Topcerin 50mg Capsule 10'S

Introduction About TOPCERIN 50MG CAPSULE

TOPCERIN 50MG CAPSULE contains Diacerein which belongs to the group of medicines
called Anthraquinones. It is used for the symptomatic management of functional
symptoms of osteoarthritis.

Osteoarthritis is a common progressive disorder affecting primarily weight
bearing joints (knee, hip), characterised by progressive destruction of
cartilage causing pain, limitation of motion, stiffness, deformity and
disability.

Prior to the management, your doctor may want you to take several blood tests to
understand your existing condition like liver disease.

Avoid taking alcohol with TOPCERIN 50MG CAPSULE as it may increase the risk of
liver damage. TOPCERIN 50MG CAPSULE is not recommended for use in patients
having liver or kidney disease, colitis or crohn’s disease, partial or complete
intestinal obstruction or abdominal pain with an unknown cause.

Inform your doctor, if you have kidney or urinary problems, history of diarrhea,
irritable bowel disease, rare hereditary diseases such as congenital
galactosemia, glucose or galactose malabsor

TOPCERIN 50MG CAPSULE is not recommended for use in pregnant and breastfeeding
women. Contact your doctor before taking.

TOPCERIN 50MG CAPSULE is not recommended for use in children and adolescents
under 15 years of age. Contact your doctor before taking.

TOPCERIN 50MG CAPSULE should be used with caution in elderly aged above 65
years. Contact your doctor before taking.

The most common side effects of taking TOPCERIN 50MG CAPSULE are diarrhea, soft
stools, pain in abdomen, frequent bowel movements, flatulence, skin rash,
itching, and eczema. Contact your doctor if any of the side effects worsen.

Uses Of TOPCERIN 50MG CAPSULE

• Used for the symptomatic management of Osteoarthritis

How TOPCERIN 50MG CAPSULE Works

TOPCERIN 50MG CAPSULE works by blocking the chemicals (interleukin-1) causing
inflammation and destruction of cartilage in the body. It also stimulates the
production of certain chemicals called transforming growth factor-β (TGF-β)
which triggers chondrocyte proliferation and stimulates the production of
collagen and proteoglycan, glycosaminoglycans and hyaluronic acid. Therefore
TOPCERIN 50MG CAPSULE manages the cartilage destruction and improves symptoms in
patients with osteoarthritis.

How to use TOPCERIN 50MG CAPSULE

Take TOPCERIN 50MG CAPSULE as advised by your physician. Swallow the medicines
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of TOPCERIN 50MG CAPSULE

Common

• diarrhea
• soft stools
• pain in abdomen
• frequent bowel movements
• flatulence
• skin rash, itching, eczema

Uncommon

• increased liver enzymes

Rare

• pigmentation of colorectal mucosa (melanosis coli)

Stop taking TOPCERIN 50MG CAPSULE and contact your doctor immediately if you
experience any of the following side effects:

• diarrhea (risk of dehydration and hypokalemia)
• signs of liver disease such as increased liver enzyme, tiredness, and loss of appetite, jaundice (yellowish discoloration of skin and white of eyes), abdominal pain, nausea, vomiting, change in stool and urine colour, reduced consciousness, itchy skin

How To Manage Side Effects

!### Bloating

Eat smaller meals but take frequently and exercise regularly. If the symptom
does not improve, contact your doctor.

!### Diarrhea

Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not
take any medicine on your own for managing diarrhea. Contact your doctor if the
symptom did not improve.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate the skin. Do not scratch the
affected area. Use sunscreen and protective clothing when outdoors. Regularly
use unscented moisturizers to soothe and hydrate the affected area. If the
symptom does not improve, contact your doctor.

!### Stomach Pain

Rest and relax. Try to have smaller meals but take frequently. Keep a heat pad
on your stomach. Do not self-manage and contact your doctor if the symptom did
not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedTOPCERIN 50MG CAPSULE is generally not recommended for use in pregnant women.
Consult your doctor before taking.

!### Breastfeeding

ContraindicatedTOPCERIN 50MG CAPSULE is generally not recommended for use in breastfeeding
women as it is not known if this medicine passes into breast milk. Consult your
doctor before taking.

!### Alcohol

Consult your doctorAvoid consum
the risk of liver damage.

!### Kidney

ContraindicatedTOPCERIN 50MG CAPSULE is not recommended for use in patients with severe kidney
disease. Consult your doctor before taking.

