Ritza 10mg Tablet 6'S

Introduction About RITZA

RITZA contains Rizatriptan which belongs to the group of medicines called
Selective serotonin 5-hydroxytryptamine receptor agonist. RITZA is used in
adults to manage headache phase of migraine attack.

RITZA is not recommended for use in patients allergic to Rizatriptan. It is also
not recommended for use in patients suffering from moderate/mild/severe high
blood pressure (which is not controlled by medication), stroke, peripheral
vascular disease (condition marked by blockage of blood vessels), heart problems
(such as heart attack, angina), and/or severe kidney/liver problems.

Before taking RITZA, inform your doctor if you have diabetes, family history of
heart disease, headache (associated with dizziness, difficulty in walking, lack
of coordination), short lived symptoms (such as chest pain, tightness), and/or
mild to moderate kidney/liver problems.

RITZA should be used with caution during pregnancy and in women planning for
pregnancy only if it is clearly necessary as it is not known whether the
medicine can cause harm to the unborn baby. It is also used with caution in
breastfeeding women only if it is clearly necessary. Breastfeeding mothers
should avoid nursing the child for next 24 hours after taking the medicine since
it may cause unwanted effects in the nursing child.

RITZA is not recommended for use in children and adolescents (aged below 18
years) and is advised to be used with caution in elderly patients (aged 65
years/above) after consulting the doctor.

The most common side effects of taking RITZA are tingling sensation of
hands/feet, headache, sleeplessness, dry mouth, nausea, vomiting, and/or
diarrhea. Consult your doctor if any of these symptoms worsens.

Uses Of RITZA

• Manage headache experienced during migraine attack in adult patients

How RITZA Works

RITZA works by constricting the blood vessels that surround the brain which
results in reduced swelling in the blood vessels thus providing relief from
headache that occurs in migraine attack in affected individuals.

How to use RITZA

Tablet

Take RITZA as advised by your physician. Swallow the medicine with a glass of
water. Do not crush or chew the medicine. Your doctor will decide the correct
dose and duration for you depending upon your age, body weight and disease
condition.

Oral Disintegrating Tablet / Mouth Dissolving Tablet:

Take RITZA as advised by your physician. Place RITZA inside your mouth and allow
it to dissolve completely. Do not swallow or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of RITZA

Common

• tingling sensation of hands/feet, headache, decreased sensitivity of skin, decreased mental sharpness
• sleeplessness
• fast/irregular heartbeat
• flushing
• throat discomfort, dry mouth, nausea, vomiting, diarrhea, indigestion
• feeling of heaviness in parts of the body, neck pain, stiffness
• pain in abdomen/chest

Uncommon

• bad taste in mouth
• ataxia (unsteadiness while walking), dizziness, tremor, fainting
• blurred vision
• confusion, nervousness
• high blood pressure
• thirst, sweating
• rash, itching, and/or red itchy welts
• swelling of face/lips/tongue, and/or throat
• feeling of tightness in parts of the body, muscle weakness
• changes in the rhythm/rate of the heartbeat
• very fast heartbeat
• facial pain, muscle pain

Rare

• wheezing
• allergic reaction
• anaphylaxis (sudden life-threatening allergic reaction)
• stroke (especially in patients with risk factors for heart and blood vessel disease)
• slow heartbeat.

Stop taking RITZA and consult your doctor immediately if you experience any of
the following:

• signs of an allergic reaction such as swelling of the face/lips/tongue, shortness of breath, rash, itching, and/or red itchy welts
• signs of serotonin syndrome (serious drug reaction) such as agitation/restlessness, sleeplessness, confusion, and/or dilated pupils
• heart attack
• signs of stroke (condition that occurs due to poor blood supply to brain) such as sudden numbness/weakness in face/arm/leg, trouble speaking, dizziness, and/or loss of balance

How To Manage Side Effects

Headache:

If RITZA causes headache, then take rest and drink plenty of fluids. Try to
avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches
should usually go away after the first week of taking RITZA. If it lasts more
than a week or severe, inform your doctor.

Dry mouth and thirst:

Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip
balm if your lips are dry. Brush your teeth twice a day and use mouthwash.
Consult and inform your doctor if the symptom gets worse.

Warning & Precautions

!### Pregnancy

RITZA should be used with caution during pregnancy and in women planning for
pregnancy only if it is clearly necessary as it is not known whether the
medicine can cause harm to the unborn baby. Consult your doctor before taking
the medicine.

