VOKMOR 50MG CAPSULE 10'S

Introduction About VOKMOR

VOKMOR contains Diacerein which belongs to the group of medicines called
Anthraquinones. It is used for the symptomatic management of functional symptoms
of osteoarthritis.

Osteoarthritis is a common progressive disorder affecting primarily weight
bearing joints (knee, hip), characterised by progressive destruction of
cartilage causing pain, limitation of motion, stiffness, deformity and
disability.

Prior to the management, your doctor may want you to take several blood tests to
understand your existing condition like liver disease.

Avoid taking alcohol with VOKMOR as it may increase the risk of liver damage.
VOKMOR is not recommended for use in patients having liver or kidney disease,
colitis or crohn’s disease, partial or complete intestinal obstruction or
abdominal pain with an unknown cause.

Inform your doctor, if you have kidney or urinary problems, history of diarrhea,
irritable bowel disease, rare hereditary diseases such as congenital
galactosemia, glucose or galactose malabsor

VOKMOR is not recommended for use in pregnant and breastfeeding women. Contact
your doctor before taking.

VOKMOR is not recommended for use in children and adolescents under 15 years of
age. Contact your doctor before taking.

VOKMOR should be used with caution in elderly aged above 65 years. Contact your
doctor before taking.

The most common side effects of taking VOKMOR are diarrhea, soft stools, pain in
abdomen, frequent bowel movements, flatulence, skin rash, itching, and eczema.
Contact your doctor if any of the side effects worsen.

Uses Of VOKMOR

• Used for the symptomatic management of Osteoarthritis

How VOKMOR Works

VOKMOR works by blocking the chemicals (interleukin-1) causing inflammation and
destruction of cartilage in the body. It also stimulates the production of
certain chemicals called transforming growth factor-β (TGF-β) which triggers
chondrocyte proliferation and stimulates the production of collagen and
proteoglycan, glycosaminoglycans and hyaluronic acid. Therefore VOKMOR manages
the cartilage destruction and improves symptoms in patients with osteoarthritis.

How to use VOKMOR

Take VOKMOR as advised by your physician. Swallow the medicines with a glass of
water. Do not crush or chew the medicine. Your doctor will decide the correct
dose and duration for you depending upon your age, body weight and disease
condition.

Side Effects Of VOKMOR

Common

• diarrhea
• soft stools
• pain in abdomen
• frequent bowel movements
• flatulence
• skin rash, itching, eczema

Uncommon

• increased liver enzymes

Rare

• pigmentation of colorectal mucosa (melanosis coli)

Stop taking VOKMOR and contact your doctor immediately if you experience any of
the following side effects:

• diarrhea (risk of dehydration and hypokalemia)
• signs of liver disease such as increased liver enzyme, tiredness, and loss of appetite, jaundice (yellowish discoloration of skin and white of eyes), abdominal pain, nausea, vomiting, change in stool and urine colour, reduced consciousness, itchy skin

How To Manage Side Effects

!### Bloating

Eat smaller meals but take frequently and exercise regularly. If the symptom
does not improve, contact your doctor.

!### Diarrhea

Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not
take any medicine on your own for managing diarrhea. Contact your doctor if the
symptom did not improve.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate the skin. Do not scratch the
affected area. Use sunscreen and protective clothing when outdoors. Regularly
use unscented moisturizers to soothe and hydrate the affected area. If the
symptom does not improve, contact your doctor.

!### Stomach Pain

Rest and relax. Try to have smaller meals but take frequently. Keep a heat pad
on your stomach. Do not self-manage and contact your doctor if the symptom did
not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedVOKMOR is generally not recommended for use in pregnant women. Consult your
doctor before taking.

!### Breastfeeding

ContraindicatedVOKMOR is generally not recommended for use in breastfeeding women as it is not
known if this medicine passes into breast milk. Consult your doctor before
taking.

!### Alcohol

Consult your doctorAvoid consum
liver damage.

