TRET 0.025% Gel 15gm

INTRODUCTION ABOUT TRET 0.025% GEL

TRET 0.025% GEL contains Tretinoin, which belongs to the group of medicines
called Retinoids. It is used to manage acne. It can also be used to manage
wrinkles, skin spots and rough skin. Acne is defined as a skin disease involving
inflammation of the sebaceous follicles of the face and upper body,
characterized by lesions on the face, back, upper chest and shoulders.

Before using TRET 0.025% GEL, inform your doctor if you have any sunburn, sun
sensitivity or any other skin problems. TRET 0.025% GEL should be used in
pregnancy only if specifically directed by your doctor. TRET 0.025% GEL should
be used with caution in breastfeeding women.

The safety and effectiveness of TRET 0.025% GEL in children (aged less than 12
years) have not been established, so consult your doctor before using it. The
most common side effect of using TRET 0.025% GEL is skin irritation like
redness, burning, stinging, dryness and peeling. Contact your doctor if any of
the side effects worsen.

USES OF TRET 0.025% GEL

• It is used to manage acne, wrinkles, skin spots and rough skin.

HOW TRET 0.025% GEL WORKS

TRET 0.025% GEL works by modifying the abnormal cavity formation that comes from
the excessive conversion of cytoplasm to keratin (a strong protein that is the
main substance that forms hair, skin, etc.) of epithelial cells, promoting
detachment of tough cells and enhancing shedding.

DIRECTIONS FOR USE

Apply TRET 0.025% GEL as advised by your physician. It is for external use only.
Your doctor will decide the correct dose and duration for you depending on your
age, body weight and disease condition.

SIDE EFFECTS OF TRET 0.025% GEL

COMMON

• skin irritation like redness, burning, stinging, dryness and peeling

RARE

Stop using TRET 0.025% GEL and contact your doctor immediately if you experience
any of the following side effects:

• excessive redness, swelling, blistering or crusting
• allergic reaction (rash, hives or peeling skin with or without fever, wheezing, chest or throat tightness, trouble breathing, swallowing or talking, abnormal hoarseness, swelling of the mouth, face, lips, tongue or throat)

WARNING & PRECAUTIONS

!### PREGNANCY

TRET 0.025% GEL should be used in pregnant women only if specifically directed
by your doctor. Consult your doctor before using it.

!### BREASTFEEDING

TRET 0.025% GEL should be used with caution in breastfeeding women. Consult your
doctor before using it.

!### ALLERGY

Do not use TRET 0.025% GEL if you are allergic to Tretinoin or any of the other
ingredients of this medicine.

OTHERS

TRET 0.025% GEL is not recommended for use if you:

• are sunburned
• have eczema or other skin conditions

Before applying TRET 0.025% GEL, inform your doctor if you:

• have sun-sensitive skin

Use in pediatrics:

The safety and effectiveness of TRET 0.025% GEL in children (aged less than 12
years) have not been established. Consult your doctor before using it.

Use in geriatrics:

The safety and effectiveness of TRET 0.025% GEL in elderly patients (65 years
and older) have not been established. Consult your doctor before using it.

INTERACTIONS

A. Drug-Drug interactions:

Before using TRET 0.025% GEL, inform your doctor if you are taking any of the
following medicines:

• other medicines used to manage acne (Ex. benzoyl peroxide, resorcinol, salicylic acid)
• medicated or abrasive soaps and cleansers
• medicines containing high concentrations of alcohol, astringents or spices

B. Drug-Food interactions:

Avoid contact of the skin with the lime peel during management with TRET 0.025%
GEL.

Overdosage:

If you or anyone else accidentally applied too much of TRET 0.025% GEL, contact
your doctor immediately. Symptoms of overdose include irritation or increased
irritation of your skin.

SYNOPSIS

Drug	:	Tretinoin
Pharmacological Category	:	Retinoids
Therapeutic Indication	:	Acne
Dosage Forms	:	Capsule, Cream, Gel, Gel (Topical)

MORE INFORMATION

• Keep TRET 0.025% GEL out of reach of children
• Store below 25°C

FAQs ABOUT TRET 0.025% GEL

Q: Can the use of TRET 0.025% GEL manage wrinkles?

A: TRET 0.025% GEL contains tretinoin, which is a derivative of vitamin A and is
commonly used for various skin conditions, including acne and photoaging (skin
aging caused by sun exposure). Tretinoin is known for its ability to stimulate
collagen production and promote skin cell turnover, which can lead to
improvements in skin texture and appearance. For wrinkles, tretinoin can be
effective in reducing fine lines and improving skin elasticity. It works by
increasing cell turnover and promoting the production of collagen, which can
help to smooth out wrinkles over time. However, it does not completely manage
wrinkles.

Q: How long does it take for TRET 0.025% GEL to show results?

