Bezip D Tablet 10'S

Introduction About BEZIP D TABLET

BEZIP D TABLET is a combination of Dutasteride and Tamsulosin which belongs to
the group of medicines called 5-Alpha reductase inhibitors and Alpha-blockers
respectively. BEZIP D TABLET is used to manage signs and symptoms of Benign
Prostatic Hyperplasia (BPH) in men. Benign Prostatic Hyperplasia (also known as
enlarged prostate) is a non-cancerous growth of prostate gland, which is
predominantly caused by excessive production of a stress hormone called
dihydrotestosterone (DHT) in men.

Symptoms of BPH includes urinary problems such as difficulty in passing urine,
urinary incontinence (unintentional passing of urine), frequent urination at
night and sexual dysfunction or painful ejaculation.

During this therapy, your doctor will regularly monitor your serum
prostate-specific antigen (PSA) levels to detect the incidence of prostate
cancer.

Before taking BEZIP D TABLET inform your doctor if you have any liver or kidney
problems. Both pregnant women and children should avoid handling the leaking
medicine, because this medicine has a high potential to get absorbed through
your skin and can affect the normal development of a male baby (especially
during the first 16 weeks of pregnancy).

Usage of condom during sexual intercourse is recommended among fertile men to
avoid conce
adolescents under 18 years of age. BEZIP D TABLET should be used with caution in
elderly patients above 65 years of age.

The most common side effects of taking BEZIP D TABLET are dizziness, enlargement
of breast in men and decreased sex drive. Consult your doctor if any of the side
effects bothers you.

Uses Of BEZIP D TABLET

• Manage signs and symptoms of benign prostatic hyperplasia (BPH) in men

How BEZIP D TABLET Works

BEZIP D TABLET reduces the symptoms of benign prostatic hyperplasia, where
dutasteride works by reducing the production of a stress hormone called
dihydrotestosterone and tamsulosin works by relaxing the muscles surrounding the
prostate gland, thus helps in shrinkage of prostate, making it easier for the
urine to pass through and relieve the symptoms.

How to use BEZIP D TABLET

Always take BEZIP D TABLET as directed by your physician. Take this medicine
with or without food, swallow the medicine as a whole and do not crush or chew
the medicine. Your doctor will decide the correct dose and duration of therapy
for you depending upon your age, body weight and disease condition. Do not stop
taking BEZIP D TABLET without informing your doctor.

Side Effects Of BEZIP D TABLET

Common

• sexual impotence (unable to achieve or maintain an erection)
• decreased sex drive
• difficulty in ejaculation
• gynecomastia (breast enlargement or tenderness)
• dizziness

Uncommon

• heart failure (signs include shortness of breath, extreme tiredness and swelling in your ankles and legs)
• low blood pressure on standing
• weakness or loss of strength
• headache
• constipation, diarrhea
• nausea, vomiting
• fast heartbeat
• itchy, blocked or runny nose
• skin rash, hives, itching
• hair loss or hair growth

Rare

• swelling of the face, eyelids, lips, arms or legs
• fainting

Stop taking BEZIP D TABLET and contact your doctor immediately if you experience
any of the following side effects:

• signs of allergic reaction (such as skin rash, itching, hives, and swelling of face, eyelids, lips, arms or legs)
• stevens-johnson syndrome (a severe widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals)

How To Manage Side Effects

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any machines
while you are feeling dizzy. Avoid consum
your dizziness. If the symptom persists for a longer time, contact your doctor
for advice.

Nausea and vomiting:

Take this medicine with or just after a meal or snack and stick to simple meals
and do not eat oil rich or spicy foods. Consult your doctor if the symptom does
not improve.

Headache:

Apply hot or cold-water bag on your head. Try taking rest in a quiet and dark
room. Drink tea or coffee. Consult your doctor if the symptom does not improve.

Constipation:

Take fiber rich foods in your diet such as fresh fruits, vegetables, whole grain
cereals and drink plenty of fluids. Exercise more regularly and stay active.
Consult your doctor if the symptom does not improve.

Warning & Precautions

!### Pregnancy

BEZIP D TABLET is intended for use only in men. Pregnant women should not come
in contact with BEZIP D TABLET as it may cause potential abnormalities in male
foetus.

!### Breastfeeding

BEZIP D TABLET is intended for use only in men and therefore should not be used
in breastfeeding women.

!### Driving and Using Machines

Do not drive or operate any machines if you experience dizziness while taking
BEZIP D TABLET.

!### Alcohol

Avoid consum
excessive drowsiness. Consult your doctor before taking BEZIP D TABLET.

