MONOLOSIN DFT Tablet 10's

Introduction About MONOLOSIN DFT TABLET

MONOLOSIN DFT TABLET is a combination of Deflazacort and Tamsulosin which
belongs to the group of medicines called Corticosteroids and Alpha-blockers
respectively. It is used in the management of kidney stone by facilitating easy
urination.

Kidney stones are abnormal hard deposits formed from minerals and salts inside
the kidney due to some underlying medical condition or certain medications. It
is characterised by severe sharp pain in the either side of the lower back,
blood in urine, vague stomach-ache, fever, chills or cloudy urine.

Do not drink grapefruit juice while taking MONOLOSIN DFT TABLET. Avoid taking
this medicine, if you are allergic to deflazacort or tamsulosin and have severe
liver infection, serious eye infection, duchenne muscular dystrophy, dizziness
(while getting up) or micturition syncope (discomfort while urination).

Before taking MONOLOSIN DFT TABLET, inform your doctor if you have high blood
pressure, osteoporosis (weak bones), kidney or heart diseases.

MONOLOSIN DFT TABLET is not recommended for use in pregnant and breast-feeding
women since it is used only in men. It is not recommended for use in children
and adolescents (aged below 18 years). Also, it is used with caution in elderly
patients.

The most common side effects of taking MONOLOSIN DFT TABLET are dizziness,
difficulties in ejaculation, increased appetite, frequent urination, nausea and
stomach pain. Consult your doctor if any of the side effect gets worse.

Uses Of MONOLOSIN DFT TABLET

• Manage kidney stone

How MONOLOSIN DFT TABLET Works

MONOLOSIN DFT TABLET helps in managing kidney stone and facilitates easy
urination where deflazacort blocks the production of certain chemical messengers
in the body that cause inflammation and enhances the muscle strength as well as
functioning and tamsulosin binds selectively and competitively to certain
receptors, causing muscle relaxation around the bladder exit and prostate gland,
thereby allowing easy passage of urine.

How to use MONOLOSIN DFT TABLET

Take MONOLOSIN DFT TABLET as advised by your physician. Swallow the medicine
with the glass of water. Do not crush or chew the medicine. Take this medicine
after breakfast or after the first daily meal. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of MONOLOSIN DFT TABLET

Common

• dizziness (especially upon an abrupt change in the position)
• difficulties in ejaculation (little or no semen ejaculated at sexual climax)
• cloudy urine following sexual climax, frequent urination
• cushingoid appearance (extra fat build-up on the face)
• increased appetite, cough
• weight gain, central obesity
• upper respiratory tract infection such as inflammation in nose and throat or runny nose
• redness of skin, rash, bruise
• fever, nausea
• back pain
• psychomotor hyperactivity, irritability
• nosebleed
• stretch marks
• abdominal discomfort/pain

Uncommon

• headache
• light-headedness or fainting (due to postural low blood pressure)
• swelling and irritation inside the nose
• constipation, diarrhoea
• vomiting, indigestion
• itching, red itchy skin
• weakness, thirst
• increased flow of tears in eyes
• infections such as hordeolum (infection in the eye lid), impetigo (red sores on face), influenza (common cold), otitis externa (an ear infection), pharyngitis (a throat infection), tooth abscess (pus formation beneath the tooth), urinary tract infection, viral infections
• irregular heart rate
• muscle spasms or pain, neck mass, neck pain, pain in extremity (legs and arms)
• mood disorders such as mood swings, aggression, depression, emotional disorder, sleeplessness, restlessness
• urinary disorders such as chromaturia (abnormal colouration of urine), painful urination, hypertonic bladder (disorder causing sudden urge to urinate)
• pain in testes
• shallow or slow breathing
• skin problems such as pimples, baldness
• dermatitis acneiform (condition marked by the formation of acne-like bumps on affected site)
• hot flush

Rare

• syncope (short-term loss of consciousness)
• signs of allergy reactions such as angioedema (rapid swelling beneath the skin) or anaphylaxis (fainting, shortness of breath and noisy breathing)

Stop taking MONOLOSIN DFT TABLET and contact your doctor if you experience any
of the following side effects:

• serious skin rashes
• signs of stevens-johnson syndrome (a serious hypersensitivity reaction) such as purplish spots or patches on the skin, blisters, skin peeling, (high) fever, joint pain, and/or eye inflammation
• serious allergic reaction such as angioedema (swelling of the face or throat)

How To Manage Side Effects

Dizziness:

MONOLOSIN DFT TABLET may cause dizziness which can be managed by lying down
until the dizziness passes and get up slowly. Do not bend down suddenly. Get a
lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking
alcohol or smoking. Consult your doctor if the symptom persists for long or gets
worsened.

Diarrhoea:

Drink lot of fluids such as water to keep yourself hydrated. Try to avoid taking
any medicine on your own to manage diarrhoea and consult your doctor if the
symptom gets worse.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and
drink plenty of water. Try doing exercise regularly (going for a daily walk or
run). If this does not help, inform your doctor for receiving alternate
managements for constipation.

Nausea and vomiting:

Try to take MONOLOSIN DFT TABLET with or just after a meal or a snack. Stick to
simple meals. Avoid eating oil rich or spicy food. Consult your doctor if the
symptom gets worse.

Warning & Precautions

!### Pregnancy

MONOLOSIN DFT TABLET is not recommended for use in pregnant women since it is
used only in men.

!### Breastfeeding

MONOLOSIN DFT TABLET is not recommended for use in breastfeeding women since it
is used only in men.

!### Driving and Using Machines

MONOLOSIN DFT TABLET should be used with caution while driving or operating
machines since it might cause dizziness. Consult your doctor before taking
MONOLOSIN DFT TABLET.

!### Alcohol

Avoid consum
alter the effect of this medicine.

