Regunine Hmg 75Iu Injection 1'S

INTRODUCTION ABOUT REGUNINE HMG 75IU INJECTION

REGUNINE HMG 75IU INJECTION contains Menotrophin which belongs to the group of
medicines called Gonadotropins. It is used to manage infertility in both men and
women. In women, it helps in egg (ovum) growth and stimulates the release of the
matured eggs from the ovaries into the uterus. This helps in managing ovulation
problems in women with polycystic ovarian disease (PCOD) especially in those who
are not responding appropriately with other medicines (Ex. clomiphene citrate).

It also helps in the growth and development of several egg follicles in women
undergoing fertility managements. In men, it improves sperm count and corrects
fertility problems.

Before receiving REGUNINE HMG 75IU INJECTION inform your doctor if you have
thyroid problems, adrenal gland problems, high blood prolactin levels, fibroids
in uterus, any tumours in the breasts, uterus, testes, prostate, pituitary gland
or hypothalamus, heavy vaginal bleeding, or blood clots. Your doctor may also
ask you to reduce body weight to achieve better results.

You must also inform your doctor if you have any damage in the fallopian tubes,
as management with REGUNINE HMG 75IU INJECTION may cause ectopic pregnancy
(pregnancy outside of the womb) in such cases.

REGUNINE HMG 75IU INJECTION is not recommended for use in pregnant or
breastfeeding women. The most common side effects of receiving REGUNINE HMG 75IU
INJECTION are stomach pain or swelling, nausea, headache, and injection site
reactions (such as pain, redness, and swelling). Consult your doctor if they
worsen.

USES OF REGUNINE HMG 75IU INJECTION

• Manage infertility in men and women
• Promotes egg growth and release in women with PCOD
• Helps women to produce multiple eggs prior to fertility managements
• Improves sperm count in men

HOW REGUNINE HMG 75IU INJECTION WORKS

REGUNINE HMG 75IU INJECTION stimulates your body to release sufficient amount of
sex hormones (Estrogen and Progesterone in females and Testosterone in males) to
maintain normal reproductive functions. In women, it helps in the growth and
maturation of the eggs followed by their release from the ovaries into the
uterus (ovulation). This improves the chances of pregnancy among women facing
difficulties in becoming pregnant. In men, it improves the levels of
testosterone (male hormone) which in turn improves sperm count and reduces
fertility problems.

DIRECTIONS FOR USE

REGUNINE HMG 75IU INJECTION will be given to you only by a doctor or a nurse
into the muscles (intramuscularly) or under the skin (subcutaneously). It can
also be self-administered by the patient if instructed by the doctor. Carefully
follow the instructions given by your doctor in case of self-administration.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

SIDE EFFECTS OF REGUNINE HMG 75IU INJECTION

COMMON

• injection site reactions (pain, redness, itching or swelling)
• headache
• nausea
• stomach pain or swelling
• pelvic pain

UNCOMMON

• vomiting, stomach discomfort, diarrhoea
• tiredness, dizziness
• hot flushes
• breast enlargement and pain, nipple discharge

RARE

• skin rash, acne

Contact your doctor immediately if you experience any of the following side
effects after receiving REGUNINE HMG 75IU INJECTION:

• signs of ovarian hyperstimulation syndrome (such as lower abdominal pain with sensation of nausea or vomiting, weight gain, difficulty in breathing, difficulty in passing urine, enlarged ovaries and fluid build-up in chest or abdomen)
• signs of allergic reactions (such as skin rash, itching, swelling of the eyes, face, lips, tongue or throat leading to difficulty in breathing or swallowing)

HOW TO MANAGE SIDE EFFECTS

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

!### Injection Site Reactions

Place an ice pack on the affected area. Do not frequently move the injection
site. Consult your doctor if the symptom did not improve.

!### Nausea And Vomiting

Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor
if your symptom worsens.

WARNING & PRECAUTIONS

!### PREGNANCY

ContraindicatedREGUNINE HMG 75IU INJECTION is not recommended for use in pregnant women.
Therefore, consult your doctor before receiving it.

