CASJOL 50 Injection 1's

Introduction About CASJOL 50 INJECTION

CASJOL 50 INJECTION contains Caspofungin which belongs to the group of medicines
called Antifungal Drugs. It is used to manage serious fungal infections of the
blood, heart, brain, eyes, bones, nose, sinuses, lungs and other parts of the
body (such as invasive candidiasis, invasive aspergillosis, etc.).

It can also be used to manage fungal infections during high-risk conditions such
as after a surgery or chemotherapy and in patients who recently underwent an
organ transplantation or having a weak immune system. It may be given to
patients to reduce fever and chills that is suspected to be a fungal infection
when management with antibiotics is not working appropriately.

CASJOL 50 INJECTION should be used under careful medical supervision. It is
suitable for use both in adults and in children. Talk to your doctor before
receiving CASJOL 50 INJECTION if you have any liver problems or taking
immunosuppressants (such as ciclosporin or tacrolimus) as a precaution.

Inform your doctor before receiving CASJOL 50 INJECTION if you are pregnant,
think you may be pregnant or planning to become pregnant. CASJOL 50 INJECTION is
not recommended for use in breastfeeding women.

The most common side effects of receiving CASJOL 50 INJECTION are pain,
swelling, irritation and redness at the site of injection, headache, fast
heartbeat, flushing, fever, chills, shortness of breath, joint pain, leg pain,
back pain, changes in taste, constipation and dry mouth. Consult your doctor if
any of these side effect worsens.

Uses Of CASJOL 50 INJECTION

• Manage and manages serious fungal infections (such as invasive candidiasis, invasive aspergillosis, etc.)

How CASJOL 50 INJECTION Works

CASJOL 50 INJECTION is an antifungal medication. It acts by disru
fungal cell wall by blocking the actions of certain cellular proteins
(beta-glucan) which is essential for the fungal cell to maintain the rigid cell
structure. As a result, it makes the fungal cells weak and fragile and
eventually destroys them, thereby reducing the severity of infection and
managing it from spreading further.

How to use CASJOL 50 INJECTION

CASJOL 50 INJECTION will be given to you only by a doctor or a nurse into the
vein (intravenously). Your doctor will decide the correct dose and duration of
therapy for you depending upon your age, body weight and severity of infection.

Side Effects Of CASJOL 50 INJECTION

Common

• headache
• fast heartbeat
• flushing, low blood pressure
• increased liver enzymes
• skin rash, itching and redness, sweating
• injection site reactions (pain, inflammation, itching, redness, swelling)
• fever, chills
• low RBC, WBC count in blood
• low blood albumin levels
• low potassium levels in the blood
• shortness of breath
• nausea, vomiting, diarrhoea
• joint pain

Uncommon

• loss of appetite, swelling of body parts
• high blood sugar levels
• changes in blood calcium levels (high or low)
• low blood magnesium levels
• increase in acid level in the blood
• nervousness, disorientation, lack of sleep
• dizziness, numbness, shakiness, sleepiness
• changes in taste
• blurred vision, watery eyes, swollen eyelids, yellow eyes
• abnormal heart rate (fast or slow)
• high blood pressure, pain, redness and swelling of legs
• shortness of breath, chest tightness
• nasal congestion, cough, throat pain
• stomach pain, bloating, constipation, difficulty in swallowing, swollen abdomen
• dry mouth
• back pain, pain in arms or legs, bone pain, muscle pain, muscle weakness
• liver problems or kidney problems
• tiredness

Rare

Contact your doctor immediately if you experience any of the following side
effects:

• severe allergic reaction (such as skin rash, itching, swelling of the face, tongue, throat with difficulty in breathing or swallowing)
• cough and breathing difficulties
• severe skin reactions with blisters and peeling of skin

How To Manage Side Effects

!### Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals.
Drink plenty of fluids. Exercise more regularly. Consult your doctor if this
side effect bothers you.

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

!### Nausea And Vomiting

Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if
nausea worsens.

Warning & Precautions

!### Pregnancy

Consult your doctorThere is no proper information regarding the use of CASJOL 50 INJECTION in
pregnant women. Therefore, it should be used in pregnant women only if
considered necessary by the physician.

!### Breastfeeding

ContraindicatedCASJOL 50 INJECTION is not recommended for use in breastfeeding women.
Therefore, consult your doctor before receiving it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected
by CASJOL 50 INJECTION.