!### Kidney

ContraindicatedVOKMOR is not recommended for use in patients with severe kidney disease.
Consult your doctor before taking.

!### Liver

ContraindicatedVOKMOR is not recommended for use in patients with liver disease. Consult your
doctor before taking.

!### Allergy

ContraindicatedDo not take VOKMOR if you are allergic to Diacerein or any of the other
ingredients of this medicine.

!### Use In Pediatrics

ContraindicatedVOKMOR is generally not recommended for use in children and adolescents under 15
years of age. Consult your doctor before taking.

!### Use In Geriatrics

ContraindicatedVOKMOR is not recommended for use in elderly patients aged above 65 years.
Consult your doctor before taking.

Others

VOKMOR is not recommended for use if you have:

• colitis or crohn’s disease
• partial or complete intestinal obstruction
• abdominal pain with an unknown cause
• rapidly progressive (worsening) hip osteoarthritis

Before taking VOKMOR, inform your doctor if you have:

• urinary system problems
• irritable bowel disease
• rare hereditary diseases such as congenital galactosemia, glucose or galactose malabsor

Interactions

A. Drug-Drug interactions:

Before taking VOKMOR, inform your doctor if you are taking any of the following
medicine:

• laxatives (medicines used to manage constipation)
• antacids (Ex. Aluminium hydroxide, magnesium hydroxide or calcium hydroxide) (medicines used to manage acidity)
• diuretics (medicines used for hypertension)
• digoxin, digitoxin (medicines used for heart failure)
• amoxicillin/clavul
• chemotherapy (medicines used to manage cancer)

Overdosage:

If you or anyone else accidentally takes too much of VOKMOR, consult your doctor
immediately or visit the nearby hospital. Symptoms of overdose are diarrhea.

Synopsis

Drug	:	Diacerein
Pharmacological Category	:	Anthraquinones
Therapeutic Indication	:	Osteoarthritis
Dosage Forms	:	Tablet, Capsule

More Information

Storage

• Keep VOKMOR out of the sight and reach of children
• Store VOKMOR below 25°C

FAQs About VOKMOR

Q: Is VOKMOR a painkiller?

A: No. VOKMOR belongs to a group of medicines called Anthraquinones with mild
anti-inflammatory and anti-catabolic properties. Contact your doctor before
taking.

Q: What is VOKMOR is used for?

A: VOKMOR is used for the symptomatic management of functional symptoms of
osteoarthritis.

Q: Who should avoid taking VOKMOR?

A: VOKMOR is avoided in patients with liver or kidney disease, colitis or
crohn’s disease, partial or complete intestinal obstruction or abdominal pain
with an unknown cause, rapidly progressive osteoarthritis of hip, allergic to
VOKMOR or rhein, pregnant or lactating women, children and elderly patients.
Consult your doctor before taking.

Q: Can I take alcohol while using VOKMOR?

A: No. Do not take alcohol with VOKMOR as it may increases the risk of liver
damage. Contact your doctor before taking.

Q: What are the side effects of VOKMOR?

A: The most common side effects of taking VOKMOR are diarrhea, soft stools, pain
in abdomen, frequent bowel movements, flatulence, skin rash, itching, and
eczema.

Q: How VOKMOR works?

A: VOKMOR belongs to proteoglycan synthesis stimulator which works by building
cartilage (soft connective tissue around the joints) leading to joint repair. It
also lowers pain and inflammation (swelling).

Q: Does VOKMOR cause liver damage?

A: Yes. VOKMOR may increase the risk of liver injury. If you experience any
unusual symptoms like tiredness, anorexia, yellowish discoloration of skin and
white of eyes (jaundice), abdominal pain, nausea, vomiting, change in stool and
urine colour, itchy skin. Stop taking VOKMOR and immediately consult your
doctor.

Useful Diagnostic Tests

• Calcium
• Rheumatoid Factor IgG Antibody
• Rheumatoid Factor IgM Antibody