Pracidep Plus Tablet 10'S

Introduction About PRACIDEP PLUS TABLET

PRACIDEP PLUS TABLETcontains a combination of Clonazepam and Escitalopram which
belongs to the group of medicines called Antidepressants. It is indicated for
the management of comorbid depression and anxiety disorder.

Comorbid depression and anxiety disorder is condition in which the person has
anxiety and depression together at the same time. Symptoms are persistent
feeling of sadness or loss of interest, changes in sleep, appetite, energy
level, concentration or daily behavior, feeling nervous or restless, fast
heartrate, heavy breathing.

Avoid consum
PRACIDEP PLUS TABLET is not recommended to use in patients having liver or heart
diseases, acute narrow-angle glaucoma (increased pressure within the eye) or if
you are taking MAO inhibitors such as isocarboxazid or moclobemide (to manage
depression), selegiline (used to manage Parkinson’s disease) or linezolid (an
antibiotic).

Before taking PRACIDEP PLUS TABLET inform your doctor if you have kidney, liver
or, lung diseases, epilepsy, low levels of sodium, tendency of bleeding and
bruising and diabetes. Patients should be monitored for signs of suicidal
ideation and behaviors and advised to seek immediate medical advice if any such
signs occur.

PRACIDEP PLUS TABLET should be used with caution in pregnant and breastfeeding
women only if clearly advised by the doctor. Consult your doctor before taking
it. PRACIDEP PLUS TABLET is not recommended for use in children and adolescents
(18 years and below).PRACIDEP PLUS TABLET should be used with caution in elderly
patients (above 65 years of age).

The most common side effects of taking PRACIDEP PLUS TABLET are nausea,
headache, diarrhea, constipation, dry mouth, increased sweating, increased or
decreased appetite, etc. Consult your doctor if any of the symptoms worsen or
persists.

Uses Of PRACIDEP PLUS TABLET

• Manage comorbid depression and anxiety disorder

How PRACIDEP PLUS TABLET Works

PRACIDEP PLUS TABLET is a combination of Clonazepam and Escitalopram, where
Clonazepam is a benzodiazepine that increases the action of gamma-aminobutyric
acid (GABA), a chemical messenger that suppresses the abnormal activity of the
nerve cells in the brain. Escitalopram is a selective serotonin reuptake
inhibitor (SSRI) that increases the levels of serotonin, a chemical messenger
that improves mood.

How to use PRACIDEP PLUS TABLET

Take PRACIDEP PLUS TABLET as advised by your physician. Swallow the medicine
with water. Do not crush or chew the medication. Your physician will decide the
correct dose and duration of PRACIDEP PLUS TABLET for you depending on your age,
body weight and disease condition.

Side Effects Of PRACIDEP PLUS TABLET

Common

• nausea
• headache
• blocked runny nose
• increased or decreased appetite
• restlessness, anxiety, abnormal dreams, difficulties falling asleep, feeling sleepy, dizziness, tremors, yawning, prickling of the skin
• diarrhea, constipation
• vomiting
• dry mouth
• increased sweating
• pain in muscles and joints
• sexual problems (problems with erection, delayed ejaculation, decreased sexual drive and women may experience difficulties achieving orgasm)
• fatigue, fever
• increased weight

Uncommon

• rash and itching
• grinding teeth, agitation, nervousness, p
• disturbed sleep
• taste disturbance
• fainting
• enlarged pupils, visual disturbance
• ringing in the ears
• hair loss
• menstrual problems (excessive bleeding or irregular menstrual period)
• vaginal bleeding
• decreased weight
• fast heartbeat
• swelling of the arms or legs
• nosebleeds

Rare

• aggression, depersonalization, hallucination
• slow heartbeat

Stop taking PRACIDEP PLUS TABLET and contact your doctor immediately if you
experience any of the following side effects:

