Termeg 50mg Injection 1ml

Introduction About TERMEG 50MG INJECTION

TERMEG 50MG INJECTION contains Tramadol which belongs to the group of medicines
called Opioids. It is used in the management of moderate to severe pain.

TERMEG 50MG INJECTION is not recommended for use in patients with seizures
(fits) which are not controlled by the management, who have consumed alcohol,
withdrawal symptoms caused by opiates (morphine-like medicines).

Before receiving TERMEG 50MG INJECTION, inform your doctor if you had or have a
head injury, breathing difficulties, severe liver or kidney problems, feeling of
faint, are in a shocking state (sign may be cold sweat), addicted to alcohol or
certain medicines (such as opioids), previously suffered from withdrawal
symptoms while stop taking drugs or alcohol (signs include agitation, anxiety,
shaking or sweating), adrenal insufficiency and seizures (fits).

TERMEG 50MG INJECTION is not recommended for use in pregnant and breastfeeding
women. TERMEG 50MG INJECTION is not recommended for use in children (below 12
years of age) and in children with breathing problems. It should be cautiously
used among elderly patients (aged 75 years and above).

The most common side effects of receiving TERMEG 50MG INJECTION are fatigue,
vomiting, headache, dry mouth and constipation. Inform your doctor if any of the
side effects worsen.

Uses Of TERMEG 50MG INJECTION

• Manage moderate to severe pain

How TERMEG 50MG INJECTION Works

TERMEG 50MG INJECTION inhibits the reuptake of the natural neurotransmitters
(norepinephrine and serotonin) and binds weakly to certain receptors (μ-opioid),
blocking the transmission of pain signals to the brain. Thus, it reduces
moderate to severe pain by acting on specific nerve cells of the spinal cord and
the brain.

How to use TERMEG 50MG INJECTION

TERMEG 50MG INJECTION will be given to you only by a doctor or a nurse into a
vein as a slow intravenous infusion or into the muscle as intramuscular
injection. Your doctor will decide the correct dose and duration for you
depending on your age, body weight and disease condition.

Side Effects Of TERMEG 50MG INJECTION

Common

• fatigue, sweating
• vomiting, headache
• constipation
• dry mouth
• somnolence (feeling of sleepiness, drowsy or low in energy)

Uncommon

• effects on the heart and blood circulation (pounding of the heart, fast heartbeat, feeling faint or collapsing during an upright position or under physical strain)
• retching (urge to be sick)
• trouble stomach (such as a feeling of pressure in the stomach, bloating and diarrhoea)
• skin reactions (such as rash and itching)

Rare

• slow heart rate elevated blood pressure
• changes in appetite
• abnormal sensations (such as itching, tingling and numbness)
• trembling, epile
• transient syncope (loss of consciousness), speech abnormalities
• hallucinations, sleep disorders, delirium, anxiety and nightmares
• mood changes (mostly high spirits, occasionally irritated mood)
• changes in activity (such as slowing down or increasing in activity)
• decreased cognitive and secondary perce
• muscle weakness
• blurred vision, dilated pupils
• pain and difficulties in passing urine or low urine output

Inform your doctor immediately if you experience any of the following side
effects while receiving TERMEG 50MG INJECTION:

• slow or shallow breathing, confusion, sleepiness, small pupils, severe nausea and or constipation, constipation and lack of appetite
• serotonin syndrome (signs include agitation, hallucination, coma, fever, increase in heart rate, unstable blood pressure, involuntary twitching, muscular rigidity, lack of coordination, nausea, vomiting and diarrhoea)
• difficulty breathing, rash or itchy skin, swollen face or tongue or difficulty in swallowing
• sleep-related breathing disorders or hypoxemia (signs include breathing pauses during sleep, night awakening due to shortness of breath, difficulties to maintaining sleep or excessive drowsiness during the day)

How To Manage Side Effects

Vomiting:

Stick to simple meals while receiving this medicine. Avoid eating oily rich,
fried or spicy foods. Do not lie down or sleep immediately after eating. Inform
your doctor if the symptom does not improve.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and
drink plenty of water. If this does not help, inform your doctor to receive
alternate management for constipation.

Headache:

Drink an ample amount of water and avoid skipping meals. Get adequate rest. Try
to be relaxed and stress-free. Apply pain relieving balm on your forehead if
necessary. Inform your doctor if the symptom does not improve.

Dry mouth:

Sip water regularly and other sugar-free liquids. Do not use mouthwashes that
contain alcohol because they can make your mouth dry, use mouthwash that is used
only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco
products. Inform your doctor if the symptom does not improve.

Warning & Precautions

!### Pregnancy

TERMEG 50MG INJECTION is not recommended for use in pregnant women or women
planning to have a baby because the baby may become dependent and may show
withdrawal symptoms after the birth. Consult your doctor before receiving TERMEG
50MG INJECTION.

!### Breastfeeding

TERMEG 50MG INJECTION is not recommended for use in breastfeeding women as it
may pass through the breast milk and will affect the baby. Consult your doctor
before receiving TERMEG 50MG INJECTION.

