DASANIA 70 Tablet 60's

Introduction About DAS

DAS
called Tyrosine Kinase Inhibitors. It is used to manage cancers of blood and
bone marrow (such as chronic myeloid leukaemia (CML) and philadelphia chromosome
positive (Ph+) acute lymphoblastic leukaemia) in adults, adolescents and in
children (aged 1 year or above).

It is primarily used in patients when management with conventional therapies is
not suitable or fails to provide adequate response.

Leukaemia is the cancer of white blood cells. It is caused due to abnormal
growth and multiplication of blood cells within the bone marrow. It is
characterized by severe tiredness, breathlessness, increased bleeding tendency,
tiredness, anemia, night sweats, fever, chills, frequent infections and weight
loss.

During management with DAS
health condition through several blood tests to avoid the risk of unwanted side
effects. Avoid eating grapefruit or drinking grapefruit juice while taking
DAS

Before taking DAS
or heart problems. You must also inform your doctor if you have or at risk of
developing hepatitis C infection as a precaution.

Avoid concomitant use of antacids or any stomach medicines along with DAS
TABLET. Leave a time gap of at least 2 hours between the medicines. DAS
TABLET is not recommended for use in pregnant or breastfeeding women.

Men and women taking DAS
to avoid pregnancy while undergoing therapy with DAS

The most common side effects of taking DAS
tendency, increased infections, feeling tired or weak, nausea, vomiting, hair
loss, mouth ulcers, changes in taste, inflammation of the food pipe or stomach,
muscle pain or spasm, skin rashes, headache, dizziness and weight loss. Contact
your doctor if any of these side effect worsens.

Uses Of DAS

It is used in adults, adolescents and in children (aged 1 year or above) to
manage:

• Cancers of blood and bone marrow (such as chronic myeloid leukaemia and philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia)

How DAS

DAS
of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that
triggers cancer formation. As a result, it reduces abnormal growth and
multiplication of cancer cells in the body.

How to use DAS

Take DAS
without meals. Swallow the medicine with a glass of water. Do not crush or chew
the medicine.

Try to take DAS
the correct dose and duration of therapy for you depending upon your age, body
weight and health condition. Do not stop taking DAS
by your doctor.

Side Effects Of DAS

Common

• increased infections
• nausea, vomiting
• diarrhea, stomach pain, bloating, constipation, heartburn
• lack of appetite, changes in taste
• mouth ulcers, hair loss
• weight loss or weight gain
• headache, tiredness, weakness
• dizziness
• skin rash, itching, dry skin, acne
• increased bleeding tendency
• joint pain, muscle pain or spasms
• increased sweating, flushing
• blurred vision, dry eyes
• depression, sleeplessness
• oedema (swelling of body parts)

Uncommon

• irregular heartbeat, chest pain, breathing difficulties
• stomach ulcers, inflammation of the food pipe
• swollen tummy, anal tears
• anxiety, confusion, mood swings, memory loss
• low sexual drive
• loss of hearing, sensitivity to light
• skin inflammation, nail disorder
• problems in passing urine
• breast enlargement in men, menstrual disorder
• high blood cholesterol levels
• swollen lymph nodes
• increased protein in the urine

Stop taking DAS
experience any of the following side effects such as:

• signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
• chest pain, cough, breathing difficulties and fainting (signs of fluid retention in lungs)
• unusual bleeding or bruising with fever, tiredness and confusion (signs of blood vessel damage)
• bloody stools/urine/vomit or black tarry stools
• blistering or peeling of skin and mucous membranes with fever and sore throat, mouth ulcers

How To Manage Side Effects

!### Constipation

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and
drink plenty of water. Try doing exercise regularly (going for a daily walk or
run). If this does not help, inform your doctor for receiving alternate
managements for constipation.

!### Diarrhea

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhoea and consult your doctor if
the symptom gets worse.

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Consult your doctor if your
dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Consult your doctor if your headache worsens.

!### Mouth Ulcers

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on
the affected areas of the mouth if required. Consult your doctor if the symptom
did not improve.

!### Nausea And Vomiting

Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea
worsens, consult your doctor for advice.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Warning & Precautions

!### Pregnancy

ContraindicatedDAS
necessary by the physician. Therefore, inform your doctor before taking DAS
70 TABLET if you are pregnant or think you may be pregnant. Women of
childbearing potential must use a suitable contrace
pregnancy while undergoing therapy with DAS

!### Breastfeeding

ContraindicatedDAS
pass through the breast milk. Therefore, consult your doctor taking it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if you feel dizzy after
taking DAS

!### Alcohol

Consult your doctorAvoid consum
feel dizzier.

!### Kidney

Use with CautionDAS
Therefore, consult your doctor before taking it.

!### Liver

Use with CautionDAS
Therefore, consult your doctor before taking it.

!### Allergy

Use with CautionDo not take DAS

!### Heart Disease

Use with CautionDAS
Therefore, consult your doctor before taking it.

!### Use In Pediatrics

ContraindicatedDAS
Bone growth and development will be closely monitored in children taking this
medicine. Therefore, consult your child’s doctor for advice.