• thoughts of killing or harming yourself
• allergic reactions (symptoms include skin rash, flaking skin, boils, swelling of the face, sore lips and mouth, fever, sudden wheezing, fluttering or tightness in the chest or collapse)
• signs of heart-related problems (breathlessness, swelling of the ankles, cough, tiredness and a racing heart, chest pain which may spread to neck and shoulders or left arm)
• change in behavior (aggressiveness, irritability, excitement, agitation, nervousness, hostile, anxiousness, sleeping problems, nightmares or vivid dreams)
• mental problems (like seeing or hearing things that are not there (hallucinations), believing in things that are not real (delusions) or problems with speech)
• seizures
• unusual bleeding (including gastrointestinal bleeding)
• serotonin syndrome (signs include high fever, agitation, confusion, trembling and abrupt contractions of muscles)
• liver problems (like hepatitis signs include yellowing of the skin or whitish of the eye)
• difficulty in urination

How To Manage Side Effects

Nausea:

Take PRACIDEP PLUS TABLET with or after meals. Stick to simple meals upon taking
this medicine. Avoid eating rich or spicy food. Do not take any medication for
nausea without your doctor’s consultation. Ask for your doctor’s advice if the
nausea doesn’t improve.

Vomiting:

Get adequate rest. Drink lots of fluids, especially water. Have small sips if
you feel sick. Do not take any medicine for vomiting without your doctor's
consultation. Contact your doctor if vomiting does not go or worsen.

Dizziness:

Lie or sit down especially when you feel dizzy. If you're feeling a severe
episode of spinning(vertigo), lie in a dark and quiet place with your eyes
closed. Try to avoid vehicle driving. Discuss with your doctor if the dizziness
worsens.

Dry mouth:

A dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free
hard candies to stimulate the flow of saliva. Sip water at regular intervals of
time. Do not use mouthwashes having alcohol because they can be drying. Consult
your physician for advice if your dry mouth doesn’t improve.

Loss of appetite:

Eat when you are hungry. Eat a nutritious snack rich in calories and protein,
such as dried fruit and nuts. If the symptom does not improve, consult your
doctor.

Constipation:

Eat more fiber-rich foods like fresh fruits, vegetables and cereals and drink
plenty of water. Exercise more regularly. If the symptom does not improve,
consult your doctor.

Headache:

Try to take rest and don’t involve yourself in exertive activities. Rest in a
quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your
doctor’s advice if headache doesn’t improve.

Diarrhea:

Drink more fluids such as water or fruit juice to keep yourself hydrated. Do not
consume any medicine on your own without your doctor’s consultation.

Warning & Precautions

!### Pregnancy

PRACIDEP PLUS TABLET should only be used in pregnant women if considered clearly
necessary by the doctor. If PRACIDEP PLUS TABLET is taken in the third trimester
(last 3 months), it may cause trouble with breathing, body temperature changes,
bluish skin, fits, feeding difficulties, vomiting, low blood sugar, stiff or
floppy muscles, irritability, lethargy, vivid reflexes, tremor, jitteriness,
constant crying, sleepiness and sleeping difficulties Consult your doctor before
taking PRACIDEP PLUS TABLET.

!### Breastfeeding

PRACIDEP PLUS TABLET should only be used in breastfeeding women if considered
clearly necessary by the doctor as it may pass through the breast milk. Consult
your doctor before taking PRACIDEP PLUS TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you feel having impaired ability to
judge or think after taking PRACIDEP PLUS TABLET.

!### Alcohol

Avoid consum
unpredictable side effects.

!### Kidney

PRACIDEP PLUS TABLET should be used with caution in patients with kidney
diseases. Consult your doctor before taking it.

!### Liver

PRACIDEP PLUS TABLET is not recommended to use in patients with significant
liver disease and should be used with caution in other liver diseases. Consult
your doctor before taking it.

!### Allergy

Do not take PRACIDEP PLUS TABLET if you are allergic to Clonazepam,
Escitalopram, other Benzodiazepines or any other ingredients of this medicine.

!### Lungs

PRACIDEP PLUS TABLET should be used with caution in patients with lung disease.
Consult your doctor before taking it.

!### Heart Disease

PRACIDEP PLUS TABLET is not recommended to use in patients heart diseases such
as abnormal heart rhythm. PRACIDEP PLUS TABLET should be used with caution in
patients with coronary heart disease, recent heart attacks, low heartrate and
fast or irregular heartbeat. Consult your doctor before taking PRACIDEP PLUS
TABLET.

