Pasitrex Ointment 20gm

Introduction About PASITREX OINTMENT

PASITREX OINTMENT contains Calcipotriol which belongs to group of medicines
called Anti-psoriatics. PASITREX OINTMENT is used to manage plaque psoriasis
(long-lasting autoimmune disease that cause thicky scaly patches on skin) in
affected individuals.

PASITREX OINTMENT is not recommended for use in patients allergic to
Calcipotriol. It is also not recommended for use in patients with a history of
hypersensitivity reaction (immune response to an allergen), calcium metabolism
disorders (due to high/low calcium levels), vitamin D toxicity, and/or severe
liver & kidney disease.

Before applying PASITREX OINTMENT, inform your doctor if you are a smoker,
undergoing ultraviolet management, and/or suffering from exfoliative/pustular
psoriasis.

[GBNKEYWORLD] should be used with caution during pregnancy only if it is clearly
necessary. It is also used with caution in breastfeeding women which is advised
not to apply on breast area while feeding the baby.

PASITREX OINTMENT is not recommended for use in children (aged below 6 years)
and is advised to be used with caution in elderly patients (aged 65 years/above)
after consulting the doctor.

The most common side effects of applying PASITREX OINTMENT are pain at the site
of application, burning/stinging sensation, skin irritation, itching, itchy
rash, and skin redness. Consult your doctor if any of these symptoms worsens.

Uses Of PASITREX OINTMENT

• Manage plaque psoriasis in affected individuals

How PASITREX OINTMENT Works

PASITREX OINTMENT works by inhibiting cell growth and its development without
causing any harm to the cell which results in decreased growth of abnormal cells
thus controlling psoriatic condition and managing the condition in affected
individuals.

How to use PASITREX OINTMENT

Always apply PASITREX OINTMENT as directed by your physician. It is for external
use only. Apply a thin layer of this medicine on the affected area. Managed
areas on the face need not be covered with a plaster or bandage. Do not use this
medicine on your face.

Side Effects Of PASITREX OINTMENT

Common

• pain at the site of application
• burning/stinging sensation
• skin irritation
• itching
• itchy rash
• skin redness
• dry skin
• peeling skin
• dermatitis (skin inflammation)
• worsening of psoriasis

Uncommon

• skin atrophy (thin skin)
• hyperpigmentation (darkened patches or spots on the skin)
• signs of hypercalcemia (high calcium level in blood) frequent urination, thirst, weakness, bone pain
• folliculitis (inflammation of hair follicle)
• red, itchy, scaly rash
• blisters may form on skin
• changes in skin colour where the medicine is used

Rare

• signs hypersensitivity reaction (immune response to an allergen) such as rash, itching, watery eyes, coughing/sneezing
• temporary increased sensitivity to sunlight
• skin swelling or puffiness
• itchy raised rash
• seborrheic dermatitis such as dandruff or cradle cap
• signs of hypercalciuria (excess calcium in the urine) such as pain while urination, lower abdominal pain

Stop taking PASITREX OINTMENT and contact your doctor immediately if:

• signs of hypercalcemia (excess calcium in blood) and hypercalciuria (excess calcium in the urine) such as increased urinary frequency, excessive thirst, loss of appetite, dry/metallic taste in the mouth, stomach upsets (includes pain, nausea, vomiting and constipation), weak muscles and/or pain in the bones, tiredness, fatigue, confusion, feeling sick and constipation
• signs of allergic reactions such as difficulty while breathing, swelling of face including eyes, severe skin rash (particularly blistering or bleeding)

How To Manage Side Effects

Dry Skin:

Try moisturizing your skin with an ointment, cream, or lotion 2 or 3 times a
day, or as often as needed.  Moisturizers help to keep the area moisture, so
they work best on damp skin. After you bathe, pat your skin dry then apply your
moisturizer. Try to avoid using skin care products and soaps that contain
alcohol, fragrances, dyes, or other chemicals.