!### Liver

ContraindicatedTOPCERIN 50MG CAPSULE is not recommended for use in patients with liver disease.
Consult your doctor before taking.

!### Allergy

ContraindicatedDo not take TOPCERIN 50MG CAPSULE if you are allergic to Diacerein or any of the
other ingredients of this medicine.

!### Use In Pediatrics

ContraindicatedTOPCERIN 50MG CAPSULE is generally not recommended for use in children and
adolescents under 15 years of age. Consult your doctor before taking.

!### Use In Geriatrics

ContraindicatedTOPCERIN 50MG CAPSULE is not recommended for use in elderly patients aged above
65 years. Consult your doctor before taking.

Others

TOPCERIN 50MG CAPSULE is not recommended for use if you have:

• colitis or crohn’s disease
• partial or complete intestinal obstruction
• abdominal pain with an unknown cause
• rapidly progressive (worsening) hip osteoarthritis

Before taking TOPCERIN 50MG CAPSULE, inform your doctor if you have:

• urinary system problems
• irritable bowel disease
• rare hereditary diseases such as congenital galactosemia, glucose or galactose malabsor

Interactions

A. Drug-Drug interactions:

Before taking TOPCERIN 50MG CAPSULE, inform your doctor if you are taking any of
the following medicine:

• laxatives (medicines used to manage constipation)
• antacids (Ex. Aluminium hydroxide, magnesium hydroxide or calcium hydroxide) (medicines used to manage acidity)
• diuretics (medicines used for hypertension)
• digoxin, digitoxin (medicines used for heart failure)
• amoxicillin/clavul
• chemotherapy (medicines used to manage cancer)

Overdosage:

If you or anyone else accidentally takes too much of TOPCERIN 50MG CAPSULE,
consult your doctor immediately or visit the nearby hospital. Symptoms of
overdose are diarrhea.

Synopsis

Drug	:	Diacerein
Pharmacological Category	:	Anthraquinones
Therapeutic Indication	:	Osteoarthritis
Dosage Forms	:	Tablet, Capsule

More Information

Storage

• Keep TOPCERIN 50MG CAPSULE out of the sight and reach of children
• Store TOPCERIN 50MG CAPSULE below 25°C

FAQs About TOPCERIN 50MG CAPSULE

Q: Is TOPCERIN 50MG CAPSULE a painkiller?

A: No. TOPCERIN 50MG CAPSULE belongs to a group of medicines called
Anthraquinones with mild anti-inflammatory and anti-catabolic properties.
Contact your doctor before taking.

Q: What is TOPCERIN 50MG CAPSULE is used for?

A: TOPCERIN 50MG CAPSULE is used for the symptomatic management of functional
symptoms of osteoarthritis.

Q: Who should avoid taking TOPCERIN 50MG CAPSULE?

A: TOPCERIN 50MG CAPSULE is avoided in patients with liver or kidney disease,
colitis or crohn’s disease, partial or complete intestinal obstruction or
abdominal pain with an unknown cause, rapidly progressive osteoarthritis of hip,
allergic to TOPCERIN 50MG CAPSULE or rhein, pregnant or lactating women,
children and elderly patients. Consult your doctor before taking.

Q: Can I take alcohol while using TOPCERIN 50MG CAPSULE?

A: No. Do not take alcohol with TOPCERIN 50MG CAPSULE as it may increases the
risk of liver damage. Contact your doctor before taking.

Q: What are the side effects of TOPCERIN 50MG CAPSULE?

A: The most common side effects of taking TOPCERIN 50MG CAPSULE are diarrhea,
soft stools, pain in abdomen, frequent bowel movements, flatulence, skin rash,
itching, and eczema.

Q: How TOPCERIN 50MG CAPSULE works?

A: TOPCERIN 50MG CAPSULE belongs to proteoglycan synthesis stimulator which
works by building cartilage (soft connective tissue around the joints) leading
to joint repair. It also lowers pain and inflammation (swelling).

Q: Does TOPCERIN 50MG CAPSULE cause liver damage?

A: Yes. TOPCERIN 50MG CAPSULE may increase the risk of liver injury. If you
experience any unusual symptoms like tiredness, anorexia, yellowish
discoloration of skin and white of eyes (jaundice), abdominal pain, nausea,
vomiting, change in stool and urine colour, itchy skin. Stop taking TOPCERIN
50MG CAPSULE and immediately consult your doctor.

Useful Diagnostic Tests

• Calcium
• Rheumatoid Factor IgG Antibody
• Rheumatoid Factor IgM Antibody