!### Breastfeeding

RITZA should be used with caution in breastfeeding women only if it is clearly
necessary. Breastfeeding mothers should avoid nursing the child for next 24
hours after taking the medicine. Consult your doctor before taking RITZA.

!### Driving and Using Machines

Do not drive/operate machines if you feel dizzy/sleepy after taking RITZA.
Consult your doctor before taking the medicine.

!### Kidney

RITZA is not recommended for use in patients with severe kidney problems. It
should be used with caution in patients with mild to moderate kidney problems.
Consult your doctor before taking RITZA.

!### Liver

RITZA is not recommended for use in patients with severe liver problems. It
should be used with caution in patients with mild to moderate liver problems.
Consult your doctor before taking RITZA.

!### Allergy

Do not take RITZA if you are allergic to Rizatriptan, and/or any other
ingredients of this medicine.

!### Heart Disease

RITZA is not recommended for use in patients with heart problems such as heart
attack, angina. It should be used with caution in patients with other heart
problems such as bundle branch block. Consult your doctor before taking RITZA.

Others

RITZA is not recommended for use if you:

• have moderately/mild/severe high blood pressure which is not controlled by medication
• have had a stroke
• suffer from peripheral vascular disease (condition marked by blockage of blood vessels).

Before taking RITZA, inform your doctor if you:

• have diabetes
• are a smoker
• have a family history of heart disease
• are a man aged above 40 years or women in postmenopausal phase
• suffer from headache associated with dizziness, difficulty in walking, lack of coordination, and/or weakness in the leg and arm
• have had short lived symptoms such as chest pain, tightness.

Use in Pediatrics:

RITZA is not recommended for use in children and adolescents (aged below 18
years). Consult your doctor before taking the medicine.

Use in Geriatrics:

RITZA should be used with caution in elderly patients (aged 65 years/above).
Consult your doctor before taking the medicine.

Interactions

A. Drug-Drug Interactions

Before taking RITZA, inform your doctor if you are taking any of the following
medicine:

• other triptans (medicines used to manage migraine) Ex. ergotamine, dihydro-ergotamine, sumatriptan, naratriptan or zolmitriptan
• medicines used to manage depression such as selective serotonin reuptake inhibitors (SSRIs) (Ex.sertraline, escitalopram oxalate, uoxetine),  serotonin noradrenaline reuptake inhibitors (SNRIs) (Ex. venlafaxine, and duloxetine), monoamine oxidase (MAO) inhibitors (Ex. moclobemide, phenelzine, tranylcypromine, pargyline)
• medicines used to manage bacterial infections (Ex. linezolid)
• propranolol (used to manage heart problems, anxiety)
• methysergide (used to manage migraine)

Overdosage:

If you or anyone else accidentally takes too much of RITZA, visit the nearby
hospital or consult your doctor immediately. Symptoms of overdose are dizziness,
drowsiness, vomiting, fainting, and/or slow heart rate.

Synopsis

Drug	:	Rizatriptan
Pharmacological Category	:	Selective serotonin 5-HT1B/1D receptor agonists
Therapeutic Indication	:	Headache in migraine
Dosage Forms	:	Tablet, Oral Disintegration Tablets

More Information

• Keep RITZA out of sight and reach of children
• Do not store RITZA above 30°C

FAQs About RITZA

What is RITZA and why it is used?

RITZA contains Rizatriptan which belongs to the group of medicines called
Selective serotonin 5-hydroxytryptamine receptor agonist. It is generally used
to manage headache phase of migraine attack in adult patients.

What are the common side effects of RITZA?

The most common side effects of taking RITZA are tingling sensation of
hands/feet, headache, sleeplessness, dry mouth, nausea, vomiting, and/or
diarrhea. Consult your doctor if any of these symptoms worsens.

Can RITZA be used in pregnant and breastfeeding women?

Yes, RITZA can be used but with caution in pregnant and breastfeeding women only
if necessary since it is not known whether the medicine can cause harm to the
unborn baby/nursing child. Consult your doctor before taking the medicine.

How RITZA works?

RITZA works by constricting the blood vessels that surround the brain which
results in reduced swelling in the blood vessels thus providing relief from
headache that occurs in migraine attack in affected individuals.

What happens if RITZA is taken more than its required dosage?

If you or anyone else accidentally takes too much of RITZA, visit the nearby
hospital or consult your doctor immediately. Symptoms of overdose are dizziness,
drowsiness, vomiting, fainting, and/or slow heart rate.