!### Kidney

BEZIP D TABLET should be used with caution if you have severe kidney disease.
Consult your doctor for advice before taking BEZIP D TABLET.

!### Liver

BEZIP D TABLET is not recommended for use in patients having severe liver
disease and it should be used with caution in patients with liver problems.
Consult your doctor for advice before taking BEZIP D TABLET.

!### Allergy

Do not take BEZIP D TABLET if you are allergic to Tamsulosin or Dutasteride and
other 5-alpha reductase inhibitors such as finasteride and soya or peanut.

!### Heart Disease

BEZIP D TABLET is not recommended for use in patients with low blood pressure
(which causes dizziness, lightheadedness or fainting (orthostatic hypotension)).
Consult your doctor for advice before taking BEZIP D TABLET.

Others

BEZIP D TABLET is not recommended for you, if you:

• are a woman (because this medicine is for men only)

Before taking BEZIP D TABLET, inform your doctor if you have:

• an upcoming cataract surgery
• blood test for PSA (Prostate Specific Antigen)

Use in pediatrics:

BEZIP D TABLET is not recommended for use in children or adolescents less than
18 years of age. Consult your child’s doctor for advice.

Use in geriatrics:

BEZIP D TABLET should be used with caution in elderly patients above 65 years of
age. Consult with your doctor for advice before taking BEZIP D TABLET.

Interactions

A. Drug-Drug interactions:

Before taking BEZIP D TABLET inform to your doctor, if you are taking any of
these medicines:

• other alpha blockers (used to manage enlarged prostate or high blood pressure) such as prazosin, doxazosin, terazosin
• medicines used to manage erectile dysfunction (Ex. vardenafil, sildenafil and tadalafil)
• medicines used to manage fungal infections (Ex. itraconazole, ketoconazole or terbinafine)
• diltiazem or verapamil (used to manage angina or high blood pressure)
• ritonavir or indinavir (used to manage HIV infection)
• paroxetine or nefazodone (medicine used to manage depression)
• cimetidine (medicine used to manage stomach ulcers)
• warfarin (used to manage blood clotting)
• erythromycin (used to manage bacterial infections)
• diclofenac (medicine used to manage pain or inflammation)

Overdosage:

If you or anyone else accidentally take too much of BEZIP D TABLET, consult your
doctor immediately. Overdosage may cause acute hypotension, nausea and vomiting.

Synopsis

Drug	:	Dutasteride, Tamsulosin
Pharmacological Category	:	5-Alpha reductase inhibitors, Alpha-blockers
Therapeutic Indication	:	Benign Prostatic Hyperplasia
Dosage Forms	:	Tablet, Capsule

More Information

• Keep BEZIP D TABLET out of reach of children
• Store at room temperature

FAQs About BEZIP D TABLET

Can BEZIP D TABLET cause prostate cancer?

This medicine can increase the risk of prostate cancer and so your doctor would
regularly monitor your serum prostate specific antigen (PSA) which is used to
detect prostate cancer, in order to avoid any untoward side effects.

Can BEZIP D TABLET cause infertility?

Yes, BEZIP D TABLET can reduce sperm count, semen volume and movement also it
can cause sexual impotence, decreased sex drive or difficulty in ejaculation in
men. Consult your doctor if you experience any of these side effects.

Can BEZIP D TABLET be used for erectile dysfunction?

Yes, BEZIP D TABLET is intended to manage signs and symptoms of benign prostatic
hyperplasia (BPH) and its associated symptoms such as urinary problems and
erectile dysfunction or painful ejaculation.

Can BEZIP D TABLET cause dizziness?

Yes, BEZIP D TABLET can cause dizziness in some people. Try to rest and relax.
Get enough sleep. Avoid driving or operating any machines while you are feeling
dizzy. Avoid consum
symptom persists for a longer time, consult your doctor for advice.

Is BEZIP D TABLET safe to use in patients with liver disease?

BEZIP D TABLET is not recommended for use in patients having severe liver
disease and it should be used with caution in patients with liver problems. Your
doctor will adjust the dose based on the severity of the impairment and will
monitor your liver function test periodically during management with BEZIP D
TABLET. Before taking this medicine, inform your doctor if you have any liver
disease.

Can BEZIP D TABLET be used in children?

BEZIP D TABLET is not recommended for use in children or adolescents less than
18 years of age. Consult child’s doctor for advice before taking BEZIP D TABLET.
Doctor may consider the effective management in managing the condition.

Useful Diagnostic Tests

• Prostate-specific antigen (PSA) test