ATRAFINE Injection 5ml

Introduction About ATRAFINE INJECTION

ATRAFINE INJECTION contains Atracurium which belongs to the group of medicines
called Muscle relaxants. It relaxes your muscles and keeps your body still
(immobile) during a surgery. It also relaxes the airway muscles which help in
artificial breathing and in facilitating easy insertion of breathing tubes into
the airways.

Before receiving ATRAFINE INJECTION inform your doctor if you have any heart
problems. You must also inform your doctor if you have a history of asthma or
allergic conditions, any nerve or muscle disorders, electrolyte imbalance or if
you are severely dehydrated.

ATRAFINE INJECTION should be used in pregnant or breastfeeding women only if it
is considered necessary by the physician. However, it may be used during a
caesarean section in pregnant women under close supervision.

ATRAFINE INJECTION may cause difficulty in breathing which is due to relaxation
of muscle involved in breathing. In such cases, your doctor might provide you
with additional ventilation support until the effect of ATRAFINE INJECTION wears
off.

Other most common side effects of receiving ATRAFINE INJECTION are pain or
irritation at the site of injection, slow of fast heart rate, low or high blood
pressure and flushing of skin. Inform your doctor if any of these symptoms
worsen.

Uses Of ATRAFINE INJECTION

• Used during surgeries to relax muscles
• Helps in artificial breathing by relaxing airway muscles
• Facilitates easy insertion of breathing tubes into the airways

How ATRAFINE INJECTION Works

ATRAFINE INJECTION is a muscle relaxant. It works by blocking the transmission
of nerve signals from the nerve fibers to the muscles. As a result, it causes
muscle relaxation and help you stay immobile during surgeries. ATRAFINE
INJECTION can also relax the airway muscles which helps in easy insertion of
breathing tubes into the airways and in artificial breathing.

How to use ATRAFINE INJECTION

ATRAFINE INJECTION will be given to you only by a doctor or a nurse into the
vein (intravenously) under close monitoring. Your doctor will decide the correct
dose for you depending upon your age, body weight and health condition.

Side Effects Of ATRAFINE INJECTION

Common

• slow or very fast heartbeat
• changes in blood pressure (low or high)
• difficulty in breathing
• flushing
• pain, itching or irritation at the site of injection
• redness or itchy rashes of the skin

Rare

• bronchospasm (tightness of airway muscles)

Contact your doctor immediately if you experience any of the following side
effects after receiving ATRAFINE INJECTION:

• severe allergic reactions (such as skin rash, severe itching of the skin with raised lumps, blisters in the skin, swelling of the face, lips, tongue and/or throat with difficulty in breathing or swallowing)
• fits, cardiac arrest

How To Manage Side Effects

!### Injection Site Reactions

Place an ice pack on the injected site. Do not move the affected area
frequently. If the symptom worsens, consult your doctor.

Warning & Precautions

!### Pregnancy

Monitoring requiredATRAFINE INJECTION should be used in pregnant women only if it is considered
necessary by the physician. Therefore, inform your doctor if you are pregnant or
think you may be pregnant before receiving ATRAFINE INJECTION. However, ATRAFINE
INJECTION can be used during a caesarean section in pregnant women under close
medical supervision.

!### Breastfeeding

Monitoring requiredATRAFINE INJECTION should be used in breastfeeding women only if it is
considered necessary by the physician. Therefore, inform your doctor before
receiving it. The nursing infant should be monitored closely when the mother
receives this medicine.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines until the effects of this medicine wears
off completely.

!### Allergy

ContraindicatedTalk to your doctor before receiving ATRAFINE INJECTION if you are allergic to
Atracurium or to any other muscle relaxants (such as pancuronium).

!### Lungs

Use with CautionATRAFINE INJECTION should be used with caution in patients with a history of
asthma. Therefore, inform your doctor before receiving it.

!### Heart Disease

Use with CautionATRAFINE INJECTION should be used with caution in patients with heart problems.
Therefore, inform your doctor before receiving it.

!### Use In Pediatrics

Consult your doctorATRAFINE INJECTION should be used in infants, children, and in adolescents (aged
above 1 month until 18 years) under close medical supervision. It is not
suitable for use in newborns aged below 1 month of age.

!### Use In Geriatrics

Use with CautionATRAFINE INJECTION should be used with caution in elderly patients. Therefore,
consult your doctor for advice before receiving it.

