TOIN 100 Tablet 100's

Introduction About TOIN 100 TABLET

TOIN 100 TABLET contains Phenytoin which belongs to the group of medicines
called Anti-epile
(fits or seizures) during or after brain surgery or severe head injury. Epilepsy
is defined by the occurrence of at least two unprovoked seizures with or without
fits (strong, involuntary contractions of the voluntary muscles) parted by at
least 24 hours. A seizure results from an excessive discharge of specific nerve
cells and it is characterized by changes in electrical activity (detected by
electroencephalogram (EEG). TOIN 100 TABLET is also used to manage trigeminal
neuralgia (facial nerve pain).

During management with TOIN 100 TABLET, your doctor might ask you to take
several blood tests, to monitor any side effects, and to check the amount of
phenytoin in blood to make dose adjustments. You should brush and floss your
teeth and see a dentist regularly while taking TOIN 100 TABLET, to manage
overgrowth of gums.

Before taking TOIN 100 TABLET, inform your doctor if you have any liver or
kidney problems, or porphyria. Avoid consum
100 TABLET as it may affect its concentration in the blood. TOIN 100 TABLET
should be used with caution in pregnant women only if advised by the doctor as
it may cause harm to the unborn baby. Women of childbearing potential should use
a suitable non-hormonal contrace
taking TOIN 100 TABLET. It is not recommended for use in breastfeeding women.

Patients taking TOIN 100 TABLET may have self-harming thoughts. If at any time
you have these thoughts, immediately consult your doctor. TOIN 100 TABLET should
be cautiously used in children and in elderly patients, particularly with kidney
or liver problems. The most common side effects of taking TOIN 100 TABLET are
irregular or involuntary eye movements, slurred speech, drowsiness, problems
with movement and balance, decreased coordination and confusion. Consult your
doctor if any of the side effects worsen.

Uses Of TOIN 100 TABLET

It is used to:

• Manage certain forms of epilepsy (that occur during or after brain surgeries or severe head injury)
• Manage trigeminal neuralgia (facial nerve pain)

How TOIN 100 TABLET Works

TOIN 100 TABLET controls seizures (fits) by reducing the abnormal activity of
the nerve cells in the brain. It also reduces the pain by blocking the
transmission of pain signals across the nervous system thus reducing the
symptoms of trigeminal neuralgia.

How to use TOIN 100 TABLET

Take TOIN 100 TABLET as advised by your physician. Swallow TOIN 100 TABLET with
a glass of water. Do not crush or chew the medicine. Your doctor will determine
the correct dose and duration for you depending on your age, body weight and
disease condition. Do not stop taking TOIN 100 TABLET unless your doctor advises
you to stop.

Side Effects Of TOIN 100 TABLET

Common

• irregular or involuntary eye movements
• slurred speech
• drowsiness
• problems with movement and balance
• decreased coordination
• morbilliform (measles-like) rash
• confusion

Rare

• allergic reactions (such as a severe rash)
• drug reaction with eosinophilia and systemic symptoms (DRESS) (signs include fever, rash, facial swelling and enlarged lymph nodes)
• dyskinesias (impaired voluntary movement) including chorea (jerky involuntary movements of the shoulders, hips, and face), dystonia (muscular spasm and abnormal posture)
• shaking and asterixis (inability to maintain sustained posture with subsequent brief jerky involuntary movements)
• certain types of dermatitis (skin inflammation)

Stop taking TOIN 100 TABLET and contact your doctor immediately if you
experience any of the following side effects:

• severe allergic reactions (swelling of the eyelids, face, lips, mouth, throat and tongue which causes breathing or swallowing difficulties and sudden wheeziness)
• signs of blood abnormalities (bruising, fever, severe sore throat, paleness, decreased red and white blood cells or platelets)
• sudden stopping of the heart known as cardiac arrest (signs include shortness of breath, being unconscious or unresponsive)
• bradycardia (signs include dizziness, tiredness, slow or skipping heartbeats and chest pain)
• suicidal thoughts or actions (like thoughts or attempts of suicide or dying, new or worsened depression, anxiety or irritability, agitation or restlessness, p
• serious skin reactions (such as stevens-johnson syndrome, toxic epidermal necrolysis and acute generalized exanthematous pustulosis) accomp
• hypersensitivity reactions (skin rash and fever, swollen glands) and in severe cases it causes an inflammatory disease called systemic lupus erythematosus (signs include pain and swelling of the joints)
• have confusion or mental illness (signs of high amount of medicine in the blood)

