Valrope Chrono 200mg Tablet 10'S

Introduction About VALROPE CHRONO 200MG TABLET

VALROPE CHRONO 200MG TABLET is a combination of Sodium valproate and Valproic
acid, which belong to the group of medicines called Anticonvulsant/Antiepile
drugs. It is used to manage epilepsy in adults and children. It is also used to
manage bipolar disorders. Epilepsy is an abnormal electrical activity in the
brain and nervous system. The symptoms may include temporary confusion, muscle
stiffness, jerky movements in legs or arms, loss of consciousness, psychological
symptoms (such as anxiety or fear), etc.

VALROPE CHRONO 200MG TABLET is not recommended for use in patients with liver
problems or with a family history of liver problems, porphyria (a hereditary
disease that affects the skin or nervous system), blood coagulation or clotting
disorders, pancreatic diseases (inflammation of the pancreas), urea cycle
disorder (a genetic disorder) or Alpers-Huttenlocher syndrome (a rare disorder
that affects brain, liver & muscles), etc.

VALROPE CHRONO 200MG TABLET should be used with caution in patients with kidney
problems or lung diseases (such as chronic obstructive pulmonary disease) and
diabetes. VALROPE CHRONO 200MG TABLET is also not recommended for use in
pregnant and breastfeeding women. It should be used with caution in children
(below 2 years of age). Consult your doctor before taking the medicine.

The common side effects of taking VALROPE CHRONO 200MG TABLET may include
dizziness, headache, sleep disorders, clumsiness/unsteadiness, trembling of
hands and arms and nervousness. Consult your doctor if any of the symptoms
worsen or persist.

Uses Of VALROPE CHRONO 200MG TABLET

• Manage epilepsy
• Manage bipolar disorders

How VALROPE CHRONO 200MG TABLET Works

VALROPE CHRONO 200MG TABLET helps in managing epilepsy, where sodium valproate
and valproic acid effectively increases the GABA (a neurotransmitter/chemical
messenger) concentration in the central nervous system by reducing its
degradation. It also blocks certain ion channels which reduce high-frequency
neuronal activity in the brain, thereby reliving seizure activity.

How to use VALROPE CHRONO 200MG TABLET

Take VALROPE CHRONO 200MG TABLET as advised by your physician. Swallow the
medicine with a glass of water with or after food. Do not crush or chew the
medicine. Your doctor will decide the correct dose and duration for you
depending on your age, body weight and disease condition.

Side Effects Of VALROPE CHRONO 200MG TABLET

Common

• headache
• sleep disorders
• clumsiness or unsteadiness
• trembling of hands and arms
• nervousness
• changing moods
• blurred vision
• ringing in ears
• deafness
• dizziness
• flu
• abdominal or stomach pain
• heartburn
• nausea and vomiting
• diarrhoea
• skin rash
• hair loss or thinning of hair
• back pain
• change in menstrual periods
• lack or loss of strength
• mental confusion
• aggression
• convulsion
• memory problems
• becoming unreactive
• bedwetting
• signs of liver damage such as skin and eyes that appear yellowish (jaundice), abdominal pain and swelling.
• signs of inflammation of the pancreas (pancreatitis) such as upper abdominal pain, abdomen tenderness, fever and rapid pulse
• signs of Fanconi syndrome (a disorder of kidney tubes) such as excessive thirst, urination, vomiting
• overgrown gum tissue
• agitation
• disturbance in attention
• abnormal behaviour
• hyperactivity
• learning disorder

Uncommon

• unusual bleeding or bruising
• abnormal dreams
• anxiety
• feeling sad
• irritability
• pain in joints
• cough
• constipation
• dry eyes
• spots before the eyes
• ear infection
• ear pain
• runny nose
• dental pain
• bloating
• muscle pains or stiffness
• tiredness
• weight gain or loss
• learning disorder
• coma
• loss of muscle control
• brittle bones and fractures
• shortness of breath
• chest pain
• blood clotting problems

Rare

Stop taking VALROPE CHRONO 200MG TABLET and contact your doctor if you
experience any of the following side effects:

