NICOREX 20mg Tablet 10's

Introduction About NICOREX 20MG TABLET

NICOREX 20MG TABLET contains Nicorandil which belongs to the group of medicines
called Potassium channel activators. It is used in adults to manage and reduce
painful signs of angina pectoris who cannot take heart medicines called
beta-blockers or calcium antagonists.

Angina pectoris is a type of temporary chest pain or discomfort which occurs as
a result of decreased blood flow to the heart muscle which is usually not a
heart attack but a sign of increased risk for heart attack that is generally
characterized by symptoms such as squeezing pressure, heaviness, tightness or
pain in the chest that can occur sudden or recur over time.

Avoid consum
may reduce your blood pressure even more.

NICOREX 20MG TABLET is not recommended for use in patients with severe low blood
pressure, low blood volume, heart problems (such as cardiogenic shock, left
ventricular failure with low filling pressure or cardiac decompensation).

Before taking NICOREX 20MG TABLET, inform your doctor if you have lung problems
such as pulmonary oedema (condition marked by fluid build-up in lungs), hepatic
impairment or kidney problems.

NICOREX 20MG TABLET is not recommended for use in pregnant and breastfeeding
women. It is also not recommended for use in children and adolescents (below 18
years of age). Consult your doctor before taking it.

The most common side effects of taking NICOREX 20MG TABLET are headache,
dizziness, skin flushing, nausea, vomiting, weakness and rapid or forceful
heartbeat. Consult your doctor if any of the symptoms worsen.

Uses Of NICOREX 20MG TABLET

• To manage and reduce painful signs of angina pectoris in adults

How NICOREX 20MG TABLET Works

NICOREX 20MG TABLET works by increasing blood flow through the heart vessels,
leading to improved blood and oxygen supply to the heart muscle thus reducing
the workload of the heart which results in reducing the frequency and severity
of angina attacks.

How to use NICOREX 20MG TABLET

Take NICOREX 20MG TABLET as advised by your physician. Swallow the medicine with
a glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of NICOREX 20MG TABLET

Common

• headache
• dizziness
• flushed skin
• nausea
• vomiting
• weakness
• rapid, uneven or forceful heartbeat
• skin abscess (swollen, pus-filled lump within or below the skin surface)
• ulcers in mouth, small and large intestines or anal

Uncommon

• low blood pressure
• pus collection in genital, anal or other areas of digestive tract
• corneal ulcer (open sore in the corneal part of eye)
• conjunctival ulcer (type of inflammatory reaction of eye)
• conjunctivitis (pink eye)

Rare

• rash
• itching
• muscle pain not caused by exercise

Stop taking NICOREX 20MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• red, itchy, swollen or watery eyes including inflammation or ulcer in cornea or conjunctiva (parts of eye)
• signs of ulcers in mouth, stomach, large and small intestine or anus such as blood in stools, vomit, fistula (abnormal opening between organs), abscess (pus collection at infected site) and weight loss
• signs of diverticular disease (infected colon) such as ulcers in the skin, genital tract and nasal passages or around a stoma (artificial opening for waste removal)

How To Manage Side Effects

Nausea:

Take NICOREX 20MG TABLET with or just after meals. Stick to simple meals. Avoid
eating oily or spicy foods. Consult your doctor if the symptom does not improve.

Vomiting:

Get adequate rest. Drink sufficient amount of fluids, especially water. Have
small sips if you feel sick. Eat when you feel hungry. Do not take any medicine
for vomiting without asking your doctor. Consult your doctor if the symptom gets
worse.

Headache:

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress
free. Apply pain relieving balm on your forehead if necessary. Consult your
doctor if the symptom does not improve.

Dizziness:

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully,
do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid
smoking cigarettes and drinking alcohol. Consult your doctor if the symptom does
not improve.

Warning & Precautions

!### Pregnancy

NICOREX 20MG TABLET is not recommended for use in pregnant women. Consult your
doctor before taking NICOREX 20MG TABLET.

!### Breastfeeding

NICOREX 20MG TABLET is not recommended for use in breastfeeding women. Consult
your doctor before taking NICOREX 20MG TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you feel dizzy or weak after taking
NICOREX 20MG TABLET.

!### Alcohol

Avoid consum
further lower your blood pressure.

!### Kidney

NICOREX 20MG TABLET should be taken with caution in patients with kidney
problems. Consult your doctor before taking NICOREX 20MG TABLET.

!### Liver

NICOREX 20MG TABLET should be taken with caution in patients with liver disease
such as fibrosis of liver and chronic liver disease. Consult your doctor before
taking NICOREX 20MG TABLET.

