PACITANE TABLET 25'S

Introduction About PACITANE

PACITANE contains Trihexyphenidyl which belongs to the group of medicines called
Central Anticholinergics. It is used to improve muscle control in patients with
Parkinson’s disease. Parkinson’s disease is a long-term brain disorder that
causes muscle stiffness, shaking, slow and unsteady movements, difficulty in
walking and loss of balance. It happens due to loss of nerve cells at certain
regions of brain (basal ganglia) that controls body movements.

PACITANE can also be used to control abnormal involuntary muscle movements (such
as extreme restlessness or muscle spasms) in the body that is caused due to the
use of certain medicines.

Trihexyphenidylis a muscle relaxant. It reduces muscle stiffness and relaxes
muscles by reducing the activity of a chemical messenger called acetylcholine in
the brain. It also restores a balance between certain brain chemicals (dopamine
and acetylcholine) that controls body movements.

Before taking PACITANE, inform your doctor if you have glaucoma, high blood
pressure, stomach ulcer or problems in your prostate gland. You must also inform
your doctor if you have any liver, kidney, or heart problems before taking
PACITANE as a precaution.

Talk to your doctor before taking PACITANE if you have myasthenia gravis (muscle
weakness) or tardive dyskinesia (unusual movements of face and tongue). Consult
your doctor before taking PACITANE if you are pregnant or breastfeeding.

The most common side effects of taking PACITANE are dry mouth, constipation,
dizziness, blurred vision, nausea, and vomiting. Consult your doctor if any of
these side effect worsens.

Uses Of PACITANE

It is used to:

• Reduce muscle stiffness and improve muscle control in patients with Parkinson’s disease
• Manage drug-induced abnormal involuntary muscle movements (such as extreme restlessness or muscle spasms)

How PACITANE Works

PACITANE is an anticholinergic medicine with muscle relaxing properties. It
reduces muscle stiffness and improves muscle control by reducing the activity of
a chemical messenger called acetylcholine in the brain. It also regulates the
release of a brain chemical called dopamine that regulates proper body movements
and coordination. As a result, it reduces abnormal muscle movements associated
with Parkinson’s disease and with the use of certain medicines.

How to use PACITANE

Take PACITANE as advised by your physician. Swallow PACITANE with a glass of
water. Do not chew or crush the medicine. It must be taken with or just before
meals.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition. Continue to take
PACITANE for the stipulated duration as advised by your doctor without any
interru

Side Effects Of PACITANE

Common

• dry mouth
• constipation
• dizziness
• blurred vision
• nausea
• nervousness

Uncommon

Stop taking PACITANE and contact your doctor immediately if you experience any
of the following side effects:

• feeling restless, agitated, or confused
• delusion (false beliefs), hallucinations (seeing or hearing things that does not exist)
• difficulty in sleeping
• immediate or short-term memory loss
• worsening of myasthenia gravis (muscle pain or weakness)
• eye problems (dilated pupils, eye discomfort and increased sensitivity to light, eye pain)
• fast heartbeat
• fever, skin rash with redness or dryness
• inability to pass urine, feeling thirsty

How To Manage Side Effects

!### Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals.
Drink plenty of fluids. Exercise more regularly. Consult your doctor if this
side effect bothers you.

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

!### Dry Mouth

Drink plenty of water or fluids at regular intervals. Frequent small sips of
water or the use of artificial saliva may be beneficial. However, if it bothers
you or if your condition worsens contact your doctor.

!### Nausea And Vomiting

Take PACITANE with or just after meals. Stick to simple meals. Avoid eating oil
rich or spicy foods. Consult your doctor if your nausea worsens.

Warning & Precautions

!### Pregnancy

ContraindicatedPACITANE is not recommended for use in pregnant women. Therefore, consult your
doctor before taking it.

!### Breastfeeding

ContraindicatedPACITANE is not recommended for use in breastfeeding women. Therefore, consult
your doctor before taking it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizzy after taking PACITANE.

!### Alcohol

Consult your doctorAvoid consum

!### Kidney

Use with CautionPACITANE should be used with caution in patients with kidney problems.
Therefore, consult your doctor before taking it.

!### Liver

Use with CautionPACITANE should be used with caution in patients with liver problems. Therefore,
consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take PACITANE if you are allergic to Trihexyphenidyl.

!### Heart Disease

Use with CautionPACITANE should be used with caution in patients with heart problems (such as
high blood pressure). Therefore, consult your doctor before taking it.