• signs of allergic reactions such as swelling of the face, lips, eyelids, throat and tongue, which may cause difficulty in breathing and swallowing
• signs of altered levels of ammonia in the blood characterized by vomiting, balance issues and lack of alertness
• signs of liver problems characterized by nausea, vomiting, tiredness, sleepiness, weakness, stomach pain, yellowing of the skin or whites of the eye
• signs of inflammation of the pancreas characterized by acute abdominal pain
• chest pain
• shortness of breath
• hallucinations
• suicidal thoughts
• psychosis (mental disorder causing disconnection from reality)
• toxic epidermal necrolysis (life-threatening skin disorder causing widespread skin pain, rashes, blisters, sores and crusting)
• Steven-Johnson syndrome (a skin disorder characterized by painful rashes and blisters on the skin)
• anaphylaxis (severe allergic reaction characterized by shortness of breath, fainting or fastened heartbeat)
• erythema multiforme (a skin condition characterized by raised red rashes on the skin)
• polycystic ovarian syndrome (a disorder of ovaries characterized by irregular periods, hair growth on the skin, acne and weight gain)
• brain diseases such as cerebral pseudo atrophy (loss of brain cells), encephalopathy (disease altering brain structure and functions) and coma (loss of consciousness)
• signs of thrombocytopenia (a condition marked by decreased platelet count) such as spontaneous bruising or bleeding
• signs of agranulocytosis (severe decrease of white blood cells or bone marrow failure) such as fever and breathing difficulty
• signs of anaemia (decreased red blood cell count) as weakness, dizziness, pale skin and shortness of breath
• signs of macrocytosis (abnormally increased red blood cell size) such as brittle nails, loss of weight or diarrhoea
• signs of pancytopenia (decreased blood cells and platelets) such as weakness, dizziness, pale skin and shortness of breath
• drowsiness
• change in consciousness level (including coma)
• confusion
• memory loss
• abnormal behaviour such as changes in attention, concentration, mood, hallucinations or fits of more frequency and severity
• signs of hypothyroidism (underactive thyroid gland) such as tiredness or weight gain
• signs of pleural effusion (build-up of fluid between the tissues that line the lungs and the chest) such as breathing difficulty and pain
• increase in the number and severity of convulsions
• signs of rhabdomyolysis (a disorder caused by the breakdown of muscle tissue) such as muscle pain and weakness
• signs of systemic lupus erythematosus (autoimmune disorder) such as joint pain, fever, fatigue or rash
• signs of increased ammonia in the blood, such as problems in balancing and co-ordination, feeling lethargic or less alert associated with vomiting
• shakiness (tremor)
• jerky muscle movements
• unsteadiness when walking due to parkinsonism (brain disorder), extrapyramidal disorder or ataxia (a disorder marked by impaired coordination)
• uncontrollable and rapid movement of the eyes
• signs of kidney disease such as renal failure, tubulointerstitial nephritis such as blood in the urine, fever, increased or decreased urine output, weakness, confusion
• signs of Fanconi syndrome (a disorder of kidney tubes) such as excessive thirst, urination and vomiting m
• signs of decreased blood sodium levels such as confusion
• confusion that occurs due to decreased sodium levels in blood and syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion (a condition marked by high levels of the antidiuretic hormone that causes retention of water in the body)

How To Manage Side Effects

Headache:

Drink sufficient water and take plenty of rest. Do not skip meals. Do not take
mental stress and strain your eyes. Consult your doctor if the condition
persists or get worse in time.

Dizziness:

Lie down until the dizziness fades away and get up slowly. Do not attempt sudden
head movements. Take adequate rest. Consult your doctor if the condition
persists for long or gets worsened.

Diarrhoea:

Stay hydrated by consuming sufficient amount of water or fruit juice. Avoid
taking medicine on your own to manage diarrhoea. Consult your doctor if the
symptom gets worse or persist.

Constipation:

Consume healthy foods with high-fiber foods such as fresh fruit and vegetables,
cereals and drink plenty of water. Maintain doing regular exercise, such as
walking and running. Consult your doctor if the symptom gets worse or persist.

Nausea and vomiting:

Try to take VALROPE CHRONO 200MG TABLET with or just after a meal or a snack.
Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if
the symptom get worse.

Warning & Precautions

!### Pregnancy

VALROPE CHRONO 200MG TABLET is not recommended for use by pregnant women. Women
with childbearing potential should use effective contrace
taking VALROPE CHRONO 200MG TABLET. Consult your doctor before taking the
medicine.

