAINE 50MG TABLET with or just after meals. Stick to simple meals. Avoid
eating oil-rich or spicy foods. Consult your doctor if the symptom worsens.

Dizziness:

If your feel dizzy, lie down, close your eyes and relax. Once you start feeling
better, get up slowly and not with a jerk. Sit like that for 5-10 minutes and
then you can continue working. Consult your doctor if the symptom worsens.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the head if required. Do not consume too much alcohol.
Consult your doctor if the symptom worsens.

Diarrhoea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do
not consume any medicine on your own without consulting your doctor. Consult
your doctor if the symptom worsens.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and more
frequent meals. Keep a heating pad on your stomach. Consult your doctor if the
symptom worsens.

Warning & Precautions

!### Pregnancy

DIVAINE 50MG TABLET is generally not recommended for use by pregnant women or
women who are planning to conceive, as it can affect the development of the
foetus. Consult your doctor before taking it.

!### Breastfeeding

DIVAINE 50MG TABLET is generally not recommended for use in breastfeeding women
as it may pass through the breast milk. Consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel dizziness, spinning sensation
while standing, headaches, eyesight problems, light-headedness, ringing in the
ears or hearing problems after taking DIVAINE 50MG TABLET.

!### Alcohol

Avoid consum
DIVAINE 50MG TABLET can be affected by food, milk or milk products.

!### Kidney

DIVAINE 50MG TABLET should be taken with caution in patients with severe kidney
disease. Consult your doctor before taking it.

!### Liver

DIVAINE 50MG TABLET should be taken with caution in patients with liver disease.
Consult your doctor before taking it.

!### Allergy

Do not take DIVAINE 50MG TABLET if you are allergic to minocycline.

Others

DIVAINE 50MG TABLET is not recommended for use if you:

• have systemic lupus erythematosus (an autoimmune disorder where the immune system of the body attacks its tissue causing damage and inflammation of various parts of the body)
• have a need for dialysis management

Before taking DIVAINE 50MG TABLET, inform your doctor if you:

• have myasthenia gravis (a condition which causes muscle weakening)

Use in paediatrics:

DIVAINE 50MG TABLET is generally not recommended for under 12 years of age as it
can affect growing bones and teeth and cause staining of teeth along with
reduced enamel content in teeth. Consult your doctor before taking it.

Use in geriatrics:

DIVAINE 50MG TABLET should be used with caution in elderly patients. Consult
your doctor before taking it.

Interactions

A.Drug-Drug interactions:

Before taking DIVAINE 50MG TABLET, inform your doctor if you are taking any of
the following medicine:

• anticoagulants (used to thin blood) Ex. warfarin
• antacids (used to manage indigestion) Ex. – magnesium hydroxide and calcium carbonate
• hepatotoxic medicine (medicines that might affect the working of the liver)
• sucralfate and bismuth salts (used to manage ulcers)
• kaolin (used to manage diarrhoea)
• quinapril (ACE inhibitor, used to manage high blood pressure)
• antibiotic (a medicine used to manage infections) Ex. – penicillin
• diuretics Ex. bumet
• retinoids (used to manage acne) Ex. isotretinoin or retinol
• ergotamine (used to manage migraines)
• ergometrine (used to induce labour or abortion)
• medicines containing zinc salts, calcium, iron, magnesium, or aluminium

B.Drug–Food Interactions:

Avoid drinking alcohol while taking DIVAINE 50MG TABLET as it may increase the
risk of side effects. The absor
food, milk or milk products.

Overdosage:

If you or anyone else accidentally take too much of DIVAINE 50MG TABLET, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdose are
dizziness and feeling sick or nauseous.

Synopsis

Drug	:	Minocycline
Pharmacological Category	:	Antibiotics
Therapeutic Indication	:	Acne
Dosage Forms	:	Tablet, Capsules, Injection

More Information

• Keep DIVAINE 50MG TABLET out of reach from children
• Store DIVAINE 50MG TABLET at room temperature

FAQs About DIVAINE 50MG TABLET

Can DIVAINE 50MG TABLET be used in pregnant women?

No, it is not recommended to use DIVAINE 50MG TABLET in pregnant women or if you
are planning to get pregnant as it can affect the growth and development of the
unborn baby. Consult your doctor before taking it.

How to take DIVAINE 50MG TABLET?

The dosage of DIVAINE 50MG TABLET will be decided by your doctor or pharmacist.
But remember to not take DIVAINE 50MG TABLET with food, milk, or other milk
products as this can reduce the absor
take this medicine after dinner just before bed, rather take it standing or
sitting upright.

Can children under the age of 12 years take DIVAINE 50MG TABLET?

No, it is not safe for children under the age of 12 years to take DIVAINE 50MG
TABLET as this medicine can affect the development of bone and cause staining of
teeth and reduced amount of enamel content in teeth.

Will taking a higher dose of DIVAINE 50MG TABLET be more effective?

No, taking a higher dose of DIVAINE 50MG TABLET will not be effective, rather
you might suffer from symptoms of overdose such as nausea, vomiting or
dizziness. Consult your doctor immediately if you have accidentally taken a
higher dose of DIVAINE 50MG TABLET.

What are the medicines that I should avoid while taking DIVAINE 50MG TABLET?

There are multiple medicines that one should avoid while taking DIVAINE 50MG
TABLET such as anticoagulants like warfarin, antacids like magnesium hydroxide,
ergotamine for migraines and ergometrine for inducing labour or abortion.

Can someone with lactose intolerance take DIVAINE 50MG TABLET?

No, if you know that you or someone you know, have lactose intolerance or
intolerance to some other sugars, consult your doctor before taking DIVAINE 50MG
TABLET.

Can we consume alcohol while taking DIVAINE 50MG TABLET?

Avoid alcohol consum
the medicine will be reduced. Also, avoid taking milk or milk products or food
while taking DIVAINE 50MG TABLET because of reduce absor

What should be done if I have missed a dose of DIVAINE 50MG TABLET?

If you miss your dose of DIVAINE 50MG TABLET do not take the missed dose even if
you remember it later and follow the scheduled regime for your medicine.

Can we take DIVAINE 50MG TABLET after meals?

No, avoid taking DIVAINE 50MG TABLET after meals or with milk or milk products,
as this can lead to reduced absor
will not work efficiently.

Is driving safe after taking DIVAINE 50MG TABLET?

No, driving is not safe after taking DIVAINE 50MG TABLET as you may feel
dizziness, headaches, lightheadedness, spinning sensation while standing,
ringing in the ears, or other hearing problems and eyesight problems. You should
avoid driving or using machines after taking DIVAINE 50MG TABLET.