DOXYLITE Injection 1's

Introduction About DOXYLITE INJECTION

DOXYLITE INJECTION contains Doxycycline which belongs to the groups of medicines
called Antibiotics. It is used for the management of various bacterial
infections like that of respiratory tract, urinary tract, skin, eyes, digestive
system, bones, blood, etc. DOXYLITE INJECTION is also used to manage sexually
transmitted infections (Ex. syphilis, gonorrhoea, chlamydia), plague (spreads
through rats), cholera (spreads through contaminated water), brucellosis
(spreads from
from sheep or cattle), etc.

DOXYLITE INJECTION can also be used to manage malaria in short-term travellers
(<4 months) to areas with chloroquine- and/or pyrimethamine
sulphadoxine-resistant strains. It is advised to reduce sun exposure and to use
fully covering clothes and sunscreen while going out as there is a chance of
getting light sensitivity during management with DOXYLITE INJECTION.

Before receiving DOXYLITE INJECTION, inform your doctor if you have myasthenia
gravis, systemic lupus erythematosus, history of intracr
oral candidiasis, liver or kidney problems, porphyria or if you are an
overweight woman of childbearing age.

There are no adequate and well-controlled studies on the use of DOXYLITE
INJECTION in pregnant women. DOXYLITE INJECTION should be used in breastfeeding
women only if your doctor finds it necessary. DOXYLITE INJECTION should be used
in children (8 years of age or less) only if the potential benefits outweigh the
risks.

Avoid consum
common side effects of receiving DOXYLITE INJECTION are mild diarrhea, nausea,
vomiting, light sensitivity, skin rash or itching, headaches and tooth
discoloration. Consult your doctor if any of the symptoms worsen with time.

Uses Of DOXYLITE INJECTION

Used to

• manage various bacterial infections like that of respiratory tract, urinary tract, skin, eyes, digestive system, bones, blood, etc
• manage sexually transmitted infections (Ex. syphilis, gonorrhoea, chlamydia), plague, cholera, brucellosis, anthrax, etc
• prevent malaria in short-term travellers (<4 months) to areas with chloroquine- and/or pyrimethamine sulphadoxine-resistant strains

How DOXYLITE INJECTION Works

DOXYLITE INJECTION reduces bacterial infection by blocking protein synthesis of
bacteria and thus managing its growth.

How to use DOXYLITE INJECTION

DOXYLITE INJECTION will be given to you only by a doctor or a nurse into a vein
as an intravenous infusion. Do not try to self-administer the medicine. Your
doctor will decide the correct dose and duration for you depending upon your
age, body weight and disease condition.

Side Effects Of DOXYLITE INJECTION

Common

• mild diarrhea, nausea, vomiting
• light sensitivity
• skin rash or itching
• headaches
• tooth discoloration

Rare

• bloody diarrhea
• low blood cell count
• migraines
• throat irritation or trouble swallowing
• chest pain, shortness of breath, irregular or fast heart rate
• worsening of systemic lupus erythematosus
• painful urination
• high blood pressure in the head
• ulcers in food pipe if taken without water

Stop receiving DOXYLITE INJECTION and contact doctor if you experience any of
the following side effects:

• Clostridium difficile*-*associated diarrhoea (blood in stool, stomach pain, watery stools, dehydration, fever)
• Steven – Johnson syndrome (skin with rashes, blisters, pain along with fever)
• overgrowth of nonsusce
• acute generalized exanthematous pustulosis (areas with redness and swelling on body along with fever)
• toxic epidermal necrolysis (painful red area without blister formation which spreads quickly and causes skin to peel, fever, chills)
• drug reaction with eosinophilia and systemic symptoms (DRESS)
• intra cr
• angioedema (swelling in face, lips, mouth, throat with difficulty in swallowing and breathing)
• anaphylactic shock (increased heart rate, over sweating, fall in blood pressure, fainting)

How To Manage Side Effects

Nausea and Vomiting:

Avoid eating fried and greasy food. Take simple, light, small meals at frequent
intervals. Drink plenty of fluids and stay hydrated always. If symptom persists,
contact your doctor.

Diarrhea:

Drink plenty of water, fluids and electrolytes such as ORS and stay hydrated. If
symptom persists, contact your doctor.

Headache:

Drink plenty of fluids and stay hydrated. Try to be tension free and relaxed.
Take adequate sleep and rest. Avoid consum
required. If symptom persists, contact your doctor.

Light sensitivity:

Reduce exposure to sunlight. While going out, wear fully covering clothes and
apply sunscreen with high SPF. If symptom persists, contact your doctor.

Skin rashes:

Do not scratch on rashes. Apply mild moisturizers if needed and avoid hot
showers. Take an oatmeal bath. If symptom persists, contact your doctor.