!### Breastfeeding

VALROPE CHRONO 200MG TABLET is not recommended for use by breastfeeding mothers,
as it may pass through breastfed milk. Consult your doctor before taking VALROPE
CHRONO 200MG TABLET.

!### Driving and Using Machines

Avoid driving or operating machines, if you feel drowsy or sleepy after taking
VALROPE CHRONO 200MG TABLET.

!### Alcohol

Avoid consuming alcohol while taking VALROPE CHRONO 200MG TABLET.

!### Kidney

VALROPE CHRONO 200MG TABLET should be used with caution in patients with kidney
diseases. Consult your doctor for advice before taking VALROPE CHRONO 200MG
TABLET.

!### Liver

VALROPE CHRONO 200MG TABLET is not recommended for use in patients with liver
problems or any family history of liver problems such as severe hepatic
dysfunction, particularly due to some medicine. Consult your doctor for advice
before taking VALROPE CHRONO 200MG TABLET.

!### Allergy

VALROPE CHRONO 200MG TABLET is not recommended for use if you are allergic to
Valproic acid, Sodium valproate or any other ingredients in this medicine.

!### Lungs

VALROPE CHRONO 200MG TABLET should be used with caution in patients with lung
diseases such as chronic obstructive pulmonary disease. Consult your doctor for
advice before taking VALROPE CHRONO 200MG TABLET.

Others

VALROPE CHRONO 200MG TABLET is not recommended for use if you:

• have porphyria (a hereditary disease that affects the skin or nervous system)
• have blood coagulation or clotting disorders such as deep vein thrombosis, pulmonary embolism
• have pancreatic diseases
• have signs of urea cycle disorder (excessive ammonia build-up in the body) such as loss of appetite, vomiting and lethargy that causes excessive ammonia builds up in the body
• have a genetic disorder called Alpers-Huttenlocher syndrome (a progressive, neurodevelopmental syndrome characterized by three co-occurring clinical symptoms which are psychomotor regression (dementia); seizures; and liver disease)

Before taking VALROPE CHRONO 200MG TABLET, inform your doctor if you:

• have diabetes
• are scheduled for surgery such as dental surgery
• have systemic lupus erythematosus (a disease of the immune system that affects bones, joints and body organs)
• have a certain brain disease or any metabolic condition affecting your brain such as hypoglycaemic encephalopathy
• have a deficiency condition such as carnitine palmitoyl transferase type II deficiency (a condition that manages the body from using certain fats for energy, particularly during periods without food)

Use in Paediatrics:

VALROPE CHRONO 200MG TABLET should be used with caution in children (below 2
years of age). Consult your doctor before taking VALROPE CHRONO 200MG TABLET.

Use in Geriatrics:

VALROPE CHRONO 200MG TABLET should be used with caution in elderly patients
(aged above 68 years). Consult your doctor before taking VALROPE CHRONO 200MG
TABLET.

Interactions

A. Drug-Drug Interactions:

Before taking VALROPE CHRONO 200MG TABLET, inform your doctor, if you are taking
any of the following medicine:

• medicines used to manage depression or Parkinson’s disease, such as monoamine oxidase inhibitors (MAOI) Ex. selegiline, phenelzin
• medicines used to manage emotional and mental conditions Ex. diazepam, olanzapine
• medicine used to manage HIV infection Ex. zidovudine
• medicines used for thinning the blood Ex. warfarin
• other medicines used to manage epilepsy Ex. phenytoin, phenobarbital, carbamazepine, primidone, rufinamide, topiramate, acetazolamide, lamotrigine and felbamate
• medicines used to manage pain and inflammation such as salicylates Ex. aspirin
• medicines used to manage malaria Ex. mefloquine, chloroquine
• medicines used to manage stomach ulcers Ex. cimetidine
• antibiotics or medicines used to manage bacterial infections such as carbapenem agents Ex. imipenem, meropenem, ertapenem, erythromycin
• medicines used to lower blood cholesterol Ex. cholestyramine
• medicines used to manage tuberculosis Ex. rifampicin
• medicines used to manage cancer Ex. temozolomide
• medicines used to manage bleeding in the brain Ex. nimodipine
• medicines used to anaesthetise Ex. Propofol
• medicines used for birth control Ex. oestrogen-containing products
• medicines used to manage pain and fever Ex. metamizole

Overdosage

If you or anyone else accidentally takes too much of VALROPE CHRONO 200MG
TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms
of overdose may include nausea, vomiting, headache, blurred vision, dizziness,
poor reflexes, confusion, memory loss, tiredness, muscle weakness, fits, loss of
consciousness, behavioural changes and breathing difficulties such as fast
breathing or shortness of breath or chest pain.

