Losfirst 25mg Tablet 10'S

Introduction About LOSFIRST

LOSFIRST is used to manage mild to moderate hypertension. It also used to manage
hypertensive patients with left ventricular hypertrophy and nephropathy in type
2 diabetic patients. It contains Losartan which belongs to the group of
medicines called Antihypertensive agents. It blocks the effects of Angiotensin
II (substance produced in your body which causes narrowing of blood vessels),
which leads to relaxation of blood vessels resulting in low blood pressure in
affected individuals.

LOSFIRST is not recommended for use in patients allergic to losartan. It is also
not recommended for use in patients with severely impaired liver function and
kidney function. Before taking the medicine, inform your doctor if you have a
history of angioedema and/or suffering from excessive vomiting/diarrhoea,
primary hyperaldosteronism kidney problems. LOSFIRST is not recommended for use
in early pregnancy and must not be taken when a woman is more than 3 months
pregnant since it may cause serious harm to the baby if used after 3-months of
pregnancy. It is not known whether the medicine is excreted in human milk, hence
consult your doctor before taking the medicine.

It is not recommended for use in children under 6 years of age. The most common
side effects are dizziness, general weakness, tiredness, low blood sugar,
changes in kidney function (associated with signs such as decreased urine
output, edema, shortness of breath) and/or anaemia. Consult your doctor if any
of these symptoms worsens.

Uses Of LOSFIRST

It is used to manage:

• mild to moderate hypertension
• hypertensive patients with left ventricular hypertrophy
• nephropathy in type 2 diabetic patients

How LOSFIRST Works

LOSFIRST blocks the effects of Angiotensin II (substance produced in your body
which causes narrowing of blood vessels), which leads to relaxation of blood
vessels resulting in low blood pressure in affected individuals.

How to use LOSFIRST

• Take LOSFIRST as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of LOSFIRST

Common Side Effects of LOSFIRST:

• dizziness, general weakness, tiredness
• low blood pressure orthostatic hypotension
• signs of low blood sugar such as fast heartbeat, shaking, sweating and/or hunger
• signs of changes in kidney function such as decreased urine output, oedema, shortness of breath
• abdominal pain, constipation, diarrhoea

Stop taking LOSFIRST and contact your doctor immediately if you experience any
of the following side effects:

• signs of severe allergic reactions such as rash, itching, swelling of the face, lips, mouth/throat that may cause difficulty in swallowing or breathing

Warning & Precautions

!### Pregnancy

ContraindicatedLOSFIRST is not recommended in early pregnancy and must not be taken when more
than 3 months pregnant, as it may cause serious harm to the baby if used after 3
months of pregnancy.

!### Breastfeeding

Consult your doctorIt is not known whether the medicine is excreted in human milk, hence consult
your doctor before taking the medicine.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizzy or drowsy after taking
LOSFIRST.

!### Kidney

Consult your doctorLOSFIRST is not recommended for use in patients with impaired kidney function.
It should be taken with caution in patients with narrowing of blood vessels to
one or both the kidneys and in patients who had recently received kidney
transplant.

!### Liver

Consult your doctorLOSFIRST is not recommended for use in patients with severely impaired liver
function. It should be used with caution in patients having impaired liver
function.

!### Allergy

ContraindicatedDo not take LOSFIRST if you are allergic to Losartan and/or any other
ingredients of this medicine.

!### Heart Disease

Use with CautionLOSFIRST should be taken with caution in patients having heart failure, problems
in heart valve and heart muscle, cardiac arrythmia (irregular and fast
heartbeat), coronary heart disease.

!### Use In Pediatrics

Consult your doctorLOSFIRST is not recommended for use in children under 6 years of age and also in
children suffering from kidney and/or liver problems. The medicine is
recommended for used in children and adolescents (aged 6 to 18 years) after
consulting the doctor.

!### Use In Geriatrics

Use with CautionLOSFIRST should be used with caution in patients (aged above 75 years).

Others

LOSFIRST is not recommended for use if you have:

• diabetes and managed with blood pressure lowering medicine containing aliskiren

Before taking LOSFIRST, inform your doctor if you:

• have a history of angioedema (swelling of the face, lips, throat and/or tongue)
• suffer from excessive vomiting/diarrhoea leading to extreme loss of fluid and/or salt in your body
• suffer from primary hyperaldosteronism (a syndrome associated with increased secretion of aldosterone hormone)
• suffer from cerebrovascular disease (caused by a reduced blood circulation to the brain)
• salt-restricted diet

Interactions

A. Drug-Drug Interactions:

Before taking LOSFIRST, inform your doctor if you are taking any of the
following medicine:

• diuretics (Ex. furosemide, bumet
• potassium-sparing diuretics (Ex. amiloride, triamterene, spironolactone)
• angiotensin converting enzyme inhibitors (Ex. enalapril, lisinopril, ramipril)
• aliskiren
• beta blockers (Ex. atenolol, propranolol, carvedilol)
• Anticoagulants (Ex. heparin)
• Antibiotics (Ex. trimethoprim)
• potassium supplements and potassium-containing salt substitutes
• antidepressants (Ex. citalopram, fluoxetine, paroxetine)
• antipsychotic agents (Ex. haloperidol, thioridazine)
• skeletal muscle relaxants (Ex. baclofen)
• cytoprotectants (Ex. amifostine)
• cox-2 inhibitors (Ex. meloxicam, etodolac)
• Antim

Overdosage:

If you or anyone else accidentally take too much of LOSFIRST, consult your
doctor immediately or visit the nearby hospital. The most common symptoms of
overdose are low blood pressure, fast heartbeat and slow heartbeat.

