Olmezest H 40mg Tablet 10'S

Introduction About OLMEZEST H 40MG TABLET

OLMEZEST H 40MG TABLET is a combination of Hydrochlorothiazide and Olmesartan
which belongs to the group of medicines called Anti-hypertensives. It is
indicated for the management of essential hypertension. Essential hypertension
(also known as primary hypertension) is a medical condition in which the force
of the blood exerted against the walls of the artery remains very high and as a
result it may lead to severe damage to the blood vessels of several organs, thus
causing heart attack, heart or kidney failure, stroke or even blindness.

Along with the management, follow a low-sodium diet and drink plenty of fluids
as advised by your physician. During the management, your doctor might regularly
check your blood pressure, blood cholesterol levels, kidney function and
electrolyte balance to avoid the risk of unwanted side effects.

Before taking OLMEZEST H 40MG TABLET, inform your doctor if you have any
problems related to kidney, liver, lungs or heart. Management with OLMEZEST H
40MG TABLET particularly for a longer period can increase the risk of certain
types of skin and lip cancer, and so protect your skin from sun exposure or UV
rays while taking this medicine.

OLMEZEST H 40MG TABLET is strictly not recommended for use in patients with
diabetes-related kidney disease and in pregnant or breast-feeding women. Consult
your doctor for alternative therapy.

The most common side effects of taking OLMEZEST H 40MG TABLET are dizziness,
headache, weakness, tiredness, nausea and vomiting. Consult your doctor if any
of the side effects worsen.

Uses Of OLMEZEST H 40MG TABLET

• To manage essential hypertension

How OLMEZEST H 40MG TABLET Works

OLMEZEST H 40MG TABLET effectively reduces elevated blood pressure, where
Olmesartan acts by inhibiting the action of Angiotensin – II (a pe
that causes narrowing of blood vessels and increase in blood pressure) by
blocking the angiotensin-II receptors and hydrochlorothiazide acts by inhibiting
the reabsor
to a marked decrease in blood volume which in turn reduces blood pressure.

How to use OLMEZEST H 40MG TABLET

Take OLMEZEST H 40MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of OLMEZEST H 40MG TABLET

Common

• dizziness and headache
• weakness, tiredness
• chest pain
• swelling of hands, arms, ankles, feet or legs
• bronchitis (inflammation of the bronchus)
• cough, runny nose, sore throat or flu-like symptoms
• nausea, vomiting, diarrhea, stomach pain, indigestion, bloating, constipation
• back pain, joint pain or bone
• urinary tract infection or blood in urine
• confusion

Uncommon

• fluttering of the heartbeat
• rash, eczema
• vertigo
• muscle cramps and muscular pain
• erection difficulties in men
• feeling unwell, allergic skin rash
• itching, exanthema (skin eru
• decreased or loss of appetite
• severe difficulty breathing
• worsening of pre-existing myopia
• erythema, skin reactions to light
• swelling of the face
• angina (chest pain)
• purplish spots or patches on the skin due to small haemorrhages (purpura)

Rare

• disturbances in consciousness
• acute kidney failure, impaired kidney function
• lack of energy
• swollen and sore salivary glands
• restlessness, feeling-un interested (apathy)
• blurred vision, dry eyes
• irregular heartbeat
• inflammation of the blood vessels
• blood clots (thrombosis or embolism)
• inflammation of the lung, fluid accumulation in the lungs
• inflammation of the pancreas
• jaundice (yellowing of the skin or white of the eyes)
• infection in the gall bladder
• symptoms of lupus erythematosus such as rash, joint pains and cold hands and fingers
• peeling and blistering of the skin
• non-infectious inflammation of the kidney (interstitial nephritis), fever, muscle weakness (sometimes causing impaired movement)
• feeling depressed
• tingling and numbness, fits

Stop taking OLMEZEST H 40MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• severe allergic reactions (such as skin rash, itching, swelling of the face, mouth and/or throat)
• hypotension (fainting or lightheadedness)
• yellowing of the whites of the eyes, dark urine and itching of the skin
• severe persistent diarrhea with a substantial weight loss
• painful eyes or decrease in vision
• signs of electrolyte depletion (nausea, vomiting, thirst, dry mouth, hypotension, feeling weak, tired, sluggish, sleepy, or restless, muscle pain, less need to pass urine or a rapid heart rate)

How To Manage Side Effects

Nausea and vomiting:

Try to take this medicine with or just after a meal or a snack. Stick to simple
meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did
not improve.