!### Use In Pediatrics

Use with CautionPACITANE should be used with caution in children and adolescents (below 18
years). Therefore, consult your doctor before taking it.

!### Use In Geriatrics

Use with CautionPACITANE should be used with caution in elderly patients (aged 65 years or
above). Therefore, consult your doctor before taking it.

Others

Before taking PACITANE, inform your doctor if you:

• have glaucoma (increased pressure in the eye)
• have problems in prostate gland
• have difficulty in passing urine
• have stomach ulcer, severe heartburn, acid indigestion or any other digestive disorders
• suffer from myasthenia gravis (muscle weakness)
• have tardive dyskinesia (unusual movements of the face and the tongue)

Interactions

A. Drug-Drug Interactions:

Before taking PACITANE, inform your doctor, if you are taking any of the
following medicines such as:

• aspirin (a medicine used to relieve pain and reduce fever)
• medicine used for depression such as monoamine oxidase inhibitors (Ex. moclobemide, tranylcypromine) or tricyclic antidepressants (Ex. amitriptyline)
• medicines used to manage mental illness (Ex. chlorpromazine, thioridazine, clozapine)
• antihistamines (medicines used to manage allergies) Ex. cetirizine, desloratadine, fexofenadine
• disopyramide (a medicine used to manage irregular heartbeat)
• levodopa (a medicine used to manage parkinson’s disease)
• amantadine (a medicine used for viral infections)
• nefopam (a medicine used for pain relief)
• metoclopramide or domperidone (medicines used for nausea and vomiting)
• parasympathomimetics (medicine used for urinary retention) ex. neostigmine, bethanechol

Overdosage:

If you or anyone else accidentally took more PACITANE, consult your doctor
immediately or visit the nearby hospital. Symptoms of overdose might include
anxiety, depression, and behavioral changes.

Synopsis

Drug	:	Trihexyphenidyl
Pharmacological Category	:	Antimuscarinic agents
Therapeutic Indication	:	Abnormal muscle movements
Dosage Forms	:	Tablet, Injection

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More Information

• Keep PACITANE out of reach of children
• Store PACITANE at room temperature

FAQs About PACITANE

Q: How long does it take for PACITANE to start acting?

A: PACITANE begins to act within 1 hour following administration. It reaches its
maximum action between 2-3 hours after administration. The effects of PACITANE
can be there in your body for around 6-12 hours.

Q: What PACITANE is used for?

A: PACITANE is used to improve muscle control in patients with Parkinson’s
disease. It can also be used to control abnormal involuntary muscle movements
(such as extreme restlessness or muscle spasms) in the body that is caused due
to the use of certain medicines.

Q: Is PACITANE safe to be taken by pregnant and breastfeeding women?

A: PACITANE is not recommended for use in pregnant or breastfeeding women.
However, consult your doctor before taking.

Q: What are the side effects of PACITANE?

A: The most common side effects of taking PACITANE are dry mouth, constipation,
dizziness, blurring of vision, nausea, and vomiting. Consult your doctor if any
of these symptoms gets worse.

Q: Is it safe to drive after taking PACITANE?

A: PACITANE may cause dizziness and blurred vision in some individuals. If you
experience these side effects, try to avoid driving or operating heavy machines.

Q: What happens if you take more PACITANE than your required dose?

A: If you or anyone else accidentally took more PACITANE, consult your doctor
immediately or visit the nearby hospital. Symptoms of overdose are anxiety,
depression, and behavioral changes.

Q: How long should I take PACITANE?

A: You are advised to take PACITANE until your doctor suggests you discontinue
the medicine. Do not stop taking PACITANE without consulting your doctor as it
may make your symptoms to reappear.

Q: Will taking a higher dose of PACITANE be more effective?

A: No. Do not take a higher dose of PACITANE than the prescribed one without
consulting your doctor. Taking a higher dose of PACITANE may not be beneficial.
Instead, it can cause serious side effects. If the prescribed dose is not
effective for you, consult your doctor. Your doctor may prescribe a suitable
higher dose or suggest an alternative therapy after evaluating your disease
condition.

Q: What should I do if I forget to take a dose of PACITANE?

A: If your forgot to take a dose of PACITANE, take it as soon as you remember.
However, if it is time to take the next dose, skip the missed one and take the
regular dose. Do not take a double dose of PACITANE to compensate the missed
dose.

Q: Can I stop taking PACITANE once my symptoms subside?

A: No. Do not stop taking PACITANE without consulting your doctor as it may
cause the symptoms to reappear. Make sure to take PACITANE for the stipulated
duration recommended by your doctor to achieve the maximum results.