A: Results from TRET 0.025% GEL, containing tretinoin, vary among individuals.
Generally, noticeable improvements in skin texture and wrinkle reduction may
take several weeks to months. In the initial 2-4 weeks, users may experience
skin adjustment, potentially including redness or flakiness. Over the first 2-3
months, fine lines may begin to diminish as collagen production increases.
Long-term and consistent use (3-6 months and beyond) is often necessary for the
most significant improvements. Following dermatologist instructions and using
sunscreen is crucial due to increased skin sensitivity. Individual responses
differ, so patience is essential, and any concerns should be addressed with a
dermatologist.

Q: Can TRET 0.025% GEL remove dark spots?

A: TRET 0.025% GEL containing tretinoin, can help reduce the appearance of dark
spots by promoting skin cell turnover and inhibiting mel
it may not completely manage dark spots, consistent and long-term use, along
with sun protection, can lead to noticeable improvements. For a comprehensive
approach, consulting with a dermatologist is recommended.

Q: Can I use TRET 0.025% GEL daily?

A: TRET 0.025% GEL should be used under careful medical supervision. Your doctor
might recommend you to consistently use this medicine for a longer period of
time to achieve best results. Following dermatologist instructions and using
sunscreen is crucial due to increased skin sensitivity. It is important to stay
with patience to notice results and if any concerns arise, kindly consult your
doctor.

Q: Does retinol brighten your skin?

Yes, retinol is a vitamin A derivative with powerful antioxidant properties. It
can contribute to skin brightening by promoting cell turnover and reducing
hyperpigmentation, resulting in a more even complexion.

Q: What is acne?

Acne is a common skin condition characterized by the presence of pimples,
blackheads, whiteheads, and inflammation, often caused by clogged hair follicles
and the overproduction of oil. It is primarily caused by a combination of
factors, including excess oil production, clogged hair follicles, bacteria
(Propionibacterium acnes), and inflammation. Hormonal changes, genetics, certain
medications, and lifestyle factors can also contribute to the development of
acne.

Q: What precautions should I take while using TRET 0.025% GEL?

A: Do not use TRET 0.025% GEL on sunburned skin, cuts, scrapes, eczema or
damaged skin. Practice good skin care and avoid exposure to sunlight as you may
get sunburned more easily. Use sunscreen and wear clothing and eyewear to
protect your skin from the sun. Some weather conditions may irritate your skin.
Talk with your doctor in such a case.

Q: Can I use makeup during management with TRET 0.025% GEL?

A: While using TRET 0.025% GEL, it is advisable to be cautious with makeup
application, especially during the initial stages of management as the tretinoin
present in the medicine can make your skin more sensitive and prone to
irritation.

Q: Can I use other skin preparations with TRET 0.025% GEL?

A: Do not use any other skin preparations with TRET 0.025% GEL without asking
your doctor. Avoid preparations that may dry or irritate your skin, like those
containing astringents, alcohol, spices or lime or certain medicated soaps,
shampoos, etc. Do not allow anyone else to use this medication. Do not use other
medicines containing retinoids which are not recommended by your doctor, as it
might cause unnecessary redness or peeling.

Q: Can the use of TRET 0.025% GEL make your skin dry?

A: Dry skin especially on your nose and lips is a prevalent side effect of using
TRET 0.025% GEL. It happens because the tretinoin present in the medicine
reduces sebum secretion on your skin. To combat this, keep yourself hydrated by
drinking plenty of water and fluids, Apply a moisturizer and lip balm that suits
your skin as advised by your physician.

Q. Is TRET 0.025% GEL safe?

A: The safety of using TRET 0.025% GEL depends on individual factors and skin
sensitivity. Consultation with a dermatologist is recommended to determine its
suitability for your specific skin type and concerns. The most common side
effect of using TRET 0.025% GEL is skin irritation like redness, burning,
stinging, dryness and peeling. Contact your doctor if any of the side effects
worsen.

Q. Can TRET 0.025% GEL be used in pregnant women?

A: TRET 0.025% GEL is not recommended for use in pregnant women as it may harm
the growing baby. Therefore, it is important to consult your doctor before using
TRET 0.025% GEL if you are pregnant or planning to become pregnant.

REFERENCES

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro.
   Acne Vulgaris. Pharmacotherapy Handbook. Ninth edition. Page- 135.

2. Athina L. Yoham; Damian Casadesus. Tretinoin. StatPearls [Internet].
   StatPearls Publishing. March 2022. [Accessed on 24th June
   2022]

3. Ortho-McNeil Pharmaceutical, Inc. U.S. Food & Drug Administration. [Revised
   in June 2022] [Accessed on 24th June
   2022]

4. DPT Laboratories. U.S. Food & Drug Administration. [Revised in January 2012]
   [Accessed on 24th June
   2022]

5. Memorial Sloan Kettering Cancer Center. Tretinoin. [Revised in June 2022]
   [Accessed on 24th June
   2022]