Synopsis

Drug	:	Losartan
Pharmacological Category	:	Angiotensin II receptor antagonists
Therapeutic Indication	:	Hypertension, Hypertensive patients with left ventricular hypertrophy, Neuropathy in type 2 diabetic patient
Dosage Forms	:	Tablet

More Information

FAQs About LOSFIRST

Q: What is LOSFIRST used for?

A: LOSFIRST is primarily used to manage high blood pressure (hypertension). It
is also prescribed to protect the kidneys in people with diabetes and to reduce
the risk of stroke in individuals with heart disease. By lowering blood
pressure, Losartan helps reduce complications such as heart attacks, strokes,
and kidney damage.

Q: How does LOSFIRST works?

A: LOSFIRST belongs to a class of drugs called angiotensin II receptor blockers
(ARBs). It works by relaxing blood vessels, making it easier for blood to flow.
It blocks the action of angiotensin II, a natural substance that tightens blood
vessels and increases blood pressure. By preventing this tightening, Losartan
lowers blood pressure and reduces strain on the heart.

Q: What is the best time to take LOSFIRST?

A: LOSFIRST is usually taken once a day, with or without food. It is often
recommended to take it at the same time each day to maintain consistent blood
levels. Some people prefer taking it in the morning to avoid nighttime
urination, while others may take it at night if it causes dizziness or tiredness
during the day. Consult your doctor for personalized advice.

Q: How many doses of Losartan can be taken in a day?

A: Most people take one dose of Losartan daily, though the dose may vary
depending on the condition being treated. For example, the typical starting dose
for hypertension is 50 mg once a day, but it can be adjusted to 25–100 mg based
on your response. Taking more than the prescribed dose can cause excessive blood
pressure lowering, so always follow your doctor’s instructions.

Q: Can LOSFIRST be used during pregnancy?

A: No, Losartan is not safe to use during pregnancy. It can harm the developing
baby, especially during the second and third trimesters, potentially leading to
kidney problems or developmental issues. If you are pregnant or planning to
conceive, inform your doctor immediately to switch to a safer alternative.

Q: Can LOSFIRST control blood pressure effectively?

A: Yes, Losartan is highly effective in controlling high blood pressure when
taken as prescribed. However, its effectiveness depends on factors such as
adhering to the prescribed dose, maintaining a healthy diet, limiting salt
intake, and incorporating regular exercise into your routine. Regular blood
pressure monitoring is also essential.

Q: Who should not use Losartan?

A: Losartan should not be used by individuals who are pregnant or breastfeeding,
have severe kidney or liver disease, are allergic to Losartan or its
ingredients, have low blood potassium or sodium levels. Consult your doctor if
you have any underlying medical conditions or are taking other medications.

Q: What are the common side effects of Losartan?

A: The most common side effects of Losartan include dizziness, fatigue, nasal
congestion, and back pain. Some people may also experience diarrhoea or high
potassium levels (hyperkalemia). If any side effects persist or worsen, seek
medical attention.

Q: Is Losartan safe?

A: Losartan is generally considered safe when taken as prescribed by a doctor.
Regular monitoring of blood pressure, kidney function, and potassium levels is
recommended to ensure safety, especially in individuals with pre-existing kidney
or liver conditions. Always inform your doctor about any other medications or
supplements you are using.

Q: Can LOSFIRST be taken on an empty stomach or before food?

A: Yes, LOSFIRST can be taken with or without food. Food does not significantly
affect the absor
your routine. Ensure you drink plenty of water when taking the tablet.

Q: Is LOSFIRST safe for kidney patients?

A: Losartan is often prescribed to protect the kidneys, especially in diabetic
patients. However, it may not be suitable for individuals with severe kidney
impairment or those on dialysis. Regular monitoring of kidney function is
essential to ensure its safe use in such cases.

Q: How long will it take for Losartan to work?

A: Losartan starts working within 1–2 hours of taking a dose, but its full blood
pressure-lowering effect may take 3–6 weeks of consistent use. If you are using
it for conditions like diabetic kidney disease, the benefits may take longer to
show, requiring regular follow-ups with your doctor.

Q: Can I stop taking Losartan once my blood pressure is controlled?

A: No, you should not stop taking Losartan without consulting your doctor. High
blood pressure is a chronic condition, and stopping the medication abruptly can
cause blood pressure to rise again, increasing the risk of complications. Your
doctor may adjust your dose or recommend lifestyle changes to complement the
treatment.

Useful Diagnostic Tests

• ECG at Home
• ECG + BP Check at Home
• Full Body Checkup with ECG & BP at Home
• Comprehensive Cardiac Risk Screening with 12 Lead ECG and BP