Rizact MD 5mg Tablet 2'S

Introduction About RIZACT MD

RIZACT MD contains Rizatriptan which belongs to the group of medicines called
Selective serotonin 5-hydroxytryptamine receptor agonist. RIZACT MD is used in
adults to manage headache phase of migraine attack.

RIZACT MD is not recommended for use in patients allergic to Rizatriptan. It is
also not recommended for use in patients suffering from moderate/mild/severe
high blood pressure (which is not controlled by medication), stroke, peripheral
vascular disease (condition marked by blockage of blood vessels), heart problems
(such as heart attack, angina), and/or severe kidney/liver problems.

Before taking RIZACT MD, inform your doctor if you have diabetes, family history
of heart disease, headache (associated with dizziness, difficulty in walking,
lack of coordination), short lived symptoms (such as chest pain, tightness),
and/or mild to moderate kidney/liver problems.

RIZACT MD should be used with caution during pregnancy and in women planning for
pregnancy only if it is clearly necessary as it is not known whether the
medicine can cause harm to the unborn baby. It is also used with caution in
breastfeeding women only if it is clearly necessary. Breastfeeding mothers
should avoid nursing the child for next 24 hours after taking the medicine since
it may cause unwanted effects in the nursing child.

RIZACT MD is not recommended for use in children and adolescents (aged below 18
years) and is advised to be used with caution in elderly patients (aged 65
years/above) after consulting the doctor.

The most common side effects of taking RIZACT MD are tingling sensation of
hands/feet, headache, sleeplessness, dry mouth, nausea, vomiting, and/or
diarrhea. Consult your doctor if any of these symptoms worsens.

Uses Of RIZACT MD

• Manage headache experienced during migraine attack in adult patients

How RIZACT MD Works

RIZACT MD works by constricting the blood vessels that surround the brain which
results in reduced swelling in the blood vessels thus providing relief from
headache that occurs in migraine attack in affected individuals.

How to use RIZACT MD

Tablet

Take RIZACT MD as advised by your physician. Swallow the medicine with a glass
of water. Do not crush or chew the medicine. Your doctor will decide the correct
dose and duration for you depending upon your age, body weight and disease
condition.

Oral Disintegrating Tablet / Mouth Dissolving Tablet:

Take RIZACT MD as advised by your physician. Place RIZACT MD inside your mouth
and allow it to dissolve completely. Do not swallow or chew the medicine. Your
doctor will decide the correct dose and duration for you depending upon your
age, body weight and disease condition.

Side Effects Of RIZACT MD

Common

• tingling sensation of hands/feet, headache, decreased sensitivity of skin, decreased mental sharpness
• sleeplessness
• fast/irregular heartbeat
• flushing
• throat discomfort, dry mouth, nausea, vomiting, diarrhea, indigestion
• feeling of heaviness in parts of the body, neck pain, stiffness
• pain in abdomen/chest

Uncommon

• bad taste in mouth
• ataxia (unsteadiness while walking), dizziness, tremor, fainting
• blurred vision
• confusion, nervousness
• high blood pressure
• thirst, sweating
• rash, itching, and/or red itchy welts
• swelling of face/lips/tongue, and/or throat
• feeling of tightness in parts of the body, muscle weakness
• changes in the rhythm/rate of the heartbeat
• very fast heartbeat
• facial pain, muscle pain

Rare

• wheezing
• allergic reaction
• anaphylaxis (sudden life-threatening allergic reaction)
• stroke (especially in patients with risk factors for heart and blood vessel disease)
• slow heartbeat.

Stop taking RIZACT MD and consult your doctor immediately if you experience any
of the following:

• signs of an allergic reaction such as swelling of the face/lips/tongue, shortness of breath, rash, itching, and/or red itchy welts
• signs of serotonin syndrome (serious drug reaction) such as agitation/restlessness, sleeplessness, confusion, and/or dilated pupils
• heart attack
• signs of stroke (condition that occurs due to poor blood supply to brain) such as sudden numbness/weakness in face/arm/leg, trouble speaking, dizziness, and/or loss of balance

How To Manage Side Effects

Headache:

If RIZACT MD causes headache, then take rest and drink plenty of fluids. Try to
avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches
should usually go away after the first week of taking RIZACT MD. If it lasts
more than a week or severe, inform your doctor.

Dry mouth and thirst:

Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip
balm if your lips are dry. Brush your teeth twice a day and use mouthwash.
Consult and inform your doctor if the symptom gets worse.

Warning & Precautions

!### Pregnancy

RIZACT MD should be used with caution during pregnancy and in women planning for
pregnancy only if it is clearly necessary as it is not known whether the
medicine can cause harm to the unborn baby. Consult your doctor before taking
the medicine.

