Hopace 2.5mg Capsule 10'S

Introduction About HOPACE 2.5MG CAPSULE

HOPACE 2.5MG CAPSULE contains Ramipril, which belongs to the group of medicines
called Antihypertensives. It is used in the management of high blood
pressure (hypertension). Blood pressure is the force exerted by the circulating
blood on the walls of blood vessels. Hypertension is a condition in which the
blood pressure is too high.

HOPACE 2.5MG CAPSULE reduces the risk of kidney problems and can be used as a
management following a heart attack. HOPACE 2.5MG CAPSULE is also used to manage
heart failure (a condition when the heart is not able to pump enough blood).
Symptoms include headache, breathlessness, excess sweating, sleep disturbance,
tingling and dizziness.

Your doctor might ask you to make certain lifestyle changes such as eating
healthy, adequate sleep, weight and stress management, quitting smoking and
alcohol. Your doctor may also advise you to take relevant tests before and
during the management with HOPACE 2.5MG CAPSULE.

HOPACE 2.5MG CAPSULE is not recommended for use in patients having kidney
problems where blood supply to the kidney is reduced (renal artery stenosis),
patients undergoing dialysis or having collagen vascular diseases (scleroderma
and systemic lupus erythematosus).

If you are pregnant or breast-feeding, consult your doctor for advice before
taking HOPACE 2.5MG CAPSULE. HOPACE 2.5MG CAPSULE is not recommended for use in
children and adolescents (under 18 years of age). The most common side effects
are headache, dizziness, hypotension (reduced blood pressure), inflammation of
the sinuses (sinusitis), diarrhea, skin rash.

Uses Of HOPACE 2.5MG CAPSULE

• Manage increased blood pressure, heart failure
• Manage and reduces the risk of getting a heart attack or stroke and slow down the worsening of kidney problems

How HOPACE 2.5MG CAPSULE Works

HOPACE 2.5MG CAPSULE decreases blood pressure by decreasing the production of
substances that raises the blood pressure (Angiotensin Converting Enzyme). This
in turn reduces constriction of veins (vasoconstriction). HOPACE 2.5MG CAPSULE
distributes extensively amongst your body tissues. As a result, it widens and
relaxes your blood vessels, leading to efficient blood circulation.

How to use HOPACE 2.5MG CAPSULE

Take HOPACE 2.5MG CAPSULE as advised by your doctor. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of HOPACE 2.5MG CAPSULE

Common

• headache, feeling tired or dizzy
• fainting, orthostatic hypotension (abnormally low blood pressure, especially when you stand or sit quickly)
• dry cough, inflamed sinuses (sinusitis)
• bronchitis, shortness of breath
• stomach pain, diarrhea, indigestion, feeling sick
• skin rash
• chest pain
• cramps or pain in your muscles and joints

Uncommon

• balancing problems (vertigo)
• paraesthesia (numbness, tingling, pricking, burning or creeping on your skin)
• loss or changes in taste
• sleep problems
• feeling depressed, anxious or restless
• breathing difficulties or worsening of asthma
• heartburn, constipation or dry mouth
• increased urination
• increased sweating
• loss or decrease of appetite (anorexia)
• increased or irregular heartbeat
• swelling in arms and legs (this may be a sign of your body holding onto more water)
• flushing
• blurred vision
• fever
• reduced sexual ability

Rare

• red and swollen tongue
• feeling confused or shaky
• nail problems (loosening or separation of a nail from its bed)
• cold extremities
• red, itchy, swollen or watery eyes
• severe peeling or flaking of the skin, lumpy, itchy rash
• bruising or skin rash
• blotches (patches) on cold extremities and skin
• feeling of weakness
• disturbed hearing and tinnitus (ringing in your ears)

Stop taking HOPACE 2.5MG CAPSULE and contact your doctor immediately if you
experience any of the following side effects:

• concentrated urine (darker than usual in color)
• confusion and fits
• faster heart rate or heartbeat (palpitations), chest pain, tightness in your chest or more serious problems including heart attack and stroke
• shortness of breath or a cough
• blood or bone marrow problems (bruising more easily, bleeding for longer than normal, any sign of bleeding (bleeding from the gums), purple spots, or getting infections more easily, fever, dizzy or having pale skin)
• pancreatitis (severe stomach pain which may reach through to your back)
• hepatitis or liver damage (fever, chills, tiredness, loss of appetite, stomach pain)
• yellowing of skin or whites of your eyes (jaundice)

How To Manage Side Effects

Inflamed sinuses:

Do steam inhalation whenever you feel a blocked nose or painful sinuses.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and
drink plenty of water. Exercise more regularly. Consult your doctor for advice.

Diarrhea:

Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated.
Do not consume any medicine on your own without consulting your doctor.

Stomach pain:

Try to rest and relax. Try to have smaller and more frequent meals and have them
slowly. Keep a heat pad on your stomach. If the symptom does not improve,
Consult your doctor for advice.

Warning & Precautions

!### Pregnancy

HOPACE 2.5MG CAPSULE is not recommended for use during pregnancy, as it may harm
the baby. Consult your doctor if you are, planning to or become pregnant while
taking HOPACE 2.5MG CAPSULE.

!### Breastfeeding

HOPACE 2.5MG CAPSULE is generally not recommended for use in breastfeeding
women. Consult your doctor before taking HOPACE 2.5MG CAPSULE.

!### Driving and Using Machines

Do not drive or operate any machines if you feel dizzy after taking HOPACE 2.5MG
CAPSULE.

!### Alcohol

Avoid consum
make you dizzier and light-headed. Consult your doctor for advice.