!### BREASTFEEDING

ContraindicatedREGUNINE HMG 75IU INJECTION is not recommended for use in breastfeeding women.
Therefore, consult your doctor before receiving it.

!### DRIVING AND USING MACHINES

Use with CautionREGUNINE HMG 75IU INJECTION does not affect your ability to drive or operate
machinery. However, do not drive or handle any heavy tools or machines if your
ability is affected by REGUNINE HMG 75IU INJECTION.

!### ALCOHOL

Consult your doctorAvoid consum

!### ALLERGY

ContraindicatedTalk to your doctor before receiving REGUNINE HMG 75IU INJECTION if you are
allergic to Menotrophin.

!### USE IN PEDIATRICS

ContraindicatedREGUNINE HMG 75IU INJECTION is not intended for use in children and adolescents
(aged below 18 years). Therefore, consult your doctor for advice before
receiving it.

!### USE IN GERIATRICS

Use with CautionREGUNINE HMG 75IU INJECTION should be used with caution in elderly patients
(aged 65 years or older). Therefore, consult your doctor before receiving it.

OTHERS

REGUNINE HMG 75IU INJECTION is not recommended for use if you:

• have any tumours in the breasts, uterus, pituitary gland or hypothalamus
• have polycystic ovarian disease or enlarged ovaries
• have undiagnosable vaginal bleeding
• had an early menopause
• have any malformation of sex organs that hinders pregnancy
• have fibroids in the uterus
• had uterus removal
• have cancer in testicles or in prostate gland

Before receiving REGUNINE HMG 75IU INJECTION, inform your doctor if you:

• have an underactive thyroid gland
• have an underactive adrenal gland (glands responsible for regulating sex hormones)
• have hyperprolactinemia (high levels of a hormone called prolactin in blood)
• have blood clots in the body or have a family history of blood clots
• are overweight
• have damaged fallopian tubes

INTERACTIONS

A. Drug-Drug interactions:

Before receiving REGUNINE HMG 75IU INJECTION, inform your doctor if you are
taking any of the following medicines:

• Clomiphene citrate (another medicine used in the management of female infertility)

Overdosage:

REGUNINE HMG 75IU INJECTION will be administered to you only by a doctor or a
nurse in a hospital, and so it is unlikely to receive an overdose. However,
consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

Drug	:	Menotrophin
Pharmacological Category	:	Gonadotrophins
Therapeutic Indication	:	Infertility
Dosage Forms	:	Injection, Pre-filled syringes

MORE INFORMATION

• Keep REGUNINE HMG 75IU INJECTION out of reach of children
• Store REGUNINE HMG 75IU INJECTION at room temperature

FAQs ABOUT REGUNINE HMG 75IU INJECTION

Q: What is the use of REGUNINE HMG 75IU INJECTION?

A: GBNKEYWORD] is used to manage infertility in both men and women. It helps in
egg (ovum) growth and egg release from the ovaries into the uterus. This helps
in managing ovulation problems in women with polycystic ovarian disease (PCOD)
and other reproductive problems. In men, improves sperm count and corrects
fertility problems.

Q: How REGUNINE HMG 75IU INJECTION works?

A: REGUNINE HMG 75IU INJECTION stimulates your body to release sufficient amount
of sex hormones (Estrogen and Progesterone in females and Testosterone in males)
to maintain normal reproductive functions. In women, it helps in the growth and
maturation of the eggs followed by their release from the ovaries into the
uterus (ovulation). This improves the chances of pregnancy among women facing
difficulties in becoming pregnant. In men, it improves the levels of
testosterone (male hormone) which in turn improves sperm count and reduces
fertility problems.

Q: How REGUNINE HMG 75IU INJECTION is administered?

A: REGUNINE HMG 75IU INJECTION will be given to you only by a doctor or a nurse
into the vein (intravenously) or under the skin (subcutaneously). It can also be
self-administered by the patients if advised by the physician. Carefully, follow
the instructions given by the doctor in case of self-administration.