!### Breastfeeding

RIZACT MD should be used with caution in breastfeeding women only if it is
clearly necessary. Breastfeeding mothers should avoid nursing the child for next
24 hours after taking the medicine. Consult your doctor before taking RIZACT MD.

!### Driving and Using Machines

Do not drive/operate machines if you feel dizzy/sleepy after taking RIZACT MD.
Consult your doctor before taking the medicine.

!### Kidney

RIZACT MD is not recommended for use in patients with severe kidney problems. It
should be used with caution in patients with mild to moderate kidney problems.
Consult your doctor before taking RIZACT MD.

!### Liver

RIZACT MD is not recommended for use in patients with severe liver problems. It
should be used with caution in patients with mild to moderate liver problems.
Consult your doctor before taking RIZACT MD.

!### Allergy

Do not take RIZACT MD if you are allergic to Rizatriptan, and/or any other
ingredients of this medicine.

!### Heart Disease

RIZACT MD is not recommended for use in patients with heart problems such as
heart attack, angina. It should be used with caution in patients with other
heart problems such as bundle branch block. Consult your doctor before taking
RIZACT MD.

Others

RIZACT MD is not recommended for use if you:

• have moderately/mild/severe high blood pressure which is not controlled by medication
• have had a stroke
• suffer from peripheral vascular disease (condition marked by blockage of blood vessels).

Before taking RIZACT MD, inform your doctor if you:

• have diabetes
• are a smoker
• have a family history of heart disease
• are a man aged above 40 years or women in postmenopausal phase
• suffer from headache associated with dizziness, difficulty in walking, lack of coordination, and/or weakness in the leg and arm
• have had short lived symptoms such as chest pain, tightness.

Use in Pediatrics:

RIZACT MD is not recommended for use in children and adolescents (aged below 18
years). Consult your doctor before taking the medicine.

Use in Geriatrics:

RIZACT MD should be used with caution in elderly patients (aged 65 years/above).
Consult your doctor before taking the medicine.

Interactions

A. Drug-Drug Interactions

Before taking RIZACT MD, inform your doctor if you are taking any of the
following medicine:

• other triptans (medicines used to manage migraine) Ex. ergotamine, dihydro-ergotamine, sumatriptan, naratriptan or zolmitriptan
• medicines used to manage depression such as selective serotonin reuptake inhibitors (SSRIs) (Ex.sertraline, escitalopram oxalate, uoxetine),  serotonin noradrenaline reuptake inhibitors (SNRIs) (Ex. venlafaxine, and duloxetine), monoamine oxidase (MAO) inhibitors (Ex. moclobemide, phenelzine, tranylcypromine, pargyline)
• medicines used to manage bacterial infections (Ex. linezolid)
• propranolol (used to manage heart problems, anxiety)
• methysergide (used to manage migraine)

Overdosage:

If you or anyone else accidentally takes too much of RIZACT MD, visit the nearby
hospital or consult your doctor immediately. Symptoms of overdose are dizziness,
drowsiness, vomiting, fainting, and/or slow heart rate.

Synopsis

Drug	:	Rizatriptan
Pharmacological Category	:	Selective serotonin 5-HT1B/1D receptor agonists
Therapeutic Indication	:	Headache in migraine
Dosage Forms	:	Tablet, Oral Disintegration Tablets

More Information

• Keep RIZACT MD out of sight and reach of children
• Do not store RIZACT MD above 30°C

FAQs About RIZACT MD

What is RIZACT MD and why it is used?

RIZACT MD contains Rizatriptan which belongs to the group of medicines called
Selective serotonin 5-hydroxytryptamine receptor agonist. It is generally used
to manage headache phase of migraine attack in adult patients.

What are the common side effects of RIZACT MD?

The most common side effects of taking RIZACT MD are tingling sensation of
hands/feet, headache, sleeplessness, dry mouth, nausea, vomiting, and/or
diarrhea. Consult your doctor if any of these symptoms worsens.

Can RIZACT MD be used in pregnant and breastfeeding women?

Yes, RIZACT MD can be used but with caution in pregnant and breastfeeding women
only if necessary since it is not known whether the medicine can cause harm to
the unborn baby/nursing child. Consult your doctor before taking the medicine.

How RIZACT MD works?

RIZACT MD works by constricting the blood vessels that surround the brain which
results in reduced swelling in the blood vessels thus providing relief from
headache that occurs in migraine attack in affected individuals.

What happens if RIZACT MD is taken more than its required dosage?

If you or anyone else accidentally takes too much of RIZACT MD, visit the nearby
hospital or consult your doctor immediately. Symptoms of overdose are dizziness,
drowsiness, vomiting, fainting, and/or slow heart rate.