Itchy Skin:

Try to pat or tap your skin instead of scratching it. Hold a damp towel to cool
your skin. Wear loose clothing and avoid tight clothes, or clothes made from
wool or synthetic fabrics. Avoid using perfumed soaps, deodorants or
moisturizers and use a skin softener regularly.

Warning & Precautions

!### Pregnancy

PASITREX OINTMENT should be used with caution in pregnant women only if it is
clearly necessary. Consult your doctor before applying it.

!### Breastfeeding

PASITREX OINTMENT should be used with caution in breastfeeding women. It is not
recommended to be applied on breast area while feeding the baby. Consult your
doctor before applying the medicine.

!### Driving and Using Machines

PASITREX OINTMENT generally does not have any effect on your ability to drive or
use machines. Consult your doctor before applying the medicine.

!### Kidney

PASITREX OINTMENT is not recommended for use in patients suffering from severe
kidney problems. Consult your doctor before applying the medicine.

Liver

PASITREX OINTMENT is not recommended for use in patients suffering from severe
liver problems. Consult your doctor before applying the medicine.

!### Allergy

Do not take PASITREX OINTMENT if you are allergic to Calcipotriol or any of the
other ingredients of this medicine.

Others

PASITREX OINTMENT is not recommended for use if you:

• have history of hypersensitivity reactions (immune response to an allergen)
• have calcium metabolism disorders marked with high or low calcium levels.
• have signs of vitamin D toxicity such as nausea & vomiting, weakness, and frequent urination.

Before taking PASITREX OINTMENT, inform your doctor if you:

• smoke
• are undergoing ultraviolet light management
• have guttate, erythrodermic, exfoliative or pustular psoriasis

Use in Pediatrics:

PASITREX OINTMENT is not recommended for use in children (aged below 6 years).
Consult your doctor before applying the medicine.

Use in Geriatrics:

PASITREX OINTMENT should be used with caution in elderly patient (aged above 65
years). Consult your doctor before taking.

Interactions

A. Drug - Drug interactions:

Inform your doctor about all the medicines you use, including prescri
non-prescri

Over dosage:

If you or anyone else applies too much of PASITREX OINTMENT or accidentally
swallows it, consult your doctor immediately or visit the nearby hospital.
Symptoms of overdose include elevated serum calcium levels with signs such as
increased urinary frequency, excessive thirst, loss of appetite, dry/metallic
taste in the mouth, stomach upsets.

Synopsis

Drug	:	Calcipotriol
Pharmacological Category	:	Synthetic vitamin D3 derivative
Therapeutic Indication	:	Plaque Psoriasis
Dosage Forms	:	Ointment, Lotion

More Information

• Keep PASITREX OINTMENT out of reach of children
• Store below 25°C

FAQs About PASITREX OINTMENT

Does PASITREX OINTMENT cause skin irritation?

Yes, PASITREX OINTMENT may cause skin irritation. Avoid harsh soaps and
detergents, lotions, perfumed soaps and known allergy triggers that may help to
soothe irritated skin. Consult your doctor before using.

Can I take other calcium supplements along withPASITREX OINTMENT?

As calcium supplements might increase calcium level in blood, consult your
doctor before applying PASITREX OINTMENT to avoid excess production of calcium
in blood which may occur with signs such as increased urinary frequency,
excessive thirst, loss of appetite, dry/metallic taste in the mouth, stomach
upsets.

How much dose ofPASITREX OINTMENT can i use in a day?

Always apply PASITREX OINTMENT as directed by your physician. It is for external
use only. Apply a thin layer of this medicine on the affected area. Managed
areas on the face need not be covered with a plaster or bandage. Do not use this
medicine on your face.

Can a patient undergoing UV light management apply PASITREX OINTMENT?

Yes, PASITREX OINTMENT can be used but with caution in patients undergoing
ultraviolet light management since the medicine may get degraded upon exposure
to ultraviolet resulting in reduced effect of the drug. Consult your doctor
before applying the medicine.

Useful Diagnostic Tests

• Skin biopsy