!### Allergy

Do not take NICOREX 20MG TABLET if you are allergic to Nicorandil or any other
ingredients of this medicine.

!### Lungs

NICOREX 20MG TABLET is not recommended for use in patients having lung disease
such as pulmonary oedema (fluid build-up in lungs). Consult your doctor before
taking NICOREX 20MG TABLET.

!### Heart Disease

NICOREX 20MG TABLET is not recommended for use in patients with heart problems
such as cardiogenic shock, left ventricular failure with low filling pressure
and cardiac decompensation. It is used with caution in patients with heart
failure. Consult your doctor before taking NICOREX 20MG TABLET.

Others

NICOREX 20MG TABLET is not recommended for use if you have:

• signs of severe low blood pressure such as dizziness, light-headedness or feeling faint
• signs of low blood volume such as confusion, difficulty breathing or fast breathing, excessive sweating and loss of consciousness

Before taking NICOREX 20MG TABLET, inform your doctor if you have:

• low blood pressure
• signs of low blood potassium levels such as constipation, weakness, muscle damage
• have glucose-6 phosphate dehydrogenase deficiency (a genetic condition)

Use in pediatrics:

NICOREX 20MG TABLET is not recommended for use in children and adolescents
(below 18 years of age). Consult your child’s doctor for advice.

Use in geriatrics:

NICOREX 20MG TABLET should be used with caution in elderly patients (aged above
65 years). Consult your doctor before taking NICOREX 20MG TABLET.

Interactions

A. Drug - Drug interactions:

Before taking NICOREX 20MG TABLET, inform your doctor if you are taking any of
the following medicines:

• medicines used to manage erectile dysfunction (Ex. sildenafil, tadalafil, vardenafil)
• riociguat (used to manage high blood pressure in lung arteries)
• medicines used to manage inflammatory conditions such as corticosteroids (Ex. hydrocortisone, prednisolone)
• medicines used to relieve pain and inflammation (Ex. aspirin, ibuprofen)
• medicines used to manage heart conditions like high blood pressure, angina (Ex. enalapril, propranolol, valsartan and nitroglycerin)
• medicines that increase blood potassium levels (Ex. spironolactone)
• cyclosporin (used to manage organ rejection after transplant)
• dapoxetine (used to manage premature ejaculation)
• medicines used to manage depression (Ex. nortriptyline, duloxetine)

Overdosage:

If you or anyone else accidentally take too much of NICOREX 20MG TABLET, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdose are
weakness, dizziness, fast or uneven heartbeat.

Synopsis

Drug	:	Nicorandil
Pharmacological Category	:	Potassium channel activators
Therapeutic Indication	:	Angina pectoris
Dosage Forms	:	Tablet, Injection

More Information

• Keep NICOREX 20MG TABLET out of reach of children
• Store at (2 - 8°C) in the refrigerator. Do not freeze

FAQs About NICOREX 20MG TABLET

Is it safe to use NICOREX 20MG TABLET in pregnant and breastfeeding women?

No, NICOREX 20MG TABLET is not recommended for use during pregnancy and in women
with childbearing potential. It is also not recommended for use in breastfeeding
women as it is not known whether it may pass in the breast milk. Consult your
doctor for advice if you are planning to get pregnant.

Is NICOREX 20MG TABLET safe to use in children?

No, NICOREX 20MG TABLET is used for adults and not recommended for use in
children and adolescents below 18 years of age. Child’s doctor will select a
suitable alternative therapy for your child depending upon the condition.

What if I forget to take a dose of NICOREX 20MG TABLET?

If you miss or forget to take a dose of NICOREX 20MG TABLET, take it as soon as
you remember. However, omit the missed dose if it is almost time for your next
dose. Do not take the medicine twice to make up for a forgotten dose.

Can NICOREX 20MG TABLET be used in patients with liver problems?

NICOREX 20MG TABLET should be taken with caution in patients with liver problems
such as fibrosis of liver and chronic liver disease. Your doctor may regularly
monitor your liver function during management with NICOREX 20MG TABLET. Consult
your doctor for advice before taking this medicine.

Is[GBNKEYWORD] safe to use in patients with heart problems?

NICOREX 20MG TABLET is not recommended for use in patients with heart problems
such as cardiogenic shock, left ventricular failure with low filling pressure
and cardiac decompensation. It is used with caution in patients with heart
failure. Consult your doctor before taking NICOREX 20MG TABLET.

Useful Diagnostic Tests

• Electrocardiogram (ECG)
• Coronary angiography
• Complete Blood Count (CBC)