!### Driving and Using Machines

Do not drive or operate any machines if you experience drowsiness, dizziness,
blurred vision or impaired reaction after receiving TERMEG 50MG INJECTION.

!### Alcohol

Do not consume alcohol while receiving TERMEG 50MG INJECTION as it may increase
the effects of this medicine.

!### Kidney

TERMEG 50MG INJECTION should be used with caution in patients with kidney
problems. Consult your doctor before receiving TERMEG 50MG INJECTION.

!### Liver

TERMEG 50MG INJECTION should be used with caution in patients with severe liver
problems. Consult your doctor before receiving TERMEG 50MG INJECTION.

!### Allergy

Do not receive TERMEG 50MG INJECTION if you are allergic to Tramadol or any
other ingredients of this medicine.

Others

TERMEG 50MG INJECTION is not recommended for use if you:

• have epilepsy (fits) which is not properly controlled by the management
• have withdrawal symptoms caused by opiates (morphine-like medicines)

Before receiving TERMEG 50MG INJECTION, inform your doctor if you:

• have a head injury or breathing difficulties
• have a feeling of fainting
• are in a shocking state (cold sweat may be a sign)
• are addicted to certain medicines (such as opioids or prescri
• tend to develop fits
• have a history of suffering from withdrawal symptoms such as agitation, anxiety, shaking or sweating (when stopped taking drugs or alcohol)
• have signs of adrenal insufficiency (low levels of cortisol) such as extreme fatigue, lack of appetite, severe abdominal pain, nausea, vomiting or low blood pressure

Use in paediatrics:

TERMEG 50MG INJECTION is not recommended for use in children (under 12 years of
age). It is also not recommended for children having breathing problems because
the toxicity of this medicine will be worse in these children. Consult your
child’s doctor for advice before administration of TERMEG 50MG INJECTION to your
child.

Use in geriatrics:

TERMEG 50MG INJECTION should be used with caution in elderly patients (aged
above 75 years). Consult your doctor before receiving TERMEG 50MG INJECTION

Interactions

A. Drug - Drug interactions:

Before receiving TERMEG 50MG INJECTION, inform your doctor if you are taking any
of the following medicines:

• benzodiazepines (medicines used to manage anxiety or sleep problems) Ex. diazepam, lorazepam
• anticoagulants (medicines used to manage or manage blood clots) Ex. warfarin
• carbamazepine (used to manage fits)
• ondansetron (used to manage or manage nausea)
• monoamine oxidase inhibitors (medicines used to manage depression) Ex. moclobemide, phenelzine and selegiline (used to manage Parkinson's disease)
• other medicines used to manage pain (Ex. pentazocine, buprenorphine, morphine, codeine)

Overdosage:

TERMEG 50MG INJECTION will be administered to you only by a physician or a nurse
in a hospital, and so it is unlikely to receive an overdose. However, consult
your physician if you experience any unusual symptoms. Overdosage symptoms of
TERMEG 50MG INJECTION are excessive constriction of the pupil of the eye,
vomiting, cardiovascular collapse, consciousness disorders up to coma,
convulsions, respiratory depression up to respiratory arrest and serotonin
syndrome (a serious drug reaction).

Synopsis

Drug	:	Tramadol
Pharmacological Category	:	Opioids
Therapeutic Indication	:	Moderate to severe pain
Dosage Forms	:	Injection, Tablet, Capsule, Suppositories

More Information

• Store at room temperature

FAQs About TERMEG 50MG INJECTION

Does TERMEG 50MG INJECTION cause withdrawal symptoms?

Yes, if you stop receiving TERMEG 50MG INJECTION suddenly you may experience
withdrawal symptoms (such as restlessness, sleeping difficulties, irritability,
agitation, anxiety, palpitations, increased blood pressure, nausea and vomiting,
shaking, shivering or sweating. Your doctor will determine the appropriate
duration of management and safely stop the management when it is not necessary
by gradually reducing the dose.

What are the common side effects of receiving TERMEG 50MG INJECTION?

The most common side effects of receiving TERMEG 50MG INJECTION are fatigue,
vomiting, headache, sweating, dry mouth, somnolence (feeling of sleepiness,
drowsy or low in energy) and constipation. Inform your doctor if any of the side
effects worsens

Is TERMEG 50MG INJECTION safe to use in children?

TERMEG 50MG INJECTION is not recommended for use in children (under 12 years of
age). It is also not recommended for children having breathing problems because
the toxicity of this medicine will be worse in these children. Consult your
child’s doctor for advice before administration of TERMEG 50MG INJECTION to your
child.

Is TERMEG 50MG INJECTION safe during breastfeeding?

TERMEG 50MG INJECTION is not recommended for use in breastfeeding women as it
may pass through the breast milk and will affect the baby. Consult your doctor
before receiving TERMEG 50MG INJECTION

Can TERMEG 50MG INJECTION be used in patients with kidney problems?

TERMEG 50MG INJECTION should be used with caution in patients with kidney
problems. Your doctor may adjust the dose depending on kidney function. Consult
your doctor for advice before receiving TERMEG 50MG INJECTION

Useful Diagnostic Tests

• Kidney function test