!### Liver

Use with CautionCASJOL 50 INJECTION should be used with caution in patients with liver problems.
Therefore, consult your doctor before receiving it.

!### Allergy

ContraindicatedTell your doctor before receiving CASJOL 50 INJECTION if you are allergic to
Caspofungin or to any other ingredients of this medicine.

Others

Use in pediatrics:

CASJOL 50 INJECTION should be used with caution in children and adolescents
(aged below 18 years). Therefore, consult your doctor before receiving it.

Use in geriatrics:

CASJOL 50 INJECTION can be used with caution in elderly patients. Therefore,
consult your doctor before receiving it.

Interactions

A. Drug-Drug interactions:

Before receiving CASJOL 50 INJECTION, inform your doctor if you are taking any
of the following medicines:

• cyclosporin or tacrolimus (medicines used to manage rejection of organ transplant or cause immune system suppression)
• efavirenz or nevirapine (used to manage HIV)
• phenytoin or carbamazepine (medicines used to manage seizures)
• dexamethasone (steroid medicine used to manage inflammations)
• rifampicin (an antibiotic used to manage tuberculosis)

Overdosage:

CASJOL 50 INJECTION will be given to you only by a doctor or nurse in a
hospital, and so it is unlikely to receive an overdose. However, if you are
worried that you may have been given too much of CASJOL 50 INJECTION, Contact
your doctor immediately.

Synopsis

Drug	:	Caspofungin
Pharmacological Category	:	Echinocandins
Therapeutic Indication	:	Fungal infections
Dosage Forms	:	Injection

More Information

• Keep CASJOL 50 INJECTION out of reach of children
• Store CASJOL 50 INJECTION in a refrigerator between 2-8°C

FAQs About CASJOL 50 INJECTION

Q: What isCASJOL 50 INJECTIONused for?

A: CASJOL 50 INJECTION is used to manage serious fungal infections of the blood,
heart, brain, eyes, bones, nose, sinuses, lungs and other parts of the body
(such as invasive candidiasis, invasive aspergillosis, etc.). It can also be
used to manage fungal infections during high-risk conditions such as after a
surgery or chemotherapy and in patients who recently underwent an organ
transplantation or having a weak immune system.

Q: Is CASJOL 50 INJECTION an antibiotic?

A: No. CASJOL 50 INJECTION is an antifungal medicine that acts by making the
fungal cells fragile and terminating their growth. Thereby it stops the spread
of infection and allows the natural defense mech
totally eradicate the infection.

Q: DoesCASJOL 50 INJECTION affect liver?

A: CASJOL 50 INJECTION may unusually cause decreased bile flow, enlarged liver,
liver disorder or injury, and yellowing of the skin and whites of the eyes.
Therefore, caution should be taken if you have ever had liver problems.
Therefore, consult your doctor before receiving it.

Q: What are the side effects of CASJOL 50 INJECTION?

A: The most common side effects of receiving CASJOL 50 INJECTION are pain,
swelling, irritation and redness at the site of injection, headache, fast
heartbeat, flushing, fever, chills, shortness of breath, joint pain, leg pain,
back pain, changes in taste, constipation and dry mouth. Consult your doctor if
any of these side effect worsens.

Q: Can a person taking CASJOL 50 INJECTION breastfeed?

A: CASJOL 50 INJECTION is not recommended for use in breastfeeding women.
Therefore, consult your doctor before receiving it.

Q: How long should I receive CASJOL 50 INJECTION?

A: You need to receive therapy with CASJOL 50 INJECTION for the stipulated
duration prescribed by your doctor. Your doctor will decide the correct dose and
duration of therapy for you depending upon your age, body weight and disease
condition.

Q: Is CASJOL 50 INJECTION safe?

A: CASJOL 50 INJECTION is safe at doses prescribed by the physician. Therefore,
do not alter the dose of CASJOL 50 INJECTION without consulting your doctor.

Q: Can I stop receiving CASJOL 50 INJECTION without consulting your doctor?

A: No. You should not stop receiving CASJOL 50 INJECTION without consulting your
doctor as it may reduce its effectiveness. Therefore, receive CASJOL 50
INJECTION for the stipulated duration recommended by your doctor to achieve
maximum results.

Useful Diagnostic Tests

• Antigen Testing
• Serological Testing
• PCR-Based Assays