GUFISOME 50mg Injection 1's

Introduction About GUFISOME 50MG INJECTION

GUFISOME 50MG INJECTION contains Amphotericin B which belongs to the group of
medicines called Anti-fungal agents. GUFISOME 50MG INJECTION is used to manage
invasive fungal infections in patients who are resistant/intolerant to
conventional Amphotericin B therapy.

GUFISOME 50MG INJECTION is not recommended for use in patients allergic to
Amphotericin B. It is also not recommended for use in patients with
common/superficial, clinically inapparent fungal infections (which are
detectable only by positive skin/serologic tests).

Before receiving GUFISOME 50MG INJECTION, inform your doctor if you are
neutropenic, and/or have liver problems (such as hepatic impairment), and suffer
from kidney problems/undergoing dialysis.

GUFISOME 50MG INJECTION should be used with caution in pregnant and
breast-feeding women only if it is clearly necessary. It is also used with
caution in children and adolescents (aged below 18 years) and in elders (aged
above 65 years) after consulting with the doctor.

The most common side effects of receiving GUFISOME 50MG INJECTION are fever,
chills, and/or rigors. Consult your doctor if any of these symptoms worsen.

Uses Of GUFISOME 50MG INJECTION

• Manage invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy

How GUFISOME 50MG INJECTION Works

GUFISOME 50MG INJECTION binds to ergosterol (steroid present on the cell
membranes of fungi) which leads to the formation of pores and ion leakage on the
cell membrane resulting in fungal cell death thus managing invasive fungal
infections in affected individuals.

How to use GUFISOME 50MG INJECTION

GUFISOME 50MG INJECTION will be given to you only by a doctor or a nurse into a
vein as an intravenous infusion. Your doctor will decide the correct dose and
duration for you depending upon your age, body weight and disease condition.

Side Effects Of GUFISOME 50MG INJECTION

Common

• fever
• chills/rigors

Warning & Precautions

!### Pregnancy

GUFISOME 50MG INJECTION should be administered with caution in pregnant women
only if it is clearly necessary. Consult your doctor before receiving the
medicine.

!### Breastfeeding

GUFISOME 50MG INJECTION should be administered with caution in breastfeeding
women only if it is clearly necessary. Consult your doctor before receiving the
medicine.

!### Driving and Using Machines

GUFISOME 50MG INJECTION is unlikely to affect your ability to drive/operate
machines.  Consult your doctor before receiving GUFISOME 50MG INJECTION.

!### Kidney

GUFISOME 50MG INJECTION should be administered with caution in patients with
kidney disease and in patients who are under dialysis.  Consult your doctor
before receiving the medicine.

!### Liver

GUFISOME 50MG INJECTION should be administered with caution in patients with
hepatic impairment, and/or other liver disease. Consult your doctor before
receiving GUFISOME 50MG INJECTION.

!### Allergy

Do not receive GUFISOME 50MG INJECTION if you are allergic to Amphotericin B,
and/or any other ingredients of this medicine.

Others

GUFISOME 50MG INJECTION is not recommended for use if you:

• have common/superficial, clinically inapparent fungal infections (which are detectable only by positive skin/serologic tests)

Before receiving GUFISOME 50MG INJECTION, inform your doctor if you:

• suffer from neutropenia (condition marked by low count of neutrophils)

Use in Pediatrics:

GUFISOME 50MG INJECTION should be used with caution in children and adolescents
(aged below 18 years). Consult your doctor before child receives the medicine.

Use in Geriatrics:

GUFISOME 50MG INJECTION should be used with caution in elderly patients (aged
above 65 years). Consult your doctor before receiving GUFISOME 50MG INJECTION.

Interactions

A. Drug–Drug interactions:

Before receiving GUFISOME 50MG INJECTION, inform your doctor if you are taking
any of the following medicine:

• nephrotoxic drugs (medicines that can cause damage to the kidney) Ex. minoglycosides, cisplatin
• zidovudine (used to manage HIV)
• cyclosporin (used to manage transplanted organ rejection)

Overdosage:

GUFISOME 50MG INJECTION will be administered to you only by a doctor or a nurse
in a hospital, and so it is unlikely to receive an overdose. However, consult
your doctor or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Amphotericin B
Pharmacological Category	:	Anti-fungal agent
Therapeutic Indication	:	Invasive fungal infection
Dosage Forms	:	Injection, Infusion, Emulsion, Gel

More Information

• Keep GUFISOME 50MG INJECTION out of reach of children
• Store GUFISOME 50MG INJECTION under refrigeration at 2°C to 8°C

FAQs About GUFISOME 50MG INJECTION

What is GUFISOME 50MG INJECTION used for?

GUFISOME 50MG INJECTION is an anti-fungal agent which is used to manage invasive
fungal infections in patients who are resistant/intolerant to conventional
Amphotericin B therapy.

What are the side effects of GUFISOME 50MG INJECTION?

The most common side effects of receiving GUFISOME 50MG INJECTION are fever,
chills, and/or rigors. Consult your doctor if any of these symptoms worsen.

How GUFISOME 50MG INJECTION works:

GUFISOME 50MG INJECTION binds to ergosterol (steroid present on the cell
membranes of fungi) which leads to the formation of pores and ion leakage on the
cell membrane resulting in fungal cell death thus managing invasive fungal
infections in affected individuals.

How GUFISOME 50MG INJECTION is administered?

GUFISOME 50MG INJECTION will be given to you only by a doctor or a nurse into a
vein as an intravenous infusion. Your doctor will decide the correct dose and
duration for you depending upon your age, body weight and disease condition.

Can GUFISOME 50MG INJECTION be used in pregnant and breast-feeding women?

Yes, GUFISOME 50MG INJECTION can be administered but with caution in pregnant
and breastfeeding women. Consult your doctor before receiving the medicine.

Useful Diagnostic Tests

• Fungal culture test