Q: What precautions must be followed while receiving REGUNINE HMG 75IU
INJECTION?

A: Before receiving REGUNINE HMG 75IU INJECTION inform your doctor if you have
any unexplained vaginal bleeding, blood clot problems or any tumours in the
testes, prostate, brain, breast, uterus or ovaries. You must also inform your
doctor if you have any damage in the fallopian tubes, as management with
REGUNINE HMG 75IU INJECTION may cause ectopic pregnancy (pregnancy outside of
the womb) in such cases. REGUNINE HMG 75IU INJECTION should not be used in
pregnant women after successful conce
perform all blood tests and ultrasounds recommended by him/her without fail.

Q: Is REGUNINE HMG 75IU INJECTION safe?

A: REGUNINE HMG 75IU INJECTION is considered safe at the doses administered by
the physician. However, consult your doctor if you experience any unusual side
effects

Q: What are the common side effects of receiving REGUNINE HMG 75IU
INJECTION?

A: The most common side effects of receiving REGUNINE HMG 75IU INJECTION are
stomach pain, nausea, headache and injection site reactions (such as pain,
redness, and swelling). Consult your doctor if they worsen.

Q: Can I stop receiving REGUNINE HMG 75IU INJECTION once my symptoms
subside?

A: Do not stop taking REGUNINE HMG 75IU INJECTION without consulting your
doctor. You need to receive REGUNINE HMG 75IU INJECTION for the duration
recommended by your doctor to achieve better results.

Q: Can I use REGUNINE HMG 75IU INJECTION during pregnancy?

A: REGUNINE HMG 75IU INJECTION is not recommended for use in pregnant women.
Therefore, consult your doctor before receiving it.

Q: Can REGUNINE HMG 75IU INJECTION be used in children?

A: REGUNINE HMG 75IU INJECTION is not intended for use in children and
adolescents (aged below 18 years). Therefore, consult your doctor for advice
before receiving it.

REFERENCES

1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical
   Pharmacology. 7th Edition. 2013. Page – 241.

2. Jared C. Robins, M.D., Andrew F. Khair, Ph.D., M.B.A.,,∗ Eric A. Widra,
   M.D.,c Michael M. Alper, M.D.,d Winnie W. Nelson, Pharm.D., M.S., M.B.A.,b Eric
   D. Foster, Ph.D.,b Anshul Sinha, B.Tech.,b Masakazu Ando, Ph.D.,b Patrick W.
   Heiser, Ph.D.,b and Gaurang S. Daftary, M.D., M.B.A. Economic evaluation of
   highly purified human menotropin or recombinant follicle-stimulating hormone for
   controlled ovarian stimulation in high-responder patients: analysis of the
   Menopur in Gonadotropin-releasing Hormone Antagonist Single Embryo Transfer–High
   Responder (MEGASET-HR) trial. NIH. National Library of Medicine. National Center
   for Biotechnology Information. PMC. PubMed Central. November 2020. [Accessed on
   10th February 2023]

3. Ferring Pharmaceuticals Ltd. Menopur 75IU. Electronics Medicines Compendium.
   [Revised in August 2019]. [Accessed on 10th February 2023]

4. Ferring Pharmaceuticals Ltd. Menopur 150IU. Electronics Medicines Compendium.
   [Revised in August 2019]. [Accessed on 10th February 2023]

5. Ferring Pharmaceuticals Ltd. Menopur 600IU. Electronics Medicines Compendium.
   [Revised in March 2022]. [Accessed on 10th February 2023]

6. Ferring Pharmaceuticals Ltd. REPRONEXÒ (MENOTROPINS FOR INJECTION, USP) FOR
   SUBCUTANEOUS INJECTION AND INTRAMUSCULAR INJECTION. U.S. Food and Drug
   Administration. [Accessed on 10th February 2023]

USEFUL DIAGNOSTIC TESTS

• Anti-Mullerian Hormone
• Glycosylated Haemoglobin
• Testosterone Total
• Thyroid Stimulating Hormone