Warning & Precautions

!### Pregnancy

There are no adequate and well-controlled studies on the use of DOXYLITE
INJECTION in pregnant women. Consult your doctor before receiving it.

!### Breastfeeding

DOXYLITE INJECTION should be used in breastfeeding women only if your doctor
finds it necessary. Consult your doctor before receiving it.

!### Alcohol

Avoid consum
reduce the efficacy of this medicine.

!### Kidney

DOXYLITE INJECTION should be used with caution in patients with kidney problems.
Consult your doctor before receiving it.

!### Liver

DOXYLITE INJECTION should be used with caution in patients with liver
impairment. Consult your doctor before receiving it.

!### Allergy

Do not receive DOXYLITE INJECTION if you are allergic to doxycycline,
minocycline, tetracycline or any of the other ingredients of this medicine.
Consult your doctor before receiving it.

Others

Before receiving DOXYLITE INJECTION, inform your doctor if you have:

• a history of yeast infections
• porphyria (rare blood disease)
• myasthenia gravis (autoimmune disorder)
• a history of lupus (autoimmune disease)
• recent colitis (inflammation of digestive tract) due to antibiotics use
• intracr

Use in pediatrics:

DOXYLITE INJECTION should be used in children (8 years of age or less) only if
the potential benefits outweigh the risks. Consult your child’s doctor for
advice.

Interactions

A. Drug – Drug interactions:

Before receiving DOXYLITE INJECTION inform your doctor if you are taking any of
the following medicines:

• medicines used to manage blood clotting (Ex. heparin, warfarin)
• penicillin (used to manage bacterial infection)
• medicines used to manage or manage acidity (Ex. aluminium hydroxide, magnesium carbonate, calcium carbonate)
• bismuth subsalicylate (used to manage diarrhoea)
• medicines used to manage mood disorders and depression (Ex. phenobarbitone, pentobarbital)
• medicines used to manage fits (Ex. phenytoin, carbamazepine)
• methoxyflurane (used to relieve pain associated with trauma)
• medicine used to manage pregnancy (Ex. ethinylestradiol, norethindrone)

Overdosage:

DOXYLITE INJECTION will be administered to you only by a doctor or a nurse in a
hospital and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms after receiving DOXYLITE
INJECTION.

Synopsis

Drug	:	Doxycycline
Pharmacological Category	:	Tetracyclines
Therapeutic Indication	:	Bacterial infections in different parts of body
Dosage Forms	:	Injection, Combipack injection, Tablet, Capsule

More Information

• Keep DOXYLITE INJECTION out of reach of children
• Store DOXYLITE INJECTION at room temperature

FAQs About DOXYLITE INJECTION

What precautions have to be followed when receiving DOXYLITE INJECTION?

Use of DOXYLITE INJECTION may result in overgrowth of nonsusce
including fungi. If this occurs, it should be discontinued. Before you take
DOXYLITE INJECTION, tell your doctor if you are using, have recently used or
might use any other medicines. Before receiving DOXYLITE INJECTION, tell your
doctor if you are allergic to doxycycline, minocycline, tetracycline, other
medications or any of the other ingredients of this medicine.

Can DOXYLITE INJECTION cause diarrhea?

Diarrhea is a common problem caused by DOXYLITE INJECTION, which usually ends
when the medicine is discontinued. Sometimes after starting the management, you
might develop watery and bloody stools (with or without stomach cramps and
fever) even as late as two or more months after having taken the last dose of
DOXYLITE INJECTION. If this occurs, you should tell the doctor as soon as
possible.

Does DOXYLITE INJECTION cause tooth problems?

Yes. The use of DOXYLITE INJECTION during last half of pregnancy, infancy and
childhood up to the age of 8 years (tooth development phases) may cause
permanent discolouration of the teeth (yellow-grey-brown). Enamel hypoplasia
(thin or absent enamel) has also been reported. Consult your doctor for further
queries.

Can DOXYLITE INJECTION be used to manage syphilis?

Yes. DOXYLITE INJECTION can be used to manage sexually transmitted diseases like
syphilis. The dose and duration of management will be determined by your doctor
according to your age, body weight and severity of infection.

Does DOXYLITE INJECTION cause sensitivity to light?

Yes. Photosensitivity (light sensitivity) m
reaction has been observed in some patients receiving DOXYLITE INJECTION.
Patients prone to be exposed to direct sunlight or ultraviolet light should know
that this reaction can occur with DOXYLITE INJECTION or similar medicines and
management should be discontinued at the first evidence of skin redness.

Useful Diagnostic Tests

• Complete Blood Count
• Peripheral smear examination