Synopsis

Drug	:	Sodium valproate, Valproic acid
Pharmacological Category	:	Anticonvulsants/Antiepile
Therapeutic Indication	:	Epilepsy, Bipolar disorder
Dosage Forms	:	Tablet

More Information

• Keep VALROPE CHRONO 200MG TABLET out of reach from children
• Store VALROPE CHRONO 200MG TABLET at room temperature

FAQs About VALROPE CHRONO 200MG TABLET

What VALROPE CHRONO 200MG TABLET is used for?

VALROPE CHRONO 200MG TABLET is used to manage epilepsy in adults and children.
It is also used to manage bipolar disorders in affected individuals. Epilepsy is
a disorder of the brain and nervous system characterized by repeated seizures
(at least two unprovoked seizures within 24 hours). Consult your doctor before
taking.

What happens if you take more VALROPE CHRONO 200MG TABLET than your required
dose?

If you or anyone else accidentally takes too much of VALROPE CHRONO 200MG
TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms
of overdose may include nausea, vomiting, headache, blurred vision, dizziness,
poor reflexes, confusion, memory loss, tiredness, muscles weakness, fits, loss
of consciousness, behavioural changes and breathing difficulties such as fast
breathing or shortness of breath or chest pain.

What side effects are seen with VALROPE CHRONO 200MG TABLET?

The common side effects of taking VALROPE CHRONO 200MG TABLET are dizziness,
headache, sleep disorders, clumsiness/unsteadiness, trembling of hands and arms
and nervousness. Consult your doctor before taking it.

Who should avoid taking VALROPE CHRONO 200MG TABLET?

VALROPE CHRONO 200MG TABLET is not recommended for use in patients with liver
problems or with history of liver problems in the family, particularly due to
some medicine. It is not recommended for use in patients with porphyria (a
hereditary disease that affects the skin or nervous system), blood clotting
disorders or pancreatic diseases (inflammation of the pancreas). VALROPE CHRONO
200MG TABLET is also not recommended for use by pregnant and breastfeeding
women. Consult your doctor before taking it.

Is VALROPE CHRONO 200MG TABLET safe to use in children?

VALROPE CHRONO 200MG TABLET should be used with caution in children (below 2
years of age) and in young girls (below 18 years of age) to ensure safety as
well as efficacy. Consult your doctor before taking VALROPE CHRONO 200MG TABLET.

What if I forget to take VALROPE CHRONO 200MG TABLET?

If you or your child have forgotten to take VALROPE CHRONO 200MG TABLET at right
time, take it as soon as remember. However, if it is almost time for the next
dose, skip the missed dose and continue the regular dosing schedule. Do not
double the dose to make up for the forgotten one.

When to stop taking VALROPE CHRONO 200MG TABLET?

Do not stop taking VALROPE CHRONO 200MG TABLET, unless as advised by your doctor
or if you experience any signs of an allergy (swelling of the face, lips,
eyelids, throat, tongue which may cause difficulty in breathing and swallowing),
abnormal levels of ammonia in the blood (vomiting, balance issues or lack of
alertness), liver problems (nausea, vomiting, tiredness, sleepiness, weakness,
stomach pain, yellowing of the skin or whites of the eye), inflammation of the
pancreas (acute abdominal pain) or chest pain, etc.

Can I drive or use machines after taking VALROPE CHRONO 200MG TABLET?

VALROPE CHRONO 200MG TABLET should be used with caution while driving or
operating machines, as it might cause drowsiness and sleepiness. Consult your
doctor before taking the medicine.

How VALROPE CHRONO 200MG TABLET works?

VALROPE CHRONO 200MG TABLET helps in managing epilepsy where sodium valproate
and valproic acid effectively increase the GABA (a neurotransmitter/chemical
messenger)) concentration in central nervous system by reducing its degradation.
It also blocks certain ion channels which reduce high-frequency neuronal
activity in the brain, thereby reliving seizures.

Useful Diagnostic Tests

• Blood test
• Urine analysis
• Liver function test
• EEG (electroencephalogram)