Others

Before receiving ATRAFINE INJECTION, inform your physician if you:

• have problems in blood circulation
• have a history of allergic reactions
• have nerve or muscle disorder (such as myasthenia gravis, poliomyelitis, Eaton-Lambert syndrome etc.)
• have severe electrolyte disorders (abnormal levels of sodium, potassium and chloride in blood)
• are suffering from burns

Interactions

A. Drug-Drug interactions:

Before receiving ATRAFINE INJECTION, inform your doctor if you are taking any of
the following medicines:

• lithium (a medicine used to manage bipolar disorder)
• quinine (a medicine used to manage malaria)
• neomycin, streptomycin, kanamycin, gentamicin, lincosamide and polype
• medicines used to manage irregular heartbeat (such as quinidine, amiodarone, propafenone, lidocaine, procainamide, digoxin)
• phenytoin, carbamazepine and thiopental (used to manage fits and seizures)
• diuretics (used to improve urine output) Ex. furosemide, chlorothiazide, acetazolamide
• medicines used to manage heart problems (such as propranolol, diltiazem, nifedipine, nicardipine, oxprenolol, trimetaphan, hexamethonium and verapamil)
• medicines used to manage rheumatism (such as chloroquine, d-penicillamine)
• corticosteroids (used to manage pain and inflammation) such as prednisolone, methylprednisolone
• anesthetics (medicines that causes loss of consciousness) such as isoflurane, desflurane, sevoflurane and enflurane, halothane, ketamine
• dantrolene (a muscle relaxant)
• magnesium sulphate (used to manage abnormally high blood pressure in pregnant women)
• chlorpromazine (a medicine used to manage psychiatric disorders)

Overdosage:

ATRAFINE INJECTION will be administered to you only by a doctor or a nurse in a
hospital, and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Atracurium
Pharmacological Category	:	Neuromuscular Blocking Agents
Therapeutic Indication	:	Muscle relaxant
Dosage Forms	:	Injection

More Information

• Keep ATRAFINE INJECTION out of reach of children.
• Store ATRAFINE INJECTION in a refrigerator between 2-8°C

FAQs About ATRAFINE INJECTION

Q: What is the use of ATRAFINE INJECTION?

A: ATRAFINE INJECTION is a muscle relaxant used to relax your muscles and keeps
your body still (immobile) during a surgery. It also helps with artificial
breathing among patients in intensive care unit (ICU) by relaxing the airway
muscles and facilitates easy insertion of breathing tubes into the airways when
artificial breathing is necessary.

Q: What ATRAFINE INJECTION does to my body?

A: ATRAFINE INJECTION is a muscle relaxant. It works by blocking the
transmission of nerve signals from the nerve fibers to the muscles. As a result,
it causes muscle relaxation and help you stay immobile during surgeries.
ATRAFINE INJECTION can also relax the airway muscles which helps in easy
insertion of breathing tubes into the airways and in artificial breathing.

Q: How long does the effects of ATRAFINE INJECTION lasts long?

A: The effects of ATRAFINE INJECTION may last between 20-40 minutes depending
upon the dosage administered.

Q: What type of drug is ATRAFINE INJECTION?

A: ATRAFINE INJECTION is a muscle relaxant. It belongs to neuromuscular blocking
agents, where it blocks the transmission of nerve signals from the nerve fibers
to the muscles.

Q: Why is ATRAFINE INJECTION used before surgeries?

A: ATRAFINE INJECTION is used prior to surgeries to relax your muscles and to
make you stay immobile by reducing involuntary muscle movements.

Q: Why is ATRAFINE INJECTION used along with anesthesia?

A: ATRAFINE INJECTION is used along with anesthesia prior to the surgeries to
relax your muscles and to make you immobile. It also helps with artificial
breathing among patients in intensive care unit (ICU) by relaxing the airway
muscles and facilitates easy insertion of breathing tubes into the airways when
artificial breathing is necessary.

Q: What are the side effects of ATRAFINE INJECTION?

A: The most common side effects of receiving ATRAFINE INJECTION are pain and
irritation at the site of injection, slow or fast heart rate, low or high blood
pressure and difficulty in breathing. Inform your doctor if any of these
symptoms worsen.

Q: Can ATRAFINE INJECTION be reversed?

A: Yes. The effect of ATRAFINE INJECTION reverses on its own and 25% of recovery
is expected to occur in 25 to 45 min and 95% of recovery is expected to occur in
45 to 65 min.

Q: Is ATRAFINE INJECTION an anesthetic drug?

A: ATRAFINE INJECTION is a muscle relaxant, used as an adjuvant with anesthetic
medicine before undergoing a surgical procedure. It is not an anesthetic.

Q: Will I be staying awake after using ATRAFINE INJECTION?

A: ATRAFINE INJECTION only relaxes your skeletal muscles and does not affect
your consciousness. However, it might make you feel dizzy or faint. However,
when ATRAFINE INJECTION is used along with an anesthetic medication to create
numbness before surgery, you may become unconscious for a while. The anesthesia
used along with ATRAFINE INJECTION is the reason for unconsciousness.

Q: Is ATRAFINE INJECTION safe for use in pregnant women?

A: ATRAFINE INJECTION should be used in pregnant women only if it is considered
necessary by the physician. Therefore, inform your doctor if you are pregnant or
planning to become pregnant before receiving ATRAFINE INJECTION. Your doctor
will decide the risks and benefits before administrating ATRAFINE INJECTION to
you. However, ATRAFINE INJECTION can be used during a caesarean section in
pregnant women under close supervision.