How To Manage Side Effects

!### Dizziness Or Drowsiness

Try a few lifestyle changes to improve your energy levels when you feel drowsy
such as taking and maintaining a consistent sleep schedule. Exercise regularly
(such as daily walks or running) and eat a nutritious diet with plenty of whole
grains, legumes, fruits, and vegetables. Consult your doctor if the symptom
worsens.

!### Skin rash Or Itching

Avoid hot bathing because hot water can irritate the skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize the skin. Consult your doctor if the symptom worsens.

Warning & Precautions

!### Pregnancy

Use with CautionTOIN 100 TABLET should be used with caution in pregnant women as it may cause
harm to the unborn baby. Women of childbearing potential should use a suitable
non-hormonal contrace
100 TABLET. Consult your doctor before taking this medicine and inform your
doctor immediately if you become pregnant during management with TOIN 100
TABLET.

!### Breastfeeding

ContraindicatedTOIN 100 TABLET is not recommended for use in breastfeeding women as it passes
into breast milk. Consult your doctor before taking TOIN 100 TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you experience dizziness or drowsiness
while taking TOIN 100 TABLET.

!### Alcohol

Consult your doctorAvoid consum
the concentration of the medicine in the blood.

!### Kidney

Use with CautionTOIN 100 TABLET should be used with caution in patients with kidney disease.
Consult your doctor before taking TOIN 100 TABLET.

!### Liver

Use with CautionTOIN 100 TABLET should be used with caution in patients with liver disease.
Consult your doctor before taking TOIN 100 TABLET.

!### Allergy

ContraindicatedDo not take TOIN 100 TABLET if you are allergic to Phenytoin or any other
ingredients of this medicine, or similar medicines like hydantoins.

!### Heart Disease

Use with CautionTOIN 100 TABLET should be used with caution in patients with underlying cardiac
disease as it may increase the risk of cardiac arrest. Consult your doctor
before taking TOIN 100 TABLET.

!### Use In Pediatrics

Use with CautionGBNKEYWORD should be used with caution in children and adolescents. Your
child’s doctor may adjust the dose depending on the age and body weight of the
child. Consult your child’s doctor for advice.

![### Use In Geriatrics

Use with CautionTOIN 100 TABLET should be used with caution in elderly patients and the dose may
be adjusted in patients with kidney or liver disease and those taking other
medicines. Consult your doctor before taking TOIN 100 TABLET.

Others

Before taking TOIN 100 TABLET, inform your doctor if you:

• have porphyria (an inherited disease that affects haemoglobin biosynthesis)
• had or have depression, mood problems or self-harming thoughts
• had or have high blood sugar

Interactions

A. Drug-Drug interactions:

Before taking TOIN 100 TABLET, inform your doctor if you are taking any of the
following medicines:

• medicines used to manage heart and circulation problems (Ex. amiodarone, digoxin, furosemide, reserpine, warfarin, mexiletine, disopyramide and calcium channel blockers such as diltiazem, nicardipine, nifedipine, nimodipine, verapamil)
• medicines used to lower blood cholesterol (Ex. atorvastatin, fluvastatin and simvastatin)
• medicines used to manage epilepsy (Ex. oxcarbazepine, carbamazepine, topiramate, phenobarbital, lacosamide, lamotrigine, sodium valproate and valproic acid and succinimides such as ethosuximide, vigabatrin)
• medicines used to manage fungal infections (Ex. amphotericin B, fluconazole, itraconazole, ketoconazole, miconazole, posaconazole, voriconazole)
• medicines used to manage tuberculosis and other bacterial infections (Ex. isoniazid, chloramphenicol, sulphonamides such as sulfadiazine, rifampicin, doxycycline, clarithromycin, sulfamethoxazole trimethoprim, ciprofloxacin)
• medicines used in the management of HIV infection (Ex. indinavir, ritonavir, efavirenz, fosamprenavir, saquinavir)
• medicines used to manage stomach ulcers (Ex. omeprazole, sucralfate, cimetidine and antacids)
• theophylline (used to manage asthma and bronchitis)
• medicine used to manage pain (Ex. aspirin)
• medicines used to manage inflammation (Ex. prednisolone, dexamethasone)
• medicines used for sleeplessness, depression and psychiatric disorders (Ex. chlordiazepoxide, clozapine, diazepam, disulfiram, fluoxetine, methylphenidate, paroxetine, phenothiazines such as chlorpromazine, trazodone, tricyclic antidepressants such as amitriptyline, fluvoxamine, quetiapine, sertraline)
• tolbutamide (used to manage high blood sugar)
• medicines used to manage pregnancy (Ex. estradiol, desogestrel)
• medicines used to suppress the immune system and manage graft rejection (Ex. ciclosporin, tacrolimus)
• medicines used to manage cancer (Ex. capecitabine, carboplatin, bleomycin, cisplatin, doxorubicin, methotrexate, fluorouracil)
• medicines used to relax the muscles (Ex. rocuronium, vecuronium)
• methadone (medicine used to manage severe pain)
• medicines used to control blood clotting (Ex. rivaroxaban, dabigatran, apixaban, edoxaban, ticagrelor)
• non-prescri

Overdosage:

If you or anyone else accidentally take too much of TOIN 100 TABLET, consult
your doctor immediately or visit the nearby hospital. Overdosage symptoms of
TOIN 100 TABLET include nystagmus (rapid eye movements), ataxia (clumsy
movements), dysarthria (trouble speaking), shaking, hyperreflexia (overactive
bodily reflexes like twitching), lethargy, slurred speech, blurred vision,
nausea, vomiting, low blood pressure, low heart rate.

Synopsis

Drug	:	Phenytoin
Pharmacological Category	:	Anti-epile
Therapeutic Indication	:	Epilepsy, Trigeminal neuralgia
Dosage Forms	:	Injection, Tablet, Capsule, Syrup, Suspension

More Information

Storage

• Keep TOIN 100 TABLET out of reach of children
• Store at room temperature

FAQs About TOIN 100 TABLET

Q: How does TOIN 100 TABLET work in the body?

A: TOIN 100 TABLET controls seizures (fits) by reducing the abnormal activity of
the nerve cells in the brain. It also reduces the pain by blocking the
transmission of pain signals across the nervous system thus reducing the
symptoms of trigeminal neuralgia.

Q: Can I drink alcohol while taking TOIN 100 TABLET?

A: No, you are not advised to consume alcohol while taking TOIN 100 TABLET
because it may affect the concentration of the medicine in the blood and may
result in unwanted effects. Consult your doctor before taking TOIN 100 TABLET.

Q: Is TOIN 100 TABLET advised being taken during pregnancy?

A: TOIN 100 TABLET should be used with caution in pregnant women only if advised
by your doctor, as it may cause abnormalities in the unborn foetus. Women of
childbearing capability should use non-hormonal contrace
getting pregnant. If you are pregnant, think you may be pregnant or planning to
get pregnant, consult your doctor before taking it. Inform your doctor
immediately if you become pregnant during management with TOIN 100 TABLET.

Q: Can TOIN 100 TABLET be taken more than the recommended dose?

A: Do not take a higher dose of TOIN 100 TABLET without consulting your doctor.
Taking a higher dose of TOIN 100 TABLET may not be beneficial. Instead, it can
cause serious side effects. If the given dose is not effective for you, consult
your doctor. Your doctor may suggest a higher dose or an alternative therapy
after evaluating your disease condition.

Q: What happens if I suddenly discontinue the use of TOIN 100 TABLET on my own?

A: Suddenly stop taking TOIN 100 TABLET may lead to seizures which can be
life-threatening. Do not discontinue taking medicine on your own without
consulting your doctor. If required, your doctor will reduce the dose slowly
before completely stopping the TOIN 100 TABLET.

Q: What if I forget to take a dose of TOIN 100 TABLET?

A: If you forget to take a dose of TOIN 100 TABLET, take it as soon as you
remember. However, omit the missed dose if it's almost time for the next dose.
Do not take the medicine twice to make up for the missed dose.

Useful Diagnostic Tests

• Complete blood count
• Electroencephalogram (EEG)