Others

PRACIDEP PLUS TABLET is not recommended for use if you have:

• acute narrow-angle glaucoma (increased pressure within the eye)
• alcohol or drug abuse

Before taking PRACIDEP PLUS TABLET, inform your doctor if you have:

• epilepsy
• diabetes
• bleeding or bruisers
• or have had mood problems, depression or suicidal thoughts or behavior
• decreased level of sodium in the blood
• salt depletion because of prolonged severe diarrhea, vomiting or water tablets
• collapse or dizziness on standing up
• to receive electroconvulsive management (psychiatric management)

Use in pediatrics:

PRACIDEP PLUS TABLET is not recommended for use in children and adolescents (18
years of age and below). Consult your child’s doctor before giving PRACIDEP PLUS
TABLET to your child.

Use in geriatrics:

PRACIDEP PLUS TABLET should be used with caution in elderly patients (above 65
years of age). Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking PRACIDEP PLUS TABLET, inform your doctor if you are taking any of
the following medicine:

• phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, bupropion, tryptophan, fluvoxamine, moclobemide, clomipramine, nortriptyline imipramine and desipramine, St. John’s Wort (herbal) (used to manage depression), lithium (used to manage m
• selegiline (used to manage Parkinson’s disease)
• tramadol (used to manage moderate to severe pain), aspirin (used to relieve pain)
• sumatriptan (used to manage migraine or cluster headaches)
• omeprazole, cimetidine (used to manage stomach problems)
• ticlopidine (used to reduce the risk of stroke), flecainide, propafenone and metoprolol (used to manage heart diseases)
• warfarin, dipyridamole, phenprocoumon (used to manage blood clots)
• mefloquine (used to manage malaria)
• sparfloxacin, moxifloxacin, erythromycin IV, pentamidine (used to manage infections)
• astemizole, mizolastine (used to manage allergies)
• medicines that cause lower potassium and magnesium levels (Ex. cisplatin, gentamycin, furosemide)

Overdosage:

If you or anyone else accidentally take too much of PRACIDEP PLUS TABLET,
consult your doctor immediately or visit the nearby hospital. The symptoms of
overdosage are excessive sleepiness, confusion, dizziness and tremor.

Synopsis

Drug	:	Clonazepam and Escitalopram
Pharmacological Category	:	Benzodiazepines and Selective serotonin reuptake inhibitors (SSRIs)
Therapeutic Indication	:	Comorbid depression and anxiety disorder
Dosage Forms	:	Tablet

More Information

• Keep PRACIDEP PLUS TABLET out of reach of children
• Store PRACIDEP PLUS TABLET at a temperature not exceeding 30°C

FAQs About PRACIDEP PLUS TABLET

Can PRACIDEP PLUS TABLET be used in children?

PRACIDEP PLUS TABLET is not recommended for use in children and adolescents (18
years of age and below). Consult your child’s doctor before giving PRACIDEP PLUS
TABLET to your child.

Can PRACIDEP PLUS TABLET be used in patients with liver problems?

PRACIDEP PLUS TABLET should be used with caution in patients with liver
problems. The dose will be adjusted by your doctor depending on your age and
disease condition. Consult your doctor before taking PRACIDEP PLUS TABLET.

Can I stop taking PRACIDEP PLUS TABLET on my own?

No. You should not stop taking PRACIDEP PLUS TABLET until and unless your doctor
advises you to. Quick or abrupt discontinuation of the medicine may cause
dizziness, sensory disturbances sleep disturbances, agitation or anxiety, nausea
and/or vomiting, tremor, confusion, sweating, headache, diarrhea, palpitations,
emotional instability, irritability and visual disturbances. If you wish to
discontinue using PRACIDEP PLUS TABLET, as for your doctor’s advice.

Is PRACIDEP PLUS TABLET a habit-forming medicine?

PRACIDEP PLUS TABLET is generally considered to be non-habit-forming medicine
when taken as prescribed by the doctor. However, PRACIDEP PLUS TABLET may cause
physical dependence. You must discuss with your doctor if you feel any unusual
symptoms while being managed with PRACIDEP PLUS TABLET.

What if I forget to take a dose of PRACIDEP PLUS TABLET?

If you forget to take a dose of PRACIDEP PLUS TABLET, take it as soon as you
remember. However, ignore the missed dose if it's almost time for the next one.
Do not take PRACIDEP PLUS TABLET two times to make up for the missed dose.

Useful Diagnostic Tests

• Serum Electrolytes