!### Kidney

HOPACE 2.5MG CAPSULE is not recommended in patients with severe kidney disease
(like renal artery stenosis) or if the patient is on dialysis. It should be used
with caution in patients with kidney disease. Consult your doctor before taking
HOPACE 2.5MG CAPSULE.

!### Liver

HOPACE 2.5MG CAPSULE should be taken with caution in patients with liver
disease. Consult your doctor before taking HOPACE 2.5MG CAPSULE.

!### Allergy

Do not take HOPACE 2.5MG CAPSULE if you are allergic to Ramipril.

!### Heart Disease

HOPACE 2.5MG CAPSULE should be taken with caution in patients who have heart
diseases. Consult your doctor before taking HOPACE 2.5MG CAPSULE.

Others

HOPACE 2.5MG CAPSULE is not recommended for use if you:

• have a history of angioedema (itching, hives (urticaria) red marks on the hands, feet and throat, swelling of the throat and tongue, swelling around the eyes and lips, difficulty in breathing and swallowing)
• have diabetes
• have abnormally low blood pressure

Before taking HOPACE 2.5MG CAPSULE, inform your doctor if you:

• have lost a lot of body salts or fluid (vomiting, diarrhea)
• have a low salt diet
• have hyperkalemia (raised levels of potassium in the blood)
• have hyponatremia (low levels of sodium in blood)
• have to undergo desensitization (management to reduce allergy due to bee or wasp stings.
• have to take anesthesia (operation or dental management)
• have collagen vascular disease (scleroderma or systemic lupus erythematosus)

Use in pediatrics:

HOPACE 2.5MG CAPSULE is generally not recommended for use in children and
adolescents (under 18 years of age). Consult your doctor before taking HOPACE
2.5MG CAPSULE.

Use in geriatrics:

HOPACE 2.5MG CAPSULE should be used with caution in elderly patients. Consult
your doctor before taking HOPACE 2.5MG CAPSULE.

Interactions

A. Drug – Drug interactions:

Before taking HOPACE 2.5MG CAPSULE, inform your doctor if you are taking any of
the following medicine:

• sacubitril, valsartan (used to manage a type of long-term (chronic) heart failure in adults)
• diuretics (used to manage high blood pressure) Ex. furosemide, hydrochlorothiazide
• anesthesia (used in operations or dental management) Ex. lidocaine
• Non-Steroidal AntiInflammatory Drugs (used to relieve pain and inflammation) Ex. ibuprofen or indomethacin and aspirin
• ephedrine, noradrenaline or adrenaline (used to manage low blood pressure, shock, cardiac failure, asthma or allergies)
• ciclosporin, sirolimus, everolimus (used in management of graft rejection after transplant)
• spironolactone, triamterene, amiloride, potassium salts, trimethoprim alone or in combination with sulfamethoxazole (used for managing infections)
• heparin (used for thinning blood)
• prednisolone (steroid used to reduce inflammation)
• allopurinol (used to lower uric acid in blood)
• procainamide (used for heart rhythm problems)
• racecadotril (used to manage diarrhea)
• immunosuppressants (used to suppress the immune system) ex. temsirolimus, everolimus, sirolimus
• vildagli
• lithium (used in management of mental health problems)
• angiotensin II receptor blocker (usen in diabetes related kidney problems) Ex. aliskiren, valsartan, telmisartan, irbesartan
• neprilysin (NEP) inhibitors (used in management of heart failure and high blood pressure) Ex. racecadotril

Overdosage:

If you or anyone else accidentally take too much of HOPACE 2.5MG CAPSULE,
consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Ramipril
Pharmacological Category	:	ACE Inhibitors
Therapeutic Indication	:	Hypertension
Dosage Forms	:	Tablet, Capsule

More Information

• Keep HOPACE 2.5MG CAPSULE out of reach from children
• Store at room temperature below 30°C

FAQs About HOPACE 2.5MG CAPSULE

Can HOPACE 2.5MG CAPSULE be used in diabetes and kidney diseases?

Yes. HOPACE 2.5MG CAPSULE can be used in kidney disease alone or in kidney
disease associated with diabetes and in diabetes without kidney disease. Your
doctor might prescribe you other drugs or will be able to decide better
according to your condition.

Is HOPACE 2.5MG CAPSULE safe to take?

Yes. HOPACE 2.5MG CAPSULE is safe and effective in managing mild to moderate
high blood pressure. Your doctor will be able to decide the correct management
for you.

Can HOPACE 2.5MG CAPSULE cause fast heart rate?

Yes. Palpitations or fast heart rate are potential side effect of HOPACE 2.5MG
CAPSULE. Contact your doctor immediately if you feel any such symptoms after
taking HOPACE 2.5MG CAPSULE.

What precautions do I need to follow while taking HOPACE 2.5MG CAPSULE?

Patients taking HOPACE 2.5MG CAPSULE must inform their doctor about their
pre-existing disease conditions like kidney, heart, or liver problems as you may
develop serious side effects. Consult your doctor immediately if you experience
any unusual symptoms after taking HOPACE 2.5MG CAPSULE.

Can HOPACE 2.5MG CAPSULE cause hyponatremia?

Yes. HOPACE 2.5MG CAPSULE can lead to hyponatremia (low sodium levels in blood).
Your doctor might ask you take timely blood tests to keep a check on your blood
sodium levels while managing you with HOPACE 2.5MG CAPSULE.

Useful Diagnostic Tests

• Serum electrolyte
• Kidney function test
• Cholesterol test
• ECG (Electrocardiogram)