Diarrhea:

Drink lots of fluids such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhea. Consult your doctor
if the symptom did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water. Apply a pain-relieving
balm on the forehead if required. Do not consume too much of alcohol. Consult
your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines while you are feeling dizzy. Do not consume too much of alcohol, as it
can aggravate your dizziness. Consult your doctor if the symptom did not
improve.

Constipation:

Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink
plenty of water. Try to exercise more regularly. Consult your doctor if the
symptom did not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals.
Keep a heat pad on your stomach. Do not self-manage on your own and consult your
doctor if the symptom did not improve on its own.

Warning & Precautions

!### Pregnancy

OLMEZEST H 40MG TABLET is not recommended for use in pregnant women as it may
cause serious harm to the growing baby. Consult your doctor before taking
OLMEZEST H 40MG TABLET.

!### Breastfeeding

OLMEZEST H 40MG TABLET is not recommended for use in breastfeeding women.
Consult your doctor before taking OLMEZEST H 40MG TABLET.

!### Driving and Using Machines

Do not drive or operate any tools or machines if you feel dizzy or sleepy after
taking this medicine.

!### Alcohol

Avoid consum
orthostatic hypotension (low blood pressure when standing up from sitting or
lying position).

!### Kidney

OLMEZEST H 40MG TABLET is not recommended for use in patients with severe kidney
problems. It should be used with caution in patients with mild to moderate
kidney problems or if you recently had a kidney transplant. Consult your doctor
before taking OLMEZEST H 40MG TABLET.

!### Liver

OLMEZEST H 40MG TABLET is not recommended for use in patients with severe liver
disease such as jaundice (yellowing of skin and eyes with fever) or biliary
obstruction (problems in drainage of bile from gallbladder), severely impaired
liver function. It should be used with caution in patients with mild to moderate
liver impairment. Consult your doctor before taking OLMEZEST H 40MG TABLET.

!### Allergy

Do not take OLMEZEST H 40MG TABLET if you are allergic to Hydrochlorothiazide,
Olmesartan or substances similar to hydrochlorothiazide (Ex. sulfonamides).

!### Lungs

OLMEZEST H 40MG TABLET should be used with caution in patients with bronchial
asthma due to increased risk of hypersensitivity reactions.

!### Heart Disease

OLMEZEST H 40MG TABLET should be taken with caution in patients with heart
diseases (such as heart failure or problems with your heart valves or heart
muscles). Consult your doctor before taking OLMEZEST H 40MG TABLET.

Others

OLMEZEST H 40MG TABLET is not recommended for use if you:

• have diabetes and managed with a blood pressure lowering medicine containing aliskiren
• have low levels of potassium or sodium in the blood
• have hypercalcemia (high calcium levels in blood) or high uric acid levels in the blood (with symptoms of gout or kidney stones)

Before taking OLMEZEST H 40MG TABLET, inform your doctor if you:

• have severe vomiting or diarrhea
• have problems in adrenal glands (Ex. primary aldosteronism)
• have lupus erythematosus (an autoimmune disease)
• other allergic disorders
• have had a skin cancer
• are due to have tests for parathyroid function
• are due to have anti-dope test (used in sports persons)

Use in pediatrics:

OLMEZEST H 40MG TABLET is not suitable for use in children and adolescents (aged
less than 18 years). Consult your child’s doctor for advice.

Use in geriatrics:

OLMEZEST H 40MG TABLET should be taken with caution in elderly patients (aged 65
years or above). Proper dose adjustments and careful monitoring are required in
such patients. Consult your doctor before taking OLMEZEST H 40MG TABLET.

Interactions

A. Drug-Drug interactions:

Before taking OLMEZEST H 40MG TABLET inform to your doctor, if you are taking
any of these medicines:

• other medicines used to manage high blood pressure (Ex. aliskiren, methyldopa, captopril, enalapril, valsartan, propranolol, atenolol)
• other diuretics (used to increase urine output) Ex. chlorothiazide, furosemide
• medicines which can alter the levels of potassium in the blood (such as potassium supplements
• heparin (used to manage or manage blood clots)
• adrenocorticotrophic hormone (used to stimulate the production of cortisol)
• carbenoxolone (used to manage mouth and stomach ulcers)
• laxatives (used to relieve constipation) Ex. liquid paraffin, ispaghula
• corticosteroids (used to manage pain or inflammation Ex. prednisolone, dexamethasone
• medicines used to induce sleep (Ex. phenobarbitone, pentobarbital, diazepam, lorazepam, clonazepam)
• medicines used to manage depression (Ex. fluoxetine, sertraline, imipramine, amitriptyline)
• medicines used to manage psychiatric disorders (Ex. chlorpromazine, trifluoperazine, levomepromazine, cyamemazine, sulpiride, amisulpride, pimozide, thioridazine, sultopride, tiapride, droperidol or haloperidol)
• medicines used to manage heart problems (Ex. digitalis, quinidine, hydroquinidine, disopyramide, amiodarone, dofetilide, ibutilide or sotalol)
• mizolastine, terfenadine (used to manage allergic reactions)
• pentamidine (used to manage pneumonia)
• medicines used to control blood sugar levels (Ex. metformin, insulin or diazoxide)
• medicines used to increase blood pressure and slow heart rate (Ex. noradrenaline)
• medicines used to manage gout (Ex. probenecid, sulfinpyrazone and allopurinol)
• skeletal muscle relaxants (used to manage muscle cramps) Ex. baclofen and tubocurarine
• medicines use to manage cancer (Ex. amifostine, methotrexate or cyclophosphamide)
• medicines used to control blood cholesterol levels (Ex. cholestyramine, colestipol, colesevelam)
• non-steroidal anti-inflammatory drugs (used to manage pain, swelling or inflammation) Ex. ibuprofen, diclofenac, aspirin
• anticholinergic agents (used to decrease muscle movements or secretions) such as atropine and biperiden
• lithium (used to manage mental illness)
• diphem
• calcium supplements
• amantadine (used to manage viral infections)
• ciclosporin (used to manage graft rejection)
• certain antibiotics (used to manage bacterial infections) such as tetracyclines, erythromycin injection, penicillin G or sparfloxacin
• amphotericin (a medicine used to manage fungal infections)
• antacids (used to neutralize stomach acid) such as aluminium hydroxide, magnesium hydroxide
• cisapride (used to increase gastrointestinal movements)
• halofantrine (a medicine used to manage malaria)

Overdosage:

If you or anyone else accidentally take too much of OLMEZEST H 40MG TABLET,
contact your doctor immediately or go to a hospital straight away. Symptoms of
overdosage might include low blood pressure, slow or fast heart rate,
parasympathetic (vagal) stimulation, electrolyte depletion, dehydration and
increased urination.

Synopsis

Drug	:	Hydrochlorothiazide, Olmesartan
Pharmacological Category	:	Thiazide diuretics, Angiotensin-II receptor blockers
Therapeutic Indication	:	Essential Hypertension
Dosage Forms	:	Tablet

More Information

• Keep OLMEZEST H 40MG TABLET out of reach of children
• Store at room temperature

FAQs About OLMEZEST H 40MG TABLET

Can OLMEZEST H 40MG TABLET cause leg swelling?

Yes, OLMEZEST H 40MG TABLETmay cause swelling of hands, arms, feet, ankles or
legs in some individuals. Try to keep your legs elevated for some time. Follow a
calorie-restricted diet as advised by your doctor. If the condition did not
improve or become worse consult your doctor.

Can OLMEZEST H 40MG TABLET be taken during pregnancy?

No, OLMEZEST H 40MG TABLETis strictly not recommended for use during pregnancy
since it may cause serious harm to the growing baby. Consult your doctor before
taking this medicine. Women of childbearing potential should follow suitable
contrace
40MG TABLETif became pregnant as early as possible.

Can I take my diabetic medicines along with OLMEZEST H 40MG TABLET?

Avoid concomitant use of anti-diabetic medicines (such as metformin, insulin,
diazoxide or others) with OLMEZEST H 40MG TABLETwithout consulting your doctor.
Your doctor may adjust the dose or frequently monitor your blood sugar levels to
safely use these medicines together.

Can OLMEZEST H 40MG TABLET cause dehydration?

Yes, OLMEZEST H 40MG TABLETmay cause severe dehydration in some individuals. If
you experience severe persistent diarrhea or vomiting, consult your doctor
immediately to avoid the risk of electrolyte imbalance.

Can OLMEZEST H 40MG TABLET cause low sodium levels?

Yes, OLMEZEST H 40MG TABLETcan cause hyponatremia (low sodium levels in blood)
in some individuals. To avoid this, your doctor will regularly check electrolyte
balance in your body and adjust your dose accordingly. However, if you
experience any symptoms of hyponatremia such as fainting, dizziness, thirst, dry
mouth, contact your doctor immediately.

What to do if I forget to take a dose of OLMEZEST H 40MG TABLET?

You should take OLMEZEST H 40MG TABLET immediately when you remember. If it is
time for your next dose skip the dose and follow your regular dose schedule. Do
not double the dose to match up your missed dose.

Useful Diagnostic Tests

• Kidney function test