!### Use In Geriatrics

Use with CautionDAS
or above). Therefore, consult your doctor before taking it.

Others

DAS

• have, ever had or at risk of having hepatitis B infection

Interactions

A. Drug-Drug Interactions:

Before taking DAS
the following medicines such as:

• medicines used for blood thinning (Ex. warfarin)
• ketoconazole, itraconazole (used to manage fungal infection)
• medicines used to manage bacterial infection (such as erythromycin, clarithromycin, telithromycin)
• ritonavir (a medicine used to manage HIV infection)
• medicines used to manage epilepsy (Ex. phenytoin, carbamazepine, phenobarbital)
• rifampicin (a medicine used to manage tuberculosis)
• medicines used to manage stomach ulcers (such as famotidine, omeprazole)
• St. John’s wort (an herbal preparation used to manage depression)
• antacids (used to neutralize stomach acids) Ex. aluminium hydroxide or magnesium hydroxide

B. Drug-Food Interactions:

Avoid eating grapefruit or drinking grapefruit juice while taking DAS
TABLET as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally took more DAS
doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Dasatinib
Pharmacological Category	:	BCR-ABL Tyrosine Kinase Inhibitor
Therapeutic Indication	:	Chronic Myeloid Leukaemia, Ph+ Acute Lymphoblastic Leukaemia
Dosage Forms	:	Tablet

More Information

• Keep DAS
• Store DAS

FAQs About DAS

Q: What is DAS

A: DAS
chronic myeloid leukaemia (CML) and philadelphia chromosome positive (Ph+) acute
lymphoblastic leukaemia) in adults, adolescents and in children (aged 1 year or
above). It is primarily used in patients when management with conventional
therapies is not suitable or fails to provide adequate response.

Q: How DAS

A: DAS
actions of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that
triggers cancer formation. As a result, it reduces abnormal growth and
multiplication of cancer cells in the body.

Q: Can DAS

A: The success rate of cancer depends upon the severity of the disease. However,
DAS
cancer cells in the body, which may help in managing the cancer completely.

Q: Can the use of DAS

A: Hair loss is one of the common side effects of taking DAS
it bothers you, consult your doctor for advice.

Q: Can the use of DAS

A: Mouth ulcers are one of the common side effects of taking DAS
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on
the affected areas of the mouth if required. Consult your doctor if the symptom
did not improve

Q: Can DAS

A: DAS
above) if prescribed by the physician. It should not be used in children aged
below 1 year due to increased risk of side effects.

Q: Is DAS

A: Yes. DAS
chemotherapeutic agent. It stops abnormal growth and multiplication of cancer
cells in the body.

Q: What happens if I forgot to take a dose of DAS

A: If you forgot to take a dose of DAS
remember. However, if it is time for the next dose of DAS
the missed dose and take the next one regularly. Do not take a double dose of
DAS

Q: What precautions must be followed while taking DAS

A: Before taking DAS
kidney or heart problems or if you have or at risk of developing hepatitis C
infection as a precaution. Avoid eating grapefruit or drinking grapefruit juice
while taking DAS
DAS
DAS
taking DAS
pregnancy while undergoing therapy with DAS

Q: Will taking a higher dose of DAS

A: No, taking a higher dose of DAS
can lead to toxicity. Always take the dose prescribed by your doctor. If the
prescribed dose is not effective for you, consult your doctor for advice. Your
doctor might increase the dose or suggest an alternative therapy

Q: What happens if I stop taking DAS

A: No. Do not stop taking DAS
may make your symptoms reappear. Therefore, take DAS
your doctor for the stipulated duration.

Q: Can DAS

A: DAS
considered necessary by the physician. Therefore, inform your doctor before
taking DAS

Q:Can the use of DAS

A: Yes. DAS
reduces the levels of red blood cells in your blood and may make you anaemic.
Consult your doctor if you experience tiredness after taking DAS
Tiredness can also occur if you have any pre-existing disease conditions such as
liver or kidney impairment while taking this medicine.

Q:Can I drive a car after takingDAS

A: DAS
or operate any heavy tools or machines if your ability is affected by DAS
TABLET.

Q: How to take DAS

A: Take DAS
with a glass of water. Do not crush or chew the medicine. DAS
be taken with or without food.

Q:How to control nausea caused due to DAS

A: Generally, anticancer medicines are associated with uncontrollable nausea and
vomiting. To avoid this, your doctor would prescribe a suitable medicine to
control them along with DAS
suitable anti-emetic medicine. Do not self-manage nausea.

Q: What are the side effects of taking DAS

A: The most common side effects of taking DAS
bleeding tendency, increased infections, feeling tired or weak, nausea,
vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food
pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and
weight loss. Contact your doctor if any of these side effect worsens.

Q: Who should avoid taking DAS

A: DAS
dasatinib. It is also not recommended for use in pregnant or breastfeeding women
and in children (aged below 1 year).

Q: IsDAS

A: DAS
problems. Your doctor will access your health condition and suggest a suitable
dose for you.

Q:Can the use of DAS

A: Yes. DAS
levels of certain liver enzymes in your body. Therefore, it should be used with
caution in patients with liver problems. Consult your doctor before taking it.