!### Kidney

MONOLOSIN DFT TABLET should be used with caution in patients with severe renal
impairment. Consult your doctor for advice before taking MONOLOSIN DFT TABLET.

!### Liver

MONOLOSIN DFT TABLET is not recommended for use in patients with severe liver
infection. Consult your doctor before taking MONOLOSIN DFT TABLET.

!### Allergy

MONOLOSIN DFT TABLET is not recommended for use if you are allergic to
deflazacort, tamsulosin, or any other ingredients of this medicine.

!### Heart Disease

MONOLOSIN DFT TABLET should be used with caution in patients with heart disease
such as congestive heart disease (inability of heart to pump sufficient blood),
a recent myocardial infarction (blockage of blood flow to heart). Consult your
doctor before taking MONOLOSIN DFT TABLET.

Others

MONOLOSIN DFT TABLET is not recommended for use if you:

• have history of angioedema (swelling due to allergic reaction) after using of certain drugs
• feel dizziness when you sit up or stand up from the lying position
• suffer from micturition syncope (malaise or discomfort during or after urinating)

Before taking MONOLOSIN DFT TABLET, inform your doctor if you:

• have high blood pressure
• have osteoporosis (condition marked by weak bones)
• are planning for vaccination
• have neuromuscular transmission disorders such as myasthenia gravis (condition marked by muscle weakness)
• have thromboembolic (obstruction of blood vessel by clot) disorders such as deep vein thrombosis and pulmonary embolism
• are scheduled to undergo cataract or glaucoma (eye disorder) surgery
• have certain gastro-intestinal (abdominal) disorders such as active or latent pe

Use in Paediatrics:

MONOLOSIN DFT TABLET is not recommended for use in children and adolescents
(aged below 18 years). Consult your child’s doctor for advice.

Use in Geriatrics:

MONOLOSIN DFT TABLET should be used with caution in elderly patients (aged above
65 years). Consult your doctor before taking MONOLOSIN DFT TABLET.

Interactions

A. Drug-Drug Interactions:

Before taking MONOLOSIN DFT TABLET, inform your doctor, if you are taking any of
the following medicines:

• erythromycin, clarithromycin, rifampin (used to manage bacterial infections)
• ketoconazole, fluconazole (used to manage fungal infections)
• diltiazem, verapamil (used to manage blood pressure)
• efavirenz (used to manage human immunodeficiency virus (HIV) infection)
• carbamazepine, phenytoin (used to manage epilepsy)
• neuromuscular blocking agents (medicines used to relax muscles) Ex. pancuronium
• over-the-counter medicines Ex. dietary supplements and herbal products
• insulin (used to manage diabetes)
• anticoagulants (medicines used to manage blood clots) Ex. warfarin
• alpha-1 adrenergic receptor (medicine used to manage benign prostatic hyperplasia) Ex. alfuzosin, doxazosin
• non-steroidal anti-inflammatory drugs (medicines used to manage inflammation and pain) Ex. diclofenac, aspirin

B. Drug-Food Interactions:

Avoid drinking grapefruit juice while taking this medicine.

Overdosage:

If you or anyone else accidentally takes too much of MONOLOSIN DFT TABLET,
consult your doctor immediately or visit the nearby hospital. Overdosage symptom
of MONOLOSIN DFT TABLET is low blood pressure.

Synopsis

Drug	:	Deflazacort, Tamsulosin
Pharmacological Category	:	Corticosteroids, Alpha-blockers
Therapeutic Indication	:	Kidney stones
Dosage Forms	:	Capsule, Tablet

More Information

• Keep MONOLOSIN DFT TABLET out of reach of children
• Store MONOLOSIN DFT TABLET at room temperature

FAQs About MONOLOSIN DFT TABLET

What is MONOLOSIN DFT TABLET used for?

MONOLOSIN DFT TABLETis used in the management of kidney stone which works by
relaxing the muscle around the bladder exit and prostate gland that results in
easy urination or free flow of urine.

What happens if you take more MONOLOSIN DFT TABLET than your required dose?

If you or anyone else accidentally takes too much of MONOLOSIN DFT TABLET,
consult your doctor immediately or visit the nearby hospital. Symptoms of
overdose are signs of low blood pressure such as light headedness, dizziness or
blurred vision.

Who should avoid taking MONOLOSIN DFT TABLET?

MONOLOSIN DFT TABLET is not recommended for use if you have a history of
angioedema (swelling due to allergic reaction) after using of certain drugs,
feel dizziness when you sit up or stand up from the lying position, suffer from
micturition syncope (malaise or discomfort during or after urinating).

Is MONOLOSIN DFT TABLET safe to use in children?

MONOLOSIN DFT TABLET is not recommended for use in children and adolescents
(aged below 18 years) because tamsulosin (one of the drugs in this medicine)
does not work in this population. Consult your doctor before taking MONOLOSIN
DFT TABLET.

Does MONOLOSIN DFT TABLET make you pee more at night?

No, MONOLOSIN DFT TABLET does not make you pee more at night. On contrary to
this, tamsulosin (one of the drugs in this medicine) reduces night-time urine
production in patients with nocturnal polyuria (disorder causing excess urine
production in the night-time). Consult your doctor before taking MONOLOSIN DFT
TABLET.

What if I forget to take MONOLOSIN DFT TABLET dose?

If you have forgotten to take MONOLOSIN DFT TABLET at the scheduled time, take
it anytime later during the day. If you realize this fact only on the next day,
continue with the usual dosage scheme. Do not take a double dose to make up for
a forgotten dose. Consult your doctor before taking MONOLOSIN DFT TABLET.

Useful Diagnostic Tests

• Urinalysis
• Abdominal and Pelvic CT (Computed tomography) scan